libera/##covid-19/ Sunday, 2020-12-27

BrainstormNew from r/WorldNews: worldnews: U.K. variant of coronavirus appears in Canada. Ontario’s chief medical officer announced Saturday that the couple had no known travel history, meaning it was probably a case of community spread. → https://is.gd/V0bdIK00:09
BrainstormUpdates for Eswatini: +197 cases (now 8367), +9 deaths (now 163) since 20 hours ago00:13
BrainstormNew from Lockdowns from Wikipedia: 79.100.143.101: spacing issue: spacing issue ← Previous revision Revision as of 23:13, 26 December 2020 Line 18: Line 18: Countries and territories around the world have enforced lockdowns of varying degrees. Some include total movement control while others have enforced restrictions based on time. Mostly, only [... want %more?] → https://is.gd/uhc8nH00:21
LjLobviously, the UK variant is everywhere00:21
BrainstormNew from r/WorldNews: worldnews: COVID-19 vaccine controversy: Chinese vaccine with pork gelatin cannot be given to Muslims, say Sunni scholars → https://is.gd/kaJ8Uw01:10
LjLde-facto, well that could be useful considering covidvax.news is dead and covidvax.org is out of date - except wait, .org has been updated, now 2 vaccines are officially "ready for distribution"!01:35
LjLso maybe i need to change my scraper01:36
LjL%vax biontech01:36
BrainstormIndexError: list index out of range (file "/home/brainstorm/brainstorm/bot/modules/covid.py", line 415, in vaccines)01:36
LjLprobably01:36
LjL%vax ad2601:36
BrainstormIndexError: list index out of range (file "/home/brainstorm/brainstorm/bot/modules/covid.py", line 415, in vaccines)01:36
LjL%vax moderna01:47
BrainstormLjL, mRNA-1273 LNPencapsulated mRNA is a RNA-based vaccine developed in USA by Moderna + NIAID + Lonza + Catalent Inc. + BIOQUAL, which began its distribution on date January 2021 → https://covidvax.org/covid19-vaccine/Moderna01:47
LjL%vax biontech01:47
BrainstormLjL, mRNA BNT162b2 is a RNA-based vaccine developed in Germany + USA by BioNTech + Pfizer + Fosun Pharma + University of Rochester Medical Center (URMC) + Rochester Regional Health (RRH), which began its distribution on date December 2020 → https://covidvax.org/covid19-vaccine/BioNTech-Pfizer01:47
BrainstormNew from Category: SARS-CoV-2 variants on Wikipedia: Biscuit-in-Chief: ce: ce ← Previous revision Revision as of 01:19, 27 December 2020 Line 2: Line 2: {{tqb|There is no universally accepted definition for the terms "strain", "variant", and "isolate" in the virology community, and most virologists simply copy the usage of terms from others. [...] [... want %more?] → https://is.gd/2D91Vs02:24
LjLfunny, Biscuit-in-Chief who seems to be the main contributor to COVID articles started out on Wikipedia in 2018 by being blocked for vandalism, apparently :P03:01
LjLbut then again, i pretty much started my experience with freenode by being k-lined03:01
BrainstormNew from r/WorldNews: worldnews: Deadly fire hits Egyptian hospital treating COVID patients → https://is.gd/e9NFKg03:01
BrainstormUpdates for Netherlands: +10288 cases (now 756938), +60 deaths (now 11004) since 23 hours ago — France: +7385 cases (now 2.6 million), +149 deaths (now 62597) since 23 hours ago — Switzerland: +2 deaths (now 7193) since 10 hours ago — United Kingdom: +157 deaths (now 70406) since 19 hours ago03:07
BrainstormNew from r/WorldNews: worldnews: Spain, Sweden and Canada report cases of UK Covid variant → https://is.gd/ld2drv03:14
BrainstormUpdates for New Zealand: +1 cases (now 2129) since 3 days ago03:26
BrainstormNew from r/WorldNews: worldnews: Some Russians, dismayed at COVID-19 vaccine exports, call for more doses at home → https://is.gd/nluvFA03:26
BrainstormNew from "Cluster 5" on Wikipedia: HueMan1: /* See also */: See also ← Previous revision Revision as of 03:09, 27 December 2020 Line 38: Line 38: ==See also== ==See also== *[[VOC-202012/01]], a variant of the SARS-CoV-2 virus found in the United Kingdom *[[VOC-202012/01]], a variant of the SARS-CoV-2 virus found in the United Kingdom − *[[501.V2 [... want %more?] → https://is.gd/74bzDF04:15
BrainstormNew from r/WorldNews: worldnews: Canada reports its first cases of new coronavirus variant → https://is.gd/ysoGJi04:53
