Brainstorm | Updates for Netherlands: +11487 cases (now 744057), +98 deaths (now 10924) since 23 hours ago | 00:03 |
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Brainstorm | New from r/WorldNews: worldnews: France finds first case of new coronavirus variant → https://is.gd/QM2fuV | 00:36 |
LjL | people have more tenuous understandings than even me https://np.reddit.com/r/worldnews/comments/kk7wtp/france_finds_first_case_of_new_coronavirus_variant/gh0ypht/ | 00:43 |
CoronaBot | 04/r/coronavirus: 1 in 5 adults developed pandemic-related mental disorders: Analysis (10007 votes) | https://www.thehindubusinessline.com/news/science/1-in-5-adults-developed-pandemic-related-mental-disorders-analysis/article33417333.ece/ | https://redd.it/kjxq3d | 00:52 |
de-facto | people are not used to think for themselves nowadays, they rather outsource that task to someone else and only repeat what they heard from someone they dont even know by first name, sad. | 00:52 |
de-facto | i think it may be partly the fault of the school systems, them rewarding blindly repeating some "knowledge" without understanding or interpreting its semantics or transferring the abstract construct behind a concept on some new environment or problem | 00:56 |
LjL | de-facto, i suppose i'm guilty of that sometimes, but like... the way they go "if it's more infectious it lessens its effectiveness or deadliness or symptoms [which of these?!] that's my understanding, anyway!" clearly that can't be an "understanding", it's just a (flawed) notion | 00:56 |
LjL | de-facto, to be fair i was always rewarded in school for coming up with things by thinking without actually having studied what i was meant to :P | 00:57 |
LjL | but then again i'm fucked up in multiple ways so, while i don't blame the school system, it didn't work out very well in the end | 00:57 |
de-facto | yeah thats what i meant, them having heard somewhere at some time that "if a virus becomes more infectious it is less severe" without any clue about why that might be the case they repeat that mantra | 00:58 |
de-facto | that it might have to do with the moment where most transmission takes place in the disease trajectory from infection to symptomatic to severe (e.g. pre-symptomatic, symptomatic, whatever), that there might be a dependence on the way it transmits (e.g. respiratory disease, fectal oral route etc) and that there might be consequences from severity in terms of efforts put into containment (e.g. symptomatic stay isolated etc) | 01:02 |
de-facto | that it strongly depends on the virus properties and that different pathogens are not comparable in such a generalized way etc pp | 01:04 |
Brainstorm | Updates for Colombia: +14941 cases (now 1.6 million), +236 deaths (now 41690) since a day ago | 01:05 |
de-facto | it always is a much better concept to try to look at differentiated properties and try to imagine the relevant (most common) transmission scenarios in a cohort that contribute the majority of new infecitons | 01:05 |
Brainstorm | Updates for Canada: +826 cases (now 536834), +8 deaths (now 14732) since 22 hours ago | 01:23 |
Brainstorm | New from r/WorldNews: worldnews: Iran Finds Way to Buy Covid Vaccine Despite U.S. Sanctions → https://is.gd/EzY52R | 01:50 |
Brainstorm | New from r/WorldNews: worldnews: Proofs of Covid-19 vaccine must be enforced. → https://is.gd/AScxxz | 02:27 |
LjL | Reddit posts with titles that make no sense must be reported. | 02:33 |
Brainstorm | Updates for France: +15218 cases (now 2.6 million), +120 deaths (now 62448) since 20 hours ago — Netherlands: +8634 cases (now 746650), +74 deaths (now 10944) since 20 hours ago | 03:33 |
Brainstorm | New from The Indian Express: World: First case of new COVID variant found in France as cases rise → https://is.gd/A4U95i | 03:41 |
Brainstorm | New from BBC Health: Coronavirus: Millions wake to tighter Covid restrictions: More areas in England enter tier 4, as lockdowns are in place in Scotland, Wales and Northern Ireland. → https://is.gd/gTf2Ve | 04:31 |
Brainstorm | New from Lockdowns from Wikipedia: 119.74.230.94: /* United Kingdom */: United Kingdom ← Previous revision Revision as of 03:41, 26 December 2020 Line 149: Line 149: {{main|COVID-19 pandemic in the United Kingdom}} {{main|COVID-19 pandemic in the United Kingdom}} {{more references needed|section|date=July 2020}} {{more references [... want %more?] → https://is.gd/uhc8nH | 04:44 |
Brainstorm | New from r/WorldNews: worldnews: Wealthy patients scramble for COVID-19 vaccine: 'If I donate $25,000 ... would that help me?' → https://is.gd/rD6N9E | 05:46 |
