libera/##covid-19/ Tuesday, 2021-01-05

de-factoi wonder if more sequencing could have been done in cluster studies if we had a more complete list of potential super spreaders00:01
de-factoi mean beyond the obvious choir members etc00:02
LjL<Brainstorm> New from r/WorldNews: worldnews: BioNTech says no data to support delayed vaccine booster shot → https://is.gd/Oghm4e00:15
LjLthank you for stating the obvious, maybe people will demand that things be done properly if they hear this00:16
de-factohttps://www.reuters.com/article/us-health-coronavirus-germany-biontech-idUSKBN2991XX00:18
de-facto.title00:18
Brainstormde-facto: From www.reuters.com: BioNTech says no data to support delayed vaccine booster shot | Reuters00:18
de-facto"BioNTech and partner Pfizer warned on Monday that they had no evidence that their jointly developed vaccine will continue to protect against COVID-19 if the booster shot is given later than tested in trials."00:18
de-facto"“The safety and efficacy of the vaccine has not been evaluated on different dosing schedules as the majority of trial participants received the second dose within the window specified in the study design,” the companies said in a joint statement, referring to prime and a booster shots given three weeks apart."00:18
de-facto"“There is no data to demonstrate that protection after the first dose is sustained after 21 days.”"00:18
de-facto"Germany was considering on Monday whether to allow a delay in administering the second dose to make scarce supplies go further after a similar move by Britain last week. Separately, Denmark approved a delay of up to six weeks between the first and second shots of the vaccine."00:18
de-factoso now that this can be considered public knowledge stated from the most competent in this question, the manufacturer itself it can be assumed that politicians know about this too. if they ignore this info on purpose they cant later state they did not know about this.00:20
de-facto.title https://www.ft.com/content/12b887b0-accd-4990-a2f1-689193d0b39800:22
Brainstormde-facto: From www.ft.com: Subscribe to read | Financial Times00:22
de-facto"BioNTech warns ‘no data’ to support UK plan to space Covid shots"00:22
de-facto"the European Medicines Agency told the FT that the BioNTech/Pfizer vaccine — the only shot currently approved for use by the regulator in the EU — had been authorised as two injections, given at least 21 days apart, and that diverging from this regimen would require separate authorisation."00:23
de-facto"“Any change to this would require a variation to the marketing authorisation as well as more clinical data to support such a change, otherwise it would be considered as ‘off label use’,” the EMA said."00:24
de-factoAfaik head of PEI (the approval institute in Germany) when asked about this stated the same, that if we want to adhere to evidence based medicine we need to vaccinate based on trials results00:25
LjLde-facto, it says "at least" 21 days apart though...?00:48
BrainstormUpdates for Nigeria: +1271 cases (now 91351), +7 deaths (now 1318) since 23 hours ago — Canada: +8991 cases (now 610644), +155 deaths (now 16020) since 23 hours ago — Barbados: +50 cases (now 606) since 23 hours ago — Germany: +11146 cases (now 1.8 million), +527 deaths (now 35632) since 23 hours ago01:19
BrainstormNew from r/WorldNews: worldnews: UK Prime Minister imposes harsh lockdown as new Covid-19 variant spreads → https://is.gd/ALFbQj01:32
de-factoi could not find any distribution for duration between primer and booster, hence id asume its exactly 21 days01:42
BrainstormNew from FDA Press Releases: FDA: FDA Statement on Following the Authorized Dosing Schedules for COVID-19 Vaccines → https://is.gd/28INx501:45
CoronaBot04/r/covid19: Variants and Vaccines (80 votes) | https://blogs.sciencemag.org/pipeline/archives/2021/01/04/variants-and-vaccines | https://redd.it/kqgrph02:05
LjLderek lowe out everyone!02:06
LjLde-facto, "The delayed-dose idea had been floated before, and I wasn’t exactly an early adopter, but the more contagious version of the virus has made me reconsider."02:09
LjL"But as I was going on about on Twitter the other day, we have to be clear that this is, in fact, an experiment on the population. It seems likely that delaying these doses will likely work out OK. But we don’t have much evidence either way. I’m in favor of doing it, but I’m not happy about ending up in that position."02:09
BrainstormNew from The Indian Express: World: UK PM Boris Johnson announces new national lockdown in England → https://is.gd/no3pTp02:09
LjL"I’ve been watching some very competent people argue these points both ways: here’s Florian Krammer with the possibility that these ideas could end up generating more resistant variants of the coronavirus."02:10
LjLthis sure has a lot of comments02:12
DocScrutinizer05*sigh*02:13
