| ryouma | highly significant news from uk today re long covid: "Harmful exercise treatment for people with ME/CFS has been dropped from latest NICE guidelines. After 13 years of recommending graded exercise therapy (GET) to people with Myalgic Encephalomyelitis (ME), a new draft guideline on ME/CFS from the National Institute for Health and Care Excellence (NICE) advises against “any programme based on fixed incremental inc | 00:01 |
|---|---|---|
| ryouma | reases in physical activity or exercise, for example graded exercise therapy”. " | 00:01 |
| LjL | that Ars article seems to be making an *overly* reassuring conclusion. "just keep monitoring the farms!" | 00:02 |
| Brainstorm | New from CNBC Health: Biden puts health care front and center with a call to expand Obamacare: Joe Biden argued for expanding the Affordable Care Act, saying the coronavirus pandemic exposed an urgent need to give more people access to health insurance. → https://is.gd/KbzYtk | 00:02 |
| LjL | ryouma, good | 00:02 |
| ryouma | still too early to tell the significance for long covid but those in the uk who get caught in the political maelstrom will be saved the harm caused by that guideline if the draft has significance. the harm includes many being forced to exercise via a bogus model of the diease. this exercise, which is contraindicated, made them bedridden for ther est of their lives. | 00:04 |
| ryouma | and a lot of long covid area already gettin gcaught in those politics including in the uk | 00:04 |
| Brainstorm | Updates for Colorado, US: +3890 cases (now 138427), +19 deaths (now 2427) since 23 hours ago — US: +135768 cases (now 10.5 million), +1300 deaths (now 245692) since 23 hours ago | 00:05 |
| CoronaBot | 04/r/covid19: Cleveland Clinic Researchers Use “Big Data” Approach to Identify Melatonin as Possible COVID-19 Treatment (83 votes) | https://www.lerner.ccf.org/news/details/?Cleveland+Clinic+Researchers+Use+%E2%80%9CBig+Data%E2%80%9D+Approach+to+Identify+Melatonin+as+Possible+COVID-19+Treatment&368b40ada56204bc8992942e8032bedb4d865564&390f8e37ac9d0069b5928b94dac2d4a31f491013 | https://redd.it/jrra5a | 00:09 |
| ryouma | what are known potential preventivs and early treatments? vitamin d3? zinc+mixed bioflavonoids? sleep? | 00:10 |
| LjL | very potential | 00:11 |
| LjL | as in who knows | 00:11 |
| LjL | this youtube doctor keeps saying lack of vitamin D is correlated with virtually every ailment, but "correlation is not causation" and vitamin D is merely a marker of fragility meaning people who are more frail tend to see less sun etc | 00:12 |
| LjL | i have seen some papers suggesting there is more than just correlation with COVID, but it's good to be reminded studies have found bogus "significant" things many times | 00:12 |
| ryouma | no prospective trials on stable healthies or sick? | 00:12 |
| ryouma | true | 00:13 |
| de-facto | btw the short report about the mink clusters in denmark is really readworthy, i can recommend anyone interested to read this https://files.ssi.dk/Mink-cluster-5-short-report_AFO2 | 00:14 |
| LjL | ryouma, if you want to convince yourself that vit D will save you, https://vitamin-d-covid.shotwell.ca/ surely has lots of pointers | 00:15 |
| ryouma | don't have the energy | 00:16 |
| LjL | de-facto, unless they updated it from the version i read, the two takeaways i got, at least the ones i could understand, were 1) as we knew, antibodies are a little les effective on the multi-mutation variant, and 2) it may be a little less effective at reproducing | 00:16 |
| Brainstorm | Updates for US: +136853 cases (now 10.5 million), +1305 deaths (now 245697) since 23 hours ago | 00:21 |
| de-facto | Their neutralization Figure 3 is pretty interesting, taking serum from patients with low, medium and high neutralization abilities and determining the difference in neutralization for wild type and mink mutant | 00:22 |
| LjL | ah alright, the version i grabbed from google cache didn't have the figures | 00:22 |
| LjL | i will look | 00:22 |
| de-facto | those covalescent plasma samples with low neutralitation titer had biggest difference between wild type and mink mutant while the high neutralization titer almost has not difference | 00:24 |
| de-facto | does this have something to do with the amount of variety in the spectrum of unique antibodies contained in such serum samples? | 00:25 |
| de-facto | e.g. "how many ingredients" the "antibody cocktail" produced by the immune system contains? | 00:26 |
| de-facto | or do the high neutralization titers target something else than the s-protein epitopes? | 00:26 |
| de-facto | according to their Figure 1 the Y453F mutation sits directly ontop of the s-protein RBD trimer, the deletion 69-70 ib the edge of the n-terminal domain | 00:28 |
| de-facto | quite interesting | 00:30 |
| de-facto | "The first was a tyrosine to phenylalanine at amino acid 453 (Y453F), a mutation that 29 also appeared during the Dutch mink farm outbreaks. It is a conservative amino acid substitution in 30 the receptor binding domain that directly contacts the host ACE2 receptor at amino acid 34 (Wang et 31 al). This ACE2 contact position differs between human and mink (histidine [34H] in humans and 32 tyrosine [34Y] in mink and other mustelids (Damas | 00:31 |
| de-facto | et al)), which suggests that Y453F is an adaptation 33 mutation to mink ACE2. Importantly, 453F increases affinity for human ACE2, which may explain its 34 successful introduction and establishment in humans." | 00:31 |
| Brainstorm | Updates for Martinique: +517 cases (now 4732), +4 deaths (now 37) since 6 days ago — US: +138392 cases (now 10.5 million), +1324 deaths (now 245716) since a day ago | 00:35 |
| de-facto | "The clinical isolates bearing the Y453F spike mutation replicated as efficiently as the unmutated/wildtype SARS-CoV-2 virus that predominates in Denmark (data not shown). Conversely, the SARS-CoV-2 virus with four mutations grew slower than both the wildtype virus and other SARS62 CoV-2 virus isolates (Fig. 2). " | 00:39 |
| de-facto | "The cytopathic effect (CPE) induced by the ΔFVI-spike mutant virus appeared later and was less pronounced and had an approximate 10-fold lower titer 24 hours post inoculation compared to human SARS-CoV-2 isolates prepared under the same conditions (Fig. 2A). At 96 hours post-inoculation the ΔFVI-spike mutant virus titer was comparable to that of the wildtype virus and exceeded other SARS-CoV-2 viruses isolated and subcultured unde | 00:39 |
| de-facto | r the same conditions (Fig. 2B)." | 00:39 |
| Brainstorm | New from "Cluster 5" on Wikipedia: LjL: LjL: /* Name */ Providing Danish paper with citation for at least one of the claimed mutation (more are listed but so far I'm just removing the {{cn}} on the one that was an obvious match) → https://is.gd/74bzDF | 00:39 |
| de-facto | " | 00:39 |
| de-facto | The ΔFVI-spike mutant virus titer increased 54.7-fold from 24 to 96 hours post-inoculation, compared to an average of 4-fold (range: 2.6 to 5.7-fold) over the same time for other SARS-CoV-2 isolates. The ability to replicate to high viral titers is consistent with high levels of the ΔFVI-spike mutant virus detected in throat swab samples of infected persons, as indicated by an average qPCR assay (E-Sarbeco) cycle threshold of 24. | 00:39 |
| de-facto | 7 (range: 20-35). Further evaluation of the SARS-CoV-2 ΔFVI72 spike strain growth kinetics in other cells systems are warranted" | 00:39 |
| LjL | de-facto, "increasing affinity for human ACE2" doesn't sound like a good thing | 00:41 |
| de-facto | hmm so its delayed and less cytopathic and grows faster in later stages, meaning it may reach higher concentrations sooner hence be more infecitous? | 00:42 |
| de-facto | all does not sound like a good thing there | 00:42 |
| LjL | i hope the wikipedia gods won't punish me for adding a primary source, unpublished at that, as a citation | 00:42 |
| LjL | argh | 00:43 |
| LjL | they should punish me for introducing spurious material | 00:44 |
| de-facto | %title https://www.ssi.dk/aktuelt/nyheder/2020/ssis-deling-af-data-om-cluster-5-sars-cov-2-minkvariant-virus | 00:47 |
| Brainstorm | de-facto: From www.ssi.dk: SSI's deling af data om "cluster 5" sars-CoV-2 minkvariant virus | 00:47 |
| de-facto | %title https://translate.google.com/translate?sl=auto&tl=en&u=https://www.ssi.dk/aktuelt/nyheder/2020/ssis-deling-af-data-om-cluster-5-sars-cov-2-minkvariant-virus | 00:48 |
| Brainstorm | de-facto: From translate.google.com: Google Translate | 00:48 |
| Brainstorm | New from "Cluster 5" on Wikipedia: LjL: Argh, the copypaste of the source wasn't meant to go there, but in the citation. Sorry!: Argh, the copypaste of the source wasn't meant to go there, but in the citation. Sorry! ← Previous revision Revision as of 23:46, 10 November 2020 Line 5: Line 5: == Name == == Name == − In Denmark there have been five [... want %more?] → https://is.gd/74bzDF | 00:49 |
| Brainstorm | Updates for US: +142861 cases (now 10.6 million), +1354 deaths (now 245746) since a day ago — Saint Lucia: +7 cases (now 148), +1 deaths (now 1) since 23 hours ago | 00:51 |
| de-facto | so they link from there to that report, i would consider it published by that then | 00:52 |
| de-facto | "Concerns about reduced susceptibility to antibodies became real after the experiments that SSI disseminated the results of Monday, November 2, 2020. These results are now summarized in a report posted on SSI's website today." | 00:52 |
| DocScrutinizer05 | de-facto: >>"how many ingredients" the "antibody cocktail" produced by the immune system contains<< I'd guess that nails it | 00:53 |
| DocScrutinizer05 | or it's an artifact from lab | 00:53 |
| DocScrutinizer05 | factor 3.something is not even yet beyond significance threshold 4, aiui | 00:54 |
| LjL | de-facto, it's "published" for wikipedia's criteria when it's on a journal, probably... and still discouraged as a primary source | 00:54 |