Brainstorm | New from r/WorldNews: worldnews: Covid-19: NSW Health Minister fears Sydney beach Christmas gathering could be a super-spreader event → https://is.gd/kmh6Fw | 05:58 |
Brainstorm | New from The Indian Express: World: One vaccine side effect: Global economic inequality → https://is.gd/68DRst | 06:11 |
Brainstorm | New preprint: SARS-CoV-2 infecting the inner ear results in potential hearing damage at the early stage or prognosis of COVID-19 in rodents by Xia Xue et al, made available as preprint on 2020-12-25 at https://biorxiv.org/cgi/content/short/2020.12.23.423942 [... want %more?] | 07:16 |
Brainstorm | New from The Indian Express: World: Boston doctor reports serious allergic reaction after getting Moderna’s COVID vaccine → https://is.gd/xrZcq6 | 07:25 |
Brainstorm | New from The Indian Express: World: Delayed due to Covid, Ethiopia to hold elections in June 2021 → https://is.gd/V4cFuD | 07:37 |
Brainstorm | Updates for Arizona, United States: +12938 cases (now 486935), +115 deaths (now 8409) since a day ago — New Jersey, United States: +5060 cases (now 454902), +51 deaths (now 18595) since a day ago — West Virginia, United States: +1597 cases (now 78836), +19 deaths (now 1247) since a day ago — Moscow Oblast, Russia: +1576 cases (now 145858), +20 deaths (now 2773) since a day ago | 07:48 |
Brainstorm | New from BBC Health: Covid-19: Millions wake up to tighter coronavirus restrictions: More areas in England enter tier four, as lockdowns begin in Scotland, Wales and Northern Ireland. → https://is.gd/gTf2Ve | 07:50 |
Brainstorm | New from The Indian Express: World: Pope Francis calls for COVID-19 vaccines to be shared → https://is.gd/FMKLIV | 08:15 |
dead | Question regarding mRNA-1273 (Moderna vaccine) as can be seen on page 20 of this PDF: https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2020-12/slides-12-19/02-COVID-Miller.pdf the percentage of covid cases in the placebo group was 1.3% and the percentage of covid cases in the vaccine group was 0.1% -- this is a difference of roughly 1.2% in absolute effectiveness in the trial. In other words bei | 08:27 |
dead | ng in the vaccine group gave you a 1% improved chance of NOT getting covid19 vs the placebo | 08:27 |
dead | now explain to me why we are selling this lie of 94% effectiveness. That is based on the total number of cases observed, which only 11 happened to fall into the vaccine group | 08:27 |
Brainstorm | New from BBC Health: Covid-19: Millions wake up to tighter coronavirus restrictions: More areas in England enter tier four, as lockdowns begin in Scotland, Wales and Northern Ireland. → https://is.gd/gTf2Ve | 08:27 |
dead | efficacy does not mean effectiveness | 08:27 |
dead | this is not valid when you are relying on the people in the trial to just organicly contract sars-cov-2 and develop covid19 | 08:28 |
de-facto[m] | dead: https://en.m.wikipedia.org/wiki/Vaccine_efficacy | 08:33 |
dead | yes i know what efficacy is | 08:33 |
dead | the general public does not | 08:34 |
dead | they think this means effectiveness | 08:34 |
dead | you see though how being in the placebo group is only 1% less effective at not getting covid19 right? | 08:34 |
de-facto[m] | please read the article especially Vaccine efficacy formula | 08:36 |
dead | i've read it | 08:36 |
dead | i understand what efficacy means, thats not my issue | 08:36 |
dead | the vaccine has 94.1% efficacy, yes | 08:36 |
dead | based on that trial which i linked above | 08:36 |
dead | look at page 20 of that trial, and you will see the number of cases of covid19 in placebo group: 185, 1.3% of total group | 08:37 |
dead | number of cases in vaccine group: 11, .1% of total vaccine group | 08:37 |
dead | You understand that not everyone in the placebo group got covid19 right? | 08:38 |
dead | only 185 people out of 14 thousand | 08:38 |
dead | so being in the placebo group you only have a 1.3% chance of getting covid | 08:38 |
dead | according to those numbers | 08:38 |
dead | do you disagree with this conclusion? | 08:38 |
de-facto[m] | Attack rate is ratio of actual cases to potentially susveptible | 08:40 |
de-facto[m] | So ARU = PlaceboCases / PlaceboGroupSize, ARV = VaccinatedCases / VaccinatedGroupSize, VaccineEfficacy = 100% (ARU - ARV) / ARU | 08:43 |
Brainstorm | Updates for Belgium: +2342 cases (now 637246), +51 deaths (now 19089) since a day ago | 08:43 |
dead | right, and? | 08:44 |
de-facto[m] | They do that with ditting statistical distributions | 08:44 |
de-facto[m] | fitting | 08:45 |
de-facto[m] | Your conclusion you stated above is wrong | 08:47 |
