Brainstorm | Updates for Netherlands: +6689 cases (now 763627), +15 deaths (now 11019) since 21 hours ago — Canada: +9281 cases (now 551540), +163 deaths (now 14963) since 6 hours ago | 00:18 |
---|---|---|
Brainstorm | Updates for Uruguay: +510 cases (now 16728), +11 deaths (now 158) since 21 hours ago | 00:25 |
Brainstorm | New from r/WorldNews: worldnews: Excess use of antibiotics due to COVID-19 triggers 'super gonorrhea' → https://is.gd/vojiGP | 00:48 |
de-facto | what is this one here? https://mednet-communities.net/inn/db/media/docs/11392.doc | 01:19 |
Brainstorm | New from r/WorldNews: worldnews: 'Super Gonorrhea' on the Rise Due to COVID-19, WHO Says → https://is.gd/VIg4eU | 01:25 |
Brainstorm | Updates for Afghanistan: +645 cases (now 52007), +24 deaths (now 2170) since 17 hours ago — France: +5184 cases (now 2.6 million) since 22 hours ago | 01:27 |
CoronaBot | 04/r/covid19: Reader response: Loss of smell in COVID-19 patients: MRI data reveals a transient edema of the olfactory clefts (80 votes) | https://n.neurology.org/content/reader-response-loss-smell-covid-19-patients-mri-data-reveals-transient-edema-olfactory | https://redd.it/kl9t8t | 01:53 |
Brainstorm | New from r/WorldNews: worldnews: Zhang Zhan chronicled China’s COVID-19 crisis. Now she is accused of spreading lies → https://is.gd/VigFvX | 02:02 |
de-facto | title https://ourworldindata.org/covid-vaccinations | 02:16 |
de-facto | .title https://ourworldindata.org/covid-vaccinations | 02:16 |
Brainstorm | de-facto: From ourworldindata.org: Coronavirus (COVID-19) Vaccinations - Statistics and Research - Our World in Data | 02:16 |
CoronaBot | 04/r/covid19: Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases (82 votes) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/#__ffn_sectitle | https://redd.it/kl6rxu | 02:17 |
de-facto | ugh | 02:22 |
LjL | "Important to note is that vaccine trials exclude those who have autoimmune diseases so we really have no idea how the vaccine will affect those who have the highest chance of this happening to them." ugh indeed :\ | 02:44 |
LjL | if ryouma were here he'd "ugh" for half an hour | 02:44 |
LjL | he wouldn't be wrong | 02:44 |
Brainstorm | New from r/WorldNews: worldnews: The new variant of COVID-19 first discovered in the UK has been found in a patient in Australia → https://is.gd/pF8evX | 03:18 |
KREYREEN | Is there any Vitamine D that i can dissolve in a water and left it there for around 10 hours? | 03:25 |
Brainstorm | Updates for Netherlands: +6811 cases (now 766217), +21 deaths (now 11037) since 19 hours ago — France: +6617 cases (now 2.6 million), +129 deaths (now 62763) since 19 hours ago — Canada: +9761 cases (now 552020) since 9 hours ago — Switzerland: +1 deaths (now 7210) since 9 hours ago | 03:30 |
LjL | KREYREEN, i've always read that vitamin D should be taken with fats to maximize absorption | 03:36 |
LjL | sometimes it is *provided* in fat (oil) | 03:36 |
LjL | when it isn't, it's often recommended to take it with some kind of fats | 03:37 |
LjL | so i think water may be a suboptimal way to take it | 03:37 |
KREYREEN | LjL, i read the same thing was thinking about it incase in something that doesn't dissolve in water (tea), but dissolves in a stomach while it being encased in a fat? | 03:37 |
LjL | i don't really know the mechanism to be honest | 03:38 |
KREYREEN | neither do i x.x | 03:38 |
KREYREEN | i guess it would be more comfortable to get a light and let it shine on me cute skin~ | 03:38 |
KREYREEN | but i dunno the light frequency for that O.o | 03:38 |
LjL | that might have to be one heck of a ligh :P | 03:38 |
LjL | and that too | 03:39 |
KREYREEN | like they have these solariums that only use those energy efficient white things | 03:39 |
LjL | there are some very bright lights that are sometimes used for sleep therapy, to "reset" people's biological clocks | 03:39 |
KREYREEN | O.O | 03:39 |
LjL | but that's a different purpose, so i have no idea if they make the body produce vitamin D | 03:39 |
KREYREEN | you can do that with light?! | 03:39 |
LjL | i just know they're very bright. also, they're probably only safe in a medical setting | 03:39 |
LjL | KREYREEN, it can help. if your body thinks the sun is suddenly shining outside, then even if it's not, it's a cue that it's daytime | 03:40 |
KREYREEN | O.O | 03:40 |
KREYREEN | interesting | 03:40 |
LjL | KREYREEN, did you know that if someone is blind, depending on the type of blindness, they may or may not "automatically" develop sleep disorders? because in some cases, if the eyes are still physically working, they can still sense light and darkness and that gets used by the body, even though they can't actually "see" anything, because the pathway used for determining night vs day is different from wherever the optical nerve goes | 03:41 |
KREYREEN | interesting o.o | 03:41 |
KREYREEN | LjL, don't you know if blue light is any relevant to that? I remember doctors keep saying something along these lines only for other doctors say that it's bs >.> | 03:42 |
KREYREEN | *pandemic | 03:43 |
LjL | KREYREEN, i am not really sure. i know that non-red light (and blue is as far from red as it gets) is most likely to disrupt rods, in other words night vision. so for example if your eyes are currently dark-adapted because you're doing astronomy or something, and you want to be able to see something, using a red light helps avoid losing the dark-adaptation. using a blue light would be worst | 03:44 |
LjL | in addition to that, the "whiteness" of the sun contains a lot more blue light during daytime than during dusk or dawn | 03:44 |
LjL | which you can see by the sun turning orange-reddish when it sets | 03:44 |
LjL | it is easy to assume that the body does take that as a cue to tell it "which time it is" | 03:44 |
KREYREEN | interesting O.o | 03:44 |
LjL | but even though it's easy to assume, i don't have a handy link to a study that proves it :P | 03:45 |
LjL | i presume you know that programs like f.lux have become so ubiquitous that now operating systems tend to just include that functionality | 03:45 |
chung | I don't know how to talk to CovBot, esp. the number of new patients each day for my location. Is there anyway? Thanks, | 03:45 |
LjL | i am wary of fads, but i don't think this is just a fad | 03:46 |
KREYREEN | LjL, yep but i found that being too annoying for me and i just lowered the brightness o.o | 03:46 |
KREYREEN | which seems to have similar effect | 03:46 |
LjL | chung, i don't run CovBot, i run Brainstorm so i can answer for Brainstorm and unfortunately, no, there is no way to get the daily number. it posts it when it obtains it, for select countries (or for countries where it's big) | 03:46 |
LjL | KREYREEN, well, lowering the brightness so that it's appropriate to the environment is definitely something you should do in general, but it's not quite the same effect | 03:47 |
LjL | KREYREEN, if you found it too annoying, it might have been set to an excessive "redness". you could try with a higher white temperature | 03:47 |