| de-facto | what i dont get is if they are that concerned about vaccines not being able to produce neutralizing antibodies to that mutant, WHY dont they take serum from vaccine trials and try to neutralize wild type and mutant with that? | 00:54 |
| LjL | de-facto, as a matter of fact there are sanctions on all COVID-19 articles for including preprints, but don't tell them i knew. if i say i didn't know i can just get away with a warning | 00:55 |
| DocScrutinizer05 | are they? aiui Drosten at least is very unconcerned about vaccine | 00:55 |
| de-facto | well right now its more important to have the most recent news from the primary expert source | 00:55 |
| de-facto | obviously they are concerned about that, why else would they use such drastic measures to contain it? | 00:56 |
| LjL | de-facto, well do they have access to the vaccines? maybe they're arranging that | 00:56 |
| de-facto | not the vaccines but the blood of the trial participants without placebo, might be difficult to get acutally | 00:57 |
| LjL | de-facto, to that, wikipedia veterans would reply that "wikipedia is not a news source" and there is no rush to add stuff | 00:57 |
| LjL | but i would reply that it serves as a simple pointer for other people wanting to expand on the article | 00:57 |
| LjL | just so we don't lose the quote around other thousands of things that float around the web | 00:57 |
| de-facto | yep | 00:57 |
| DocScrutinizer05 | they take measures to contain covid, nothing unusual | 00:57 |
| LjL | no, they took measures to contain COVID gotten from mink specifically | 00:58 |
| DocScrutinizer05 | de-facto: I highly suggest listening to today's Drosten podcast | 00:58 |
| LjL | let's not pretend this mink mutation is not being treated as anything special by Denmark | 00:58 |
| LjL | Drosten is not Denmark | 00:58 |
| LjL | clearly it's being treated by both government and media as a big thing in Denmark | 00:58 |
| DocScrutinizer05 | because it's NEWS | 00:59 |
| de-facto | i did not have time yet to listen to Drostens newest podcast | 01:00 |
| LjL | the government doesn't care whether it's news or not. they were going to cull all mink, then parliament stopped it. it's being a big thing | 01:00 |
| DocScrutinizer05 | you should, he reviews that very paper in depth | 01:00 |
| LjL | sometimes you're a bit like "la la la i can't hear you because Drosten is saying correct things too loud", if you don't mind me saying | 01:01 |
| DocScrutinizer05 | incl why it got hyped in media | 01:01 |
| DocScrutinizer05 | it's *normal* to cull a whole region of infected animals, no matter what the infection, as long as there's no treatment | 01:02 |
| de-facto | uff 1h22m podcast | 01:03 |
| de-facto | ok going on 2x speed | 01:03 |
| LjL | DocScrutinizer05, well then it's big news that they *aren't* doing it | 01:03 |
| DocScrutinizer05 | yes, THAT is insane | 01:04 |
| LjL | anyway, i don't think it's reasonable to pretend that their official notice, parroted by the WHO, specifically talked about concerns on antibody AND vaccine efficacy on the mutated strain | 01:04 |
| LjL | that was an official government announcement that made the news because it was deserving of it | 01:04 |
| LjL | they may be WRONG about it, sure, that's possible, they may have overreacted to what their researchers said | 01:05 |
| LjL | but it's a big deal that it was even said | 01:05 |
| Brainstorm | Updates for US: +144834 cases (now 10.6 million), +1379 deaths (now 245771) since a day ago — Canada: +3948 cases (now 273168), +64 deaths (now 10643) since 21 hours ago | 01:05 |
| DocScrutinizer05 | they are supposed to act in best "better safe than sorry" manner | 01:06 |
| DocScrutinizer05 | LjL: this warning was absolutely OK... until today with the new data | 01:07 |
| Brainstorm | New from r/WorldNews: worldnews: A Muslim couple find the vaccine for Covid-19 → https://is.gd/ZXZsQ6 | 01:07 |
| de-facto | there Drosten says the same, possible decoupling between tracing and testing and real incidence | 01:07 |
| de-facto | meh i wish Antennapod would allow 3x speed or more | 01:09 |
| DocScrutinizer05 | even with data of that new paper, it's still ok to WARN, but the final outcome will most likely be "there's no particular risk or impact from it" | 01:09 |
| de-facto | hmm | 01:10 |
| CoronaBot | 04/r/coronavirus: COVID 'super-spreader' wedding that infected 34 costs country club its liquor license (10241 votes) | https://abcnews.go.com/US/covid-super-spreader-wedding-infected-34-costs-country/story?id=74125307 | https://redd.it/jrsaqi | 01:15 |
| de-facto | finally | 01:15 |
| LjL | better stock on liquor before everyone loses their license | 01:16 |
| DocScrutinizer05 | :-D | 01:18 |
| Brainstorm | Updates for France: +10943 cases (now 1.8 million) since 22 hours ago — US: +145911 cases (now 10.6 million), +1385 deaths (now 245777) since a day ago — Netherlands: +3525 cases (now 420472) since 22 hours ago — Canada: +4123 cases (now 273343), +65 deaths (now 10644) since 22 hours ago | 01:21 |
| LjL | France is getting about as terrible as Spain at counting cases (or my bot is) | 01:21 |
| LjL | one day it's 80000, one day it's 10000 | 01:21 |
| de-facto | Y453F happened in many mink farms already, was contained by culling | 01:25 |
| de-facto | e.g. in Netherlands | 01:26 |
| de-facto | due to the aminoacid difference mentioned above | 01:26 |
| LjL | well it would be nice if culling actually took place then | 01:27 |
| de-facto | hmm what? Drosten said stronger ACE2 binding can also be seen as possibly leaving the "optimum" for the virus in humans | 01:28 |
| LjL | but it's not very popular to compaign *for* killing millions of animals, even though when you look at the small print, you realize they'd soon die anyway | 01:28 |
| de-facto | that i dont understand | 01:28 |
| LjL | de-facto, can be seeing if you look at it through an overeagerly optimistic lens? :P | 01:28 |
| LjL | seen | 01:28 |
| de-facto | would the virus have to also cut the connection to the ACE2 receptor at some point in replication, e.g. if it is "too sticky" it would be blocked? | 01:29 |
| LjL | i don't know how exactly entry works... | 01:29 |
| LjL | i read about it at some point but it was a bit over my head | 01:29 |
| LjL | maybe you should invoke a yuriwho | 01:30 |
| LjL | and ideally, teach him german | 01:30 |
| de-facto | its going to be published as script though in German | 01:31 |
| de-facto | hmm Drosten says the reduction in neutralization is not so drastic | 01:32 |
| de-facto | but this Y453F probably will occur in future outbreaks in mink farms too | 01:33 |
| de-facto | since it did exactly that already independently | 01:34 |
| LjL | de-facto, it may not be so drastic when exposed to a natural set of antibodies... but what about monoclonal antibodies or cocktails thereof? i know, DocScrutinizer05 said that's why they are cocktails, but still, one of them losing power wouldn't be good news, even if for now, the other is still effective | 01:35 |
| LjL | they should borrow Regeneron and company and try them on these mutants | 01:35 |
| Brainstorm | New from CNBC Health: Remote work is 'here to stay' — even with a vaccine, says former IBM CEO: Investors wonder whether tech-driven trends such as working from home will continue after a vaccine arrives. Ginni Rometty has an answer. → https://is.gd/j4C88I | 01:36 |
| de-facto | yeah thats the reason they are cocktails not only one monotype of antibody | 01:36 |
| de-facto | to catch escape mutations | 01:36 |
| Brainstorm | Updates for US: +145580 cases (now 10.6 million) since a day ago | 01:36 |
| LjL | but that's mostly in case such a mutation happens inside the body of someone taking the cocktail | 01:36 |
| LjL | if one of the antibodies in the cocktail is just rendered ineffective in advance, that sucks a bit | 01:37 |
| LjL | you lose a degree of redundancy, so to say | 01:37 |
| de-facto | afaik thats also what an immune response would do, develop antibodies "in parallel" so at some point a whole range of them, each slightly different would be produced | 01:37 |
| de-facto | some of them fit very efficiently hence are highly neutralizing, others less so, and maybe some not alt all | 01:37 |
| de-facto | now there is an immense selective pressure from that hence an escape mutation to the very efficient antibodies *could* have a significant reproduction advantage if none of the other antibodies would fit that new mutated variant | 01:39 |
| de-facto | so its a bit like a shotgun of antibodies, the broader the spread the more likely some of them will hit and neutralize the target | 01:39 |
| LjL | but also create issues, which is one of the reasons why a small number of good neutralizing antibodies is preferred to just giving covalescent plasma | 01:40 |
| de-facto | if such monoclonal antibody cocktails only contain few ingredients they are more likely to miss the target than if they would contain a broader variety of them | 01:40 |
| de-facto | not sure if the antibodies themselves create issues or a less specific T-cell response that would cause more "collateral damage" | 01:41 |
| LjL | well there is a reason we try to get *monoclonal* antibodies though. two of them, three of them, okay. but we don't aim to obtain "a range" | 01:42 |
| DocScrutinizer05 | >><LjL> you lose a degree of redundancy, so to say<< yes, absolutely | 01:43 |
| DocScrutinizer05 | de-facto: it's actually even closer to a shotgun as those different antibodies take effect on same virus just on different locations aiui | 01:45 |
| DocScrutinizer05 | in a antibody remedy you use a cocktail because all of the used antibodies are effective against the virus. So if one spike for example mutates, this very virus still gets 'killed' by the other hits of bullets | 01:47 |
| LjL | monoclonal antibodies are *really expensive* though. what are the chances we might get them cheap enough to afford using only one, but not a cocktail, on a wider population? | 01:48 |