de-facto[m] | About that 1% | 08:47 |
dead | in what regard | 08:47 |
dead | in pure propability, you have a .1% chance of getting covid19 in vaccine group, and a 1.3% chance in the placebo group. Subtracing those you get roughly 1.2% difference | 08:49 |
de-facto[m] | You have to divide by the unvaccinated attack rate | 08:49 |
de-facto[m] | Then times 100% | 08:49 |
dead | why? im not calculating efficacy | 08:49 |
dead | this is just chance | 08:49 |
de-facto[m] | because the number of interest is how many of potentiall cases can be prevented from happening | 08:51 |
dead | the science used, doesn't isolate the vaccine as a variable | 08:51 |
de-facto[m] | variable? | 08:51 |
dead | the conclusion is that the vaccine reduced case count, in the vaccine group | 08:52 |
dead | but how is that proven? | 08:52 |
dead | there is plenty of reason to believe it could be other causes | 08:52 |
dead | such as the people in the vaccine group, simply didn't contract sars-cov-2 at the same rate as those in the placebo group | 08:52 |
de-facto[m] | With comparing ti the placebo group under same xonditio s | 08:52 |
dead | these people were not kept in a locked cage or anything, they were living their normal lives | 08:52 |
dead | the conditions were not the same | 08:52 |
dead | by any stretch | 08:52 |
dead | this is 30000 people living normal lives in diverse areas | 08:53 |
dead | their exposure rate is not the same | 08:53 |
de-facto[m] | Transmission prevention vs disease prevention is an open question indeed | 08:53 |
dead | the groups were chosen randomly which definitely will help but still not perfect | 08:53 |
dead | yeah this vaccine only stop sthe disease, not transmission. | 08:53 |
de-facto[m] | Hence group size to average out | 08:54 |
de-facto[m] | Its unknown to what degree it prevenrs transmission, there are good hopes it wilk stop that to some degree too | 08:54 |
dead | science should not be based on hope and good intentions | 08:56 |
de-facto[m] | .title https://www.nejm.org/doi/full/10.1056/NEJMoa2024671 | 08:56 |
Brainstorm | de-facto[m]: From www.nejm.org: Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates | NEJM | 08:56 |
dead | not to mention, it erodes public trust | 08:56 |
de-facto[m] | Look at their Figure 3 | 08:56 |
de-facto[m] | 100ug works 10 ug not so much in apes | 08:57 |
DocScrutinizer05 | dead: seems you are mistaken on the general concept of double blind studies and vaccination | 08:58 |
de-facto[m] | We will know such numbers in humans soon probably | 08:58 |
dead | well thats good sign at least | 08:58 |
de-facto[m] | Yes | 08:58 |
dead | what is the absolute efficacy of the vaccine DocScrutinizer05 | 09:04 |
Brainstorm | New from r/Coronavirus: Daily Discussion Thread | December 26, 2020: The WHO pages contain up-to-date and global information. Please refer to our Wiki for additional information. → https://is.gd/G9qcdy | 09:05 |
DocScrutinizer05 | ohmy | 09:08 |
DocScrutinizer05 | what's so hard with understanding the concept that with a 95% effective vaccination I'm twenty times less likely to contract the virus in a certain situation, compared to a person that did not receive vaccination? | 09:10 |
DocScrutinizer05 | random statistical noise bias between two completely random cohorts from identical location with a size in the 10s of k? very very very unlikely | 09:13 |
DocScrutinizer05 | and that's what confidence intervals are meant for, telling you how likely it is | 09:14 |
CoronaBot | 04/r/covid19: Asymptomatic transmission of covid-19 (80 votes) | https://www.bmj.com/content/371/bmj.m4851 | https://redd.it/kk3y9y | 09:31 |
de-facto[m] | ok lets do the numbers from https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2020-12/slides-12-19/02-COVID-Miller.pdf page 20: ARU = 185/14073 ~ 1.3%; ARV=11/14134 ~ 0.07%; VE = (ARU - ARV) / ARU = ( (185/14073) - (11/14134) ) / (185/14073) = 0.740797... ~ 94.1% so exactly their claim | 09:46 |
de-facto[m] | as described in https://en.m.wikipedia.org/wiki/Vaccine_efficacy | 09:46 |
de-facto[m] | ok lets do the numbers from https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2020-12/slides-12-19/02-COVID-Miller.pdf page 20: ARU = 185/14073 ~ 1.3%; ARV=11/14134 ~ 0.07%; VE = (ARU - ARV) / ARU = ( (185/14073) - (11/14134) ) / (185/14073) = 0.940797... ~ 94.1% so exactly their claim as described in https://en.m.wikipedia.org/wiki/Vaccine_efficacy | 09:48 |
CoronaBot | 04/r/covid19: COVID19 is a seasonal climate-driven disease across both hemispheres (80 votes) | https://www.medrxiv.org/content/10.1101/2020.12.16.20248310v1 | https://redd.it/kk3sum | 09:55 |