BrainstormUpdates for New Zealand: +15 cases (now 2144) since 2 hours ago05:30
danielp3344https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/05:45
danielp3344This is a really cool informative writeup05:46
danielp3344kinda changed my perspective on RNA vaccines05:46
BrainstormNew from r/WorldNews: worldnews: 'We Feel Safe': Americans Keep Visiting Mexico Despite Pandemic Risks → https://is.gd/AvN2VQ05:55
BrainstormNew from This Week In Virology: TWiV 699: Arboviruses at ASTMH: From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses. → https://is.gd/7nXXGP06:20
BrainstormNew from The Indian Express: World: Europe rolls out vaccines in bid to leave pandemic behind → https://is.gd/ruwPjO06:32
CoronaBot04/r/covid19: UK recruits first global patient to antibody treatment study to protect against COVID-19 (80 votes) | https://www.nihr.ac.uk/news/uk-recruits-first-global-patient-to-antibody-treatment-study-to-protect-against-covid-19/26458 | https://redd.it/kks92w06:33
BrainstormUpdates for Belgium: +784 cases (now 638030), +69 deaths (now 19158) since 22 hours ago — Germany: +109 deaths (now 30077) since 14 hours ago06:57
BrainstormNew from r/WorldNews: worldnews: Don’t hesitate to seek help, it’s your right: The welfare ministry is trying to eradicate the stigma of people applying for public assistance by widely publicizing the fact it is a right of anyone facing dire economic circumstances, especially in light of the novel coronavirus pandemic. → https://is.gd/bV1xYh07:22
BrainstormUpdates for California, United States: +59813 cases (now 2.1 million), +260 deaths (now 24218) since 23 hours ago — North Carolina, United States: +19419 cases (now 513930), +166 deaths (now 6526) since 3 days ago — Florida, United States: +17042 cases (now 1.3 million), +140 deaths (now 21135) since 2 days ago [... want %more?]07:34
BrainstormNew from r/WorldNews: worldnews: Europe rolls out vaccines in bid to leave pandemic behind → https://is.gd/I35S0u08:00
CoronaBot04/r/coronavirus: One in 1,000 Americans have died from Covid-19 (10202 votes) | https://www.independent.co.uk/news/world/americas/us-death-toll-coronavirus-b1779173.html | https://redd.it/kksrz108:04
BrainstormNew from r/WorldNews: worldnews: Mexico City's COVID-19 'excess mortality' reaches 214 deaths a day → https://is.gd/GRnjPf08:49
BrainstormNew from r/Coronavirus: Daily Discussion Thread | December 27, 2020: The WHO pages contain up-to-date and global information. Please refer to our Wiki for additional information. → https://is.gd/hM2Vul09:02
DocScrutinizer05https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ WOW, just WOW! brilliant article explaining brilliant science09:08
BrainstormNew from The Indian Express: World: Deadly fire hits Egyptian hospital treating COVID patients: sources, media → https://is.gd/nxKsaZ10:05
BrainstormUpdates for Germany: +10069 cases (now 1.6 million), +110 deaths (now 30078) since 18 hours ago10:28
CoronaBot04/r/coronavirus: Remembering Li Wenliang: the Wuhan doctor who warned the world about coronavirus (10194 votes) | https://www.scmp.com/news/china/article/3115445/remembering-li-wenliang-wuhan-doctor-who-warned-world-about-coronavirus | https://redd.it/kku3ek10:35
drytrumpetDocScrutinizer05:  Thanks a lot for the link. 10:47
BrainstormNew from BBC Health: Covid: Cardiff health board plea for critical care help: The health board running Wales' largest hospital issues an appeal for help with Covid patients. → https://is.gd/AdrQCQ10:55
DocScrutinizer05drytrumpet: yw, I just echoed it, been mentioned hetre a few times during last 2411:17
DocScrutinizer05[26 Dec 2020 15:54:20] <ubLIX[m]> fun read: https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/11:20
DocScrutinizer05%tr <de Während der Feiertage und zum Jahreswechsel ist bei der Interpretation der Fallzahlen zu beachten, dass zum einen meist weniger Personen einen Arzt aufsuchen, dadurch werden weniger Proben genommen und weniger Laboruntersuchungen durchgeführt. Dies führt dazu, dass weniger Erregernachweise an die zuständigen Gesundheitsämter gemeldet werden. Zum anderen kann es sein, dass nicht alle Gesundheitsämter und zuständigen 11:23