| DocScrutinizer05 | so a virus hat to get 3 concurrent mutations at once to escape a 3 types of antibodies cocktail | 01:48 |
| LjL | i.e. what if you're not Trump but just "a lot of people in ICU" | 01:48 |
| DocScrutinizer05 | had to get* | 01:48 |
| LjL | are we going to afford a composite cocktail or will we go for one antibody mass-produced | 01:48 |
| de-facto | hmm not sure if mutations can be excluded that evade multiple types of antibody at once | 01:49 |
| Brainstorm | Updates for US: +143906 cases (now 10.6 million), +1379 deaths (now 245785) since a day ago | 01:50 |
| de-facto | its all a big puzzle of molecular surfaces | 01:51 |
| DocScrutinizer05 | nope, it's negligence to use less than 3 independent chemicals/antibodies in treating e.g. TBC, and quite obviously sars for the very same reasons and rationale | 01:51 |
| DocScrutinizer05 | de-facto: nothing can get excluded, it's a matter of probability | 01:52 |
| DocScrutinizer05 | the broader the variations in cocktail, the better for us and more difficult for the virus to escape | 01:54 |
| de-facto | there Drosten says exactly that, natural immune response creates a polyclonal antibody response, hence probably also vaccination | 01:54 |
| DocScrutinizer05 | using a single antibody remedy is almost begging for a mutation that renders that particular antibody type useless if the virus spreads then | 01:55 |
| de-facto | also exactly about the monoclonal antibody cocktails what we talked about above | 01:55 |
| DocScrutinizer05 | >>are we going to afford a composite cocktail or will we go for one antibody mass-produced<< the problem is not the amount of different types of antibodies, it's rather the simple problem that every antibody is expensive to clone in large scale. Don't ask me why, I had to guess wildly | 01:58 |
| de-facto | hmm ok Drosten indeed is not so much concerned and he is THE expert | 01:58 |
| DocScrutinizer05 | :-) | 01:59 |
| de-facto | well that might be good then | 01:59 |
| de-facto | still i think they should cull those minks and end mink farming all together | 02:00 |
| DocScrutinizer05 | toldya, you should listen to the podcast ;-> | 02:00 |
| DocScrutinizer05 | yes, I'm with you on that | 02:00 |
| de-facto | i normally do, but sometimes a few days later | 02:00 |
| DocScrutinizer05 | it's completely nuts not to do | 02:01 |
| DocScrutinizer05 | ((cull minks)) | 02:01 |
| de-facto | i mean due to the difference in the aminoacid structure between mink and human this Y453F will occur again if mink farming is not ended | 02:01 |
| de-facto | and who knows what other mutations can be "bruteforced" in such mink populations | 02:01 |
| LjL | thing is | 02:01 |
| LjL | if Denmark and Holland cull them all, and as we're seeing that's not so certain either | 02:02 |
| LjL | the fur made by Poland and China, and for that matter also Italy, the US and all the others that were mentioned will become *pricier* | 02:02 |
| LjL | which means they will have more incentive to keep the industry going | 02:02 |
| de-facto | yes and there are outbreaks aswell known to have happened in those farms too | 02:03 |
| LjL | so unless all mink-producing countries agree to end it together all at once, then if only a few end it, it may have a negative effect on the others ending it | 02:03 |
| LjL | and good luck getting them all to agree. who will mediate? WHO will mediate? haha. | 02:03 |
| de-facto | so they might very well also have contained Y453F and it just was not seen by sequencing. or it was seen (as in netherlands) but not spread to humans yet. | 02:03 |
| de-facto | but again what about other possible mutations? we really should not provoke their emergence by allowing "bruteforcing" in animal populations such as in farms | 02:04 |
| de-facto | and since minks are HIGHLY susceptible to this its INSANE to allow their mass farming in this pandemic | 02:04 |
| LjL | but others coming from different viewpoints would probably call it insane to kill 1% of a country's GDP | 02:05 |
| LjL | (which sounds like a little but is really quite a lot) | 02:05 |
| Brainstorm | Updates for Canada: +4377 cases (now 273597), +69 deaths (now 10648) since 22 hours ago — US: +142374 cases (now 10.6 million) since a day ago | 02:06 |
| de-facto | well but the possible impact on a countries GDP by not being able to regain control over the pandemic is much larger than only 1% | 02:06 |
| LjL | probably | 02:07 |
| de-facto | thing is we need to have such things ended WORLDWIDE since the pandemic also is with that spread | 02:07 |
| de-facto | Dutch and Danish should not have a disadvantage from being the only ones acting responsible | 02:08 |
| de-facto | probably but then for vaccinating mink populations | 02:09 |
| de-facto | they do that already for other pathogens in such farms afaik | 02:09 |
| DocScrutinizer05 | *Doctor* WHO, please! b ;-D | 02:10 |
| DocScrutinizer05 | we earned thad damn virus how? from too close contact to bats? breeding zillions of minks sure sounds like "an extremely brilliant idea¡" in that context | 02:12 |
| Brainstorm | New from CNBC Health: El Paso hospitals see patients with both the coronavirus and the flu: Texas pulmonologist Dr. Emilio Gonzalez-Ayala details how the coronavirus pandemic and case surge has wreaked havoc on healthcare infrastructure in El Paso. → https://is.gd/83IvIe | 02:13 |
| Brainstorm | Updates for US: +139731 cases (now 10.6 million), +1370 deaths (now 245794) since a day ago | 02:20 |
| de-facto | DocScrutinizer05, so for example if you visit now https://corona.rki.de the warning of expired data (yesterday) is displayed | 02:32 |
| de-facto | %title https://en.wikipedia.org/wiki/Carnivora | 02:34 |
| Brainstorm | de-facto: From en.wikipedia.org: Carnivora - Wikipedia | 02:34 |
| Brainstorm | Updates for US: +140157 cases (now 10.6 million) since a day ago | 02:35 |
| DocScrutinizer05 | de-facto: ahh, thanks | 02:39 |
| LjL | so it looks like my "Germany: +16668 cases (now 705640), +203 deaths (now 11860) since a day ago" doesn't match official data for today | 02:43 |
| LjL | current logic is "last 24 hours + the one before that *if* it was within the 25th hour" | 02:44 |
| LjL | the latter rule is mostly to avoid showing "0" when there was only one data point within the past 24 hours, but i made it more complicated than "the one before if it's 0 otherwise" just you know, because when you have data coming at discrete time, using 24h as a window really means you're using *less* than 24 hours in most cases | 02:45 |
| Brainstorm | Updates for US: +1351 deaths (now 245799) since a day ago | 02:51 |
| de-facto | LjL, the data from RKI accumulated the reporting delay, so its probably behind JHU or such | 02:51 |
| de-facto | but its the official confirmed numbers reported to RKI, JHU collects the data themselves from the upstreams afaik | 02:52 |
| de-facto | for my local city RKI is at least one day behind their website, so i also grab directly from the city website | 02:54 |
| de-facto | looks like your accumulated case numbers (JHU 705640) are +18440 from the data on RKI website (with disclaimer its yesterdays data 687200) | 02:57 |
| de-facto | so thats roughly the incidence of one day | 02:57 |
| de-facto | %cases Germany | 02:57 |
| Brainstorm | de-facto: In Germany, there have been 705640 confirmed cases (0.8% of the population) and 11860 deaths (1.7% of cases) as of 3 hours ago. 23.4 million tests were performed (3.0% positive). Fatality can be broadly expected to lie between 0.5% (assuming prevalence as in tests) and less than 2.6% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Germany for time series data. | 02:57 |
| de-facto | hmm discrepancy in fatalities is 11860-11506 = 354 thats hopefully more than one day delay | 02:58 |
| LjL | de-facto, 11860 is the number from both jhu and covidly though | 03:01 |
| LjL | no, i mean | 03:02 |
| LjL | the other thing and covidly | 03:02 |
| de-facto | is it not jhu? | 03:02 |
| LjL | tinwhiskers, i have a momentary lapse, the realname data that's not covidly is our world in data? | 03:03 |
| LjL | oh, worldometer? | 03:03 |
| tinwhiskers | yeah | 03:03 |
| de-facto | which one? | 03:03 |
| rpifan | you mean a momentary lapse of reason? | 03:03 |
| LjL | of memory | 03:04 |
| LjL | de-facto, worldometer | 03:04 |
| tinwhiskers | oh, worldometer | 03:04 |
| LjL | de-facto, so it's basically: on the website, it's JHU and Covidly, but for the previous day. on the bot, it's Worldometer and Covidly, whatever they currently give | 03:04 |
| de-facto | oh ok thats good to know | 03:05 |
| Brainstorm | Updates for France: +16488 cases (now 1.8 million) since 23 hours ago — Netherlands: +4692 cases (now 421639), +83 deaths (now 8151) since 23 hours ago — Canada: +4553 cases (now 273773), +70 deaths (now 10649) since 23 hours ago — New Zealand: +1 cases (now 1988) since a day ago | 03:05 |
| LjL | de-facto, what the bot gives is the same as what used to be the "live" data on the website, but that's gone | 03:06 |
| LjL | plus, my bot always takes the highest number, and refuses to ever become lower than the highest it has | 03:06 |
| LjL | i found that was the simplest way to avoid random glitches | 03:06 |
| de-facto | which one scores highest most often? worldometers? | 03:07 |
| de-facto | btw positivity for testing should be above 7% already in Germany | 03:10 |
| de-facto | so 3% is probably based on old data | 03:11 |
| LjL | de-facto, worldometers is frequent, but i don't know which offers highest. i just *pick* the highest in the code | 03:16 |
| LjL | yeah the testing data sucks | 03:16 |
| de-facto | %title https://ars.rki.de/Content/COVID19/Main.aspx <-- describes testing in great detail but in German only | 03:17 |
| Brainstorm | de-facto: From ars.rki.de: ARS - Antibiotika Resistenz Surveillance | 03:17 |
| de-facto | %title https://imgur.com/a/aOCQrg2 https://i.imgur.com/hQLMJ7p.png source: https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Situationsberichte/Nov_2020/2020-11-04-de.pdf?__blob=publicationFile | 03:27 |