DocScrutinizer05 | aka ~19/20, so out of 20 risky situations it will save me 19 times. Or of a 20 vaccinated persons it will protect 19 of them completely | 09:59 |
DocScrutinizer05 | de-facto: apropos numbers: sucks to have no meaningful numbers for the next week at lwast | 10:06 |
Brainstorm | New from r/WorldNews: worldnews: Russia's total number of COVID-19 cases crosses 3 million mark → https://is.gd/CDwi6U | 10:06 |
de-facto | yeah we only will know in the first week of January if "shutdown" had any effect | 10:07 |
de-facto | i hope they will let the schools closed for a few months at least | 10:07 |
DocScrutinizer05 | +1 | 10:08 |
de-facto | unfortunately vaccinations wont have any significant impact on reproduction until late summer or such | 10:09 |
de-facto | so we need to bring incidence down purely by non-pharmaceutical interventions | 10:10 |
DocScrutinizer05 | yep | 10:12 |
de-facto | RKI COVID-19 Germany 2020-12-26 (Xmess rep.): Weekly incidence 170.7/100k, Infections +14455 (1627103 total), Fatalities +240 (29422 total), COVID@ICU 5453 (incl. 2891 on ventilator) | 10:13 |
DocScrutinizer05 | too many politicians and minion fools are not communicating this in utter clearness, rather they insinuate the opposite | 10:14 |
DocScrutinizer05 | +14k is prolly a lie | 10:14 |
DocScrutinizer05 | well, bogus | 10:15 |
DocScrutinizer05 | yeah, lol https://i.imgur.com/7BJ2AQj.png | 10:17 |
de-facto | 2020-12-04: 4001 COVID@ICU 22 days later 2020-12-26: 5453 COVID@ICU hence (5453-4001) / 22 = 66 *additional* ICU beds are occupied permamently by COVID cases | 10:17 |
DocScrutinizer05 | vs the normal https://i.imgur.com/yXYd2wh.png | 10:18 |
de-facto | so every single day we have between 60-70 additional ICU beds nationwide occupied in Germany, 5453 and raising... thats unacceptable | 10:19 |
de-facto | https://www.intensivregister.de/#/aktuelle-lage/zeitreihen | 10:21 |
DocScrutinizer05 | your most used phrase ;-D | 10:23 |
DocScrutinizer05 | nobody thinks it was acceptable, so what's the intention with stating that? | 10:23 |
de-facto | its an expression that prevents me from ranting about whos fault it is etc pp | 10:26 |
DocScrutinizer05 | how about an occasional "we are not amused!" then? ;-) | 10:26 |
de-facto | idk imho nothing about all of this disaster could be associated with amusement | 10:28 |
Brainstorm | New from BBC Health: Covid-19: Tougher Covid rules begin for millions in UK: More areas in England enter tier four, as lockdowns begin in Scotland, Wales and Northern Ireland. → https://is.gd/gTf2Ve | 10:31 |
DocScrutinizer05 | neither with acceptance | 10:32 |
de-facto | i think we will need to stay in lockdown until end of April or such, people dont understand how they should behave themselves to prevent transmission of the pathogen with implementing non-pharmaceutical interventions | 10:32 |
de-facto | and when i see Querdenker i get furious violent sadist fantasies tbh | 10:33 |
de-facto | but yeah i will behave myself and not get started on ranting again | 10:34 |
DocScrutinizer05 | yes, I seen it with close friends telling me abpout their xmas planning and that they did a test on 21st so there's no problem meeting other people, "only mother on christmas eve, and 3 good friends on 25 and 4 other on 26", and me on 21st :-/ | 10:35 |
DocScrutinizer05 | *headdesk* | 10:36 |
DocScrutinizer05 | it really seems difficult to completely understand what it's all about | 10:36 |
de-facto | my parents invited a friend playing the Saxophone, i was like "was he quarantined and tested?" they said "probably" hence i was like *quadrupplefacepalm* | 10:37 |
de-facto | i mean i stay away from them to protect them and they do such BS | 10:37 |
DocScrutinizer05 | *sigh* | 10:37 |
DocScrutinizer05 | https://www.phrases.org.uk/meanings/we-are-not-amused.html just for context | 10:45 |
de-facto | i am not going to have a single human contact until early January, i just wish everyone else would do the same, then incidence would more or less end | 10:46 |
DocScrutinizer05 | same here | 10:46 |
DocScrutinizer05 | Phoenix: Spahn live about start of vaccinations | 10:51 |
de-facto | Phoenix? | 10:53 |
DocScrutinizer05 | so you may zapp in, or avoid to do so, whatever you prefer ;-D | 10:53 |
DocScrutinizer05 | https://www.ardmediathek.de/ard/live/Y3JpZDovL3Bob2VuaXguZGUvTGl2ZXN0cmVhbS1waG9lbml4/ | 10:54 |
de-facto | https://www.youtube.com/watch?v=rYwWlHBJrA4 | 10:55 |
DocScrutinizer05 | don't know if the link will work for you | 10:55 |
DocScrutinizer05 | yours is the better option of course | 10:56 |
