libera/##covid-19/ Saturday, 2020-10-24

de-factoso if a cell gets instructed to produce the antigen s-protein it obviously would produce an immune reaction by exposing those antigens on its surface. why would the immune response let such a cell alive if it would assume it does something worth producing antibodies?00:22
BrainstormUpdates for US: +10510 cases (now 8.7 million), +134 deaths (now 229160) since 2 hours ago — Canada: +787 cases (now 211973), +9 deaths (now 9902) since 2 hours ago00:23
de-factoi am pretty sure such cells will get killed and removed so also the mRNA recipe for the s-protein inside of them00:23
de-factoi mean if the immune system tries to neutralize the virions with the s-protein, why would it let the factory of them (the infected cell) alive instead of stopping the production?00:38
kiwi_52de-facto you're in med ?00:40
de-factonope00:40
kiwi_52now you are00:42
de-factohehe i could have said anything, you would not be able to verify anyhow00:44
kiwi_52indeed00:44
kiwi_52my knowledge is sorely lacking00:44
kiwi_52I have all the books on the planet at my reach and yet00:45
de-factobut i think its logical that the immune response would target the factory of the invader when the natural selection optimized for the most efficient removal00:45
de-factoan i think that is what killer cells do00:46
BrainstormNew from The Lancet: [Correspondence] Misuse of SARS-CoV-2 testing in symptomatic health-care staff in the UK – Authors' reply: We thank Bernard Freudenthal for his response to our previous Correspondence.1 We agree that use of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing among health-care workers (HCWs) solely to reduce [... want %more?] → https://is.gd/JZ2iEv01:05
BrainstormUpdates for US: +7115 cases (now 8.7 million), +65 deaths (now 229225) since 49 minutes ago01:08
CoronaBot04/r/covid19: FDA authorises restart of the COVID-19 AZD1222 vaccine US Phase III trial (81 votes) | https://www.astrazeneca.com/content/astraz/media-centre/press-releases/2020/fda-authorises-restart-of-the-covid-19-azd1222-vaccine-us-phase-iii-trial.html | https://redd.it/jgufcp01:16
de-factothere its on again01:26
LjLde-facto, only needed a small negotiation involving half a billion bucks01:53
de-factowhut?01:57
LjLde-facto, afaik the CDC or the White House, well America anyway, struck a deal with AstraZeneca to get another thing they're developing, a monoclonal antibody [cocktail?] that could potentially provide prophylactic immunity for 6-12 months (so if things go as well as they plan, it's effectively similar to a vaccine, without technically being one), and they'd inject about $500m into the company for it02:06
LjLi don't know if that's going to be the thing that they'll unveil at november and that Trump can use to say "here! i gave you a vaccine before the elections! behold!" although that was my hypothesis02:07
LjLbut anyway, it look place while the vaccine trial was on hold in the US02:07
LjLso i call that suspicious02:07
de-factopoliticizing science again02:07
LjLyeah02:07
de-factohmm that really sounds suspicious indeed02:07
LjLi'll see if i find the article where i read about it02:08
LjLde-facto, https://medicalxpress.com/news/2020-10-funding-covid-antibody-trial-phase.html02:09
tinwhiskersI just saw a link yesterday I think that said something about monoclonal antibodies not proving very successful, but not sure which one they were talking about.02:09
tinwhiskersI was a bit surprised, tbh02:09
tinwhiskersI mean, the whole point is you find an effective antibody then produce it artificially so you'd think it would be effective.02:10
de-factothats interesting indeed thanks for the link02:11
de-factobinding strength may vary i guess02:11
de-factolike how well it binds to the spikes and how sticky it will remain there02:11
de-factoalso i think they use a cocktail to have several types of binding categories (epitopes?) just in case there may be escape mutations to one of them so the others still might catch those to nullify its selective advantage02:14
tinwhiskersahh02:15
ryoumathat is forward thinking02:21
ryoumawill the vaccines do that too?02:22
ryoumaor could that be dangerous02:22
ryoumae.g. by risking autoimmunity02:22
LjLnot quite the same thing, but there's a vaccine or two that are using a cocktail of two *different* adenoviruses in case you're immune to one of them02:23
BrainstormUpdates for US: +7739 cases (now 8.7 million), +54 deaths (now 229279) since an hour ago — Canada: +469 cases (now 212442), +2 deaths (now 9904) since 2 hours ago — France: +458 cases (now 1.0 million) since 6 hours ago — Netherlands: +9 deaths (now 6973) since 11 hours ago02:23
de-factoi think the sputnik V is Ad26 primer and Ad5 booster02:24
LjLi didn't know that, but i think i had in mind ones where it's actually mixed within the same one02:25
LjLsomewhere on Lowe's blog02:25
de-factocould very well be indeed, would make sense i guess, just to ensure one comes through02:25
ryoumawhat are primer and booster in the context of vaccines?02:25
de-factofirst and second shot02:25
de-factolike with some weeks delay in between02:25
LjLsome vaccines only need one but it looks with COVID's immunity not looking all that long-lasting, a booster may well be a necessity02:26
LjLi think most vaccines being developed (not all though) include a booster dose02:26
de-factoi think the Oxford has it too, at least Timewarp said he is waiting for a second shot but now the trial is on hold (well its back now)02:26
ryoumado we know the length of immunity in toto?  including t cells?02:27
LjLde-facto, i read somewhere that people waiting for a booster shot would get it anyway regardless of the hold02:27
de-factoi guess we dont until time will tell?02:27
LjLryouma, not really02:27
LjLwe don't even know whether T cells are providing any immunity02:27
LjLit's something that may prove true, or not02:27
LjLright now what we do have is (few) people already re-infected02:28
LjLand an article that popped up recently about "why some people may not mount an effective immune response" which you may want to check out02:28
de-factoLjL, oh did not know that interesting, how can they give it anyhow if the trial was on hold? i mean would that not be the whole purpose of the hold to stop until its known that they could proceed?02:28
de-factoryouma, i think some measurements can be done like ELISA antibody tests or also to provoke T-cells with the antigen (the spike protein) and see how "angry" they get by giving out their chemical signals02:29
de-factoyet i guess thats not too easy to do, needs quite some skills02:30
LjLokay i can't find the article i meant but i found one about the same thing https://www.sciencemag.org/news/2020/08/coronavirus-may-shut-down-immune-system-s-vital-classrooms02:30
LjLgerminal centers were involved02:31
LjLde-facto, i don't know, i may just be wrong, but i guess a rationale is if you are not getting new participants, fine, you can still get them later when the hold is lifted... but if you skip the booster shots for the participants you already have, you fuck up the entire trial02:32
de-factoyeah that would make sense if they can assume that the hold is due to something that was directly caused by the first shot and is unlikely to develop at later stage when participants are ready for second booster shot02:37
de-factointeresting that germinal center absence in COVID, could that be causative for fast decaying natural immunity and give hope that vaccine induced immunity potentially may last longer if they would be able to somehow involve those germinal centers in the vaccination process?02:39
de-factoi dont even know that they really are02:39
LjLme neither02:39
LjLthe other article said something like, for some reasons that are unknown at this time (some defect in those people's germinal centers?) those centers get *destroyed* in severe COVID infections02:40
LjLbut with vaccines, since there is no virus actively replicating, it would be unlikely they'd be destroyed02:40
LjLsooooo let's hope02:40
LjLnot much left than hope really, SNAFU02:40
de-factoso its not like their fuction is not triggered or suppressed but rather that they are destroyed by the virus?02:41
de-factothat sounds nasty :(02:41
LjLthat's how the article read but keep in mind i don't even remember where the article was on :P02:44
LjLwhatever sciencemag says is probably more reliable than whatever i originally read02:44
ryoumawhat do germinal centers do?  i thought b cells just gathered in lymph nodes and did their replication and gene shuffling02:44
ryoumathe article did not say02:44
de-factoi vaguely remember there was one type of macrophage or lymph cells that was infected by the virus directly and we discussed about if that could potentially be another transport for it02:46
de-factobut i dont remember details anymore02:46
ryoumawhy is europe bad?02:49
de-factoyeah ACE2-expressing CD68+CD169+ macrophages as potential "trojan horses"?02:50