| Brainstorm | de-facto: From imgur.com: COVID-19 Germany: Proportion of positive tests over time - Album on Imgur | 03:27 |
| de-facto | Hence proportion of positive tests in Germany is approaching 0.075 hence 7.5% or such at start of November | 03:29 |
| de-facto | %title https://imgur.com/a/ofF0xEk https://i.imgur.com/ytuiqEy.png source: https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Situationsberichte/Nov_2020/2020-11-10-de.pdf?__blob=publicationFile | 03:30 |
| Brainstorm | de-facto: From imgur.com: COVID-19 Germany: Weekly Incidence per 100k by demographic groups - Album on Imgur | 03:30 |
| de-facto | This one is quite interesting, it shows the weekly incidence in a heatmap for age groups over time | 03:30 |
| de-facto | it looks like it started with the young 20-29 high contact rate and high mobility groups, then continued to diffuse into the working age groups while at the same time diffusing into the very old high risk groups | 03:31 |
| de-facto | the group still best shielded are the very young children and the risk group in their 70s | 03:32 |
| de-facto | probably those are still living alone isolated at their homes, while the older may be in elderly care homes? not sure | 03:33 |
| de-facto | but for some reason the 80+ group is not well shielded, thats very sad | 03:33 |
| de-facto | because they will just die. | 03:33 |
| de-facto | We NEED much more testing capacity. | 03:34 |
| de-facto | and we need regular testing in the environment of such old risk groups | 03:35 |
| de-facto | i dont know the median age for fatalities but i would guess its on that cluster there around the 80s or such | 03:37 |
| de-facto | IFR(age) = 100% Exp[ Log[2] age / 5.75] / 1682 hence IFR(60) = 0.82%; IFR(65) = 1.50%; IFR(70) = 2.75%; IFR(75) = 5.02%; IFR(80) = 9.17%; IFR(85) = 16.76%; IFR(90) = 30.61% | 03:41 |
| DocScrutinizer05 | well, the problem is, no matter what the need for testing, the supply is limited. They are literally running short of reagents | 03:44 |
| DocScrutinizer05 | globally | 03:45 |
| DocScrutinizer05 | BIG plus for LAMP test, uses unlimited supply simple reagents I heard | 03:45 |
| de-facto | and also out of lab material such as stupid plastic pipette tips | 03:46 |
| DocScrutinizer05 | :nod: | 03:46 |
| de-facto | we need to change the strategy to minimize the amount of consumables and maximize the throughput and supply chain dependence and scaling | 03:46 |
| de-facto | to be honest i dont understand why they did not do that in advance, it was expected by all experts that incidence would raise in the fall | 03:48 |
| Skunny | I'm going to drive thru for tacos | 03:49 |
| Skunny | day 11 | 03:49 |
| Skunny | I'm going outside! | 03:49 |
| de-facto | hmm you still can be contagious to others | 03:50 |
| de-facto | for most people the viral shedding reduces significantly 7 days after onset of symptoms | 03:50 |
| de-facto | but there are always exceptions, so without a (antigen quicktest) you just dont know that | 03:51 |
| Skunny | hrm | 03:51 |
| Skunny | I was gonna wear a mask | 03:51 |
| Skunny | and I have spray sanitizer for my debit card | 03:51 |
| de-facto | cant you get it delivered to your home and let them put it in front of your door, you pay online? | 03:52 |
| de-facto | do you have a cough? | 03:52 |
| Skunny | maybe | 03:52 |
| Skunny | never got the cough | 03:52 |
| Skunny | and my temp has been around 98.0 for last few days | 03:52 |
| Skunny | never had breathing problems too | 03:52 |
| Skunny | either way I can taste just lil bit right now | 03:53 |
| de-facto | well congratz it sounds like you might have been among the lucky ones | 03:53 |
| Skunny | yup | 03:53 |
| de-facto | still be careful, assume you might be contagious to others until some safety margin is reached like 14 days or such | 03:53 |
| Skunny | and my wife is negative on here test saturday | 03:53 |
| Skunny | right | 03:53 |
| Skunny | Now I'm going to give plasma too | 03:54 |
| de-facto | then if you are symptom free at some point you either have to get another test or just assume you are recovered due to the time safety margin | 03:54 |
| Skunny | tomorrow morning I get another test | 03:54 |
| de-facto | well then please wait for that result, its just another few days | 03:54 |
| Skunny | yeah, you're right | 03:55 |
| Skunny | I got some leftovers I'll reheat | 03:55 |
| de-facto | if you continue and bring this to a safe end then you ended an infection chain, congratz | 03:56 |
| de-facto | if everyone would be more careful the pandemic would be under control, some countries demonstrated that its possible to wrestle it down | 03:57 |
| Skunny | I got to clean my guest room | 04:00 |
| Skunny | I think I might just shut the door for 7 days | 04:00 |
| Skunny | But I'm going to have to clean the bathroom cause it's a main bathroom | 04:00 |
| Skunny | everyones been going upstairs | 04:00 |
| Skunny | Wife was sleep ing your MB, son has been in his room with his own bathroom | 04:01 |
| Skunny | I been downstairs using guestroom and bathroom | 04:01 |
| de-facto | good system, you seem to have succeeded in protecting them if they tested negative | 04:02 |
| de-facto | im curious, did you take special care about air exchange? | 04:02 |
| Skunny | I guess so | 04:06 |
| Skunny | I had fans going in the living room | 04:06 |
| Skunny | even though it was cold | 04:07 |
| Skunny | and windows cracked on each end | 04:07 |
| de-facto | yeah removing air and replacing with fresh from outdoors is the best method | 04:07 |
| Skunny | well still waiting on sons test | 04:07 |
| Skunny | also because I did not have cough or breathing issues I think it helped out a lot | 04:08 |
| de-facto | afaik bathrooms and toilets were found to be highly contaminated in hospitals because its how the body gets rid of the virus, they tested with PCR for the virus RNA, so its not clear if those were infectious "functional" virions or just "garbage", still the concentration was high afaik | 04:08 |
| de-facto | yeah makes sense | 04:08 |
| de-facto | if you cough or sneeze you shed gigantic amounts of aerosol from saliva that may contain the virus | 04:09 |
| yuriwho | it's worth it to minimize your exposure to anyone until you test negative. Stop the chain of transmission. | 04:10 |
| Skunny | yeah, cause I got it and I am super super careful | 04:10 |
| Skunny | so I was apalled when I got it | 04:11 |
| de-facto | so even if symptomatic and asymptomatic carriers would have comparable viral loads on their mucosa and saliva the symptomatic carriers spread it more efficiently due to coughing, sneezing etc | 04:11 |
| Skunny | are you in the uS? | 04:11 |
| Skunny | US | 04:11 |
| de-facto | me? nope im in Germany | 04:12 |
| Skunny | ahhh | 04:12 |
| Skunny | I'm German :-D | 04:12 |
| Skunny | last name Kraft :-p | 04:13 |
| de-facto | oh nice :) | 04:13 |
| Skunny | how's COVID over there doing? | 04:13 |
| de-facto | is it true that the largest immigrant group to US are Germans? | 04:13 |
| de-facto | exponentially :/ | 04:13 |
| Skunny | damn | 04:13 |
| de-facto | we are in lockdown currently, but a "light" version of it with schools and stores open | 04:14 |
| Skunny | Currently 40 to 60 million Americans cite “German” as their primary origin and thus represent the largest immigrant group – even greater than those descended from Irish and Italians | 04:14 |
| de-facto | early effects may possibly show themselves, but numbers still are raising | 04:14 |
| de-facto | but if this lockdown does not work we might very well run out of ICU beds in 3-4 weeks, so its a one shot | 04:15 |
| Brainstorm | New from The Indian Express: World: Suicide halts Brazil trial of Chinese vaccine attacked by Bolsonaro → https://is.gd/VYKmpR | 04:15 |
| de-facto | what? Sinovac ^^ | 04:17 |
| de-facto | "Brazil’s health regulator, Anvisa, suspended the trials late on Monday saying the event occurred on Oct. 29. The state government of Sao Paulo, where the trial is being run, said the death of a trial volunteer had been registered as a suicide and was being investigated. A police report of the incident was seen by Reuters." | 04:20 |
| de-facto | hmmm | 04:20 |
| de-facto | how credible is that source? | 04:20 |
| de-facto | exactly the same what is written on https://www.reuters.com/article/us-health-coronavirus-brazil-sinovac/brazil-suspends-sinovac-covid-19-vaccine-trial-due-to-adverse-event-idUSKBN27Q04C | 04:22 |
| de-facto | oh btw yuriwho have you seen https://www.ssi.dk/aktuelt/nyheder/2020/ssis-deling-af-data-om-cluster-5-sars-cov-2-minkvariant-virus and the report on cluster 5 in english on https://files.ssi.dk/Mink-cluster-5-short-report_AFO2 ? | 04:24 |
| de-facto | contains quite interesting details | 04:24 |
| Brainstorm | New from CNBC Health: Covid vaccine won’t be an ‘instant stimulus’ to the U.S. economy, warns economist: The U.S. economy can't depend on a coronavirus vaccine to "solve all our problems," said Carl Tannenbaum, chief economist at Northern Trust. → https://is.gd/ihLgb5 | 04:43 |
| Brainstorm | Updates for Belize: +184 cases (now 4414), +2 deaths (now 73) since a day ago — Belgium: +4293 cases (now 507475), +345 deaths (now 13561) since a day ago | 04:51 |
| DocScrutinizer05 | >><de-facto> early effects may possibly show themselves, but numbers still are raising<< hmmm, we reached R_eff=1 during last 4 days, and effects of the lockdown-lite are not to be seen yet.What we see are effects of the MK and mama Merkel warning about pending doom 2 weeks earlier | 04:57 |
| de-facto | well yes but both effects transition smoothly so id guess we see a combination of both | 04:59 |
| de-facto | and yeah R may approach 1 IF we could trust that there is not too much decoupling of overwhelming tracing and testing relative to real incidence. That is a big IF that even Drosten mentioned. | 05:01 |