Brainstorm | New from r/WorldNews: worldnews: Japan: Man fled hospital after testing positive for coronavirus, visited public bath → https://is.gd/hHsdX0 | 10:57 |
de-facto | btw from German IP addresses there also is the Zapp livestreaming App for Android, its open source and very neat https://f-droid.org/de/packages/de.christinecoenen.code.zapp/ | 10:58 |
DocScrutinizer05 | >>congrats, you won a 10000€ fine and a strict quarantine, plus reconpensation claims from all those whose next week you spoiled<< | 10:59 |
DocScrutinizer05 | re >>Man fled hospital...<< | 10:59 |
DocScrutinizer05 | idiots getting better every day | 11:00 |
de-facto | i think it begins | 11:01 |
DocScrutinizer05 | ^^^ [26 Dec 2020 10:14:40] <DocScrutinizer05> too many politicians and minion fools are not communicating this in utter clearness, rather they insinuate the opposite | 11:02 |
de-facto | hmm we need 16M doses for the high priority group | 11:05 |
de-facto | so not enough doses until summer to reach that ... | 11:05 |
de-facto | like June or such? | 11:05 |
de-facto | yeah they should have bought more doses :/ | 11:06 |
de-facto | https://twitter.com/jensspahn | 11:07 |
de-facto | first elderly homes, 80+ will be informed | 11:10 |
de-facto | additional production capabilities for BioNTech in Marburg? that would be neat | 11:13 |
DocScrutinizer05 | >><de-facto> yeah they should have bought more doses<< wouldn't ramp up the production at all, neither would it change the distribution ratio between european countries | 11:15 |
DocScrutinizer05 | damn dropouts! | 11:15 |
de-facto | btw RNA sequences for SARS-CoV-2 in Germany https://civnb.info/germany/?c=city&r=city | 11:16 |
de-facto | https://civnb.info/sequences/ | 11:17 |
de-facto | wtf is wrong with their transmission, is it being sabotaged? | 11:17 |
de-facto | thats it finished | 11:21 |
DocScrutinizer05 | ((sabotaged?)) noisy line I guess, or a wrecked encoder | 11:26 |
DocScrutinizer05 | ugh! laschet | 11:26 |
DocScrutinizer05 | is "fremdschaemen" already an english term, like "schadenfreude"? | 11:31 |
DocScrutinizer05 | seems not my dict says "empathic embarrassment" | 11:32 |
DocScrutinizer05 | is what I feel when I hear Laschet | 11:32 |
de-facto | so TL;DR from "Beginn der Corona-Impfungen: Jens Spahn zum Einsatz des Impfstoffs am 26.12.20" | 11:33 |
de-facto | first target group for vaccination are the ones in medical need and elderly as well as the personal caring for them | 11:33 |
de-facto | young and healthy need patients and reduce their contacts, distancing, hygiene and masks | 11:34 |
de-facto | vaccinations will start EU wide, without national exceptions or national emergengy approvals | 11:34 |
DocScrutinizer05 | patience | 11:34 |
de-facto | In Germany we will have up to 1.3M doses till end of 2020, in Janurary about ~0.7M doses each week, hence over 10M BioNTech and 1.5M Moderna doses in first quarter of 2021 | 11:34 |
de-facto | if other vaccine candidates will get approved we may achieve to offer everyone a vaccination beginning in mid 2021 | 11:34 |
de-facto | COVID vaccinations are a offer: free of costs and remains voluntarily, the clear goal is to take any chance of transmission from the virus | 11:34 |
DocScrutinizer05 | mission "Aermel hoch!" | 11:37 |
de-facto | hence if we have 8M people in the first priority group each in need of two doses we would need 16M doses for those, so 14.7M = 16M - 1.3M in begin of 2021, so if we had 0.7M doses each week in 2021 those would need 14.7M / 0.7M = 21 weeks or till 2021-05-28 | 11:38 |
de-facto | only for that 8M in the high risk group | 11:38 |
DocScrutinizer05 | https://www.spiegel.de/consent-a-?targetUrl=https%3A%2F%2Fwww.spiegel.de%2Fpolitik%2Fdeutschland%2Fcorona-krise-bundesregierung-startet-werbekampagne-fuer-corona-impfungen-a-6568fac8-1e8d-489c-948a-6e85433c789c&ref=https%3A%2F%2Fwww.startpage.com%2F | 11:39 |
DocScrutinizer05 | Spahn hopes for Moderna and additional BNT fabs | 11:40 |
de-facto | .title https://www.rki.de/DE/Content/Infekt/Impfen/ImpfungenAZ/COVID-19/Impfempfehlung-Zusfassung.html | 11:40 |
Brainstorm | de-facto: From www.rki.de: RKI - Impfungen A - Z - STIKO veröffentlicht Empfehlungen zur COVID-19-Impfung | 11:40 |
de-facto | that are the recommondations for priorities in Germany language | 11:42 |
de-facto | .title https://investors.biontech.de/news-releases/news-release-details/biontech-acquire-gmp-manufacturing-site-expand-covid-19-vaccine/ | 11:44 |
Brainstorm | de-facto: From investors.biontech.de: BioNTech to Acquire GMP Manufacturing Site to Expand COVID-19 Vaccine Production Capacity in First Half 2021 | BioNTech | 11:44 |