KREYREEN | Hm true O.o will research | 03:48 |
LjL | KREYREEN, ideally, the light from your screen should match the light from your environment. which means... if it's sunny outside and it comes through the window, it should match the sun's temperature (presumably a "cold" white during daytime), while if it's dawn or dusk or you're using artificial lighting, it should match the color temperature of that lighting, which is often 2700K to 3000K unless you have "cold" lamps | 03:49 |
LjL | %cases thailand | 03:49 |
Brainstorm | LjL: In Thailand, there have been 6123 confirmed cases (0.0% of the population) and 60 deaths (1.0% of cases) as of 20 hours ago. 1.3 million tests were performed (0.5% positive). See https://offloop.net/covid19/?default=Thailand for time series data. | 03:49 |
KREYREEN | Hm i see O.o | 03:49 |
KREYREEN | %newzealand | 03:50 |
KREYREEN | %zeland | 03:50 |
KREYREEN | ah | 03:50 |
KREYREEN | %cases newzealand | 03:50 |
chung | LjL: Thanks, I shall also try Brainstorm. | 03:50 |
Brainstorm | KREYREEN: Sorry, newzealand not found. Either there aren't cases, or it's under a different name. | 03:50 |
KREYREEN | x.x | 03:50 |
KREYREEN | %cases new zealand | 03:50 |
Brainstorm | KREYREEN: In New Zealand, there have been 2144 confirmed cases (0.0% of the population) and 25 deaths (1.2% of cases) as of 22 hours ago. 1.4 million tests were performed (0.2% positive). Fatality can be broadly expected to lie between 0.3% (assuming prevalence as in tests) and less than 1.2% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=New%20Zealand for time series data. | 03:50 |
KREYREEN | yay~ | 03:50 |
KREYREEN | > (0.0% of the population) | 03:51 |
LjL | KREYREEN, basically, aside from the presumed health benefit, what your eyes perceive as "white" is whatever the current light source is. that's true for reflective objects: like, a "white" sheet of paper will reflect the color of your current light source. but with computers/phones, the screen itself is a light source, so if it has its own white point, there can be a mismatch. this is not about health, it's simply about working with light | 03:51 |
chung | %cases beijing | 03:51 |
Brainstorm | chung: In Beijing, China, there have been 971 confirmed cases (0.0% of the population) and 9 deaths (0.9% of cases) as of 20 hours ago. Fatality can be broadly expected to lie between 0.3% (assuming deaths/cases with ⅔ undetected) and less than 0.9% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Beijing for time series data. | 03:51 |
LjL | sub-regions are available for some countries, but not all | 03:51 |
LjL | generally, city or county data are not available | 03:51 |
KREYREEN | > and 25 deaths (1.2% of cases) | don't the have 5M people there? Or are they murdering the infected to keep the numbers down as Spitting Image said? O.o | 03:51 |
LjL | i could and probably should provide something for daily new cases... but the code is a mess and so far i haven't :\ | 03:51 |
KREYREEN | LjL, like using orang-y light from a lamp and then white light from a monitor is harmful? | 03:52 |
LjL | KREYREEN, 25 deaths is 1.2% of 2144 (which is the cases) | 03:52 |
KREYREEN | ah i see | 03:53 |
gigasu_shida | hey ljl how's lombardia coping? | 03:53 |
chung | LjL: which symbol seperates region and sub-region? | 03:53 |
LjL | KREYREEN, no, as i said, this is not about the health aspect per se. it's not necessarily "harmful", it's just... wrong. if you were editing images, you'd edit them wrong. if you *aren't* editing images, it probably still feels wrong to your brain to some extent | 03:53 |
chung | %cases china;wuhan | 03:53 |
Brainstorm | chung: Sorry, china;wuhan not found. Either there aren't cases, or it's under a different name. | 03:53 |
KREYREEN | O.o | 03:53 |
chung | %cases china,wuhan | 03:54 |
Brainstorm | chung: Sorry, china,wuhan not found. Either there aren't cases, or it's under a different name. | 03:54 |
LjL | chung, there is no distinction between region and sub-region. by "sub-region" i only meant whatever is smaller than the country. so Beijing is the sub-region, and China is the country. that's all i have i'm afraid | 03:54 |
LjL | chung, oh, that, no, you just type the region name without the country | 03:54 |
LjL | %cases Hubei | 03:54 |
Brainstorm | LjL: In Hubei, China, there have been 68149 confirmed cases (0.1% of the population) and 4512 deaths (6.6% of cases) as of 24 days ago. Fatality can be broadly expected to lie between 2.2% (assuming deaths/cases with ⅔ undetected) and less than 6.5% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Hubei for time series data. | 03:54 |
chung | %cases wuhan | 03:54 |
Brainstorm | chung: Sorry, wuhan not found. Either there aren't cases, or it's under a different name. | 03:54 |
LjL | Wuhan is a city and i don't think it's listed | 03:54 |
LjL | Hubei contains Wuhan, but i only have data for the whole of Hubei | 03:54 |
chung | %cases hubei | 03:55 |
Brainstorm | chung: In Hubei, China, there have been 68149 confirmed cases (0.1% of the population) and 4512 deaths (6.6% of cases) as of 24 days ago. Fatality can be broadly expected to lie between 2.2% (assuming deaths/cases with ⅔ undetected) and less than 6.5% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Hubei for time series data. | 03:55 |
chung | LjL, your suggestion is very helpful, thanks a lot. | 03:55 |
gigasu_shida | is lombardia still the hardest hit metro region in the world? | 03:55 |
LjL | chung, you're welcome. i'll try to provide daily new cases later. | 03:55 |
gigasu_shida | err, province | 03:55 |
LjL | gigasu_shida, no | 03:55 |
LjL | region | 03:55 |
LjL | also it's a pet peeve of mine but please please call it Lombardy unless you're speaking italian or spanish :P | 03:56 |
LjL | it's called Lombardy in English! | 03:56 |
gigasu_shida | oh sorry lol | 03:56 |
LjL | anyway in italy the divisions are like, regions: Lombardy, Latium, Tuscany, etc; provinces: Milan, Rome, Florence, etc | 03:56 |
LjL | regions usually contain multiple provinces | 03:57 |
gigasu_shida | oh Milan is a province i see | 03:57 |
LjL | except Val d'Aosta which is weird, and Trentino-Alto Adige-Südtirol-South Tyrol-all the other names you can decide to call it, which is also weird | 03:57 |
LjL | gigasu_shida, yes, it is also a municipality though, and that's smaller than the province | 03:57 |
LjL | as in, the municipality (city) of Milan is the capital of the province of Milan | 03:58 |
LjL | (actually, the "province" is now called the "metropolitan city of Milan", they did that for a bunch of provinces, but nobody cares and we still call it a province really) | 03:58 |
LjL | so, it used to be: Milan, Province of Milan, Lombardy, Italy | 03:58 |
LjL | now it is: Milan, Metropolitan City of Milan, Lombardy, Italy | 03:58 |
LjL | you know, just to make addresses easier to type :P | 03:59 |
LjL | but what we actually type on letters is "Milano (MI)", with MI being the province abbreviation | 03:59 |