LjLwhy europe bad, your guess is as good as mine, but i'd say it was bound to become "bad" again to some extent (imperial college paper back then described how there would be a worse second wave after a lockdown). which imo doesn't mean the lockdowns were a bad idea, just that we didn't make good use of the time they bought us02:51
LjLand now, nobody wants to enter a full lockdown again, so for as long as they refuse, it'll keep getting very bad02:52
de-factoi think it partly is due to the "prevention paradox" people got used to low prevalence situation in summer and are fatigue of the pandemic and its requirements for containment now in high prevalence times02:53
ryoumasome study said americans are wearing masks02:53
ryoumawhat about eu?02:53
LjLmasks are mandatory here, most people are wearing them02:54
LjLi don't know how adhered to it is in the rest of italy, but in milan most people *are* wearing them, and yet we're the worst city right now02:54
ryoumaagain02:55
LjLnot again02:55
LjLLombardy was the worst region, but within it, Milan was relatively spared the first time02:55
ryoumalombardy?02:55
ryoumaok02:55
LjLrelatively, of course, since we are the big city in the middle of it02:55
LjLbut before, we had lower prevalence than the rest of Lombardy02:55
LjLnow it's the reverse, about half the cases in all Lombardy are from Milan02:56
LjLdespite Milan only making up 3 million out of around 10 million people in Lombardy02:56
LjLin fact there are rumors of a Milan-specific lockdown being a possibility, not sure how substantiated02:56
ryoumaless urban first then urban?02:56
ryoumain the us it is said it is urban first then less urban02:57
LjLit seems kind of the reverse here02:57
LjLeven in Bergamo, i think the most badly hit municipalities were not the city of Bergamo itself02:58
LjLwhile *now*, Milan, Naples, Rome, Turin, are all badly hit, and perhaps to a lesser extent Venice, Florence02:58
LjLso it's hitting all the big (Italy-size-big) cities now02:58
LjLhttps://lab24.ilsole24ore.com/coronavirus/en/#box_303:00
de-factodamn ist steeper than the first peak it looks03:10
de-factoi still dont get why they use cummulative graphs though03:10
LjLde-facto, well you have to adjust for the fact we had less testing so it couldn't be as steep even if it was in reality03:17
LjLbut i suspect it really is steeper anyway03:17
LjLyou can get non-cumulative in other graphs of theirs, but not that one03:17
LjLlike, the very first graph (well, the very second graph, it being the non-cumulative version of the first)03:17
de-factoyeah testing may vary indeed, thats why i was for that 1% random sampling idea03:18
de-factoyou never really know how much comes from testing, how much from targeting and how much from infection otherwise03:18
LjLyou know how full the hospitals are03:19
de-factohow full are they there?03:19
LjLde-facto, ICUs are at 20%, which is a lot when things are growing exponentially, but the regular non-ICU beds are pretty much already all taken03:20
LjLin the critical areas, anyway, Milan etc03:20
LjLand perhaps also critically, they've given up on contact tracing entirely in milan03:21
LjLthey cannot keep up with testing at all03:21
de-factooh thats bad they should continue tracing at all costs, maybe alter strategy to cluster targeting but not give up03:22
de-factoICU are at 20% of what?03:22
LjLcapacity03:22
de-factoso 20% of all ICU beds are still unoccupied? usually they are not exclusively used for COVID though, e.g. in germany they are half full also but only a little of that is covid03:24
LjLde-facto, no, 20% are occupied. right now the critical part is normal beds03:26
LjLbut... we know that a certain amount of the normal beds will need ICU later, so it's just a matter of time for ICU to also be at capacity03:26
de-factooh so there is 5x more space for covid in icus available then?03:27
LjLi believe so, although i don't know if they're counting just *beds and equipment* or also the personnel needed for running them, since as i told you, that's what's missing the most03:27
LjLbut people who simply need to be in a hospital bed with oxygen and monitoring... are no longer finding space03:28
de-factodamn thats not good but still at least ICUs are not full yet, so there still is time to avoid that from happening 03:29
de-factobtw this is the situation for germany, they have a register for that https://www.intensivregister.de/#/intensivregister?tab=kartenansicht03:29
ryouma20% ic seems low in the context of az which i guess having so many private hospitals tries to keep utilization high or ... it was propaganda that 80+ percent was not bad.03:29
de-factoroughly 1118 in ICUs 484 on ventilator but both on exponential raise03:30
de-factoso currently COVID occupies 14% of available ICU capacity in germany03:32
de-factobut as i said on exponential raise unfortunately03:32
LjLryouma, keep in mind we created a LOT of beds and bought a LOT of ventilators between spring and now03:32
LjLand created hospitals from places that weren't hospitals before03:32
LjLmain problem now is doctors don't grow on trees03:32
ryoumayou can ship them around i hope03:34
LjL%tr <it In Italia, alla data del 31 dicembre 2019, prima della pandemia di coronavirus, i posti letto in terapia intensiva erano 5.179. A causa dell’emergenza sanitaria sono stati creati nuovi posti letto aggiuntivi: il decreto Rilancio ne ha programmati 3.553, molti dei quali sono in fase di completamento. Il totale, nel giro di poco tempo, dovrebbe arrivare a 8.732. Per ora, secondo gli ultimi dati disponibili i posti letto effettivi sono 6.628, ma i03:34
LjLn continuo aumento03:34
psiborg1The covid-19 equipment was bought in 2018 according to worldbank logs which were altered in september03:34
BrainstormLjL, Italian to English: In Italy, as of December 31, 2019, before the coronavirus pandemic, there were 5,179 beds in intensive care. Due to the health emergency, new additional beds have been created: the Relaunch decree has planned 3,553, many of which are being completed. The total is expected to reach 8,732 in a short time. For now, according to the latest available data, [... want %more?]03:34
LjLpsiborg1, oh lord i'm not in the mood for conspiracy theorists. which covid-19 equipment are you even talking about? which country?03:35
psiborg1Several countries - Ive mentioned a fact youve called fact theory03:36
LjL%tr In Lombardia i posti letto in terapia intensiva pre-Covid erano 861. Con il decreto Rilancio n. 34/2020 sono stati programmati altri 585 posti letto. Alla data del 9 ottobre, contando quelli già stabilizzati del piano Arcuri, il numero dei posti letto è arrivato a 983.03:36
LjL%tr <it In Lombardia i posti letto in terapia intensiva pre-Covid erano 861. Con il decreto Rilancio n. 34/2020 sono stati programmati altri 585 posti letto. Alla data del 9 ottobre, contando quelli già stabilizzati del piano Arcuri, il numero dei posti letto è arrivato a 983.03:36
BrainstormLjL, English to English: In Lombardia i posti letto in terapia intensiva pre-Covid erano 861. Con il decreto Rilancio n. 34/2020 sono stati programmati altri 585 posti letto. Alla data del 9 ottobre, contando quelli già stabilizzati del piano Arcuri, il numero dei posti letto è arrivato a 983. (Google)03:36
BrainstormLjL, Italian to English: In Lombardy there were 861 beds in pre-Covid intensive care. A further 585 beds have been planned with The Relaunch Decree No. 34/2020. As of 9 October, counting those already stabilized in the Arcuri plan, the number of beds has reached 983. (MyMemory) [... want %more?]03:37
LjLthis doesn't sound impressive...03:37
LjLpsiborg1, okay evidence of this fact please?03:37
ryoumai wnt to know why japan has so many more beds per population than many more countries.  why is there such a difference.03:37
ryouma(regular beds presumably)03:37
LjLryouma, Germany is also pretty high03:38
LjLalthough i confuse now regular ones with ICU ones, numbers i've read months ago are getting hazy03:38
psiborg1Like hell your getting evidence. Its on archive.org but facts are a conspiracy theory? Youre a loon03:38
LjLand you're quieted03:38
ryoumagermany is best for icu https://en.wikipedia.org/wiki/List_of_countries_by_hospital_beds03:39
LjLif you're asked for evidence for a claim that is at least controversial, provide it. if it's on archive.org, provide the relevant URLs. also don't call people names.03:40
LjLthis for the next time you get unquieted, which according to my current mood is "not soon"03:40
de-factoits not such a big difference anyhow, in an exponential increase it only is worth a small duration in time, what really does matter is to use that window in time to regain control about the cause and that is prevent infections03:43
ryoumafor a pandemic like this, yes03:44
LjLde-facto, well gov.it doesn't want to full lockdown, and has only taken meek measures and told regions "eeeeeh you can do more things if you want, maybe"03:44
LjLso a full lockdown will probably only happen after the useful limit has already been passed03:45
de-factoexactly as in germany i am quite unhappy with this03:45
LjLand curfews are a bit silly03:45
LjLat least as implemented in italy03:45
LjLso i think they will do more bad than good03:45