DocScrutinizer05Landesbehörden an allen Tagen an das RKI übermitteln.11:23
BrainstormDocScrutinizer05, German to English: During the holidays and at the turn of the year, it should be noted when interpreting the number of cases that, on the one hand, fewer people usually visit a doctor, which means that fewer samples are taken and fewer laboratory tests are carried out. This means that fewer pathogens are reported to the responsible health authorities. On the [... want %more?]11:23
DocScrutinizer05corona.rki.de    +13,755    -- well, ^^^ yet lol11:24
DocScrutinizer05%more11:25
BrainstormDocScrutinizer05, [...] Variant ]], a variant of the SARS-CoV-2 virus found in South Africa + *[[501.V2 variant ]], a variant of the SARS-CoV-2 virus found in South Africa *[[Severe acute respiratory syndrome coronavirus 2 variants]] *[[Severe acute respiratory syndrome coronavirus 2 variants]] → https://paste.ee/p/YIoas11:25
BrainstormDocScrutinizer05, [...] other hand, it may be that not all health authorities and responsible (MyMemory) → https://paste.ee/p/rRGq411:25
generaya it is funny. the law is explicit and demands zeitnah and yet some of the Gesundheitsämter think the christian holidays are prior11:27
DocScrutinizer05genera: indeed11:27
DocScrutinizer05my chart looks ridiculous :-/11:28
DocScrutinizer05 http://reisenweber.net/et_al/covid/covid19_statistics.htm11:30
DocScrutinizer05and I'm afraid starting after 12-23 the curve is not just bogus but actually the inverse of what we'll see looking back at this time period in 2 weeks11:34
DocScrutinizer05meanwhile they just sent live "official start of vaccination, from Frankfurt Hospital" take 2. As if that could make a difference for the next 8 weeks11:38
DocScrutinizer05genera: then >>fewer people usually visit a doctor, which means that fewer samples are taken and fewer laboratory tests are carried out<< would render a 24/7 service in municipal health offices rather pointless right at the moment anyway11:41
DocScrutinizer05unlike in the WW-I fire trenches there won't be a christmas wonder with corona11:44
generahttps://www.spiegel.de/politik/deutschland/jens-spahn-zeigt-sich-irritiert-ueber-vorzeitigen-impfbeginn-in-sachsen-anhalt-a-36fd8ea1-44e7-4368-a4d0-4415467d1de811:44
DocScrutinizer05LOL11:45
BrainstormNew from Emma Hodcroft: @firefoxx66: Very honoured to be one of the 'under-40' people featured by @NZZaS in 2020!2020 has been an intense & crazy year, but I am grateful I have been able to help, in science & in communication, during this #COVID19 pandemic. → https://is.gd/VIZlw611:45
generaand actual science come from Emma :-)11:45
DocScrutinizer05:nod:11:46
BrainstormNew from BBC Health: Covid: Cardiff health board plea for critical care help: The health board running Wales' largest hospital issues an appeal for help with Covid patients. → https://is.gd/AdrQCQ12:09
DocScrutinizer05re >> jens-spahn-zeigt-sich-irritiert-ueber-vorzeitigen-impfbeginn-in-sachsen-anhalt<<  SA never wastes an opportunity to show they are "spevial" in Germany. If only specially ignorant12:14
DocScrutinizer05not sure if there been a single germany-wide NPI that SA didn't mess up by doing it in a different usually flawed way than the rest of states12:16
generawell the EU said the vaccine is certified so there is no bureacrat left  in .de to wait on 12:17
DocScrutinizer05yeah sure, so fsck dat agreement to start today, SA *can* do it 12h earlier. They question is *why*12:18
DocScrutinizer05-y12:18
de-factoRKI Germany COVID-19 2020-12-27: Weekly Incidence 161.3/100k, Infections +13755 (1640858 total), Fatalities +356 (29778 total), COVID@ICU 5548 (incl 2957 on ventilator)12:22
de-factoXmess rep.12:22
DocScrutinizer05SA... just look at whatever news you find, like >>Rundfunkgebühren: Streit um 86 Cent. Sachsen-Anhalts Ministerpräsident Reiner Haseloff<< always they're showing the stinky finger to rest of germany12:25
DocScrutinizer05pegidaland12:25
de-facto.title https://imgur.com/a/MhsW04b https://i.imgur.com/CZvcgZ0.png source: https://www.intensivregister.de/#/aktuelle-lage/zeitreihen 12:35
Brainstormde-facto: From imgur.com: COVID-19 Germany: Occupied ICU beds and their daily change - Album on Imgur12:35