LjL | gigasu_shida, anyway no Lombardy's data are... not low, but not terribly high either, but some other regions are becoming worrisome, like Veneto and some others | 04:00 |
LjL | i suspect maybe they have more of the "UK variant" | 04:00 |
LjL | i do think the variant is more infectious (personal, not scientific or medical opinion) | 04:00 |
gigasu_shida | oh gosh | 04:00 |
gigasu_shida | hadn't heard about Venete | 04:01 |
LjL | ooooh | 04:01 |
LjL | it's all white outside! | 04:02 |
chung | %cases rome | 04:02 |
Brainstorm | chung: Sorry, rome not found. Either there aren't cases, or it's under a different name. | 04:02 |
chung | %cases milan | 04:02 |
Brainstorm | chung: Sorry, milan not found. Either there aren't cases, or it's under a different name. | 04:02 |
LjL | %cases latium | 04:02 |
Brainstorm | LjL: Sorry, latium not found. Either there aren't cases, or it's under a different name. | 04:02 |
LjL | %cases lazio | 04:02 |
Brainstorm | LjL: Sorry, lazio not found. Either there aren't cases, or it's under a different name. | 04:02 |
LjL | uh | 04:02 |
LjL | i thought i *had* those | 04:02 |
LjL | %cases lombardia | 04:02 |
LjL | %cases lombardy | 04:02 |
Brainstorm | LjL: In Lombardy, Italy, there have been 471489 confirmed cases (4.7% of the population) and 24818 deaths (5.3% of cases) as of 20 hours ago. 196302 tests were performed (240.2% positive). Fatality can be broadly expected to lie between 0.1% (assuming prevalence as in tests) and less than 6.0% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Lombardy for time series data. | 04:02 |
Brainstorm | LjL: In Lombardy, Italy, there have been 471489 confirmed cases (4.7% of the population) and 24818 deaths (5.3% of cases) as of 20 hours ago. 196302 tests were performed (240.2% positive). Fatality can be broadly expected to lie between 0.1% (assuming prevalence as in tests) and less than 6.0% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Lombardy for time series data. | 04:02 |
LjL | okay so what the hell does Covidly call Latium O.o | 04:02 |
chung | %compare cn;us | 04:03 |
Brainstorm | chung: I need exactly two IPA phones! | 04:03 |
LjL | chung, nope, that's not a command it has (well, it does, but for an unrelated thing). maybe CovBot does, i think? | 04:03 |
LjL | !compare cn;us | 04:03 |
LjL | sorry, i don't really know how to use CovBot :\ | 04:03 |
jacklsw | there is no comparison now | 04:04 |
chung | Yes CovBot does. | 04:04 |
jacklsw | xD | 04:04 |
LjL | Covidly seems a bit random. Lombardy is called Lombardy, Tuscany is called Tuscany, etc, but Latium is called Lazio as in italian | 04:06 |
LjL | and still, my bot doesn't get its data | 04:06 |
LjL | Brainstorm, reload covid | 04:06 |
Brainstorm | LjL: <module 'covid' from '/home/brainstorm/brainstorm/bot/modules/covid.py'> (version: 2020-12-28 03:06:32) | 04:06 |
gigasu_shida | if Lombardy has about 10M people, then it's definitely harder hit so far than Los Angeles metro region | 04:06 |
LjL | %cases latium | 04:06 |
Brainstorm | LjL: Sorry, latium not found. Either there aren't cases, or it's under a different name. | 04:06 |
LjL | gigasu_shida, it does have about 10m | 04:06 |
Brainstorm | LjL: An error occurred while searching. | 04:06 |
gigasu_shida | but i have a feeling that could change next year | 04:06 |
Brainstorm | LjL: An error occurred while searching. | 04:06 |
LjL | %cases lazio | 04:06 |
Brainstorm | LjL: In Lazio, Italy, there have been 156790 confirmed cases (2.7% of the population) and 3513 deaths (2.2% of cases) as of 20 hours ago. Fatality can be broadly expected to lie between 0.7% (assuming deaths/cases with ⅔ undetected) and less than 4.4% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Lazio for time series data. | 04:06 |
LjL | alright | 04:06 |
LjL | gigasu_shida, but they are probably not comparable population density-wise... Lombardy is pretty dense (heh), but it's not a whole metro area. it has three somewhat distinct metropolitan areas in it, more or less, but then also a fair amount of mountain and countryside. the metropolitan area of Milan is between 3 million and 6 million or so depending on who you ask | 04:08 |
LjL | (the actual province is 3 million) | 04:08 |
LjL | %wa population density of los angeles | 04:08 |
Brainstorm | LjL, Wolfram|Alpha (Los Angeles, California, United States | population density): Result: 3295 people per square kilometer → https://www.wolframalpha.com/input/?i=population+density+of+los+angeles | 04:08 |
LjL | %wa population density of milan | 04:08 |
Brainstorm | LjL, Wolfram|Alpha (Milan, Lombardy, Italy | population density): Result: (data not available) → https://www.wolframalpha.com/input/?i=population+density+of+milan | 04:08 |
LjL | %wa population density of lombardy | 04:08 |
Brainstorm | LjL, Wolfram|Alpha (Lombardy, Italy | population density): Result: 420 people per square kilometer → https://www.wolframalpha.com/input/?i=population+density+of+lombardy | 04:09 |
LjL | yeah, a fair bit less | 04:09 |
gigasu_shida | i can't think of a metro area hit harder than Milan tho | 04:09 |
gigasu_shida | maybe somewhere in Brazil | 04:10 |
gigasu_shida | i'll have to research it | 04:10 |
LjL | gigasu_shida, Milan was actually the *least* hit area within Lombardy, in the first wave. second wave was different, so i'm not sure on balance | 04:10 |
LjL | but Bergamo is also in Lombardy and definitely fared worse | 04:10 |
LjL | Madrid was also in shambles in both the first and the second wave | 04:10 |
gigasu_shida | omg i didn't even hear about Bergamo | 04:10 |
chung | LjL: What is %wa? | 04:11 |
LjL | chung, wolfram alpha | 04:12 |
LjL | gigasu_shida, https://www.arcgis.com/apps/opsdashboard/index.html#/4f74fc222b7041cd9cc3c52e62af1b8c ← have a look at these numbers... yes, Milan is first, but Brescia and Bergamo are both in Italy and *much* smaller than Milan, so comparatively, they were much harder hit | 04:12 |
LjL | err | 04:12 |
LjL | although that's only updated to the first wave | 04:12 |
LjL | this is actually up to date for Lombardy https://lispa.maps.arcgis.com/apps/opsdashboard/index.html#/637ec3dc28ec4ea591cc5c724f127701 | 04:13 |
chung | LjL: I query private messages with Brainstorm, I only know 2 commands i.e. %modules and %commands, %wa is not mentioned. | 04:13 |
LjL | chung, yes, i've done a bad job of documenting them, i'm sorry. many commands are about linguistics, also, since that's what the bot was initially created to do | 04:13 |
LjL | the commands relevant to COVID are %cases, %papers, %links and %vaccines | 04:14 |
LjL | (it also accepts some variants of that) | 04:14 |
LjL | and things like %wa are also generally useful... when they work, as Wolfram Alpha is quite temperamental with its timeouts | 04:14 |
euod[m] | I realised the gpt2 neural network was made with pre-pandemic text sources, so it's blissfully unaware of covid19. | 04:14 |
chung | %papers | 04:15 |
Brainstorm | chung: Specify search terms with the syntax explained at https://preview.zbmed.de/ | 04:15 |