de-factothey tried to force close of all nightlife at 23:00 but courts directly nullified that in Berlin afaik, not sure about other states03:46
de-factosome things i just cant understand even when i try really hard03:47
LjLhmm courts have also undone things in Spain03:47
LjLi mean some measures are probably quite unconstitutional03:48
LjLone would just have hoped that the courts would declare them so *after* this thing ends03:48
de-factoyes its good that they are able to do that, but i dont understand the rationale behind their actions03:48
LjLthe curfew at 23:00 here has meant that Naples is rioting tonight03:49
LjLand also, nightlife will just be "compressed" so that it can end at 23:0003:49
LjLwhich will mean... MORE people packed together until 23:0003:49
LjLi could understand a curfew at 21, that would pretty much prevent it03:49
LjLbuuuut that wasn't okay with restaurants so they didn't do it03:49
de-factomaybe they should force close all such locations and prohibit alcohol completely03:49
LjLalcohol consumption is prohibited in Lombardy after 18:00 unless you're seated03:50
LjLwhich is also a bit ridiculous03:50
LjLyou cannot buy alcohol after 18:00 in supermarkets03:50
LjLbut if you're seated in a pub? yeah, sure, you can03:50
de-factoyeah and if people could buy it they would just do party at home then instead03:50
de-factoeven more difficult to control03:50
LjLand i bet many pubs don't really *care* whether you're seated03:50
de-factoindeed03:51
LjLpubs have actually been telling people not to take photographs with their phones because if they ended up on social media police could close the place03:51
de-factodamn there too? i heard same story about clubs requiring their guest to tape phones for that reason03:52
LjLokay no i said "pubs" generically but i don't know which kind of locations have been shown to do this03:53
de-factoi thought that is either completely nuts or maybe also a story to denunciate them 03:54
LjLi didn't heard they actually asked guests to take their cameras though, "just" please don't take pictures and post them on social media03:54
de-factoanyhow in my opinion they should be force closed and given the rent so they can somewhat survive03:54
de-factoits just not the time for such things at all03:54
LjLde-facto, the PM quite clearly stated yes, we'll help business, but we can't give "money like it's raining, like last spring"03:55
LjLso if their idea of giving money like it's raining is last spring, well03:55
LjLi don't expect much money coming03:55
de-factowell if incidence keeps raising like that it will be much more expensive than only the rent of a few clubs03:56
LjLalso they don't want to take the money from https://en.wikipedia.org/wiki/European_Stability_Mechanism because it's "stigmatized"03:56
de-factowhats the meaning of "stigmatized" in that regard?03:57
de-factodoes it require them to sell their soul?03:57
LjLthat it's associated with the money being given to Greece in 2008, which many people in the EU viewed as undeserved03:57
de-factoah i see03:58
LjLalso it comes with a set of strict requirements (basically, your government stops governing and EU people start governing most financial things instead), but my understanding is that in this case after some negotiations those requirements were waived, and instead, it was agreed that the money could only be used for healthcare improvements. which sounds fine to me. but mainly the Five Star party still don't want to take it03:58
de-factowell at last if they see it as option when they really do need it it may provide some sort of safety hopefully04:00
de-factoto be honest i hoped for a more coordinated containment approach in Europe, like that they would agree on a common strategy and help out each others more04:02
de-factobut now i see that they are not even able to agree with the federal states inside of germany04:02
de-factoor only agree on the very least common denominator, not nearly enough at all04:03
LjLde-facto, when the ICUs in Lombardy were full, they only managed to move a ridiculously small amount of patients to ICUs in other regions. but as a matter of fact, a considerable proportion was transferred to Germany instead. my understanding is that the same mechanism called "cross"-something was used for the inter-region transfers as for the transfers to germany04:03
LjLso you could see that as the EU working as a country i suppose, but also not very well04:04
BrainstormNew from r/WorldNews: worldnews: 'It is terrifying': Europe braces for lengthy battle with COVID → https://is.gd/HG7wWC04:04
de-factoit would be a chance to improve coordination and organization as well as solidarity and agreement for installing well designed biosafety systems and containment strategies04:04
de-factoyes there is hope for such mechanisms but my hope would be that this crisis would be used to form more strong bonds and build upon those very early collaborations to form something more stable and useful to all participants04:06
LjLtinwhiskers, you there?04:06
tinwhiskersyep04:06
LjLtinwhiskers, can you have a look at ##coronalinks?04:06
de-factoits a rule of network theory, in a network with n nodes the network itself is worth n^2 to each of its nodes04:07
LjLde-facto, maybe the EU did things in the background that we didn't see, but, *because* we didn't see them... i think most people now are going to consider the EU as less close to them than they thought it was (and many were already thinking it was too far removed)04:07
tinwhiskersLjL: sorted?04:08
LjLtinwhiskers, probably!04:08
tinwhiskersheh. ok04:08
LjLtinwhiskers, i'd have pointed out to him that it just isn't a discussion channel, but then he'd have been in ##coronavirus just getting banned one more time, soooo04:08
LjL(not sure how he managed to find one but not the other)04:09
LjLtinwhiskers, heh, if he PMs you enjoy trying to get the actual archive.org links that prove his claim. i mean, maybe he's actually got something interesting on his hands and is just too rude to convey it04:10
tinwhiskersthat's not impossible04:11
LjLoh, he *was* in -vox, yet said nothing there04:11
LjLfun04:11
CoronaBot04/r/coronavirus: U.S. reports more than 83,000 new coronavirus cases, biggest one-day increase on record (10366 votes) | https://twitter.com/bnodesk/status/1319774472250032128?s=21 | https://redd.it/jgxs6y04:23
BrainstormUpdates for Belgium: +17568 cases (now 287700), +70 deaths (now 10658) since a day ago — France: +10508 cases (now 1.1 million) since 2 hours ago — US: +1808 cases (now 8.7 million), +5 deaths (now 229284) since 2 hours ago — Netherlands: +565 cases (now 272966), +11 deaths (now 6984) since 2 hours ago04:24
LjLalways good news from belgium04:24
LjLde-facto, another article explained more clearly: 15% of ICU in Italy are taken up by COVID patients, but the 100% that is taken from includes beds hosting non-COVID patients. the government has set aside 30% of all ICU as "dedicated to COVID", so 15% being taken means that actually 50% of the ones "dedicated to COVID" are taken up04:31
LjLthat is better of course in some regions, and worse in others04:31
LjLthe worst region has 28% occupied04:31
LjLLombardy is around 15%04:31
de-factoin understand, its like that in all countries, roughly half or even more are taken by usual patients but then covid usage of icus is on fast raise but other causes also still happen (e.g. accidents or such)04:33
de-factoi think italy and germany still may be behind other countries a few weks04:35
de-factoweeks04:35
BrainstormNew from The Indian Express: World: It Was the Worst Day of the Pandemic. Until Now. → https://is.gd/Sbztxo04:38
BrainstormNew from r/WorldNews: worldnews: Thailand’s playboy king secretly rushed to hospital for 2am Covid test after bodyguard tests positive → https://is.gd/vXoA7W05:22
LjLryouma, de-facto: i found the article i had originally read that involves germinal centers https://www.virology.ws/2020/10/22/an-explanation-for-the-poor-short-lived-antibodies-produced-during-serious-sars-cov-2-infection/05:31
LjLit explains in a bit more detail although it was a bit over my head anyway05:31
de-factonice, thank you :)05:37
de-factoi think i am gonna have to read the paper tomorrow though05:37
LjLyeah in particular it's the paper that it links to, https://www.cell.com/cell/pdf/S0092-8674(20)31067-9.pdf05:38
LjL(which isn't loading for me right now)05:38
de-factowget loads it though05:38
de-factohad the same issue05:38
ryoumaLjL: thanks that helps (only read the virology one).  my tnf alpha has tested at 10.5.  i hope chronic high levels do not affect germinal centers.05:43
LjLi really have no idea, this gets too technical for me05:44
ryoumathe nature paper it links to as a possible biomarker for severe covid says il-6 and tnf alpha05:45
LjLwell aren't you always quite the lucky one05:45
ryoumamy il-6 is 7.005:45
ryoumai also wonder if allergies (extremely dusty, moldy environment) raise both of those05:47
ryoumai also wonder if long covid has been tested for those two plus il-805:49
ryoumaand if they are high in a subset05:49
LjL%papsers il-8 long covid05:50
LjL%papers il-8 long covid05:50