| de-facto | i would very much like to believe its real incidence dropping, and it would make sense, but until numbers of hospitalizations stop raising we cant be sure | 05:02 |
| rmonten[m] | What were the dates of those (Merkel's warning & lockdown light?) | 05:03 |
| de-facto | good question, lockdown light started on Nov 2nd | 05:03 |
| rmonten[m] | I see, yeah I guess you could see that in the number of cases, no? Maybe not in 7-day averages yet | 05:04 |
| rmonten[m] | Anybody know the current best estimate on these delays, like drop in cases, hospitalizations & deaths after lockdown? | 05:07 |
| de-facto | i think the meeting for the first pre-lockdown measures was on 2020-10-14 | 05:08 |
| de-facto | so the address of the nation with the warning must have been around that date | 05:09 |
| de-facto | rmonten[m], thats actually the question, can it be seen in the number of cases? | 05:09 |
| de-facto | lets assume a worst case scenario: the capacity for tracing is exceeded, they find only a portion of all new infections that becomes smaller and smaller, hence without testing those cases would go "unknown underground". Ok then the testing capacity itself, it does not increase exponentially as does the incidence of new infections, so people wait much longer for their test results or even cant get a test at all (because testing capacity | 05:13 |
| de-facto | must be prioritized and targeted the most probable susceptible e.g. the symptomatic) | 05:13 |
| de-facto | so both effects would lead to a decoupling of raise in real prevalence (still raising exponentially maybe slowed down due to contact rate reduction) from the numbers reported by positive test results (due to saturation in the testing capacity) | 05:15 |
| de-facto | i am sure both all three effects are at work: 1) slowing down of the increase of new (unknown) infections 2) tracing capacity overwhelmed hence the ratio of dark to known cases raises 3) saturation in testing capacity decoupling from real incidence requiring a change of targeting | 05:17 |
| de-facto | so the question now is: how to account the change in reported cases to each of those three effects? | 05:17 |
| de-facto | in my opinion: reserve 1% of testing capacity and do a random representative sampling in the population to get a proper estimate for real prevalence: randomly choose people from the public register and test them. | 05:19 |
| de-facto | but since they dont do that, maybe its more difficult than i think for some reason | 05:19 |
| de-facto | another (delayed) approach would be to look at daily new hospitalizations, as long as hospital capacity is not exceeded they might show the infection numbers 10-14 days in the past | 05:26 |
| rmonten[m] | You're probably right that it's all 3, as you said before it'll reflect in the number of hospitalizations pretty quickly afterwards, so I'd say you can keep 100% of your tests for those most at risk | 05:27 |
| rmonten[m] | jinx | 05:27 |
| de-facto | oh btw i am not saying there is no effect in real incidence (actually i would expect there is a real effect, otherwise we are doomed anyhow), its just hard to distinguish those 3 contributions to reported cases | 05:28 |
| rmonten[m] | True. But it sounds like getting R_eff around 1 a week after lockdown light is pretty good. One big risk may be that the population starts thinking it wasn't necessary and stops taking precautions. There's always pressure from that part of the population, only a matter of time before they become the loudest again. | 05:33 |
| de-facto | yes and winter is long, we really need to get ontop of this and control it | 05:40 |
| de-facto | lets assume the real R would approach 1, this would only mean we are able to influence it, but the real hard work is to hold it significantly below 1 to force daily new infections to go down to a level where it can be controlled by tracing again. the expensive time in lockdown needs to be used to prepare for that, increase capacities of tracing, testing, treatment etc | 05:42 |
| de-facto | and this would have to be achieved in all of EU | 05:42 |
| de-facto | borders are open, travel discouraged but allowed as far as i know | 05:43 |
| de-facto | well but in Germany hotels closed for tourists | 05:43 |
| de-facto | and there they are the new numbers | 05:44 |
| de-facto | RKI: Germany daily new infections +18 487 (705 687 total), daily fatalities +261 (11 767 total) | 05:46 |
| de-facto | damn fatalities are raising fast :( | 05:46 |
| de-facto | was to be expected | 05:46 |
| rmonten[m] | I think most personal travel happened during the summer. Now it's probably mostly business. The next big family thing will probably be the holidays. Get ready for lots of generational mixing. It would be a very good thing if the amount of virus in circulation would be down significantly by that time. | 05:46 |
| de-facto | indeed very true | 05:47 |
| de-facto | and afaik thats the plan, force incidence down in order to allow for family gathering on holidays | 05:47 |
| rmonten[m] | Yeah that sucks, I hope it stops growing soon but probably not for a while | 05:47 |
| de-facto | some even suggest to do a "cool down" precautious quarantine prior to meeting multi generation family | 05:48 |
| de-facto | so actually those 18k new infections are exactly the difference we calculated earlier | 05:49 |
| de-facto | "looks like your accumulated case numbers (JHU 705640) are +18440 from the data on RKI website (with disclaimer its yesterdays data 687200)" | 05:50 |
| de-facto | so only 0.25% deviation from that | 05:51 |
| rmonten[m] | What would a cool down mean? Literally quarantine with a small bubble before meeting the grand parents? | 05:51 |
| de-facto | yep | 05:51 |
| kreyren | %cases slovakia | 05:52 |
| de-facto | assume everyone is asymptomatic carrier hence isolate to wait for infectiousness to cool down prior to meeting risk groups | 05:52 |
| Brainstorm | kreyren: In Slovakia, there have been 77123 confirmed cases (1.4% of the population) and 390 deaths (0.5% of cases) as of 19 hours ago. 913096 tests were performed (8.4% positive). See https://offloop.net/covid19/?default=Slovakia for time series data. | 05:53 |
| de-facto | when did they do the mass screening in Slovakia? | 05:55 |
| rmonten[m] | Good idea, don't think many people will have the discipline or motivation to actually do it though.. | 05:56 |
| rmonten[m] | Not more so than usual | 05:56 |
| de-facto | yeah | 05:56 |
| de-facto | yet its about their loved ones | 05:56 |
| de-facto | so maybe that plays a role too | 05:57 |
| rmonten[m] | Maybe a bit, but that's not going to be enough | 05:57 |
| rmonten[m] | Right but we also for some reason are less careful around our loved ones, it's so weird to wear masks around people you're comfortable with | 05:57 |
| de-facto | yeah true, and actually when thinking about it exactly the opposite of how one should behave: wearing a mask means caring about preventing contagion to the people in proximity, so why would we want to infect our family? | 05:59 |
| de-facto | its probably more emotionally feeling like trusting the family environment or such | 06:00 |
| de-facto | but thats risky as you pointed out above probably most would not really have to discipline to cool down | 06:00 |
| rmonten[m] | Yes exactly | 06:05 |
| Brainstorm | New from r/WorldNews: worldnews: Jair Bolsonaro asks Brazilians not to deal with Covid-19 'like f*gs' → https://is.gd/CdHA66 | 06:24 |
| Brainstorm | Updates for Germany: +26547 cases (now 715693) since a day ago — Anhui, China: +1 cases (now 992) since 4 months ago | 07:05 |
| iacukhweuiocvnoa | how is everyone doing | 07:15 |
| Brainstorm | Updates for Delhi, India: +7830 cases (now 451382), +83 deaths (now 7143) since a day ago — Missouri, US: +6559 cases (now 228907), +119 deaths (now 3454) since a day ago — Louisiana, US: +5020 cases (now 194702) since 12 hours ago — Stockholm, Sweden: +4762 cases (now 46377), +11 deaths (now 2467) since 3 days ago | 07:20 |
| Brainstorm | Updates for Saint Lucia: +2 deaths (now 2) since 10 hours ago | 07:51 |
| Brainstorm | Updates for Georgia: +2911 cases (now 66561), +45 deaths (now 566) since a day ago | 08:21 |
| Brainstorm | New from Medical Xpress: Vitamin C's effectiveness against COVID may hinge on vitamin's natural transporter levels: High doses of vitamin C under study for treating COVID-19 may benefit some populations, but investigators exploring its potential in aging say key factors in effectiveness include levels of the natural transporter needed to get the [... want %more?] → https://is.gd/tbsXdZ | 09:11 |
| Brainstorm | New from Medical Xpress: Targeted therapies developed to reduce lung fibrosis: A new treatment option for lung fibrosis is being developed by Purdue University scientists. Lung fibrosis has been a concern for COVID-19 patients. → https://is.gd/JIi6lB | 09:20 |
| Brainstorm | New from CNBC Health: (news): Fed's Rosengren says next 6 months will be 'pretty choppy' despite vaccine news → https://is.gd/2FfaJ5 | 09:32 |
| Brainstorm | New from The Indian Express: World: Covid kills 15,000 US mink as Denmark prepares for nationwide cull → https://is.gd/bu6BuL | 09:43 |
| Brainstorm | New from Medical Xpress: Recordings reveal WHO's analysis of pandemic in private: As the coronavirus explodes again, the World Health Organization finds itself both under intense pressure to reform and holding out hope that U.S. President-elect Joe Biden will reverse a decision by Washington to leave the health agency. → https://is.gd/4qs6lQ | 09:53 |
| Brainstorm | New from Medical Xpress: US hits record COVID-19 hospitalizations amid virus surge: The U.S. hit a record number of coronavirus hospitalizations Tuesday and surpassed 1 million new confirmed cases in just the first 10 days of November amid a nationwide surge of infections that shows no signs of slowing. → https://is.gd/iZf3ds | 10:03 |