DocScrutinizer05 | what are those 14.7M ? | 11:44 |
de-facto | doses needed for high risk group in 2021 | 11:44 |
DocScrutinizer05 | errr | 11:44 |
de-facto | "Facility will become one of the largest mRNA manufacturing sites in Europe and the third site in the BioNTech manufacturing network in Germany expected to produce BNT162 for global supply" | 11:44 |
de-facto | "Expected to be fully operational in the first half 2021 with an annual production capacity up to 750 million doses of potential COVID-19 vaccine" | 11:45 |
de-facto | "The manufacturing site will expand BioNTech’s COVID-19 vaccine production capacity by up to 750 million doses per year, or over 60 million doses per month, once fully operational." | 11:45 |
de-facto | "The Company plans to be able to produce up to 250 million doses of BNT162b2 in the first half of 2021, thanks to the established team and well-established drug substance and drug product manufacturing capabilities at the site." | 11:46 |
de-facto | "The industrial park is located within one hour from the Frankfurt airport and within 90 minutes from BioNTech’s headquarters in Mainz, Germany. " | 11:46 |
de-facto | well thats good news i guess | 11:47 |
de-facto | "The facility is expected to operate as one of the largest mRNA manufacturing sites in Europe alongside two of BioNTech’s existing GMP facilities which currently produce the COVID-19 vaccine candidates for clinical trials, and in addition to at least four Pfizer production sites in the United States and Europe" | 11:47 |
de-facto | "The Marburg facility is expected to start the production of mRNA and the LNP formulation for a COVID-19 vaccine in the first half of 2021, pending regulatory authorization or approval." | 11:48 |
de-facto | "In addition, BioNTech intends to use the Marburg facility to contribute to the production of the COVID-19 vaccine for global supply, including to China, where it is partnered with Fosun Pharma, subject to regulatory authorization or approval." | 11:48 |
DocScrutinizer05 | 10M BioNTech and 1.5M Moderna doses in first quarter of 2021, So 2021-04-01 we have a 8M - (1.3M + 10M + 1.5M)/2 = 1.6M elderly vaccinations to go | 11:49 |
DocScrutinizer05 | 1.4M double-doses per month, seems like we're done early in 2021-05 | 11:50 |
de-facto | yeah or that, sounds realistic | 11:50 |
de-facto | with those 8M in the high risk group | 11:51 |
DocScrutinizer05 | plus Moderna, plus BNT ramp-up, plus further vaccine brands to speed that up | 11:51 |
DocScrutinizer05 | possibly | 11:51 |
DocScrutinizer05 | then, a signioficant fraction of those >80 will not be interested in getting vaccinated, particularly early on | 11:53 |
DocScrutinizer05 | I hope that fraction to be rather small, but we'll see... | 11:53 |
DocScrutinizer05 | then otoh it's maybe a useful message when a significant fraction *can't* get vaccinated so the need to mandatory mask wearing etc until *everybody* else got vaccinated is more clear and obvious | 11:56 |
DocScrutinizer05 | will be interesting to see how fast industry ramps up new fabs for the best money maker deal of the century | 11:57 |
DocScrutinizer05 | one thing's for sure: those who are joining in late are the losers of the vaccine business | 11:58 |
de-facto | i hope CureVac can get their mRNA on market soon enough | 11:59 |
de-facto | .title https://www.curevac.com/en/2020/12/09/curevac-and-fareva-sign-agreement-for-fill-finish-manufacturing-of-curevacs-covid-19-vaccine-candidate-cvncov-joint-press-release/ | 12:03 |
Brainstorm | de-facto: From www.curevac.com: CureVac and Fareva Sign Agreement For Fill & Finish Manufacturing of Curevac’s COVID-19 Vaccine Candidate, CVnCoV – joint press release – CureVac | 12:03 |
de-facto | .title https://www.curevac.com/en/2020/12/14/curevac-commences-global-pivotal-phase-2b-3-trial-for-covid-19-vaccine-candidate-cvncov/ | 12:03 |
Brainstorm | de-facto: From www.curevac.com: CureVac Commences Global Pivotal Phase 2b/3 Trial for COVID-19 Vaccine Candidate, CVnCoV – CureVac | 12:03 |
de-facto | .title https://www.curevac.com/en/2020/12/21/curevac-and-the-university-medical-center-mainz-start-phase-3-clinical-trial-for-covid-19-vaccine-candidate-cvncov-in-healthcare-workers/ | 12:05 |
Brainstorm | de-facto: From www.curevac.com: CureVac and the University Medical Center Mainz Start Phase 3 Clinical Trial for COVID-19 Vaccine Candidate, CVnCoV, in Healthcare Workers – CureVac | 12:05 |
Brainstorm | Updates for Malaysia: +2335 cases (now 103900), +2 deaths (now 451) since a day ago | 12:08 |