BrainstormLjL, 10 papers: Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a Long-term Care Facility during Covid-19 Outbreak by Peter Sabaka et al, published on 2020-07-13 at [u'https://doi.org/10.21203/rs.3.rs-42503/v2', u'https://www.researchsquare.com/article/rs-42503/v2.pdf'] [... want %more?]05:50
LjL%papers il-6 "long covid"05:50
BrainstormLjL: An error occurred while searching.05:50
LjL%papers tnf alpha05:50
BrainstormLjL, 9 papers: Observational Study of Metformin and Risk of Mortality in Patients Hospitalized with Covid-19 by Carolyn Bramante et al, published on 2020-06-20 at http://medrxiv.org/cgi/content/short/2020.06.19.20135095 [... want %more?]05:50
LjL%more05:50
BrainstormLjL, [...] absenteeism is inappropriate. Freudenthal correctly outlines the risks, posed by false-negative results, of advising potentially infectious HCWs to return to work. Moreover, staffing levels are currently far less problematic within UK health-care settings than during the peak of the pandemic. → https://paste.ee/p/DACee05:50
BrainstormLjL, [...] The Endothelial Dysfunction and Pyroptosis Driving the SARS-CoV-2 Immune-Thrombosis by Seigo Nagashima et al, published on 2020-06-19 at http://medrxiv.org/cgi/content/short/2020.06.17.20133124 [...] → https://paste.ee/p/B2WsS05:50
ryouma(i haven't figured out how to get pdfs to display in reverse video or with a non-white bg, and can't look at them at night)05:51
de-factoryouma, if you are using Evince (the Gnome standard viewer) try Ctrl + I (for invert)05:56
BrainstormNew from r/WorldNews: worldnews: NAPLES: riots against the lockdown. Violent clashes against the police with the cry of "freedom". → https://is.gd/OKwfgS05:57
LjLmorons05:57
LjLbut also, flagged, article is not in english06:00
ryoumade-facto: thanks.  i do use evince (without gnome), and could in principle close eyes really tightly while it comes up and then c-l and hope that it works, but i was trying to find somthing that would make it default.06:05
de-factoi think it remembers it (either per pdf or in general)06:09
de-factodamn damn damn06:09
de-facto+14714 new infections in Germany thats a LOT :(((06:10
de-factoalmost all of NRW, BW and BY are red06:10
de-factooh my where is the lockdown06:10
de-factowe need it right now, things are completely out of control06:11
de-factoactually we should be in lockdown from last Sunday already, but where is it??!!06:14
Jigsy%cases UK06:17
BrainstormJigsy: In United Kingdom, there have been 830998 confirmed cases (1.3% of the population) and 45712 deaths (5.5% of cases) as of 12 hours ago. 31.2 million tests were performed (2.7% positive). See https://offloop.net/covid19/?default=United%20Kingdom for time series data.06:18
ryoumahmm us is twice as bad as eu.  i thought they were about the same.06:18
BrainstormNew from r/WorldNews: worldnews: Fears mount as South Korea probes cause behind 36 people's deaths after flu vaccination → https://is.gd/vAwUnP06:30
BrainstormNew from r/WorldNews: worldnews: 'It is terrifying': Europe braces for lengthy battle with COVID → https://is.gd/VlnnSx06:53
BrainstormNew from r/WorldNews: worldnews: Worldwide coronavirus cases cross 41.99 million, death toll at 1,140,145 → https://is.gd/NhguHH07:04
BrainstormNew from r/WorldNews: worldnews: North Korea says China dust could spread COVID-19, warns people to stay inside → https://is.gd/mEFZZV07:15
BrainstormNew from r/WorldNews: worldnews: Coronavirus updates: AstraZeneca vaccine trials resume in US; more than 71K daily cases in US, first time since July → https://is.gd/OeGyBr07:50
BrainstormUpdates for Lombardy, Italy: +4916 cases (now 143645), +7 deaths (now 17159) since a day ago — France: +10667 cases (now 1.1 million), +14 deaths (now 34522) since 3 hours ago — Netherlands: +2508 cases (now 275474), +11 deaths (now 6995) since 3 hours ago — United Kingdom: +1506 cases (now 832504) since 14 hours ago07:55
derpadmin%cases canada08:37
Brainstormderpadmin: In Canada, there have been 212962 confirmed cases (0.6% of the population) and 9913 deaths (4.7% of cases) as of 47 minutes ago. 9.5 million tests were performed (2.2% positive). Fatality can be broadly expected to lie between 1.2% (assuming prevalence as in tests) and less than 5.2% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Canada for time series data.08:37
BrainstormNew from The Indian Express: World: US election wrap, October 24: White House, US Capitol prepare for Inauguration of new president amid pandemic → https://is.gd/5Au8e008:58
BrainstormNew from The Indian Express: World: WHO’s Tedros says countries on “dangerous track” in pandemic → https://is.gd/rvyahL09:09
Meowerlmfao09:44
Meower##chat "free speech meme" and "asshole"09:44
Meowernot compatible because it was assholes that wouldn't let me speak freely about things that weren't considered in the "asshole" category 09:45
Meower:D09:45
Meower#ircdoesntcareaboutblacklives09:45
Meower#unlesstheyarehoes09:45
Meowerhey there09:46
Meowerare you done with the black hoe that was just controlling some of the mods here or the brothers dealing her around the gang?09:46
Meoweras it seems to be no true female unity here09:47
Meowerjust more like a competition between females of which one gets the males the hardest at the thought of them09:47
Meowerwhich is kind of gross09:47
Meowerand not saying that black lives matter at all09:47
Meower:D09:47
Meoweror are you done with the white racist one that hates all women of color because they have better proportions statistically?09:48
kiwi_52relativism 10109:51
koleno159hi10:01
kiwi_52o/10:03
Meoweroh10:05
BrainstormUpdates for US: +911 cases (now 8.7 million), +8 deaths (now 229292) since 6 hours ago10:20
BrainstormNew from The Indian Express: World: Austria’s postal service is printing Covid-themed stamps on toilet paper → https://is.gd/zGQITL10:28
drytrumpet2plot Italy differemce confirmed cases  https://is.gd/8j3LAr510:33
drytrumpet2O.K again then, plot Italy, difference confirmed cases  https://svgur.com/s/Qr710:39
Meowerhuh10:45
BrainstormNew from r/WorldNews: worldnews: Poland’s President Duda tests positive for coronavirus → https://is.gd/UCyCcv10:50
BrainstormNew from Medical Xpress: Biden pledges free Covid vaccine for 'everyone' in US if elected: Democrat Joe Biden said Friday that if elected president he would mandate COVID-19 vaccines be free for all Americans, part of a national strategy to "get ahead" of the coronavirus. → https://is.gd/FyzgwL11:02
BrainstormNew from Gazzetta Ufficiale italiana: MINISTERO DELLE INFRASTRUTTURE E DEI TRASPORTI - DECRETO 13 ottobre 2020: Decadenza dell'autorizzazione  rilasciata  all'organismo  INNOVHUB  -Stazioni sperimentali per  l'industria  (Area  stazione  sperimentalecarta, cartoni e paste per carta - SSCCP) in Milano, con  conseguentecancellazione dall'elenco degli [... want %more?] → https://is.gd/EzKluP12:10
bolovanosola12:43
bolovanosde-facto, btw - ad yesterdays need for proper test picking most likely worsening patient - https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30402-3/fulltext12:55
bolovanosit has been 2 weeks since publish so maybe it was already here12:58
CoronaBot04/r/covid19: PTSD symptoms among health workers and public service providers during the COVID-19 outbreak (80 votes) | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0241032 | https://redd.it/jh30z713:09
BrainstormNew from The Indian Express: World: Czech health minister set to resign after violating his own Covid guidelines → https://is.gd/YVyxUS13:18
bolovanoshttps://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30402-3/fulltext13:19
bolovanosstrange bot does not take it13:20
bolovanosmaybe it was already here13:20
bolovanoswe are in press even in india...13:22
BrainstormUpdates for US: +4257 cases (now 8.8 million), +25 deaths (now 229317) since 3 hours ago13:36
BrainstormNew from The Indian Express: World: School children seem unlikely to fuel Coronavirus surges, scientists say → https://is.gd/kWyHDd14:15
CoronaBot04/r/covid19: Smell and taste changes are early indicators of the COVID-19 pandemic and political decision effectiveness (80 votes) | https://www.nature.com/articles/s41467-020-18963-y?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=NGMT_USG_JC01_GL_NRJournals | https://redd.it/jh10a314:47
BrainstormUpdates for US: +3448 cases (now 8.8 million), +46 deaths (now 229363) since an hour ago15:22
BrainstormNew from The Indian Express: World: US sets coronavirus infection record; deaths near 224,000 → https://is.gd/GqsHXz15:45
BrainstormNew from r/Coronavirus: Coronavirus: Daily Discussion Post - October 24 | Questions, images, videos, comments, unconfirmed reports, theories, suggestions → https://is.gd/Zd8tGl16:08
BrainstormNew from CNBC Health: U.S. reports more than 83,000 coronavirus cases, record daily total, as experts warn of difficult winter: The U.S. reported more than 83,700 new Covid-19 cases on Friday, passing the last record seen in mid-July, according to data compiled by Johns Hopkins University. → https://is.gd/bUyTHg16:30
BrainstormNew from r/WorldNews: worldnews: Poland president tests positive for COVID-19 → https://is.gd/uJsqfn17:15