| Brainstorm | New from Medical Xpress: Texas becomes 1st state to surpass 1 million COVID-19 cases: Texas health officials say new cases of the coronavirus that causes COVID-19 have hit a new peak. According to the Johns Hopkins website, the state recorded 1,010,364 cases early Wednesday with 19,337 deaths since the pandemic began in early March. → https://is.gd/uOXTjh | 10:14 |
| Brainstorm | New from The Indian Express: World: Chinese man sells newborn after losing job during pandemic → https://is.gd/n64EyP | 10:24 |
| Brainstorm | New from Medical Xpress: Planes, dry ice, pharmacies: the logistical challenges of COVID-19 vaccines: The United States could be the first country to launch one of the most ambitious vaccine operations in history: distributing and administering up to 600 million doses of a COVID-19 vaccine in just a few months. → https://is.gd/97579m | 10:36 |
| Brainstorm | New from Medical Xpress: Supreme Court inclined to save Obamacare as Covid-19 pandemic widens: The US Supreme Court appeared inclined Tuesday to reject Trump administration arguments and let stand former president Barack Obama's signature health care program, ending the threat to the insurance coverage of 20 million people in the midst of the [... want %more?] → https://is.gd/nFqtNY | 10:47 |
| fuhlu | set nick conjo23 | 11:34 |
| blkshp | /nick conjo23 | 11:35 |
| Brainstorm | New from BMJ: David Oliver: Heed HSIB on covid transmission in hospital: The Healthcare Safety Investigation Branch (HSIB) recently published its report of a four month safety investigation into covid-19 transmission in hospitals.1 The findings are complex and nuanced,... → https://is.gd/zzhH7p | 11:41 |
| CoronaBot | 04/r/covid19: Validation of home oxygen saturations as a marker of clinical deterioration in patients with suspected COVID-19 (80 votes) | https://www.medrxiv.org/content/10.1101/2020.11.06.20225938v1 | https://redd.it/jrtenl | 11:42 |
| Brainstorm | Updates for Belarus: +1057 cases (now 109357), +6 deaths (now 1022) since 22 hours ago | 11:50 |
| Brainstorm | Updates for Iran: +11780 cases (now 715068), +462 deaths (now 39664) since a day ago | 12:20 |
| Brainstorm | New from The Indian Express: World: Covid superspreader risk is linked to restaurants, gyms, hotels → https://is.gd/0AptUV | 12:20 |
| Brainstorm | Updates for Switzerland: +8270 cases (now 243472), +120 deaths (now 3057) since a day ago | 12:36 |
| Brainstorm | Updates for Latvia: +453 cases (now 8848), +2 deaths (now 105) since a day ago — Germany: +199 deaths (now 11878) since a day ago | 12:50 |
| Brainstorm | New from CNBC Health: (news): Russia says its coronavirus vaccine is 92% effective, as battle to beat Western drugmakers heats up → https://is.gd/omUoJL | 12:59 |
| Brainstorm | New from Medical Xpress: Mongolia reports first domestic coronavirus transmissions: Mongolia Wednesday reported its first domestic transmissions of the coronavirus, from a truck driver who infected his wife and two other relatives after three weeks of quarantine. → https://is.gd/5JIb0E | 13:09 |
| CoronaBot | 04/r/covid19: The first interim data analysis of the Sputnik V vaccine against COVID-19 phase III clinical trials in the Russian Federation demonstrated 92% efficacy (84 votes) | https://sputnikvaccine.com/newsroom/pressreleases/the-first-interim-data-analysis-of-the-sputnik-v-vaccine-against-covid-19-phase-iii-clinical-trials-/ | https://redd.it/js5ef1 | 13:18 |
| Brainstorm | New from BBC Health: Covid vaccine: 'No decision' on under 50s vaccine plan: Uncertainty about how the Covid vaccines work mean there is no plan for younger people yet. → https://is.gd/8DRlGn | 13:37 |
| rpifan | nice | 13:45 |
| Brainstorm | New from Medical Xpress: COVID-19 report reveals major hit to the northern England's health and economy: The North has been hit harder than the rest of the country during COVID-19 and this has increased inequality in England, a new study involving Newcastle University has revealed. → https://is.gd/wmABbT | 14:05 |
| Brainstorm | New from Medical Xpress: EU proposes new agency for future health crises: The European Union declared a health emergency on Wednesday and launched moves to build a new agency and joint plan to prepare for crises like the coronavirus epidemic. → https://is.gd/1CuVrb | 14:15 |
| Brainstorm | Updates for Gibraltar: +28 cases (now 842), +1 deaths (now 1) since a day ago | 14:21 |
| Brainstorm | Updates for US: +142293 cases (now 10.6 million), +1442 deaths (now 245963) since 22 hours ago — Netherlands: +5407 cases (now 424819), +74 deaths (now 8215) since 22 hours ago — Germany: +181 deaths (now 11881) since a day ago | 14:35 |
| Brainstorm | Updates for US: +144487 cases (now 10.6 million) since 22 hours ago — Switzerland: +103 deaths (now 3071) since a day ago | 14:51 |
| Brainstorm | New from r/Coronavirus: Coronavirus: Daily Discussion Post - November 11 | Questions, images, videos, comments, unconfirmed reports, theories, suggestions → https://is.gd/c9Q5vZ | 14:53 |
| Brainstorm | New from CNBC Health: U.S. prepares for worst four months of the pandemic as it stares down the 'darkest' days yet: The U.S. is heading for a “dark winter,” a “Covid Hell" that will make the next few months of the coronavirus pandemic unlike anything the nation has seen yet. → https://is.gd/TeyOll | 15:03 |
| Brainstorm | Updates for Switzerland: +119 deaths (now 3087) since a day ago — Germany: +189 deaths (now 11889) since a day ago | 15:05 |
| BoondockSaint[m] | 11000 peope died a day ago? | 15:08 |
| Brainstorm | New from Medical Xpress: Will low-income countries miss out on the COVID-19 vaccine?: A new global assessment of purchasing agreements for COVID-19 vaccines reveals that high-income countries, as well as a few middle-income countries flush with manufacturing capacity, have already purchased nearly 3.8 billion doses, with options for another five billion. → https://is.gd/hdAX4z | 15:12 |
| Brainstorm | Updates for Serbia: +3536 cases (now 70424), +21 deaths (now 936) since a day ago | 15:21 |
| Brainstorm | New from The Indian Express: World: Pandemic spurs EU to seek more preparation, coordination → https://is.gd/HgINdj | 15:22 |
| DocScrutinizer05 | >> Likewise, the @US_FDA should have announced it [vaccine] earlier, not for political purposes, but for saving lives!<< [Trump] Is there any aspect how earlier *announcement* would save lifes? | 15:28 |
| Brainstorm | New from Medical Xpress: Q&A: Uncertain times take their toll on teeth and jaws: If it seems like you've been gnashing your teeth over the woes of the world, there's a good chance that you have been. Dentists are seeing signs that tooth-grinding and jaw-clenching are on the rise during the pandemic, just as they were during the Great Recession a little [... want %more?] → https://is.gd/lqezRk | 15:32 |
| Brainstorm | Updates for US: +144629 cases (now 10.6 million), +1444 deaths (now 245965) since 23 hours ago — Germany: +181 deaths (now 11897) since a day ago | 15:36 |
| Brainstorm | Updates for Germany: +196 deaths (now 11912) since a day ago | 15:50 |
| Brainstorm | New from Scientific American: The Real Danger Posed by Coronavirus-Infected Mink: Mink farmers in Denmark move a batch of animals they were ordered to kill because of worries about a mutated strain of coronavirus. The order was later put on hold because the government lacked the authority to issue it. → https://is.gd/1Us5kp | 15:51 |
| Brainstorm | Updates for US: +145885 cases (now 10.6 million), +1461 deaths (now 245982) since a day ago | 16:06 |
| Brainstorm | Updates for West Virginia, US: +885 cases (now 30201), +7 deaths (now 553) since 22 hours ago — US: +146770 cases (now 10.6 million), +1468 deaths (now 245989) since a day ago | 16:20 |
| DocScrutinizer05 | de-facto: LjL: where could I find number of tests stats for Germany? | 16:25 |
| Brainstorm | New from Medical Xpress: A survey on artificial intelligence in chest imaging of COVID-19: In a new article for BIO Integration journal, a group of researchers from China consider the application of artificial intelligence imaging analysis methods for COVID-19 clinical diagnosis. → https://is.gd/iMsjKo | 16:28 |
| Brainstorm | Updates for US: +148364 cases (now 10.6 million), +1483 deaths (now 246004) since a day ago | 16:36 |
| Brainstorm | New from Medical Xpress: EU could see first Covid-19 jabs in early 2021: health agency: The first vaccinations in the European Union against COVID-19 could happen in the first three months of 2021 under an optimistic scenario, the EU health agency chief told AFP on Wednesday. → https://is.gd/w5S8HX | 16:38 |
| Brainstorm | New from Medical Xpress: Domestic abuse and mental ill-health: Twin shadow pandemics stalk the second wave: The coronavirus crisis has been stalked by two shadow pandemics—one of domestic abuse and one of mental health. Since the first outbreak of the virus, numerous reports have highlighted a marked increase in forms of domestic violence and abuse, [... want %more?] → https://is.gd/qA8t9T | 16:47 |
| Brainstorm | Updates for Maryland, US: +1714 cases (now 158423), +16 deaths (now 4249) since a day ago — US: +150078 cases (now 10.6 million), +1499 deaths (now 246020) since a day ago — Canada: +4340 cases (now 274463) since a day ago | 16:50 |
| Brainstorm | New from Medical Xpress: Gibraltar suffers first virus death: An elderly woman living in a care home has become the first person to die of COVID-19 in Gibraltar, the government said on Wednesday. → https://is.gd/bcLWq2 | 16:57 |
| Brainstorm | Updates for Algeria: +811 cases (now 64257), +16 deaths (now 2093) since 23 hours ago — Italy: +32961 cases (now 1.0 million), +623 deaths (now 42953) since 23 hours ago — Germany: +184 deaths (now 11920) since a day ago | 17:06 |
| Brainstorm | New from Scientific American: How We Can Avoid a 'Twindemic' of COVID and Flu: There’s no vaccine against the coronavirus yet, but we have influenza vaccines—and we need to use them -- Read more on ScientificAmerican.com → https://is.gd/NceS21 | 17:07 |
| rpifan | i tried to get the flu vaccine at my dr | 17:12 |
| rpifan | and they said they were all out | 17:12 |