LjL | %papers long covid blood clots | 04:15 |
Brainstorm | LjL: An error occurred while searching. | 04:15 |
LjL | i guess not | 04:15 |
LjL | %papers blood clots | 04:15 |
Brainstorm | LjL, 7 papers: Cumulative effect of aging and SARS-CoV2 infection on poor prognosis in the elderly: Insights from transcriptomic analysis of lung and blood by Upasana Bhattacharyya et al, made available as preprint on 2020-06-16 at http://biorxiv.org/cgi/content/short/2020.06.15.151761 [... want %more?] | 04:15 |
LjL | it gives you preprints | 04:15 |
chung | %papers covid | 04:15 |
LjL | chung, they are all about COVID, so that search keyword will probably crash the API a little :P | 04:16 |
LjL | it will probably answer your command in a couple of minutes :D | 04:16 |
Brainstorm | chung, 19042 papers: Proposal of COVID-19 Clinical Risk Score for the management of suspected COVID-19 cases: a case control study by Sho Nakakubo et al, made available as preprint on 2020-07-14 at [u'https://doi.org/10.21203/rs.3.rs-42603/v1', u'https://www.researchsquare.com/article/rs-42603/v1.pdf'] [... want %more?] | 04:16 |
chung | LjL: alright | 04:16 |
chung | great! | 04:16 |
gigasu_shida | omg, some article said over half of ppl tested have antibodies in Bergamo | 04:17 |
gigasu_shida | and it was a supposedly random sampling of ppl | 04:17 |
LjL | gigasu_shida, i think it was in some specific parts of the Bergamo provinces, but... you could be right | 04:17 |
LjL | there's definitely a very high prevalence there | 04:17 |
LjL | but also i'm always wary of antibody tests because some of them suck | 04:18 |
gigasu_shida | oh okay | 04:18 |
LjL | we do have a nationally run antibody survey and i wonder if they ever released *official* data, since i only saw interim data | 04:18 |
euod[m] | it's basically useless false positive rate right? | 04:18 |
LjL | euod[m], it all depends on the test. some are probably okay | 04:21 |
LjL | but i'm pretty bummed at how ISTAT has only run that one national survey in May, and then no more | 04:21 |
LjL | and they only have some preliminary data for it, in Italian only, meh | 04:22 |
LjL | http://www.salute.gov.it/imgs/C_17_notizie_4998_0_file.pdf | 04:22 |
johnguyy[m] | Flew into NY the other day and was greeted by a few military personnel asking for paperwork and a few ladies screaming about a “potential $10k fine if you didn’t sign them | 04:22 |
gigasu_shida | what kind of paperwork? | 04:23 |
LjL | i'm not going to fly anywhere if i can at all avoid it (which i probably can) | 04:23 |
gigasu_shida | i was already scared of flying | 04:24 |
LjL | i'm not so much scared of flying per se but i'm scared of the security checks, customs checks, check-in, and all of that stuff | 04:25 |
LjL | once i'm on the plane, it will... probably not crash, with overwhelming chances | 04:25 |
johnguyy[m] | Paperwork- covid test, quarantine mandate, blah blah blah | 04:27 |
gigasu_shida | i came across an article recently about how airplane cabins are pressurized. kinda freaked me out how some airplane personnel have fainted. the air system takes air directly from some part of the jet engine so in some cases some burned or unburned fuel can make its way into the cabin air at higher than acceptable concentrations | 04:27 |
johnguyy[m] | Phone number/adress which I did not provide | 04:27 |
gigasu_shida | so now i have two things to be scared about ljl | 04:27 |
gigasu_shida | and yeah waiting in longs lines is annoying too | 04:27 |
danielp3344 | gigasu_shida: yeah 'bleed air' is supplied by the first stage or two of compressors from a jet engine | 04:28 |
danielp3344 | as they suck air in and compress it some is taken to perform various aircraft functions, the rest is mixed with fuel and burned | 04:28 |
gigasu_shida | looking back on my flight experiences i always thought the cabin air smelled faintly of jet fuel at times | 04:28 |
danielp3344 | lol | 04:29 |
johnguyy[m] | It’s dirty air that’s for sure | 04:29 |
johnguyy[m] | I always feel Particularly greasy after a flight | 04:29 |
gigasu_shida | usually it was when we were still on the tarmac | 04:29 |
LjL | gigasu_shida, a lot of freakish things can happen on an airplane. however, another data point you can look at is that even in people who are involved in things classified as *accidents*, the vast majority survives | 04:29 |
gigasu_shida | it could have been just the bad air on the tarmac | 04:29 |
gigasu_shida | ljl a lot of coverups happen when airplane personnel faint or what not, don't kid yourself | 04:30 |
danielp3344 | johnguyy: if I'm gonna inhale unburned fuel and exhaust it had better be mine :P | 04:30 |
gigasu_shida | hahhahahaha | 04:30 |
LjL | i... don't think i'm "kidding myself". also where is the evidence of these coverups? or do you just assume they happen because there is no evidence? | 04:31 |
LjL | something i would recommend is to *not* be sleeping during the takeoff and landing phases (including climb and approach) | 04:31 |
LjL | because of two things | 04:31 |
LjL | 1) that's when (de)pressurization happens, and if your Eustachian tubes are clogged, during sleep you may not realize that you need to click them to unplug your ears, and at some point the pressure could damage the inner ear | 04:32 |
gigasu_shida | i know ppl in the industry. stewardesses etc | 04:32 |
LjL | 2) that's also when the vast majority of accidents happen, so even though chances of an accidents are still very low, takeoff and landing are when you should be most aware of your surroundings, shoes on, and all that | 04:33 |
gigasu_shida | yeah i have felt that pressure as well and forgot to squeeze the air against my squeezing my nose | 04:33 |
gigasu_shida | and my tubes are usually clogged it would seem | 04:33 |
LjL | if you do that nose-squeezing thing, do it very gently | 04:33 |
LjL | it may be enough to just plug your nose and only barely push any air, and click your ears | 04:34 |
gigasu_shida | sorry that penultimate sentence was whack....i'm losing it. need coffee | 04:34 |
LjL | yeah it kinda was :P but i understood you're probably talking about | 04:34 |
LjL | %wik Valsalva maneuver | 04:34 |
LjL | (at least one of its variants) | 04:34 |
Brainstorm | LjL, from English Wikipedia: The Valsalva maneuver is performed by moderately forceful attempted exhalation against a closed airway, usually done by closing one's mouth, pinching one's nose shut while expelling air out as if blowing up a balloon. Variations of the maneuver can be used either in medical examination as a test of [... want %more?] → https://en.wikipedia.org/wiki/Valsalva_maneuver | 04:34 |
LjL | done for this purpose https://en.wikipedia.org/wiki/Valsalva_maneuver#Normalizing_middle-ear_pressures | 04:35 |
LjL | (but it's also done for other purposes) | 04:35 |
gigasu_shida | it's an amazing maneuver | 04:39 |
gigasu_shida | like the heimlich maneuver | 04:39 |
gigasu_shida | and thank you i didn't know the name of it till now | 04:39 |