BrainstormUpdates for Italy: +19640 cases (now 504509), +151 deaths (now 37210) since a day ago — US: +8861 cases (now 8.8 million), +134 deaths (now 229497) since 2 hours ago — Netherlands: +5578 cases (now 281052), +32 deaths (now 7019) since 9 hours ago17:22
BrainstormUpdates for US: +347 cases (now 8.8 million) since 18 minutes ago17:37
kreyren> 2020 novel bunyavirus outbreak https://en.wikipedia.org/wiki/2020_novel_bunyavirus_outbreak -- What?!17:59
kreyrenseems like fake though18:00
generalike Chikken Gunya18:00
CoronaBot04/r/coronavirus: Dr. Fauci says: ‘If people are not wearing masks, then maybe we should be mandating,’ as new U.S. COVID-19 cases hit 85,000 (10281 votes) | https://www.marketwatch.com/story/dr-fauci-says-if-people-are-not-wearing-masks-then-maybe-we-should-be-mandating-as-new-us-covid-19-cases-hit-85000-2020-10-24 | https://redd.it/jh7d3k18:06
BrainstormUpdates for United Kingdom: +21506 cases (now 854010) since 10 hours ago — US: +1736 cases (now 8.8 million), +24 deaths (now 229521) since 35 minutes ago — Canada: +765 cases (now 213727), +12 deaths (now 9920) since 10 hours ago18:07
LjLkreyren: https://lymediseaseassociation.org/news/sfts-virus-outbreak-in-china-from-ticks/18:09
kreyrenLjL, thanks18:10
kreyrenLjL, they said that 37 people got it and 7 people died? so that's 2.59% death rate so far?18:14
kreyrenany info about the patients?18:14
LjLUh, check your math again there18:14
kreyren37 / 100 * 7 ?18:15
kreyrenchecks to me O.o18:15
LjL7 is about one fifth of 3718:15
kreyrenah right18:15
kreyrenwait what18:16
LjLAnd I don't know what that formula you gave is18:16
LjLBut the result is not 2.5918:16
kreyrenLjL, i though that's how you calculate the death rate O.o by calculating the percentage of fatalities in relation to infected?18:17
kreyrenhttps://i.imgur.com/f9jcgw2.png eh.. ?18:17
kreyrenam i retarded x.x18:17
LjLkreyren: what that formula gives you is a number between 0 and 1. Just like 37/100 is 0.37 but that means 37%, the number 2.59 there means 25.9%, not 2.59%18:19
kreyren37 / 100 defines one percent of 37 and that multiplied by 7 gives 7% ?18:20
LjLWhat, no18:20
kreyreno.o18:20
LjLMake your confusion go away by forgetting about formulas you don't understand and seeing that 7*5 is 35, which is just short of 37, which means more than one out of five patient has died18:21
LjLSurely one out of five is 20%, not 2%18:22
BrainstormUpdates for US: +3223 cases (now 8.8 million), +42 deaths (now 229563) since 19 minutes ago — Canada: +321 cases (now 214048) since 19 minutes ago18:22
BrainstormNew from The Indian Express (Health): Art and Culture: Coronavirus shadows darken Dussehra, leaves Ravana effigy business on last legs → https://is.gd/awRoHy18:23
kreyrenLjL, that would be one out of 5.285 which translates to 2.59% ?18:26
LjLNo18:27
kreyrenah wait18:27
LjLOne out of about five is obviously around 20% not 2%18:27
LjLYou're an order of magnitude off and I'm at a loss understanding how that could be18:28
LjLForget the maths and just use your fingers18:28
kreyrenx.x18:28
LjL20 fits in 100 five times. 1 fits in 5 five times. Ergo 1 out of 5 is 20%18:28
kreyrentrue18:29
LjLkreyren: honestly I'm very confused what 37/100*7 would be. Where did you get it from again? 7 is the people who died, right? So it's a proportion of the total patients. So it should be at the numerator of the total patients. In other words, 7/37, which is about 0.19. That's a ratio, then if you want a percentage from that it is just 19% (0.19*100)18:33
kreyrenLjL, I am taking 37 as 100% and from that deviding by 100 to get 1% which is 0.37 and that multiplied by 7 to give me 7%18:34
kreyrenah wait18:34
kreyreni am not calculating 7% of 37 ..18:34
kreyren>.<18:34
LjLI don't know what to answer to that because it makes no logical sense to me18:35
kreyrenso 37/7 = 5.285% right18:35
LjLGood lord no18:35
LjLRead what I wrote18:35
LjLI just wrote that division the exact other way around18:35
LjLIf I write 7/37 and you reply with writing 37/7 I don't know if we're even speaking the same language18:36
CoronaBot04/r/covid19: Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to six months post disease onset (80 votes) | https://onlinelibrary.wiley.com/doi/10.1002/eji.202048970 | https://redd.it/jh5wdw18:36
kreyreni didn't read the message when i wrote it sorry! 18:36
kreyrenchecking18:36
kreyrenLjL, yep makes sense to me now >.< sorry 18:37
LjLA percentage is just a sometimes convenient (not very this time, apparently) way to write a ratio. 7/37 is the ratio, which as a decimal number is around 0.19. If you will that is roughly the probability for one patient to die. So out of 100 patients? 19. That's what 19% is about (of course you can't conclude that's the actual probability out of just 7 deaths but it's just an approximation to to explain it: if you got it 100 times, you'd probably die somewhere 18:40
LjLaround 19 times)18:40
LjLI'm not very mathematically inclined myself so someone else may have a more understandable explanation.18:41
kreyrenye i got confused because CFR of covid is calculated as deaths devided by confirmed times 100 according to WHO x.x18:42
kreyren- https://www.who.int/news-room/commentaries/detail/estimating-mortality-from-covid-1918:42
kreyrenwait i am confusing that again and swapped the death for confirmed >.< 18:43
kiwi_52hi LjL18:48
LjLDeaths divided by confirmed, result times 100, is exactly what I just said18:48
LjLHi18:48
LjLIt is 7/37, times 10018:48
python479o/18:48
LjLWhich is definitely not 2.5918:48
python479how is it going 18:48
LjLOh hey18:49
LjLPretty shit thanks18:49
kreyrenLjL, yep and i was doing confirmed devided by deaths which is wrong O.o18:49
python479yeah it seems I always come when it's shit18:49
LjLRelatives are infected and I am depressed18:49
python479maybe i'm the problem18:49
python479you sis ?18:49
LjLMaybe it's just always shit18:49
python479your*18:49
LjLNo, less close relatives, aunt and cousin18:49
python479aight18:49
python479no drama yet i hope 18:50
python479I assume they're simply home, not at the hospital18:50
LjLFor now they just have fever18:50
python479aight18:50
python479be strong18:50
LjLIt's been a week but she told us yesterday since she got tested positive yesterday18:50
LjLBut I'm also just feeling shit regardless18:50
kreyrenHow many people were infected day 1 on covid-19 and how many of them died? i am unable to find that data >.>18:51
LjLAnd going ragey on kreyren (sorry kreyren) is the only emotion I seem to get out of myself successfully18:51
kreyrenLjL, so my stupidity is helping with your depression? ^-^18:52
Specpython479: and how are you?18:52
python479nice of you to keep the LjL functionning kreyren18:52
LjLkreyren: what information would that give you?18:52
python479hello Spec 18:52
LjLkreyren: that could be one way of seeing it I suppose18:52
kreyrenLjL, allegedly the https://www.news.com.au/technology/novel-bunyavirus-reemerges-in-china/news-story/b833406e5b2b391aac62dc52db554e64 reported 60+ people infected and 7 died i wanted to compare that to day 1 of covid or ideally the first 60 cases 18:52
python479i'm a mess, I had a 3 month job, it's over and family is harassing me18:53
LjLkreyren: but why? The longer it continues the more, not the less, precise you are able to get18:53
kreyrenexcluding the patient health as we don't have the information to bunyavirus 18:53
python479on the covid side no issues though18:53
Specpython479: what happened to your 3 month  job? :(18:53
python479it was a limited time contract I was ok not to stay18:53
Specah18:53
kreyrenLjL, because i had reserves accounting for another 8 months and if bunyavirus is a concern i would like to prepare for it18:53
Specand family is harassing you to get new job? or just harassing for fun?18:53
LjLkreyren: this virus has been around since at least 200918:54
kreyrenLjL, but allegedly it spikes again in china now?18:54
LjLkreyren: it looks very nasty and maybe slowly over time it will transfer over to European and american ticks18:54
python479it's just toxic family making me go crazy and thus harder to find another job (which I want but I need to have normal morale)18:54
kreyrenye that's what i am afraid of 18:54
python479Spec parents are quite unstable so it's a chronic disease, the job thing is almost an excuse18:55
python479how is it on your side spec ?18:55
Specwe are staying sane and pretty much isolated18:55
LjLkreyren: but if it only slowly crawled through east Asia since 2009 (probably earlier), it's likely not an immediate concern18:55
Specpython479: i throw myself into work to ignore reality i suspect :(18:55
kreyrenLjL, true, but i would like to have more info in case it is a concern O.o18:55
kreyrenespecially for me who used to travel quite a lot and assuming that people also travel when there is no pandemic O.o18:56
python479Spec at this point I believe it's a healthy thing, to an extent18:56
python479what is it that you do ? (pardon my memory)18:56
Specpython479: my country is exhibiting some troubling trends, and showing some worrying signs18:56