| rpifan | i dont usually take them | 17:12 |
| rpifan | but ive got hiv | 17:12 |
| rpifan | so im slightly higher risk | 17:12 |
| Brainstorm | New from Medical Xpress: Millions at risk as coronavirus disrupts immunisation campaigns: UN: Millions of people, including in Africa's most populous country Nigeria, risk contracting diseases such as polio and measles as the coronavirus pandemic has halted vaccination campaigns, the UN said Wednesday. → https://is.gd/8Kzef2 | 17:16 |
| Brainstorm | Updates for US: +146573 cases (now 10.6 million), +1445 deaths (now 246034) since a day ago — Canada: +4537 cases (now 274660), +76 deaths (now 10657) since a day ago | 17:20 |
| Brainstorm | New from CNBC Health: (news): What you need to know about BioNTech — the European company behind Pfizer's Covid-19 vaccine → https://is.gd/m08hzm | 17:26 |
| Brainstorm | Updates for United Kingdom: +22950 cases (now 1.3 million), +595 deaths (now 50365) since 22 hours ago | 17:37 |
| LjL | rpifan: isn't it great they told everyone to absolutely get their flu shot, months in advance, and then they didn't stock nearly enough of them | 17:42 |
| rpifan | well thats germany for you | 17:43 |
| rpifan | i dont even really want it | 17:43 |
| rpifan | but ive been told its recommended | 17:43 |
| de-facto | DocScrutinizer05, https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Testzahl.html | 17:45 |
| DocScrutinizer05 | wow, they really suck at indexing their info, eh? | 17:45 |
| de-facto | its all at their website if you look at https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/nCoV_node.html | 17:46 |
| DocScrutinizer05 | thanks a lot, never seen this before | 17:48 |
| LjL | rpifan: that's also Italy for me | 17:48 |
| rpifan | yea | 17:49 |
| DocScrutinizer05 | LjL: it's normal the flu shots come in batches, over 2 months | 17:49 |
| DocScrutinizer05 | they didn'T consider the run they create by their call | 17:50 |
| LjL | Oooooh it's normal but they didn't *consider* that the whole situation is not normal. How could they | 17:50 |
| DocScrutinizer05 | that's also normal for politicians ;-D | 17:51 |
| Brainstorm | Updates for Turkey: +2693 cases (now 402053), +86 deaths (now 11145) since a day ago — Vermont, US: +73 cases (now 2535) since a day ago — US: +145666 cases (now 10.6 million) since a day ago | 17:51 |
| DocScrutinizer05 | </sarkasm> I don't think we see a "drop in positive tests by saturation of testing" *yet*, in Germany | 17:53 |
| DocScrutinizer05 | I have little evidence for this, just a gut feeling and the info that there's still priorization in test processing in labs | 17:54 |
| Brainstorm | New from In The Pipeline: Good News on T-Cell Response: There are several recent preprints and publications that bear on the T-cell immunity story for the coronavirus pandemic, and I wanted to highlight these, since it’s been a big part of the story that’s needed more information for a long time now. Here, for one, is a multi-institute study from [... want %more?] → https://is.gd/V9yE2n | 17:55 |
| DocScrutinizer05 | otoh there's zilch evidence for "test count reduced" | 17:55 |
| CoronaBot | 04/r/coronavirus: Anthony Fauci: "Hang in there a bit longer. Do the things you need to do and we'll be OK. When you know help is on the way, you don't give up." (10183 votes) | https://edition.cnn.com/2020/11/10/health/us-coronavirus-tuesday/index.html | https://redd.it/js47he | 18:02 |
| Brainstorm | Updates for Pennsylvania, US: +4098 cases (now 248144) since 20 hours ago — US: +149764 cases (now 10.6 million) since a day ago — Canada: +4555 cases (now 275841), +52 deaths (now 10669) since a day ago — Germany: +197 deaths (now 11953) since 23 hours ago | 18:05 |
| DocScrutinizer05 | anyway RKI report says German R_eff_avg[4d] = 0.88 (95% within 0.73- 1.05 and R_eff_avg[7d] = 0.92 (95% within 0.,84 - 1.00) | 18:06 |
| DocScrutinizer05 | and I realyl can't think of a way they would "forget" about testing saturation atrifacts even in their confidence interval estimations | 18:07 |
| Brainstorm | New from CNBC Health: (news): Pfizer CEO sold $5.6 million of stock as company announced vaccine data that sent shares soaring → https://is.gd/FM4fPy | 18:14 |
| Brainstorm | Updates for US: +154653 cases (now 10.6 million), +1466 deaths (now 246092) since a day ago | 18:21 |
| hirogen | \topic | 18:25 |
| Brainstorm | New from BBC Health: Coronavirus: Northern England 'worst hit' by pandemic: Health inequalities have led to Covid-19 taking a "devastating grip" on the north, a report says. → https://is.gd/TtN2j9 | 18:45 |
| Brainstorm | Updates for US: +153127 cases (now 10.6 million), +1409 deaths (now 246130) since a day ago — Germany: +17812 cases (now 716814), +220 deaths (now 11976) since a day ago | 18:50 |
| Brainstorm | New from Medical Xpress: Study finds lasting fatigue common after COVID-19 infection: More than half of people with acute COVID-19 infection continue to have persistent fatigue 10 weeks after their initial illness, according to a new study published November 9 in the open-access journal PLOS ONE by Liam Townsend of Trinity College Dublin, Ireland and colleagues. → https://is.gd/pbSVBm | 19:06 |
| Brainstorm | Updates for Indiana, US: +5036 cases (now 224374), +31 deaths (now 4762) since a day ago — US: +148441 cases (now 10.6 million), +1350 deaths (now 246161) since a day ago — Switzerland: +99 deaths (now 3112) since 19 hours ago | 19:06 |
| Brainstorm | New from Medical Xpress: Yes, you can get the flu and the coronavirus at the same time: We've been dealing with the coronavirus for months. And now the dreaded flu season is upon us. Is it possible that both viruses could infect your body at once? → https://is.gd/MlvPSe | 19:16 |
| Brainstorm | Updates for US: +150704 cases (now 10.6 million), +1362 deaths (now 246173) since a day ago | 19:20 |
| LjL | we don't know if my parents should even *try* to get a flu shot. usually they'd get them at their doctor's office, but this time everything's messed up and, assuming it will be possible at all, it will have to take place in much larger structures. with the rampant COVID in Lombardy, i'm not really sure the odds are worth it | 19:21 |
| Brainstorm | Updates for Illinois, US: +12657 cases (now 523840), +153 deaths (now 10798) since 23 hours ago — US: +161211 cases (now 10.6 million), +1521 deaths (now 246362) since a day ago — Arizona, US: +2030 cases (now 265163), +36 deaths (now 6228) since a day ago | 19:37 |
| LjL | "Only 42.2% of the patients (54/128) reported feeling back to their full health. Importantly, there was no association between COVID-19 severity, need for hospital admission, or routine laboratory markers of inflammation with the likelihood of experiencing persistent fatigue after infection." | 19:44 |
| Brainstorm | New from Ars Technica: Science: US healthcare on brink as COVID-19 hospitalizations hit all-time high → https://is.gd/pWAdNK | 19:46 |
| Brainstorm | Updates for France: +33652 cases (now 1.9 million), +328 deaths (now 42535) since 22 hours ago — US: +162318 cases (now 10.6 million), +1539 deaths (now 246380) since a day ago — Canada: +4916 cases (now 276585) since 23 hours ago | 19:51 |
| LjL | the US is picking up pace case number-wise, but from about the same time, testing also picked up pace | 19:53 |
| Brainstorm | Updates for US: +168156 cases (now 10.6 million), +1587 deaths (now 246428) since a day ago | 20:05 |
| Brainstorm | New from Medical Xpress: Brazil allows trials of Chinese vaccine to resume: Brazil's national health regulator allowed clinical trials of a Chinese-developed COVID-19 vaccine to resume Wednesday, two days after suspending them in what critics called a decision tainted by politics. → https://is.gd/pyFKCO | 20:06 |
| Brainstorm | New from Medical Xpress: Travelers to Spain must provide negative COVID-19 test: The Spanish Health Ministry said Wednesday that foreign travelers from countries considered high-risk areas for the coronavirus will be asked to provide proof of a negative test to visit Spain. → https://is.gd/wgSf7Z | 20:16 |
| Brainstorm | Updates for US: +170587 cases (now 10.6 million), +1640 deaths (now 246496) since a day ago — Canada: +5064 cases (now 276733), +66 deaths (now 10688) since a day ago | 20:21 |
| Brainstorm | New from Medical Xpress: UK becomes 5th country to exceed 50,000 coronavirus deaths: The United Kingdom on Wednesday became the fifth country in the world to record more than 50,000 coronavirus-related deaths, a level that one of the nation's leading doctors says "should never have been reached." → https://is.gd/Oy2Iao | 20:26 |
| tinwhiskers | !title https://redd.it/jsbjoz | 20:29 |
| tinwhiskers | erm | 20:29 |
| tinwhiskers | Nearly every U.S. state is now classified as having "uncontrolled spread" of COVID-19 : Coronavirus | 20:30 |
| tinwhiskers | "uncontrolled" or "out of control"? The former is more of a political statement I think? | 20:30 |
| tinwhiskers | Although it's pretty much true because there seems to be no efforts to control it, so it is indeed uncontrolled. | 20:31 |
| tinwhiskers | But then, that's hardly news :-/ | 20:31 |
| Skunny | morning, Kevins came back negative | 20:33 |
| Skunny | My son lol | 20:33 |
| Brainstorm | Updates for US: +171506 cases (now 10.6 million), +1650 deaths (now 246506) since a day ago — Germany: +17745 cases (now 717002), +213 deaths (now 11977) since a day ago | 20:36 |
| Brainstorm | New from Medical Xpress: Treatments for people with early COVID-19 infection is an urgent research focus: COVID-19 treatments for people with early infection are needed urgently, according to a JAMA Viewpoint article by National Institute of Allergy and Infectious Diseases (NIAID) Director Anthony S. Fauci, M.D., and colleagues. Treating people early [... want %more?] → https://is.gd/3Pc4Y4 | 20:36 |
| Brainstorm | Updates for Spain: +19096 cases (now 1.5 million), +349 deaths (now 40105) since a day ago | 20:50 |