Brainstorm | New from BBC Health: Covid-19: Hospitals face 'pressure' as coronavirus cases rise: Rising demand is down to the "rapid spread" of the new variant of Covid-19, health bosses say. → https://is.gd/y1sn4E | 04:57 |
Brainstorm | Updates for Belgium: +847 cases (now 638877), +42 deaths (now 19200) since 22 hours ago | 05:53 |
Brainstorm | New from The Indian Express: World: Europe rolls out ‘new weapon’ vaccines in bid to slay COVID → https://is.gd/pp0B4F | 06:12 |
Brainstorm | New from r/WorldNews: worldnews: Zhang Zhan: China jails citizen journalist for Wuhan reports → https://is.gd/smAaQa | 06:37 |
Brainstorm | New from The Indian Express: World: Trump signs pandemic aid and spending bill, averting government shutdown → https://is.gd/2yHKfj | 07:02 |
Brainstorm | Updates for Texas, United States: +22848 cases (now 1.7 million), +50 deaths (now 26966) since 23 hours ago — South Carolina, United States: +7287 cases (now 296179), +31 deaths (now 5155) since 23 hours ago — Quebec, Canada: +6793 cases (now 192665), +110 deaths (now 8023) since 2 days ago — Minnesota, United States: +2516 cases (now 409061), +40 deaths (now 5206) since 23 hours ago | 07:13 |
DocScrutinizer05 | >>no, jackass, when you got your vac shot doesn't mean you get special privileges now and may drop the habit to wear a mask and keep distance. You already got the privilege to get vaccinated, now the only special privilege you got is to STFU and behave until everybody got their shot<< | 07:41 |
Brainstorm | New from r/WorldNews: worldnews: China jails citizen journalists for Wuhan reports → https://is.gd/H1tJpo | 07:52 |
Brainstorm | New from Medical Xpress: US surpasses 19 mn Covid-19 cases: Johns Hopkins: The United States surpassed 19 million coronavirus cases Sunday, figures from Johns Hopkins University showed, adding one million new cases in less than a week. → https://is.gd/tAjmEz | 08:05 |
Brainstorm | New from The Indian Express: World: China jails citizen-journalist for four years over Wuhan virus reporting → https://is.gd/qrOyxW | 08:17 |
Brainstorm | New from BBC Health: Covid-19: Hospitals face 'pressure' as coronavirus cases rise: Rising demand is down to the "rapid spread" of the new variant of Covid-19, health bosses say. → https://is.gd/y1sn4E | 08:54 |
Brainstorm | New from Science-Based Medicine: 2020 and the pandemic: A year of physicians behaving badly: Looking back on 2020, if there's one thing that the COVID-19 pandemic has taught us, it's that crises reveal character. Unfortunately, the character of too many physicians has been found wanting, as they spent 2020 denying the pandemic, peddling quack cures, or [... want %more?] → https://is.gd/haCTlo | 09:06 |
Brainstorm | New from The Indian Express: World: Italy turns to flower power to help spread vaccine message → https://is.gd/mm4Jc4 | 09:44 |
Brainstorm | New from The Indian Express (Health): Health: Wondering what the new coronavirus strain is all about? A doctor explains → https://is.gd/q6PmXO | 09:56 |
Brainstorm | New from Reddit (test): CoronaVirus_ITALIA: Il presidente De Luca si fa vaccinare ma non è in lista: le dosi erano solo per medici e infermieri → https://is.gd/iJpciw | 10:08 |
Brainstorm | New from Medical Xpress: China ramps up virus controls to head off winter wave: Temperature checks, queues for tests and inspections at airports—Chinese authorities have stepped up health checks to snuff out the threat of a coronavirus resurgence. → https://is.gd/sVvciP | 10:21 |
Brainstorm | New from BBC Health: Covid-19: Hospitals under pressure as coronavirus cases rise: Rising demand is down to the "rapid spread" of the new variant of Covid-19, health bosses say. → https://is.gd/y1sn4E | 10:34 |
de-facto | RKI COVID-19 Germany 2020-12-28 (btween years rep:): Weekly Incidence 157.7/100k, Infections +10976 (1651834 total), Fatalities +348 (30126 total), COVID@ICU 5604 (incl 3011 on ventilator) | 10:44 |
Brainstorm | New from Reddit (test): nCoV: Zhang Zhan: China jails citizen journalist for Wuhan reports | 28DEC20 → https://is.gd/10FrAl | 10:46 |
Arsanerit | not sure if the phrase "between years" exists in English | 10:58 |
Brainstorm | New from Reddit (test): CoronaVirus_ITALIA: No, l’Italia non ha meno vaccini rispetto agli altri Paesi UE → https://is.gd/NoHipQ | 10:58 |
DocScrutinizer05 | de-facto: my chart already shows a new edge for yesterday. We'll see how long it takes until numbers for 24. ff stabilize on reasonable non-bogus values | 11:11 |
Brainstorm | New from BBC Health: Covid-19: Hospitals under pressure as coronavirus cases rise: Rising demand is down to the "rapid spread" of the new variant of Covid-19, health bosses say. → https://is.gd/y1sn4E | 11:11 |
DocScrutinizer05 | https://i.imgur.com/z1YRZQJ.png https://i.imgur.com/7l24OUl.png https://i.imgur.com/e8We3Ar.png | 11:22 |
Brainstorm | New from ProPublica: After a Violent Crime, Arizona Promised Reforms for People With Developmental Disabilities. It Has Yet to Deliver.: by Amy Silverman for Arizona Daily Star ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. This article was produced in [... want %more?] → https://is.gd/WqHxKd | 11:24 |
DocScrutinizer05 | %why | 11:25 |
Brainstorm | We are unable to find any reasons *why* this should work. | 11:26 |
Brainstorm | New from r/WorldNews: worldnews: South Korea reports cases of COVID variant - and says they came from UK → https://is.gd/AKcs2f | 11:49 |
Brainstorm | New from BBC Health: Covid-19: Hospitals under pressure as coronavirus cases rise: Rising demand is down to the "rapid spread" of the new variant of Covid-19, health bosses say. → https://is.gd/y1sn4E | 12:13 |
mobidrop | is there really a new variant or is this just their failure to manage spread? | 12:15 |
de-facto | mobidrop, https://en.wikipedia.org/wiki/Variant_of_Concern_202012/01 | 12:37 |
de-facto | thats the UK variant | 12:37 |
de-facto | SA variant https://en.wikipedia.org/wiki/501.V2_variant | 12:38 |
de-facto | for updates on newest info look at "Dr Emma Hodcroft" twitter at https://twitter.com/firefoxx66 | 12:39 |
de-facto | https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 | 12:41 |
de-facto | https://www.krisp.org.za/publications.php?pubid=315 | 12:48 |
de-facto | https://www.medrxiv.org/content/10.1101/2020.12.21.20248640v1 | 12:48 |
de-facto | https://www.ecdc.europa.eu/en/publications-data/threat-assessment-brief-rapid-increase-sars-cov-2-variant-united-kingdom | 12:49 |
de-facto | https://www.who.int/publications/m/item/statement-of-the-who-working-group-on-covid-19-animal-models-(who-com)-about-the-uk-and-south-african-sars-cov-2-new-variants | 12:51 |
de-facto | mobidrop, ^^ and lots of more info | 12:52 |
genera | so basically sis is nCoV-dezember-2020 | 13:02 |
de-facto | one of the mutations of those that might be of importance is on the S-protein at position 501 | 13:08 |
de-facto | N501Y (3876 sequences): 3116 England, 478 Wales, 202 South Africa, 37 Australia/VIC, 18 Scotland, 10 Denmark, 5 USA/MA, 2 Netherlands, 2 Australia/NSW, 1 USA/OR, 1 Italy, 1 USA/NY, 1 Gibraltar, 1 Brazil, 1 USA/IL | 13:08 |