de-factoThe daily increase in occupied ICU beds has been down to +25 around end of Nov start of Dec, yet unfortunately started to raise again now over +75 ICU beds get occupied by COVID-19 each day12:38
de-factoWhat happened mid of November that caused the trend reversal?12:42
BrainstormNew from Emma Hodcroft: @firefoxx66: A "Zwischen den Jahren" (between the years) update of the focal S:N501 build, with data from 25th Dec. ❄️In 20B/501Y.V1 (SE England variant), we have new sequences from Australia, Israel, & Hong Kong:1/5#Newcoronavirusvariant #SARSCoV2 #COVID19 [... want %more?] → https://is.gd/3GeVxe12:47
de-factoWhoa how nice :))12:52
de-factoLjL, did you integrate twitter upstream?12:52
de-factothats awesome :)))12:52
de-factoSARS-CoV-2 full sequences: 3876 N501Y Mutation found: 3116 England, 478 Wales, 202 South Africa, 37 Australia/VIC, 18 Scotland, 10 Denmark, 5 USA/MA, 2 Netherlands, 2 Australia/NSW, 1 USA/OR, 1 Italy, 1 USA/NY, 1 Gibraltar, 1 Brazil, 1 USA/IL13:00
BrainstormUpdates for Germany: +10074 cases (now 1.6 million), +113 deaths (now 30081) since 21 hours ago13:22
BrainstormNew from The Indian Express: World: China’s Walvax to make COVID-19 vaccine candidate similar to AstraZeneca’s – media → https://is.gd/DO6Cbg13:37
BrainstormNew from The Indian Express: World: Wars, instability pose vaccine challenges in poor nations → https://is.gd/QKlSzU13:50
BrainstormNew from Emma Hodcroft: @firefoxx66: Are you using PCR/Sanger to detect the new #SARSCoV2 501Y variants (20B/501Y.V1 & 20C/501Y.V2)?Is there a place where people are trading protocols/primers/targets that work? I'm getting inquiries from countries trying to do this, but it is not my expertise!Advice appreciated! → https://is.gd/mWEq3V14:02
BrainstormNew from ScienceNews: The science stories that defined 2020: coronavirus, diversity movements and more: While this year was all about the coronavirus pandemic, climate change effects continued, diversity movements were born and research carried on. → https://is.gd/faWsmu14:15
BrainstormNew from BBC Health: Covid: Cardiff health board plea for critical care help: Its position has since improved but the health board says it is "extremely busy" due to Covid-19. → https://is.gd/AdrQCQ14:27
BrainstormNew from r/WorldNews: worldnews: "Believe in science:" EU kicks off COVID-19 vaccine campaign → https://is.gd/tzpOgK14:52
BrainstormNew from "Cluster 5" on Wikipedia: TGCP: /* Lockdown and culling */ status of culling: Lockdown and culling: status of culling ← Previous revision Revision as of 14:03, 27 December 2020 Line 20: Line 20: === Lockdown and culling === === Lockdown and culling === − As a preventative measure, Frederiksen announced that the country was already in the [... want %more?] → https://is.gd/74bzDF15:05
BrainstormNew from Reddit (test): nCoV: COVID-19 will not be last pandemic: WHO | 27DEC20 → https://is.gd/ga69n415:17
BrainstormNew from r/WorldNews: worldnews: Sony uses COVID-19 recession as excuse to cut jobs while benefiting from stay-at-home economy → https://is.gd/qoiGVE15:30
CoronaBot04/r/covid19: S-variant SARS-CoV-2 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-PCR (80 votes) | https://www.medrxiv.org/content/10.1101/2020.12.24.20248834v1 | https://redd.it/kl2mhy15:55
BrainstormNew from BBC Health: Covid: Cardiff health board plea for critical care help: Its position has since improved but the health board says it is "extremely busy" due to Covid-19. → https://is.gd/AdrQCQ16:08
BrainstormNew from The Indian Express: World: Oxford/AstraZeneca vaccine should be effective against new variant: Report → https://is.gd/BetCT916:20
de-factoyuck @ CoronaBot 17:18
euod[m]yeah I'm pretty sad nobody learned anything 17:20
euod[m]why countries are allowing flights at all is idiotic. 17:21
danielp3344euod: IMO the alternative would be worse17:21
euod[m]oh no, people can't go on holiday this year?17:21
danielp3344restricting people's movement in general is a dangerous thing for governments to do17:22
euod[m].. oh fuck off17:22
danielp3344what?17:22
euod[m]having drivers licenses is "restricting movement". you can't use that argument.17:22