| de-facto | %title https://imgur.com/a/iY9TpR6 https://i.imgur.com/ZR6s8VT.png source: https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Testzahl.html | 21:03 |
| Brainstorm | de-facto: From imgur.com: COVID-19 Germany Tests, Cases, Tests Positivity, Tests Queued - Album on Imgur | 21:03 |
| Brainstorm | Updates for US: +150847 cases (now 10.6 million), +1674 deaths (now 246732) since a day ago — Germany: +20152 cases (now 721722), +226 deaths (now 12024) since a day ago | 21:06 |
| Brainstorm | New from CNBC Health: (news): Two more people from Trump's Election Night party at White House test positive for coronavirus → https://is.gd/yqw3rL | 21:07 |
| LjL | RKI isn't loading for me today. are those +20000ish numbers for Germany mostly accurate, or an overestimate? | 21:09 |
| Arsanerit | LjL: they're scheduling maintenance | 21:17 |
| Arsanerit | but RKI is still working for me, reporting 18,457 | 21:18 |
| rpifann | so what is happening with germany | 21:20 |
| rpifann | is it getting worse | 21:20 |
| rpifann | or stabilziing | 21:20 |
| CoronaBot | 04/r/coronavirus: Nearly every U.S. state is now classified as having "uncontrolled spread" of COVID-19 (10362 votes) | https://twitter.com/bnodesk/status/1326566347556446208?s=21 | https://redd.it/jsbjoz | 21:21 |
| Brainstorm | Updates for Canada: +4364 cases (now 276771) since 22 hours ago | 21:22 |
| genera | they stopped testing patients without symptoms. makes sense because they need the tests inside the hospitals | 21:23 |
| DocScrutinizer05 | de-facto: did we talk about price of quicktests? if yes, https://www.praxisdienst.de/Laborbedarf/Tests/Schnelltests/Panbio+COVID+19+Antigen+Schnelltest.html is 190 bucks for 25 tests. 15min to result. >90% sensitivity | 21:25 |
| DocScrutinizer05 | 7.60€ per test | 21:26 |
| DocScrutinizer05 | thanks to buerocratic idiocy it's *not allowed* to sell them to anybody but healthcare qualified personal | 21:27 |
| de-facto | yeah i heard somewhere that this also is the price that gets paid for by the insurances or such | 21:28 |
| de-facto | around 7 Euros | 21:28 |
| de-facto | DocScrutinizer05, oh btw i made a graph from the testing data i linked above https://imgur.com/a/iY9TpR6 https://i.imgur.com/ZR6s8VT.png source: https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Testzahl.html | 21:29 |
| de-facto | LjL, 20k daily new cases sounds realistic for Germany | 21:29 |
| de-facto | remember your numbers are a day ahead of RKI | 21:30 |
| DocScrutinizer05 | my new meme (translated): KMK [conference of school ministers): >>schools are no hotspots<< me: >>WRONG! schools HAVE no hotspots<< | 21:30 |
| LjL | RKI has more deaths | 21:30 |
| DocScrutinizer05 | nice :-D | 21:32 |
| de-facto | %cases Germany | 21:33 |
| Brainstorm | de-facto: In Germany, there have been 721722 confirmed cases (0.9% of the population) and 12024 deaths (1.7% of cases) as of 31 minutes ago. 23.4 million tests were performed (3.1% positive). Fatality can be broadly expected to lie between 0.5% (assuming prevalence as in tests) and less than 2.6% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Germany for time series data. | 21:34 |
| Brainstorm | Updates for US: +160641 cases (now 10.6 million), +1724 deaths (now 246845) since a day ago — Germany: +19257 cases (now 724598), +214 deaths (now 12067) since a day ago | 21:35 |
| de-facto | Brainstorm - RKI Germany: total cases 721722 - 705687 = +16035; total deaths 12024 - 11767 = 257 | 21:36 |
| de-facto | those are realistic numbers imho | 21:36 |
| de-facto | unfortunately :/ | 21:36 |
| LjL | de-facto, well you see, the numbers went down since the previous time. it's the effect of the window, and maybe it's a little higher because of the 24"+1"h window | 21:37 |
| LjL | (although it doesn't take the *full* hour, only the latest number during it) | 21:37 |
| de-facto | yeah id guess +18k or more tomorrow | 21:37 |
| de-facto | so ~20k per 24h or such | 21:38 |
| Brainstorm | New from Virology.ws: TWiV 679: Mink, mutation, and myocytes: Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers [... want %more?] → https://is.gd/BaX2Gt | 21:40 |
| de-facto | Nipah out of academic interest or is there something going on with it recently? | 21:41 |
| LjL | i'm betting academic interest, but there's no way i'm listening, i have no patients for podcasts, i'll read the transcript when it's out if i remember | 21:43 |
| de-facto | DocScrutinizer05, btw if we are super lucky there might be a tiny first sign that hospitalizations may increase a bit below an exponential for the most recent data points | 21:43 |
| de-facto | or its some reporting delay, who knows | 21:44 |
| de-facto | https://www.intensivregister.de/#/intensivregister?tab=laendertabelle choose tab Zeitreihen | 21:44 |
| de-facto | they still increase like crazy though | 21:45 |
| de-facto | pretty clear beyond first wave | 21:46 |
| de-facto | LjL, yeah TWIV is awesome and very interesting but also super long, even on 2x speed | 21:48 |
| de-facto | also curious what they will say about mink stuff | 21:48 |
| Brainstorm | New from CNBC Health: Former Aetna CEO says repealing Obamacare 'would be a huge mistake' and the law can be fixed: Getting rid of Obamacare "now, in the midst of this pandemic and huge unemployment, would be a huge mistake," former Aetna CEO Mark Bertolini told CNBC. → https://is.gd/OUuDcu | 21:51 |
| Brainstorm | Updates for US: +158548 cases (now 10.7 million), +1756 deaths (now 246974) since a day ago — Germany: +20600 cases (now 725941), +226 deaths (now 12079) since a day ago | 21:51 |
| DocScrutinizer05 | >>tiny first sign that hospitalizations<< yeah, I seen that too, pretty weak but we may hope | 21:54 |
| DocScrutinizer05 | actully I seen a tiny ditch in fatalities | 21:56 |
| DocScrutinizer05 | prolly closely related | 21:56 |
| bin_bash | pffft ACA wasn't meant to be fixed, it was meant to force universal healthcare | 21:57 |
| bin_bash | so it should be repealed and replaced with a better subsidized syste, | 21:57 |
| Brainstorm | New from PLOS ONE: Verification of the role of exosomal microRNA in colorectal tumorigenesis using human colorectal cancer cell lines: by Gyoung Tae Noh, Jiyun Kwon, Jungwoo Kim, Minhwa Park, Da-Won Choi, Kyung-Ah Cho, So-Youn Woo, Bo-Young Oh, Kang Young Lee, Ryung-Ah Lee Exosomes are a group of small membranous vesicles that are shed into the [... want %more?] → https://is.gd/O7GH57 | 22:03 |
| Brainstorm | Updates for North Macedonia: +1318 cases (now 42540), +26 deaths (now 1212) since a day ago — US: +148038 cases (now 10.7 million), +1609 deaths (now 246983) since a day ago | 22:06 |
| DocScrutinizer05 | bin_bash: just I don't see the last part (replaced by better...) happening, no way | 22:10 |
| de-facto | but that is in the second time derivative of total hospitalizations, e.g. a possibly shy first indication that the increase of the daily increase of total hospitalizations possibly might be slower | 22:10 |
| de-facto | so a very weak statement if at all | 22:11 |
| bin_bash | DocScrutinizer05: frankly it would hard to be worse. | 22:11 |
| DocScrutinizer05 | if the goal is to eliminate from history everything with "obama" somewhere in the list of suthors, then yes | 22:13 |
| DocScrutinizer05 | and that's exactly what Trump said he's aiming for, nothing else, nothing better | 22:14 |
| Brainstorm | Updates for US: +147721 cases (now 10.7 million), +1573 deaths (now 247028) since a day ago — Canada: +4860 cases (now 277267) since 23 hours ago | 22:20 |
| Brainstorm | Updates for US: +145329 cases (now 10.7 million), +1566 deaths (now 247037) since a day ago — Germany: +20536 cases (now 726176), +222 deaths (now 12082) since 22 hours ago | 22:37 |
| Brainstorm | Updates for Arkansas, US: +1962 cases (now 126197), +14 deaths (now 2126) since a day ago — US: +152944 cases (now 10.7 million), +1622 deaths (now 247093) since a day ago | 22:52 |
| Jigsy | %cases UK | 22:59 |
| de-facto | where is the rest? | 22:59 |
| de-facto | people still connect to IRC manually? | 23:00 |
| Jigsy | Yes? | 23:01 |
| de-facto | ~72 to reconnect manually | 23:02 |
| the-wes | my client doesn't have a rate-limit feature | 23:06 |
| the-wes | so every time I reconnect to freenode, I have to rejoin channels one at a time | 23:06 |
| de-facto | since i ever used znc i never want to miss its features | 23:07 |
| Brainstorm | Jigsy: In United Kingdom, there have been 1.3 million confirmed cases (1.9% of the population) and 50365 deaths (4.0% of cases) as of 5 hours ago. 37.1 million tests were performed (3.4% positive). See https://offloop.net/covid19/?default=United%20Kingdom for time series data. | 23:08 |
| Brainstorm | Updates for Kentucky, US: +2698 cases (now 127344), +14 deaths (now 1604) since a day ago — US: +149796 cases (now 10.7 million), +1622 deaths (now 247119) since a day ago — Curacao: +51 cases (now 1182) since a day ago | 23:09 |
| Brainstorm | New from CNBC Health: (news): New York to impose curfew on restaurants, bars and gyms as Covid worsens across the U.S. → https://is.gd/qTxhCf | 23:13 |
| LjL | Nice mess | 23:21 |
| Brainstorm | Updates for Massachusetts, US: +2660 cases (now 177541), +38 deaths (now 10222) since a day ago — US: +150109 cases (now 10.7 million), +1643 deaths (now 247157) since a day ago | 23:22 |
| DocScrutinizer05 | [11 Nov 2020 22:57:32] [Notice] -tomaw- [Global Notice] Sorry about the noice, but that's over with now. | 23:30 |
| LjL | noice, uh? | 23:38 |
| Arsanerit | no ice is a label for elevation models that present the bedrock elevation below ice caps | 23:42 |
| Brainstorm | Updates for US: +156845 cases (now 10.7 million), +1700 deaths (now 247219) since a day ago — Canada: +4683 cases (now 277306) since a day ago | 23:52 |
| Brainstorm | New from CNBC Health: (news): Widespread Covid testing credited with catching and stopping asymptomatic spread among Marine recruits, study says → https://is.gd/eSkPcj | 23:58 |
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