de-facto | but thats not representative because it depends on how may sequences a country collects | 13:09 |
de-facto | e.g. UK collects 100x more than most other EU contries | 13:09 |
Brainstorm | New from The Indian Express (Health): Life-style: How WFH in pandemic changed our home decor, furniture → https://is.gd/4mUM9z | 13:28 |
Brainstorm | New from r/WorldNews: worldnews: Piecemeal data releases threaten to undermine Sinovac's COVID-19 vaccine → https://is.gd/uF1ZiM | 14:30 |
Brainstorm | New from BBC Health: Covid-19: Hospitals under pressure as coronavirus cases rise: Rising demand is down to the "rapid spread" of the new variant of Covid-19, health bosses say. → https://is.gd/y1sn4E | 14:43 |
Brainstorm | Updates for Germany: +10833 cases (now 1.7 million) since 23 hours ago | 14:53 |
Brainstorm | Updates for Lesotho: +231 cases (now 2956) since 5 days ago — Switzerland: +10087 cases (now 438284), +74 deaths (now 7283) since 21 hours ago | 15:11 |
Brainstorm | New from Emma Hodcroft: @firefoxx66: Many are interested in using the 69/70 deletion to scan for cases of the new #SARSCoV2 variants.As it can impact some primers (seen as an 'S drop-out' in PCR), it can be a high-throughput way to check for the 'SE England' variant - but some important things to remember!1/5 → https://is.gd/RspWfc | 15:21 |
Brainstorm | New from Medical Xpress: More work needed to identify risk from Nigeria strain, says researcher: A researcher who identified a novel coronavirus variant in Nigeria has cautioned against automatic assumptions that it poses similar risks to strains that have emerged elsewhere. → https://is.gd/YFwyI1 | 15:34 |
CoronaBot | 04/r/covid19: SARS-CoV-2-specific T cell memory is long-lasting in the majority of convalsecent COVID-19 individuals (84 votes) | https://www.biorxiv.org/content/10.1101/2020.11.15.383463v1.full | https://redd.it/klpvp7 | 15:47 |
Brainstorm | New from Emma Hodcroft: @AdamJKucharski: RT by @firefoxx66: Why a SARS-CoV-2 variant that's 50% more transmissible would in general be a much bigger problem than a variant that's 50% more deadly. A short thread... 1/ → https://is.gd/dnJ7uG | 16:12 |
Brainstorm | Updates for Liechtenstein: +20 cases (now 2038), +4 deaths (now 35) since 21 hours ago | 16:13 |
Brainstorm | Updates for Netherlands: +7976 cases (now 771603), +39 deaths (now 11058) since 16 hours ago | 16:32 |
Brainstorm | New from r/WorldNews: worldnews: 19 SARS-CoV-2 mutations in India can evade antibodies, 1 causes reinfection → https://is.gd/FgbmBm | 16:50 |
Brainstorm | New from Scientific American: Debunking the False Claim That COVID Death Counts Are Inflated: President Trump and other conspiracy fantasists touted the fake claim that COVID death counts are exaggerated. But three kinds of evidence point to more than 250,000 deaths -- Read more on ScientificAmerican.com → https://is.gd/SIZ5Zm | 17:16 |
Jigsy | %cases UK | 17:25 |
Brainstorm | Jigsy: In United Kingdom, there have been 2.3 million confirmed cases (3.4% of the population) and 70806 deaths (3.1% of cases) as of 10 hours ago. 52.3 million tests were performed (4.4% positive). See https://offloop.net/covid19/?default=United%20Kingdom for time series data. | 17:25 |
Jigsy | UK now has 40K/day. | 17:25 |
Jigsy | And they're opening schools next week. | 17:25 |
Jigsy | This should be a fun trainwreck to watch. | 17:26 |
Brainstorm | Updates for United Kingdom: +35421 cases (now 2.3 million), +350 deaths (now 70907) since 22 hours ago | 17:28 |
Brainstorm | New from BBC Health: Covid-19: Hospitals under pressure as coronavirus cases rise: Rising demand is down to the "rapid spread" of the new variant of Covid-19, health bosses say. → https://is.gd/y1sn4E | 17:28 |
Arsanerit | why fun? | 17:29 |
Jigsy | Because the UK are still doing such a shit job of managing this situation | 17:30 |
Jigsy | + . | 17:30 |
Jigsy | A year later. | 17:30 |
Jigsy | It's like this. | 17:30 |
Jigsy | "We'll be doing this." | 17:30 |
Jigsy | *COVID CASES SPIKE 1000%* | 17:30 |
Jigsy | surprised_pikachu.jpg | 17:30 |
Jigsy | Every time. | 17:31 |
Arsanerit | is that fun? | 17:33 |
Arsanerit | people are suffering and dying, livelihoods are damaged and destroyed, I don't really find it fun personally | 17:34 |
Jigsy | I'm thinking more of a government angle, not a people angle. | 17:35 |
Jigsy | Though the people aren't exactly helping this situation either... | 17:35 |
Arsanerit | some are, some aren't | 17:35 |
Jigsy | You'd be amazed how many people I see not wearing masks. | 17:36 |
Jigsy | And the only time they put them on is in the store. | 17:36 |
Jigsy | I walk past people outside and they're not wearing shit. | 17:36 |
Arsanerit | is there a general outdoor mask requirement where you are? | 17:37 |
Jigsy | I don't believe so. | 17:38 |
Jigsy | But they're walking past other people... | 17:38 |
Jigsy | How is this not common sense? | 17:38 |
Arsanerit | I don't wear a mask when walking in the forest, but I do keep ≥1.5 metre distance. | 17:38 |
Arsanerit | I don't know. I'm confused. The Robert Koch Institut defines a class I contact person as having been less than 1.5 metre distant for 15 minutes. Does that mean that when I just quickly walk by someone outside that there is a negligible risk of transmission (when not outright coughing in their face)? | 17:39 |
Arsanerit | That's the criteria for the Corona Warn App, at least the way it's configured/programmed in Germany. | 17:39 |
de-facto | imho masks should be worn without exceptions in any place (also outdoors) where there is the chance the people might not keep at least 2m distance to each others, even short times, noone sneezes, coughs or talks with the purpose to infect others, yet it happens | 17:49 |
de-facto | yet when i would go for a walk alone in the forest or on the fields i would not wear a mask because then its several hundred meters at least till next human contact, but i always would put it on as soon as i expect to come into a situation with less distance even if its only a few seconds | 17:50 |
de-facto | simply because its not only my own personal risk but also the risk of all of society and economy | 17:51 |
Brainstorm | New from EMA: What's new: General: COVID-19 vaccines: key facts → https://is.gd/ssCPcx | 17:54 |
Brainstorm | Updates for Canada: +8546 cases (now 553112), +136 deaths (now 14970) since 23 hours ago | 18:05 |
Brainstorm | New from In The Pipeline: Holiday Recipe: Banana Bread: We just finished off a loaf of this not long ago around here; it’s a recipe that my wife makes when we have overripe bananas (and since we have both our college-aged kids at home for now, it goes pretty quickly). Like most such recipes, it comes together quickly. You’ll need shortening [... want %more?] → https://is.gd/mg6k1I | 18:07 |