BrainstormNew from StatNews: Opinion: STAT+: ‘There are a lot of potential Modernas’: The ‘Massachusetts Miracle’ is alive and well: Ours is a story not about one company and one vaccine, but rather of countless doctors and doctorates at dozens of labs and companies that have risen to the occasion… → https://is.gd/QcnMfg17:22
danielp3344actually I do17:22
euod[m]you know, visas are restricting movement. 17:23
euod[m]go take a gun to your nearest airport and protest it.17:23
danielp3344euod: well visas are generally used only at borders between countries17:23
danielp3344where there's a transition from one government to the next17:24
danielp3344<euod[m] "go take a gun to your nearest ai"> FWIW the government here in it's infinite wisdom has decided I can't own any firearms17:25
danielp3344and I couldn't carry them anywhere even if I could own them17:25
de-factopassenger flights are a unnecessary risk and should be illegal.17:33
euod[m]obviously. as someone who normally flies like, monthly at a minimum, nothing you are doing needs you to fly anywhere.17:34
euod[m]I was flying to commute most of last year because, why not?17:35
euod[m]the idea of doing that in a pandemic is unreal.17:35
de-factoi never took a flight ever and i really think its unnecessary to have those in general. 17:35
euod[m]nothing like sitting in a small tube with largely recycled air slightly too close to a bunch of strangers and stewardesses. 17:36
de-factoi mean sure it might be nice to be entertained and travel in holidays causing irreversible climate change and spreading deadly pathogens is the price for that. imho enough to ban passenger flights permanently. people will recognize those are unnecessary in general.17:38
danielp3344<de-facto "passenger flights are a unnecess"> surely people should be able to take their own risks?17:40
de-factono.17:40
euod[m]it's not your risk.17:40
de-factoits not their own risks, its the risk for everyone in society17:40
danielp3344well sure it is17:40
euod[m]it's you taking a risk for everyone.17:40
euod[m]well no.17:40
danielp3344everyone who doesn't want to take risks can isolate themselves17:40
euod[m]fuck you.17:40
de-factoits my risk, i might be exposed to new mutations of SARS-CoV-2, i get affected from climate change etc17:41
danielp3344euod: ...17:41
danielp3344de-facto: lets not drag another difficult topic in here...17:41
de-factook17:41
de-factoim sorry if i am in bad mood sometimes, its just these times are frustrating17:42
danielp3344I feel it too :P17:42
euod[m]doesn't help that Daniel Peterson: has the IQ of a loaf of bread. 17:42
ubLIX[m]euod: that is enough17:42
danielp3344euod: at least I'm the one trying to have a civil conversation17:42
de-factook lets stop this.17:42
BrainstormUpdates for Canada: +3906 cases (now 542259) since 23 hours ago — Switzerland: +16 deaths (now 7209) since 14 hours ago17:43
euod[m]at some point we've just got to acknowledge that a fair number of people are not capable of making decisions which are of benefit to society. blathering about people being able to take their own risks and just staying home if they don't want to be infected is just dangerous.  17:45
de-factodoes anyone know if there is a full sequence for the Moderna vaccine available?17:45
de-factoid like to compare it to the BioNTech sequence17:45
danielp3344euod: if those people are a majority of society then the decisions you make for them won't benefit 'society', just you17:46
de-factodoes CDC/FDA publish such info?17:47
euod[m]Daniel Peterson: societal benefits still are still an asset to those too stupid to understand them. 17:47
danielp3344euod: my life has been negatively impacted by decisions made for the good of 'society' much more than getting COVID has17:49
euod[m]Daniel Peterson: I'm sure when you need to be intubated you'll be happy that there's some capacity left in whatever healthcare system you'll be weighing down. 17:50
danielp3344...17:50
danielp3344euod: in my age group more people have died of the flu this year than covid17:50
danielp3344I feel sick but it's really not bad17:50
ubLIX[m]we can hope that is not an undue prejudgement17:51
danielp3344yeah17:52
danielp3344but I think I'll be OK17:52
danielp3344everyone I know personally who has gotten COVID has been fine17:53