kreyrenLjL, also it apparently is not a hard thing to get box of ticks from china and then release that in europe for a bad actor 18:57
Specpython479: i'm a cloud infrastructure engineer18:57
Specso i just poke buttons all day 18:57
Speci'm not on the k8s team, but i do use k8s as a user sometimes18:58
python479so how is the vaccine side of things ?18:59
LjLpython479, well that's his job now but he used to work for the mafia19:00
LjLhowever that's all in the past19:00
Spec^19:00
python479as long as you confessed all your crimes19:00
jacklswwow some story you got there19:01
Specpython479: what work do you do, that is contract oriented?19:02
kreyrenhmm apparently bunyavirus has CFR of 12~30% based on the provided data which would fit in the current assumed 19%19:02
Specbunyavirus is a cuter name than the rona, that's for sure19:02
kreyrenbut i like rona~ she's just causing me a fever and headache~19:03
python479Spec i'm recovering so I take any gig without skills. That last job was assisting clerk at an auxiliary court room19:03
Specoh, neat19:03
python479on paper19:03
Specany interesting cases or was it dull?19:03
python479it was a very odd place19:03
python479dull as f.19:03
Spec:(19:03
python479dull is no problem , but people were super dismayed by the whole system, so cranky / 2019:04
Speci'd rather be overworked for 10 hours than bored for 619:04
LjLkreyren, you're positive to covid?19:04
python479Spec it's a subtle art19:04
Specpython479: the balance of life-work, i'm terrible at it19:04
kreyrenand apparently bunyavirus is able to cause leucopenia and thrombocytopenia so i guess the treatment would be a blood transfusion O.o19:04
python479LjL you managed to be covid free btw ?19:04
LjLpython479, so far19:04
python479Spec even intra work balance19:04
kreyrenLjL, nope! Got exposed to it like 3 times and each time i had fever, headache and sore throat and it went away within day or two O.o19:05
python479how is the hifi repair :)  ?19:05
Speci have a friend who is sick and in hospital, if you want some depression in your day19:05
python479kreyren the black market is ready to sell your blood19:05
LjLkreyren, each time O.o19:05
LjLkreyren, did you get tested?19:05
python479Spec tough19:05
Speci think it's mostly unrelated, although there are some covid-related complications19:05
LjLpython479, it has turned out that getting it repaired involves picking up the phone to make a call so nothing has happened19:06
Specliver failure due to extreme alcoholism and drug abuse for a good decade19:06
python479oh not covid ?19:06
kreyrenLjL, like the first exposure was the worst i had high fever and sore throat day 3 and felt miserable, but then it went away and the two other exposures just gives me a fever and headache 19:06
Specpython479: also covid19:06
python479oh shit19:06
Specalthough i thought he had mostly recovered/discharged from hospital19:06
Specturns out he left hospital against dr order19:06
kreyrenLjL, yep never tested positive19:06
LjLkreyren, it would be interesting if you had gotten tested, especially all three times, because how likely it is for people to get infected more than once is very unclear19:07
LjLkreyren, ah19:07
Specso now he's back in icu afaik, waiting on something that will never come (liver transplant)19:07
LjLkreyren, maybe you could get an antibody test too19:07
kreyreneven though i was literally kissing with a girl that had covid assuming that she was later tested positive and the other guy she kissed also was O.o19:07
Speci wonder how many people will suffer long term health impacts due to covid without ever getting covid19:07
CoronaBot04/r/covid19: Vitamin D Treatment Is Associated with Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study (82 votes) | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3690902 | https://redd.it/jha2cm19:07
SpecLjL: you need the D ^^19:08
LjLkreyren, when did you get tested? when you had symptoms, or before?19:08
kreyrenLjL, none wants to give me that x.x19:08
kreyrenafter i had symptoms like 5 days after19:08
Speckreyren: did you stay isolated during this time where you were presumably positive19:08
LjLSpec, yes, these studies about vitamin D being helpful keep coming up, and yet no government is recommending routine supplementation19:08
kreyrenSpec, yep19:08
SpecLjL: i wonder why19:08
Speci thought vitamin d supplements weren't really seen as effective19:09
kreyrenwhere i am a person who is wearing an industrial gas mask in the public 19:09
Specand the best vitamin d is made from exposing your fleshy bits to the glorious sun19:09
kreyrenSpec, fwiw i am taking vitamin D suppliments weekly and i was sunbathing a lot 19:09
LjLSpec, they may only be effective when you have a deficiency, however it's winter and most people have some degree of deficiency especially when stuck inside19:09
Speckreyren: most industrial gas masks have outlet valves but ok19:09
kreyrenSpec, yep for exhailing x.x19:09
SpecLjL: oh19:09
Speckreyren: which fails to protect others19:09
kreyrenSpec, i wasn't outside when i through that i might be positive O.o19:10
LjLSpec, that's something that some people think, but i don't think it's been established that supplemental vit D "doesn't work" compared to the sun-produced kind19:10
SpecLjL: yeah, dr said i was deficient in the D19:10
Speckreyren: ah ok, excellent19:10
LjLSpec, well then i strongly recommend taking some19:10
Speckreyren: a civic duty19:10
SpecLjL: i have some that i don't take, that's pretty close19:10
LjLSpec, actually the entrymsg in this channel, which i wrote, says no medical advice, so let me rephrase19:10
LjLSpec, if i were you which i'm obviously not and i were diagnosed with vit D deficiency one of my priorities re COVID would be to get some supplementa 1000 IU a day at least19:11
Spechaha19:11
Speccan you prove, without a doubt, that you are not me19:11
LjLideally taken with some fats which reportedly increase absorption19:11
kreyrenfwiw the first infection was when i was wearing a nano fibre respirator and walked around a guy that caught like crazy and was smoking i could smell the smoke behind the mask and then day after didn't felt good, day 2 same and day 3 got worse, but day 4 Ok again19:11
Specor that I am not you? just how sane do you think you are19:11
kreyrengot the gas mask after that x.x19:11
LjLSpec, less than you to enough of an extent that we seem distinctly different19:11
SpecLjL: i didn't realize that, do the vitamin d pills not come with ... fats or oils to help absorption?19:12
kreyrenafaik vitamin D has to be dissolved in an oil so i usually take it with a milk 19:12
kreyrenin a form of D3 drops 19:12
LjLSpec, yes, the one we have isn't a pill, it's drops that *are* in (rancid, terrible) oil19:12
Specoh, mine are in big pills19:12
Speci think, i haven't opened it in some months. maybe a year. :P19:12
kreyrenye i hated the pills so they gave me the drops :319:13
Speckreyren: i think that's why i don't take them, large gross pills19:13
LjLSpec, pills are probably of somewhat more dubious efficacy, but for sure, it means i would take them with fats even more so19:13
Specmore dubious efficacy, nice19:13
Specmaybe i will just praise the sun like the lord commands of me19:13
kreyrenSpec, ye doc didn't like me separating the pills in three parts by myself~19:13
LjLSpec, yeah get drops, the terrible taste goes away if you have them with a spoonful of hazelnut cream, and it comes with fats too!19:13
kreyrenso i got drops and was called a baby19:13
Speckreyren: would you care to see a picture i took of it who must be praised?19:14
LjLSpec, someone has a site with all the papers they could find about vit D and COVID (obviously he's in favor) now https://vitamin-d-covid.shotwell.ca/ used to be on github but i just realized it's been moved19:14
LjLSpec, i haven't actually checked out their papers but if you think we don't think vit D helps with COVID i'm sure there's some that will say otherwise!19:15
LjL%papers vitamin d19:15
BrainstormLjL: An error occurred while searching.19:15
LjL:(19:15
SpecAn error!19:15
Specsay it isn't so!19:15
LjLwell that can also mean it didn't find results, but that would be strange19:15
kreyrenSpec, O.o19:16
Speckreyren: https://specops.network/sun_20200101.png19:16
kreyrenSpec, i want to be a doctor, but i don't like looking at sick people that i can't help enough~19:16
kreyrenah sun19:16
kreyrenlol19:16
LjLSpec, oh i think it probably doesn't like "D" as a term that's too short19:16
LjLSpec, sometimes the D is too short you see19:16
kreyrenthat's a great picture o.o how did you made it19:17
Specyes, although i'm not personally familiar with that issue, i have heard it said19:17
kreyrenand can you supply me with these~19:17
LjLSpec, however this beta API i'm used just throw an internal server error no matter what exactly it going on19:17
Specwhat api?19:17
LjLSpec, https://preview.zbmed.de/19:17
Speckreyren: i have quite a few pictures of the sun, but this is the best one i think19:17
LjLwell the API being https://preview.zbmed.de/api/beta/19:17
LjLat least that's the beta version i'm using, there is a non-beta version but it's silly because it doesn't use GET parameters19:17