IndoAnon | 9,99> Elsewhere in Germany, in the Vorpommern-Ruegen district, authorities said eight workers in an elderly care home in Stralsund city received five times the recommended dose of the BioNTech/Pfizer vaccine on Sunday. | 18:17 |
de-facto | OMG did they inject them a whole ampule? | 18:20 |
Brainstorm | New from Medical Xpress: German care home workers given five times vaccine dose: Eight care home workers in Germany were accidentally injected with five doses of the COVID-19 vaccine, local authorities said Monday—but are suffering no serious ill effects so far. → https://is.gd/pLdH1D | 18:20 |
de-facto | in each vile there are 5 doses of 30 µg | 18:20 |
genera | thats what modeRNA needs anyway, no? | 18:24 |
de-facto | its not like they would have any problems selling, its more like they cant produce enough of the doses | 18:30 |
IndoAnon | It's more like these clowns can't read the instruction | 18:32 |
IndoAnon | 99,11https://www.reuters.com/article/reutersComService_2_MOLT/idUSKBN29214Q | 18:33 |
de-facto | please strip the colors | 18:34 |
de-facto | https://www.deutsche-apotheker-zeitung.de/_Resources/Persistent/8/3/e/d/83ed6a12587eb295d25f04e980c80dec0717b737/226386603-5400x3036-637x358.jpg | 18:34 |
IndoAnon | lel | 18:34 |
de-facto | https://www.pharmazeutische-zeitung.de/fileadmin/_processed_/2/6/csm_69084_5891f2e145.jpg | 18:35 |
IndoAnon | Can't they use samething like epipen, seriously | 18:35 |
de-facto | "After dilution, vial contains 5 doses of 0.3ml" | 18:35 |
de-facto | hmm what could that mean? "5 doses"? Anyone any ideas? | 18:36 |
de-facto | https://www.deutsche-apotheker-zeitung.de/_Resources/Persistent/d/d/2/c/dd2c06dde275ce9f20a8646b2145f99a2512747a/imago0108699619h-3000x1688-637x358.jpg | 18:37 |
IndoAnon | They probably need to withdraw the 0.3ml equivalent before being tittered | 18:37 |
de-facto | https://www.nytimes.com/interactive/2020/health/pfizer-biontech-covid-19-vaccine.html | 18:38 |
de-facto | https://static01.nyt.com/newsgraphics/2020/12/05/how-coronavirus-vaccines-work/assets/images/201208-pfizer-vial-600.jpg | 18:38 |
IndoAnon | Well, 0.3ml after meant it's equivalent to ~6 droplets. That's really smol quantity | 18:38 |
de-facto | so what? use a small syringe, i am sure it was possible to know that in advance and order the correct equipment | 18:39 |
de-facto | https://www.aerztezeitung.de/Bilder/Der-Corona-Impfstoff-von-BioNTechPfizer-soll-noch-in-dieser-192483h.jpg | 18:40 |
IndoAnon | The fact that the mishaps happened meant they're not using the correct wordings, as most vial is supposed to be single use. | 18:41 |
IndoAnon | *vaccine vial usually is single use only | 18:42 |
de-facto | https://www.deutsche-apotheker-zeitung.de/_Resources/Persistent/8/f/e/d/8fed2ebb3eb95af0cce5f033166c65d84f7f50f2/Biontech%20Quelle%20%20ZUMA%20Press%20imago0108454452h_DAZ-637x359.jpg | 18:42 |
IndoAnon | A big warning label could've prevented this | 18:42 |
de-facto | "WARNING, keep away from idiots"? | 18:42 |
IndoAnon | More like >this is 5 doses, moron | 18:43 |
de-facto | like seriously its written there "5 doses" in German "5 Dosen" | 18:43 |
IndoAnon | Funny, because dosen in indonesian is lecturer | 18:44 |
IndoAnon | LoL | 18:44 |
de-facto | anyhow is anything known about how they tolerated this experiment of getting 150µg modRNA? | 18:44 |
Brainstorm | New from Medical Xpress: Phase 3 trial of Novavax investigational COVID-19 vaccine opens: The Phase 3 trial of another investigational coronavirus disease 2019 (COVID-19) vaccine has begun enrolling adult volunteers. The randomized, placebo-controlled trial will enroll approximately 30,000 people at approximately 115 sites in the United States and [... want %more?] → https://is.gd/IFp719 | 18:44 |
IndoAnon | Dunno, because we skipped so many procedure | 18:46 |
IndoAnon | I hope governments order them to fulfill the necessary research that was cut short | 18:47 |
IndoAnon | If they still want to kept the immunity from being sued | 18:48 |
de-facto | Did you read anything about the Moderna mRNA-1273 vaccine having a full RNA sequence available? | 18:49 |
de-facto | i am still searching for it | 18:49 |
de-facto | i only found the two sequences for the German vaccines | 18:50 |
de-facto | https://www.who.int/medicines/publications/druginformation/issues/WHO_DI_34-3_PL124-SpecialEdition.pdf | 18:51 |
de-facto | bnt162b2: tozinameran, Spike (modRNA) https://mednet-communities.net/inn/db/media/docs/11889.doc | 18:51 |
de-facto | zorecimeran: CureVac, RBD (no 1mΨ) https://mednet-communities.net/inn/db/media/docs/11868.doc | 18:51 |
de-facto | both seem to contain the mutations K986P and V987P to stabilize the spike glycoprotein in prefusion configuration | 18:52 |
de-facto | id guess Moderna uses the same sequence but id like to see their data too | 18:53 |
IndoAnon | Well, i missed that... I went to ikea on christmast and still fatigued | 18:54 |
Brainstorm | Updates for Italy: +8581 cases (now 2.1 million), +445 deaths (now 72370) since 23 hours ago | 18:54 |
IndoAnon | I think I saw that conversation on the thread too. Let me search a bit | 18:55 |
de-facto | afaik both BioNTech and Moderna use modRNA hence with 1-methyl-3'-pseudouridylyl (m1Ψ) instead of uridine (U) https://en.wikipedia.org/wiki/Nucleoside-modified_messenger_RNA | 18:57 |
de-facto | CureVac uses conventional mRNA | 18:57 |
de-facto | .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449617/ | 18:58 |
Brainstorm | de-facto: From www.ncbi.nlm.nih.gov: N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density | 18:58 |
IndoAnon | hmm, nope | 19:00 |
IndoAnon | Not much of discussion | 19:00 |
IndoAnon | https://www.fda.gov/media/144245/download | 19:03 |
IndoAnon | >Among non-serious unsolicited adverse events, there was a numerical imbalance of four cases of Bell’s palsy in the vaccine group compared with no cases in the placebo group, though the four cases in the vaccine group do not represent a frequency above that expected in the general population. | 19:03 |
IndoAnon | >Otherwise, there were no notable patterns or numerical imbalances between treatment groups for specific categories of non-serious adverse events (including other neurologic, neuroinflammatory, and thrombotic events) that would suggest a causal relationship to BNT162b2 vaccine | 19:03 |
de-facto | do they provide an modRNA sequence anywhere for mRNA-1273? | 19:05 |
de-facto | i wonder how their polyA tail looks like in comparison to BNT162b2 | 19:06 |
de-facto | because mRNA1273 is a 100µg dose vs BNT162b2 is 30µg modRNA per dose | 19:06 |
de-facto | CureVac even only 12µg | 19:07 |
IndoAnon | hmm | 19:07 |
IndoAnon | nope, I don't see the discussion regading the modRNA | 19:08 |
IndoAnon | specifically for the mRNA-1273 | 19:09 |
de-facto | its going to come, its on twitter already | 19:09 |
de-facto | like discussion about the sequences | 19:09 |