ubLIX[m]the only case i know personally was incapacitated for several months. age mid-thirties17:57
LjL<de-facto> LjL, did you integrate twitter upstream? ← no, i just realized that Nitter has RSS feeds17:57
danielp3344ubLIX: someone at work, mid 50s, was pretty sick for two weeks but didn't require and outside medical care17:57
danielp3344any*17:57
de-factoLjL,  this is awesome :))17:58
de-factoif producing the S-protein (N-protein too?) is so easy, why would the LNP (Liposomes) for delivering the mRNA not employ: a) S-protein fusion capabilities b) N-protein mRNA stabilization capabilities?18:12
generaa) the liposomething can fuse without ACE2 b) what you describe would be an pseudovirus?18:14
de-factoa) if S-protein could select the same type of cells (exposing ACE2) the immune response might possibly be refined to target an infection even better? b) the SARS-CoV-2 virion wraps its ssRNA around the N-protein in its core, possibly making it much more stable (e.g. at room temperature)?18:17
generasomething stable at roomtemperature i would not certify for sale ))18:18
generabut that is me..18:18
de-factocrazy idea: modify a cell line to include something absolutely essential for replication of SARS-CoV-2, then delete that from the ssRNA sequence of SARS-CoV-2 so it only could replicate in those cells18:22
de-factois that possible to ensure such a modified SARS-CoV-2 would be ensured to stay replicant-deficit in any other (unmodified) cells?18:23
BrainstormNew from Lockdowns from Wikipedia: RMCD bot: Notifying subject page of move discussion on Talk:COVID-19 pandemic lockdowns: Notifying subject page of move discussion on Talk:COVID-19 pandemic lockdowns ← Previous revision Revision as of 17:19, 27 December 2020 Line 1: Line 1: {{short description|Restrictions imposed during COVID-19 pandemic}} {{short [... want %more?] → https://is.gd/uhc8nH18:24
de-factobut still be able to infect them, and make them produce all the proteins necessary for provoking the immune response against real wild type?18:24
de-factoif that was possible and applied as nasal spray it would come very close to a real wild type infection id guess18:25
BrainstormUpdates for Italy: +2987 cases (now 2.0 million), +104 deaths (now 71724) since 23 hours ago18:26
generaor some white powder for the nose ^^18:28
de-factomaybe that something essential for replication but not present in the modSARS-CoV-2 ssRNA anymore could be give in the vaccine in some LNPs so it enables a few replications but then depletes at some point because its not produced by the cells themselves18:30
de-factolike make it behave like wild type for a limited amount of cycles (until depletion) then replication would die off because the recipe is not contained in the replication-deficient ssRNA18:32
generai think the immune system will not like that18:34
de-factothats the idea18:38
de-factoid guess it would have to be one of the non-structure-proteins e.g. NSP-X18:41
de-factowhat would happen if NSP-5 was deleted from SARS-CoV-2 RNA and the 3CLPro main protease instead delivered via a limited amount of LNPs to cells infected with such a variant to enable them a few replication cycles until depletion?18:47
de-factonot really sure if that would be the best target18:47
BrainstormUpdates for United Kingdom: +13023 cases (now 2.3 million), +152 deaths (now 70557) since 23 hours ago18:57
LjLde-facto, do you know anything about the vaccine doses received by EU countries? the news here are saying that Germany is getting 150000, France 20000, and Italy less than 1000019:34
LjLthey say the total doses should be proportional to the populations of the various countries, but that doesn't hold for the initial doses19:35
de-factoafaik i heard Germany got ~9k or such?19:41
de-factonor sure though19:41
LjLde-facto, ~9k is the number for italy, i don't know, it does seem an absurd difference but it's on virtually all of our media. i'm trying to find articles that explain what's behind it19:45
LjLalso19:45