Brainstorm | New from Reddit (test): CoronavirusUK: The second/third wave is now higher than the first, for covid patients in hospital. → https://is.gd/JOfteU | 12:11 |
de-facto | "CureVac is building an integrated European vaccine manufacturing network with several Contract Development and Manufacturing Organization (CDMO) partners. With this strategy, the company will significantly increase CureVac’s existing manufacturing capacity, allowing CureVac to develop up to several hundred million doses of its vaccines per year and to manage potential supply chain risks by working with partners during each of the ke | 12:14 |
de-facto | y steps in the manufacturing process." | 12:14 |
de-facto | vaccination centers are ready, now we need to MASSIVELY ramp up production as fast as possible | 12:17 |
de-facto | like wartime production priority | 12:17 |
de-facto | there should not be any higher priority than production scaling | 12:18 |
DocScrutinizer05 | :nod: | 12:46 |
Brainstorm | New from Medical Xpress: After early success, S. Korea sleepwalks into virus crisis: South Korea had seemed to be winning the fight against the coronavirus: Quickly ramping up its testing, contact-tracing and quarantine efforts paid off when it weathered an early outbreak without the economic pain of a lockdown. But a deadly resurgence has reached new [... want %more?] → https://is.gd/ZZCbE3 | 13:13 |
Brainstorm | New from Medical Xpress: EU readies vaccine rollout as new virus strain spreads: The European Union teed up a vaccine rollout Saturday, even as countries in the bloc were forced back into lockdown by a new strain of the virus, believed to be more infectious, that has spread from Britain to France and Spain and even as far as Japan. → https://is.gd/JUUpgY | 13:25 |
Brainstorm | New from Medical Xpress: Russia tops 3 million COVID-19 infections: Russia on Saturday passed three million confirmed coronavirus infections, as authorities hold out against reimposing a national lockdown while the country is battered by a second wave. → https://is.gd/yOAlVz | 13:38 |
Brainstorm | New from Medical Xpress: France confirms first case on its soil of British virus variant: France has confirmed the first case of a new coronavirus variant that recently emerged in Britain, its health ministry said. → https://is.gd/e3fB5R | 13:50 |
Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 26DEC20 → https://is.gd/OkFlwM | 14:02 |
Brainstorm | New from BBC Health: Covid-19: Tougher Covid rules begin for millions in UK: More areas in England enter tier four, as lockdowns begin in Scotland, Wales and Northern Ireland. → https://is.gd/gTf2Ve | 15:04 |
CoronaBot | 04/r/covid19: Carriers of some genetic mutations more at risk of Covid-19: Belgium and Spain have the highest percentage of people with the genetic anomalies (82 votes) | https://www.israel21c.org/carriers-of-some-genetic-mutations-more-at-risk-of-covid-19/ | https://redd.it/kkhb6r | 15:28 |
ubLIX[m] | fun read: https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ | 15:54 |
Brainstorm | Updates for Germany: +12972 cases (now 1.6 million) since 22 hours ago | 15:57 |
Brainstorm | Updates for Switzerland: +60 deaths (now 7191) since 23 hours ago | 16:16 |
Brainstorm | New from r/Coronavirus: Coronavirus: Japan to close all borders (from all countries) starting from 28th Dec until the end of January → https://is.gd/TApgDo | 16:45 |
de-facto | really interesting read thanks for that link ubLIX[m] | 17:06 |
ubLIX[m] | many more, including a handful related to COVID-19: https://berthub.eu/articles/ | 17:08 |
de-facto | neat :) | 17:09 |
Brainstorm | New from r/WorldNews: worldnews: Spain confirms first 4 cases of new mutated coronavirus strain found in the UK, a day after similar cases were found in Lebanon and France → https://is.gd/iLIufS | 17:09 |
Brainstorm | New from BBC Health: Covid-19: Tougher Covid rules begin for millions in UK: More areas in England enter tier four, as lockdowns begin in Scotland, Wales and Northern Ireland. → https://is.gd/gTf2Ve | 17:22 |
de-facto | so they actually published the full sequence of "Messenger RNA encoding the full-length SARS-CoV-2 spike glycoprotein" https://mednet-communities.net/inn/db/media/docs/11889.doc | 17:32 |
danielp3344 | :/ | 17:34 |
ubLIX[m] | tests are not readily available where you are, danielp3344? | 17:41 |
danielp3344 | they are but I'm supposed to be at work in 20 minutes, lol | 17:42 |
danielp3344 | ubLIX: earliest I can get a test is tomorrow, which I will be doing | 17:42 |
ubLIX[m] | i hope your boss is the sensible kind | 17:43 |
ubLIX[m] | good luck with the test | 17:44 |