Brainstorm | New from Medical Xpress: Model used to evaluate lockdowns was flawed: In a recent study, researchers from Imperial College London developed a model to assess the effect of different measures used to curb the spread of the coronavirus. However, the model had fundamental shortcomings and cannot be used to draw the published conclusions, claim Swedish [... want %more?] → https://is.gd/W97KIY | 19:09 |
de-facto | but yeah i havent found data for Moderna mRNA-1273 yet | 19:09 |
IndoAnon | http://web.archive.org/web/20200917125542/https://www.modernatx.com/sites/default/files/mRNA-1273-P301-Protocol.pdf | 19:10 |
IndoAnon | That's all i got | 19:10 |
de-facto | yeah thats the clinical protocol for the study | 19:11 |
IndoAnon | https://archive.4plebs.org/pol/thread/289634862/#289665704 > all it is as far as I can tell is a strand of RNA that encodes a covid spike protein with a methylated cap and a poly-A tail to ensure translation and half life in cells. this provokes an immune response so when live virus is introduced it provokes the same response and prevents productive infection | 19:13 |
IndoAnon | Seems fellow anon is aware of this | 19:14 |
IndoAnon | >So, why has everybody seemingly gotten memoryholed of the 33 poly-A-tail of this virus in the early genomes that's seemingly disappeared or changed, but why? | 19:15 |
de-facto | yeah except probably not only the cap is methylated but rather all uridine replaces with 1-methyl-3'-pseudouridylyl (i guess, i dont have that info about Moderna) | 19:16 |
de-facto | afaik that poly-A tail may get shorter with each transcription hence they want to make it as long and durable (with some intermediate sequences allowing over 100 A's) as possible | 19:17 |
de-facto | same idea about the modRNA make its biological half life in a cell longer, because it will get destroyed pretty quickly anyhow | 19:18 |
IndoAnon | yea | 19:23 |
IndoAnon | It makes my mate wonder abaut tha | 19:24 |
Arsanerit | AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA? | 19:25 |
Arsanerit | https://bioinformatics.stackexchange.com/q/11227 | 19:26 |
IndoAnon | LOL | 19:26 |
Arsanerit | (why) can't vaccines designed such that vaccinated people "infect" other vaccinated people, just like the virus does? It would make things faster? | 19:27 |
IndoAnon | do you know about the borg? | 19:30 |
Arsanerit | no | 19:30 |
CoronaBot | 04/r/coronavirus: People with coronavirus are still getting on planes. No one knows how many. (10558 votes) | https://www.washingtonpost.com/travel/2020/12/28/passenger-covid-flight-airlines-positive/ | https://redd.it/klrnsx | 19:31 |
ubLIX[m] | "We have infected a pool of people with a highly transmissible sterilising 'vaccine' that will now spread throughout the population." | 19:32 |
ubLIX[m] | yup, this will go down extremely well with the anti-vax crowd :p | 19:32 |
Brainstorm | New from NPR: 'I Regret Nothing': Doctor Who Criticized Trump Parade Works Last Day At Walter Reed: "I stand by my words," says Dr. James Phillips, the Walter Reed physician who said the president's decision to drive by supporters while being treated for COVID-19 endangered his security detail. → https://is.gd/srg3di | 19:34 |
IndoAnon | lel | 19:34 |
Arsanerit | ubLIX[m]: maybe they will finally adopt distancing? :) | 19:35 |
ubLIX[m] | haha. as if by magic, they streets would be empty | 19:36 |
Brainstorm | Updates for France: +236 deaths (now 62907) since 22 hours ago | 19:38 |
IndoAnon | aaaaaaaaaaa | 19:38 |
IndoAnon | >Is it possible to project/calculate the probable vacc efficacy based on the mRNA sequence they harbor, when you also have the sequences of the currently circulating strains' spike proteins with their mutations? | 19:40 |
IndoAnon | Damn, moar question de-facto | 19:40 |
Brainstorm | New from Gazzetta Ufficiale italiana: MINISTERO DELLA SALUTE - ORDINANZA 24 dicembre 2020: Ulteriori misure urgenti in materia di contenimento e gestionedell'emergenza epidemiologica da COVID-19. (20A07237) → https://is.gd/fc3IU8 | 19:47 |
de-facto | well when both RNA sequences are known (e.g. vaccine and mutant wild type) then also the S-protein structure is known for both, so good luck calculating the binding of antibodies to that... | 19:52 |
de-facto | if the antibodies are known that is | 19:53 |
Brainstorm | New from Medical Xpress: SARS-CoV-2 infection rate low in patients receiving antitumor therapy: (HealthDay)—The rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is 0.68 percent among patients receiving antitumor treatment, according to a research letter published online Dec. 17 in JAMA Oncology. → https://is.gd/PWYqbt | 19:59 |
rmonten[m] | So what are we thinking about the strategy to give everyone the first dose of a 2-dose vaccine first, before going back through the population for the 2nd dose? Do we expect a longer term interval between the 2 doses to be better/worse (dangerous?) in comparison to a 21 day interval? | 20:08 |
Brainstorm | New from BBC Health: Covid-19: Concern at 'unprecedented' infection level in England: Covid cases rise in the UK as the number of people in England's hospitals goes above the first peak. → https://is.gd/y1sn4E | 20:12 |
Brainstorm | Updates for Spain: +23796 cases (now 1.9 million), +298 deaths (now 50122) since 4 days ago | 20:15 |
Brainstorm | Updates for Netherlands: +7978 cases (now 771605) since 20 hours ago | 20:59 |
Brainstorm | New from Lockdowns from Wikipedia: 36.76.233.37: /* Indonesia */Indonesia still no lockdown within their territoriea: Indonesia: Indonesia still no lockdown within their territoriea ← Previous revision Revision as of 20:14, 28 December 2020 Line 105: Line 105: LSSR measures were lifted throughout the month of May despite continued community [... want %more?] → https://is.gd/uhc8nH | 21:26 |
Brainstorm | New from BBC Health: Covid-19: Concern at 'unprecedented' infection level in England: Covid cases rise in the UK as the number of people in England's hospitals goes above the first peak. → https://is.gd/y1sn4E | 22:04 |
Brainstorm | Updates for Eswatini: +203 cases (now 8687), +2 deaths (now 167) since 23 hours ago | 22:13 |
Brainstorm | Updates for France: +363 deaths (now 63109) since 21 hours ago | 23:09 |
Brainstorm | New from r/WorldNews: worldnews: Australia insists WHO inquiry into Covid origin must be robust, despite China tensions → https://is.gd/tePd9y | 23:31 |
CoronaBot | 04/r/covid19: Novavax Announces Initiation of PREVENT-19 Pivotal Phase 3 Efficacy Trial of COVID-19 Vaccine in the United States and Mexico (81 votes) | https://ir.novavax.com/news-releases/news-release-details/novavax-announces-initiation-prevent-19-pivotal-phase-3-efficacy | https://redd.it/klrydb | 23:32 |
CoronaBot | 04/r/covid19: Vitamin D deficiency correlates with a reduced number of natural killer cells in intensive care unit (ICU) and non-ICU patients with COVID-19 pneumonia (80 votes) | https://www.sciencedirect.com/science/article/pii/S1109966620302840 | https://redd.it/klxnjm | 23:38 |
Brainstorm | New from FDA Press Releases: FDA: Coronavirus (COVID-19) Update: December 28, 2020 → https://is.gd/CE7MD6 | 23:57 |
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