LjL%tr <it Perché Germania ha più vaccini dell’Italia? Non si trovano documenti ufficiali che spieghino il motivo di questa disparità in quel numero che era stato indicato come simbolico. L’unico è lo specchietto con i contratti fatti dal nostro Paese che ha puntato decisamente su AstraZeneca, Sanofi e Jessen (a differenza degli altri Stati che hanno scelto Pfizer-BioNTech e Moderna).19:45
BrainstormLjL, Italian to English: Why does Germany have more vaccines than Italy? There are no official documents that explain the reason for this disparity in that number which was indicated as symbolic. The only one is the mirror with the contracts made by our country which has definitely focused on AstraZeneca, Sanofi and Jessen (unlike the other states that have chosen [... want %more?]19:45
LjL%more19:45
BrainstormLjL, [...] Pfizer-BioNTech and Moderna). (MyMemory, Google) → https://paste.ee/p/SIzlE19:45
BrainstormLjL, [...] description|Restrictions imposed during COVID-19 pandemic}} + {{User:RMCD bot/subject notice|1=Lockdowns related to COVID-19|2=Talk:COVID-19 pandemic lockdowns#Requested move 27 December 2020 }} − {{Use dmy dates|date=July 2020}} + {{Use dmy dates|date=July 2020}} {{update|inaccurate=|type=|date=September 2020|reason=}} [...] → https://paste.ee/p/CH1F119:45
LjLaside from the Germany-Italy difference, *sigh* at Italy "choosing" AstraZeneca and Sanofi and Jenssen (which aren't even available yet) when other countries are, of course, picking Pfizer and Moderna :\19:46
LjLi found that on this table https://static.nexilia.it/giornalettismo/2020/12/EqO99kFXcAAE0ff-1536x462.jpeg which (at the bottom) claims to come from the EMA website, but i don't see it on that page19:47
LjL(which is however an interesting page i don't think i had in my links)19:47
BrainstormNew from The Indian Express: World: Putin decides to receive coronavirus vaccine: Kremlin → https://is.gd/IN4Dkq20:02
BrainstormNew from Medical Xpress: EU begins vaccinations to end COVID 'nightmare': EU countries on Sunday embarked on a vaccination campaign to defeat the "nightmare" of COVID-19, with the first to be immunised expressing emotion after their jab and leaders hailing a milestone in the fight against the pandemic. → https://is.gd/nIHfmP20:15
LjLde-facto, was it you who said that Johnson & Johnson may at some point become the best option, cost-effectiveness wise and everything? i remember someone mentioning that (just so i can be less annoyed at Italy picking all the vaccines that aren't actually out yet)20:16
LjLalso have a look at the page the bot just posted from my links20:16
LjLif you haven't seen it before20:16
de-factonice i think i have linked that some time ago too20:18
de-factoi was not the one saying that about J&J20:19
LjLde-facto, sorry i probably missed it, there are a lot of interesting pages and not so much memory in my head20:19
LjL%vax sanofi20:20
BrainstormLjL, S protein baculovirus production is a Protein subunit vaccine developed in France + UK by Sanofi Pasteur + GSK, which began its testing on humans on date Sep 3 → https://covidvax.org/covid19-vaccine/SanofiGSK [... want %more?]20:20
LjL%vas jenssen20:20
LjL%vax jenssen20:20
BrainstormLjL, no such vaccine found. Try checking https://covidvax.org 20:20
de-facto%vax Johnson20:20
Brainstormde-facto, Ad26 alone or with MVA boost is a Non-replicating viral vector vaccine developed in Belgium + USA by Janssen (Johnson & Johnson) + Beth Israel Deaconess Medical Center (Harvard Medical School) + Emergent BioSolutions + Catalent, which began its testing on humans on date Aug 11 → https://covidvax.org/covid19-vaccine/Janssen20:20
LjLJanssen Jenssen Johnson, confusion20:20
LjLit's "Janssen (Johnson & Johnson)"20:20
LjLanother adenovirus vaccine meh20:21
de-factoyeah hmm 20:21
LjLwe can't just bet on adenovirus vaccines :(20:21
de-factoi want an attenuated SARS-CoV-2 vaccine20:21
LjLi think there is... one in development, in India maybe?20:21
LjLanyway i still haven't found this table https://static.nexilia.it/giornalettismo/2020/12/EqO99kFXcAAE0ff-1536x462.jpeg anywhere on the EMA website, although the total number of vaccines does seem to match the total that Italy means to get20:22
LjLit would be interesting to see the same table for all EU countries20:22