kreyrenSpec, If you have a new pictures i would be happy to see them ^-^19:17
Speckreyren: i take them with a hydrogen alpha filtered scope, taking a thousand pictures, and doing somoe small processing19:17
LjLi emailed them and they told me to try the beta version to avoid escapings going wrong19:18
kreyrenSpec, i see O.o19:18
kreyrenSpec, what kind of processing ?19:18
kreyrencan i help as a hobbist~19:18
Speckreyren: here's a bad but cool picture, of the mercury transit https://specops.network/sun_full_mercury_transit.png19:18
Speckreyren: and here's the same event, but with that super zooms https://specops.network/sun_zoom_mercury_transit.png19:19
kreyrenmercury transit?19:19
Specyes, last year mercury went in front of the sun, so we could see its shadow as it passed 19:19
kreyrenah i see O.o19:19
kreyrencool19:19
Specusually mercury is unseeable 19:19
kreyreni think i was watching the event in planetarium in brno O.o19:19
kreyrendidn't see much though x.x19:20
Spec:)19:20
Specthat zoom-mercury picture is one of my favorite19:20
Specbut out of context it is pretty unimpressive19:20
kreyrenye looks pretty cool to me too ^-^19:20
kreyrenCan you get more resolution from that?19:21
Specwhat do you mean by resolutio19:23
Specthat super zoomy picture, i could photo the whole sun with that setup and create a mosaic19:24
Specthe problem is the sun changes quickly, so you have to take all the images within a 5 min period or so 19:25
kreyrenlike seeing more detail O.o 19:25
LjLthe edge between the sun and the planet seems pretty sharp to me19:25
Specso full disc usually turns out better19:25
LjLso i'm not sure what more detail there is to see19:25
Specyes, i mean, if i could get this shit up into space :P19:25
Specyou can get more angular resolution with a better telescope/larger aperature, a camera sensor with smaller pixels, etc19:25
Specall $$$$19:25
Speckreyren: if i become a billionaire, as we all are sure to be destined to be, i will buy a solar observatory and send you pictures19:26
kreyrenit might be a dumb question but i like to watch the details of the invidual "clounds" in the sun i.e. https://cdn.theatlantic.com/thumbor/IQLs9M3p0M0LAr8dRqogwxnWlH4=/720x405/media/img/mt/2019/12/Nasa/original.gif19:27
kreyrenbut i guess that ain't possible to observe from the earth?19:27
Speckreyren: not uhh, like that19:28
Speckreyren: i could get better tho, and do a zoomy capture of the proms19:28
kreyrenproms?19:29
Specprominances, the things off the side of the sun that you like to look at19:29
kreyrenah 19:29
Speckreyren: i have a short video for you though, you might like. it is clouds going across the sun19:29
Specraw footage of what i capture19:29
kreyreni would like to get images like https://www.thesun.co.uk/wp-content/uploads/2020/04/NINTCHDBPICT000576015951.jpg from the earth ideally x.x19:29
kreyrenthat would look soo good interpreted in the interior x.x19:30
Speckreyren: https://i.imgur.com/d5iRb1a.mp419:30
Speccan't really process that footage because of the clouds19:30
kreyrenthat's cool o.o19:30
kreyrendoes spacelink affect your observing ?19:31
kreyrenor satelites in general?19:31
Speckreyren: here's what zoom looks, this can be processed but would need more images, https://i.imgur.com/bS08ihH.mp419:31
Spechaha, it does not impact taking pictures of the sun, lol19:31
Specit does impact taking pictures of galaxies and nebulas, but we can process them out19:31
kreyreni see O.o19:31
Speckreyren: the wiggling is due to the heat of air raising through atmosphere in front of my scope19:32
Specso i take a thousand pictures and throw out 80% of them19:32
kreyreni see O.o Seems like something that can be processed by AI for more detail though 19:32
kreyrenwhich would be probably inaccurate but might be good enough for the interior O.o19:32
Speckreyren: i guess AI could make up missing data reasonably well, but it wouldn't be accurate19:33
kreyrenye.. but there ain't any way to get more detailed images from the earth no?19:34
Speckreyren: i also take decent pictures of the moon, which is currently free of coronavirus as is the sun19:34
Speckreyren: yeah, bigger scope haha, larger aperature means you can increase zoom19:34
Specif i use a 3x barlow for example, instead of 2x like my zoom'd pictures use, we would approach the limits of magnification for aperture ratio, so it would become blurry19:34
Speckreyren: here are some moon pictures, to balance the sun https://specops.network/moon1.png and https://specops.network/moon_09052020_final.png -- i like them19:35
kreyrenthat's cool x.x19:35
Speci am tempted to get them printed, but i don't know how to get them printed well19:36
kreyreno.o19:37
kreyrentbh i don't like printed things of the univers makes me feel like they will be out of date after i look at them for a longer time >.>19:37
BrainstormUpdates for US: +3983 cases (now 8.8 million), +28 deaths (now 229591) since an hour ago — Canada: +1 cases (now 214049) since an hour ago19:38
kreyreni wonder what caused the South Pole-Aitken crater19:39
Speckreyren: many structures in space will be vast and unchanging for our entire lives19:39
Spec:)19:39
kreyreni like to theoretize that it was a nuke from previous civilization19:39
kreyrenSpec, ye because of the time it takes for a light to get to us from these x.x19:39
Speckreyren: i don't know how to map the resolution of my digital file to the paper size such that it turns out good looking, or what quality of printed material/inks work well19:40
Specit's a whole world that is dull and boring to me19:40
Spec:P19:40
LjLtinwhiskers, python444: for the benefit of providing an article about this with a less slanted headline than what that silly person kiwi_52 gave before, https://news.sky.com/story/coronavirus-oxford-astrazeneca-vaccine-behaves-as-desired-analysis-finds-12111085  although i'm kind of confused that this had not already been ascertained (since it's not about "working" as in "stopping COVID", but about giving the desired instructions to the cells), but the 19:42
LjLnews about this appear to be recent so maybe they really hadn't, or i don't understand what is different this time19:42
kreyrenSpec, o.o19:42
Specso do we have multiple viable vaccines that are in various stages of progress? i haven't been paying much attention19:43
LjL<kreyren> Spec, ye because of the time it takes for a light to get to us from these x.x ← no, that's not the reason...19:43
LjLSpec, uh, yeah19:43
kreyrenLjL, eh?19:43
LjLhundreds, with perhaps a dozen at an advanced stage19:43
LjLkreyren, the reason many space objects appear to be unchanging for our entire life has nothing to do with the time the lights get to us19:44
kreyrenLjL, justify19:44
Specit has to do with not having enough resolution to see the changes19:44
LjLkreyren, it does take a long time to get to us, but that just means that we see whatever is happening to them... delayed19:44
LjLit doesn't mean that they somehow appear to stay still why they're not19:44
Specthe objects are so vast and huge, despite them changing, they appear unchanging due to the vastness19:44
LjLthey are just massive and distant enough that we're not going to notice any visible changes in our short lifetimes19:44
Specfrom our viewpoint and resolution capabilities19:44
Specwith the exceptions of violent activities, such as a supernova19:45
Specwe do see some things change through vast distances -- the dimming of a star as a planet occludes it, etc19:45
kreyrenLjL, true, but some of these objects are very far away and i wasn't able to observe any change in things like galaxies O.o19:45
LjLkreyren, why would you expect to?19:46
LjLkreyren, unless some massive things happens like a giant supernova, they are not changing at a speed that allows you to observe any changes from your limited ability to view them from earth19:47
kreyrentrue i was hoping to get more information about the galaxy19:47
LjLtelescopes like Hubble may see some changes, though, or again we may see them if something really big happens. has nothing to do with the speed of light19:47
Speckreyren: if you would like to do some math....19:48
Speckreyren: take a common optical setup and figure out the angular resolution of what you can see19:48
kreyrenSpec, after i hugged up the CFR calculation19:48
kreyreno.o19:48
Speckreyren: and see how much 1 pixel maps to19:48
Spectake my sun picture for example19:48
kreyreno.o19:48
Specthe sun is close, too19:48
Spec865,370 miles wide -- my image's full disc is 845 pixels wide, ... so each 1 pixel in my sun picture is about 1024 MILES19:51
Specnow imagine a nebula, 10 lightyears across, but still mapped to 800-1000 pixels19:51
LjLSpec, that's about standard driving distance for driving to the grocery store in America, right?19:51
SpecLjL: a little bit under ya19:51
Speckreyren: you see that a solar feature travelling a thousand miles an hour, would take an entire hour to just shift 1 pixel in this picture19:52
Speckreyren: this is just under 6 lightyears diameter https://specops.network/NGC7023.png about 1560 pixels to be generous, so each pixel maps to .00384 lightyears, or 22573921000 miles per pixel19:58