danielp3344 | ubLIX: he's pretty great, I doubt he'll be bothered I just feel silly (since it's the second time this month I've missed work) | 17:46 |
Brainstorm | Updates for United Kingdom: +34062 cases (now 2.2 million), +330 deaths (now 70371) since 23 hours ago — Netherlands: +10226 cases (now 754283), +61 deaths (now 10985) since 17 hours ago — Canada: +1519 cases (now 538353), +30 deaths (now 14762) since 16 hours ago | 18:02 |
danielp3344 | boss took it quite well, that's good | 18:06 |
Brainstorm | New from This Week In Virology: TWiV 698: COVID-19 clinical update #42 with Dr. Daniel Griffin: Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more. → https://is.gd/kXMeTt | 18:12 |
Brainstorm | Updates for Ireland: +1296 cases (now 85394), +6 deaths (now 2200) since a day ago | 18:20 |
de-facto | ubLIX[m], seems it that sequence contains two mutations compared to Spike hCoV-19/Wuhan/WIV04/2019: K986P, V987P stabilizing that vaccine S-protein in its prefusion configuration | 18:20 |
ubLIX[m] | long may the awesome sauce's engineering evolve | 18:41 |
Elpolaco | !corona se | 18:42 |
CoronaBot | Sweden: Global rank: #33, cases: 396,048, fatalities: 8,279, active cases: -, total recovered: -, in a serious condition: 302. Mortality: 2.09%, case fatality rate: -, cases/1M: 39097.0, deaths/1M: 817.0. Case rate: 0/24h, death rate: 0/24h. Tests: 3,989,420, tests/1M: 393,830. | 18:42 |
CoronaBot | 04/r/coronavirus: Japan to close all borders (from all countries) starting from 28th Dec until the end of January (10784 votes) | https://www.news24.jp/articles/2020/12/26/04793555.html | https://redd.it/kkjdra | 18:47 |
Brainstorm | New from r/WorldNews: worldnews: Dr. Fauci says up to 90% of population needs to get vaccinated for herd immunity against virus → https://is.gd/K6QxSK | 18:49 |
Brainstorm | Updates for Italy: +10405 cases (now 2.0 million), +261 deaths (now 71620) since 22 hours ago | 19:03 |
CoronaBot | 04/r/covid19: Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 (81 votes) | https://www.pnas.org/content/117/45/28046 | https://redd.it/kkkcol | 19:05 |
CoronaBot | 04/r/covid19: Remdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2 (80 votes) | https://www.biorxiv.org/content/10.1101/2020.12.23.424232v1 | https://redd.it/kjyslu | 19:05 |
Brainstorm | New from BBC Health: Covid-19: Tougher Covid rules begin for millions in UK: More areas in England enter tier four, as lockdowns begin in Scotland, Wales and Northern Ireland. → https://is.gd/gTf2Ve | 19:13 |
Brainstorm | Updates for France: +155 deaths (now 62516) since 23 hours ago | 20:05 |
Brainstorm | New from r/WorldNews: worldnews: Chinese economy to overtake US 'by 2028' due to Covid → https://is.gd/wJ9neN | 20:15 |
Brainstorm | New from BBC Health: Covid-19: Tougher Covid rules begin for millions in UK: More areas in England enter tier four, as lockdowns begin in Scotland, Wales and Northern Ireland. → https://is.gd/gTf2Ve | 20:40 |
CoronaBot | 04/r/covid19: Outsmarting SARS-CoV-2 by empowering a decoy ACE2 (81 votes) | https://www.nature.com/articles/s41392-020-00370-w | https://redd.it/kkio3x | 21:06 |
de-facto | .title https://www.precisionvaccinations.com/covid-19-vaccines | 21:40 |
Brainstorm | de-facto: From www.precisionvaccinations.com: COVID-19 Vaccines — Precision Vaccinations | 21:40 |
Brainstorm | New from r/WorldNews: worldnews: Belarus accused of deliberately spreading Covid-19 among jailed critics → https://is.gd/CJEFmi | 21:41 |
Brainstorm | New from r/WorldNews: worldnews: 'Militant neo-Nazis' have spearheaded coronavirus protests : At anti-lockdown protests, hooligans have provided the muscle to break through police lines. They may have their roots in football, but they're now more likely to be found practicing combat sports than on the terraces. → https://is.gd/9CUTns | 22:06 |
Brainstorm | New from NPR: Millions Face Loss Of Jobless Benefits As Trump Withholds Signature On Relief Bill: The nearly $900 billion package includes an extension of jobless aid. President Trump's criticisms of the bill, including that relief checks were too small, caught much of Washington by surprise. → https://is.gd/6QbAvx | 22:30 |
CoronaBot | 04/r/covid19: Underdetection of COVID-19 cases in France threatens epidemic control (80 votes) | https://www.nature.com/articles/s41586-020-03095-6 | https://redd.it/kkfbte | 23:31 |
Brainstorm | New from r/WorldNews: worldnews: US House gives $500 million to Israel, only $600 per person in covid relief → https://is.gd/DxYWOq | 23:44 |
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