de-factosteal something essential from SARS-CoV-2 RNA to make it replication deficient then only supply that "something essential" in small doses to have a bit of controlled replication that dies off on depleting that "something essential"20:23
BrainstormNew from Medical Xpress: Israel enters third nationwide lockdown as vaccinations ramp up: Israel began Sunday its third coronavirus lockdown, as Prime Minister Benjamin Netanyahu voiced optimism that a "world record" vaccination drive will restore a degree of normality within weeks. → https://is.gd/oHjFYZ20:27
LjL%vax Comirnaty20:29
BrainstormLjL, mRNA BNT162b2 is a RNA-based vaccine developed in Germany + USA by BioNTech + Pfizer + Fosun Pharma + University of Rochester Medical Center (URMC) + Rochester Regional Health (RRH), which began its distribution on date December 2020 → https://covidvax.org/covid19-vaccine/BioNTech-Pfizer20:29
LjLnames are so very confusing20:29
BrainstormUpdates for France: +106 deaths (now 62671) since 23 hours ago20:41
LjLde-facto, apparently AstraZeneca's CEO has said something about "having tweaked things" to get up to 95% efficacy like the others20:43
LjLi'll even just *start* vaguely believing it when there's a press conference, so far i understand it's just this person saying this to media20:43
LjLThe Coronavirus vaccine being developed by AstraZeneca and the University of Oxford is "as effective as the Pfizer and Moderna" alternatives and is likely to protect "95 per cent of patients", NDTV quoted chief executive of AstraZeneca Pascal Soriot as telling British daily The Sunday Times. The CEO also asserted that scientists who developed the Oxford Coronavirus vaccine figured out "winning formula to get efficacy up there with everybody else".20:45
LjLthis has the hallmarks for bullshit marketing, to my ear20:45
LjLbased on the media i see, they are particularly pushing this bit of news to Indian outlets, and India is producing a ton of AstraZeneca doses20:46
LjL“We think we have figured out the winning formula and how to get efficacy that, after two doses, is up there with everybody else,” Soriot said. “I can’t tell you more because we will publish at some point.”20:47
LjLde-facto, as far as i'm understanding at this time, every German state will receive 9750 doses, while Italy will receive 9750 in total... of course only italian media seems to be talking (a lot) about this20:51
BrainstormNew from BBC Health: (news): Covid-19: London Ambulance Service receives as many 999 calls as first wave → https://is.gd/VnzIPV20:52
de-factoLjL, did you get my message?21:09
LjLde-facto, err yes, i replied too21:17
LjLi think there's something with PMs to you...? i kinda thought you didn't want to get PMs but are you getting them at all O.o21:18
de-factoyes sorry i have replied21:22
BrainstormNew from r/WorldNews: worldnews: Coronavirus crisis will not be the last pandemic: WHO chief Tedros Adhanom Ghebreyesus → https://is.gd/9q2rXu22:31
de-factoi have found... things:23:45
de-factomRNA vaccines from WHO INN https://www.who.int/medicines/publications/druginformation/issues/WHO_DI_34-3_PL124-SpecialEdition.pdf23:45
de-factobnt162b1: abdavomeran, RBD-T4-fibritin (modRNA) https://mednet-communities.net/inn/db/media/docs/11888.doc23:46
de-factobnt162b2: tozinameran, Spike (modRNA) https://mednet-communities.net/inn/db/media/docs/11889.doc23:46
de-factobnt162b3: ganulameran, RBD-T4-fibritin-Spike_TM (modRNA) https://mednet-communities.net/inn/db/media/docs/11890.doc23:46
de-factobnt162c2: pidacmeran, VEEV-Spike (saRNA) https://mednet-communities.net/inn/db/media/docs/11891.doc 23:46
BrainstormNew from r/WorldNews: worldnews: WHO chief warns that COVID-19 won't be the world's last pandemic as he tells countries to prepare for future emergencies → https://is.gd/lcQ4V023:46
de-factozorecimeran: CureVac, RBD (no 1mΨ) https://mednet-communities.net/inn/db/media/docs/11868.doc23:46
de-factoINO-4800 (pGX9501) https://mednet-communities.net/inn/db/media/docs/11746.doc23:46
CoronaBot04/r/coronavirus: Long Covid patients haunted by smells of fish, sulphur and burnt toast (10054 votes) | https://www.independent.co.uk/news/coronavirus-advice/long-covid-smells-symptoms-b1779215.html | https://redd.it/kl2evf23:58

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