python444yo mamma zinc supplements20:02
BrainstormNew from University of Washington: Hydroxychloroquine Fails to Prevent COVID-19 (includes Ruanne Barnabas): hydroxychloroquine_gettyimages_smaller-1222029807.jpg Close A careful look at hydroxychloroquine finds it ineffective in protecting exposed people from contracting COVID-19. Getty Images. View image caption Results to appear in Open Forum [... want %more?] → https://is.gd/OyizdW20:16
BrainstormUpdates for US: +16578 cases (now 8.8 million), +136 deaths (now 229727) since 54 minutes ago — Arizona, US: +890 cases (now 236772), +4 deaths (now 5869) since a day ago — Canada: +338 cases (now 214387) since 48 minutes ago20:23
kreyrenSpec, i see O.o So each of those pixels are adapted based on some algorithm that adapts the pixels to represents the source image?  20:28
BrainstormUpdates for US: +371 cases (now 8.8 million) since 43 minutes ago20:53
Jigsy3>Reopening schools causes R transmission rate to surge, study suggests21:15
tinwhiskerskreyren: probably something like astrostack, which overlays and aligns all the images (after discarding bad ones), then basically you get an average image.21:15
JigsyIn other news, water is wet.21:15
JigsyI like how they needed to conduct a study to find that out.21:16
LjLJigsy, and yet our government still insists that schools are a negligible cause of new clusters :\21:16
tinwhiskerswell, it may not have caused that if, as some people claimed, children were not responsible for much of the spread. It needed to be confirmed that those people were wrong :-)21:17
LjLalthough they can't really know that anymore since they ADMITTED that in Lombardy at least, but also elsewhere, they've lost control of knowing the origin of at least 30% of the cases21:17
LjLtinwhiskers, those people included me, tentatively, and i still don't necessarily think that's wrong21:17
LjLschools are a problem in various ways21:17
LjLand "children" can mean various things21:17
LjLif people thought that "children" meant highschool kids, well that's bollocks21:18
LjLanyway, schools mean people taking public transport, teachers, personnel, a number of thigns that aren't just the kids21:18
LjLhere it means public transport gets much more crowded21:19
JigsyChildren are literally one of the biggest vectors of disease.21:19
tinwhiskersthat's a bold claim21:19
LjLJigsy, does "literally" give your cliam more credit?21:19
Jigsy"I can't come in to work, I caught a cold off my child who got it from someone at school."21:19
LjLthere are studies showing children are *not*21:19
JigsyOkay, maybe it's not the children per se.21:19
LjLthere are also some studies showing otherwise21:19
JigsyBut the schools.21:19
LjLi think it's fair to say that we don't know21:19
tinwhiskerswe've seen enough instances or soaring rates now when schools reopen to know that reopening schools is a risky thing to do.21:20
LjLi agree with that21:22
zini[m]afaik, even places like sweden haven't don't have significant herd immunity21:22
LjLalthough i personally think elementary schools should be opened, while other schools should stay closed21:22
LjLi have three reasons for that which i think i mentioned before21:22
zini[m]a lot of places locked down wave 1, but still the 1st wave was pretty bad21:22
LjLone, there are still these studies showing children below 10-11 may not spread much really21:22
zini[m]why aren't places having bad wave 2s compared to wave 1?21:22
LjLtwo, those are the children who if they stay at home, they need caretakers which can make things worse in turn21:23
zini[m]afaik, even places like sweden don't** have significant herd immunity21:23
LjLthree, high school kids can understand remote learning (doesn't mean they'll do it, but that's on them), kids under 10 may be a bit of a problem telling them the tablet is their new teacher21:23
tinwhiskersfair21:23
kreyrentinwhiskers, o.o21:23
LjLzini[m], where lockdowns were full during the first wave, it seems to me that the wave eventually stopped, although it may have taken longer than hoped21:24
LjLthen... it started again21:24
LjLi don't know yet if we are having bad second waves compared to first waves21:24
LjLthey sure look bad21:24
LjLbut in the first wave we didn't really have meaningful numbers21:24
LjLwe were testing much, much less21:24
LjLnow, again, we are in a situation where we're no longer testing enough21:24
LjLbut for a while we were testing enough-ish21:24
zini[m]LjL: the best example i have in mind is america. wave 1 had a high kill rate, but wave 2 not so much21:24
kreyrennorth korea now looks like a nice place to live eh?21:25
LjLwhich means seeing many more cases, while deaths are still low (for now, i'm not brushing it off) compared to the first wave21:25
tinwhiskerskreyren: lol. I think you can do better.21:25
LjLzini[m], compared to Europe though, you don't really *see* a clear wave 1 - wave 2 distinction in the US graph (maybe individual states)21:25
zini[m]LjL: true, they kinda gave up half way thru21:26
kreyrentinwhiskers, how~ they are socially distancing since 90s and doesn't have diseases apparently :p21:26
kreyren+ they like me there x.x21:26
zini[m]afaik, iran looks like it had: wave 1 - bad. wave 2 worse. wave 3 even worse.21:26
LjLhttp://offloop.net/covid19/?default=EU;US  the US is a mostly linear, slightly wavy line. the EU has two clear waves21:26
tinwhiskersWell, here in Tonga we don't have any covid, and there's some other bonuses about not starving and living in an authoritarian hellhole that, on balance, makes this more preferable.21:27
zini[m]maybe crazy idea:21:27
zini[m]most of the ppl who were extremely susceptible to death/infection via covid got hit in the first wave. Ex old age homes21:28
LjLi don't see very clear waves in the Iran graph either21:28
LjLit kinda just kept going, both cases and deaths21:28
LjLi mean sure, if you look at the derivative, you can probably define wave in some sense21:29
zini[m]whereas now, there aren't as many old age home clients alive21:29
LjLbut they don't look very meaningful compared to the EU situation21:29
zini[m]i mean if u look at iran's death wave21:29
zini[m]iran, like a sound wave, has troughs and peaks of death21:30
zini[m]in italy, is it mostly the "general" population that is getting sick now?21:31
LjLzini[m], yes, the median age of cases reached as low as 29 years, then it started rising again, although at the end of september it was going *down* again21:40
LjLdata for october aren't published yet21:40
LjLthere's a report in english here https://www.epicentro.iss.it/en/coronavirus/bollettino/Report-COVID-2019_22_october_2020.pdf but it doesn't have that particular graph21:41
zini[m]so i might be on to something!21:41
zini[m]also, is eng an official language in italy?21:42
LjLthis one in italian does https://www.epicentro.iss.it/coronavirus/bollettino/Bollettino-sorveglianza-integrata-COVID-19_20-ottobre-2020.pdf but apparently it has changed, now the age is going up again21:42
LjLno21:42
LjLofficial language in italy nationwide is just italian, then french, german and slovenian (and maybe romantsch?) are official in some places21:43
zini[m]<LjL "no"> why do they release so many english reports? 21:43
zini[m]and why are you fluent? :p21:43
zini[m]the comorbidy section is interesting21:45
zini[m]hypertension most likely killer comorbidity21:46
BrainstormUpdates for France: +23789 cases (now 1.1 million), +137 deaths (now 34645) since 14 hours ago — US: +15465 cases (now 8.8 million), +163 deaths (now 229890) since an hour ago — Canada: +103 cases (now 214490), +17 deaths (now 9937) since an hour ago21:53
zini[m]offline22:16
BrainstormUpdates for US: +5309 cases (now 8.8 million), +81 deaths (now 229971) since 37 minutes ago22:24
BrainstormNew from r/WorldNews: worldnews: France reports record of over 45,000 new coronavirus cases in a day → https://is.gd/9c2abd22:31
ryoumahttps://www.washingtonpost.com/health/long-haul-covid-patients/2020/10/23/ab7c5324-0712-11eb-9be6-cf25fb429f1a_story.html23:02
python444o/23:04
python444https://archive.is/cxYGz23:07
ryoumathanks23:10
BrainstormNew from r/WorldNews: worldnews: Europe becomes second region to cross 250,000 deaths as second COVID wave hits → https://is.gd/4PX4kQ23:27
LjLpython4441, can you be python27 just so i don't have to port my bot when it goes discontinued23:28
LjLwhich is soon23:28
LjLno no i need new style classes23:29
LjLat least23:29
LjLthat's more like it23:29
python27lts*guido left the chat*23:29
LjLi mean he should admit that nobody wanted to port their stuff23:30
LjLthere might be a reason for that23:30
LjLat this pace, if after 2021 we still aren't porting things to python 3, he might start threatening us with guns23:30
python27ltsafaik it's pretty much over now23:31
python27ltsit was a long long road though23:31
LjL%title https://www.youtube.com/watch?v=fR4HjTH_fTM23:32
BrainstormLjL: From www.youtube.com: The Long And Winding Road (Remastered 2009) - YouTube23:32
dTalsuch a ridiculous fiasco23:32
python27ltscult classic23:33

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