DocScrutinizer05is that already 4 years now since I coined "Make America Great Britain Again"02:15
DocScrutinizer05seems even FDA now disagrees >>we want to remind the public about the importance of receiving COVID-19 vaccines according to how they’ve been authorized by the FDA in order to safely receive the level of protection<<02:16
DocScrutinizer05"either it works for us or it will explode into the face of the world" Thank You England!02:17
DocScrutinizer05>>here’s Florian Krammer with the possibility that these ideas could end up generating more resistant variants of the coronavirus<< exactly my thought02:18
de-factowell i have to say i disagree with Derek Lowe on that one then02:21
de-factohe may have his opinion, sure, but just his name does not convince me on this, i want to see data, otherwise i stay with that we should stick, absolutely strictly without exception, to the approved vaccination schemes02:23
LjLi kind of agree with you, but lately you sure like to say "absolutely strictly without exception"02:23
de-factoi am not against launching further trials 02:23
de-factoyes because it annoys me that everyone is talking about it without providing data02:23
LjLwhat should the UK do, in your opinion, if they calculate their odds, and realize that with the variant now running rampant, they simply *cannot* vaccinate everyone in time "the proper way" and the virus will come sooner to most people?02:24
de-factowe have the trials, we have that data, its all we have about this, so we really should stick to them02:24
de-factootherwise why did we wait for the trials at all?02:24
LjLto be fair, we barely did wait02:25
LjLbut yes02:25
de-factoi mean why did we not just go ahead and test a bit in spring then go ahead and experiment on the population with vaccinations in the summer02:25
de-factothen we could have prevented all this winter wave maybe?02:25
LjLbut i'm also a believer that very few things should be done "absolutely strictly without exception", and i agree with Derek Lowe that if a country is in a really bad situation, they should consider all possibilities. then maybe discard them. but if the possibility that remains is "everyone gets COVID", then i'd try... just about anything else02:25
de-factoto be clear this is not a suggestion, its absolutely unacceptable to experiment on vaccination deployment with the population, its will destroy whats left of trust hence sabotage not only on a biological level but also on a psychological and even economical (to the manufacturers)02:26
de-factowell if a country wants to experiment with vaccination deployment without prior ensuring safety and efficiency and that the benefits outway the risks with approvals, i could understand if manufacturers cancel the contract with them and stop shipping any vaccines to them02:28
LjLi'll buy that when it comes to mixing vaccines, because we really don't know the possible side effects. but just delaying the second dose... the worst that could happen is that immunity wouldn't last as long?02:28
ubLIX[m]i think.. failing to produce enough vaccine produces a known (calculable) outcome, that surely will include overwhelmed heath services, and a quite possibly horrific death toll and health burden. but also that boosting the odds of generating new and interesting strains is an unknown quantity with unbounded downside. how stupendously bad does a thing have to get before you vote for unbounded downside?02:28
DocScrutinizer05>>as the majority of trial participants received the second dose **within the window specified in the study design**...<<02:29
de-factoEven Derek Lowe admits this with saying "But as I was going on about on Twitter the other day, we have to be clear that this is, in fact, an experiment on the population."02:32
DocScrutinizer05>>they simply *cannot* vaccinate everyone in time "the proper way" and the virus will come sooner to most people<< well, consider appropriate NPI. When they successfully breed an immune variant then they for sure not only lost this battle, they donated covid-21 to the world02:32
LjLyes. he's saying that in his opinion the risks are now so high that an experiment on the population has lower risk02:33
LjLmaybe he's wrong, but this is not an impossible scenario02:33
de-factomaybe it works, maybe it works not and maybe it makes things worse (maybe thats unlikely), yet i dont like to base assumptions on maybe02:34
de-factoincidence must be brought down with NPIs imho02:34
de-factonot with vaccinations02:34
LjLDocScrutinizer05, oh come on, now let's not label the UK as the plague-spreaders like some blame China. the variant could have sprung up in Germany or Italy or just about anywhere else. anyway my not-so-hypothetical question wasn't based on "what ifs" of the past, but on the present situation. you can't change NPIs that were done badly in the past now02:34
DocScrutinizer05100% ack02:34
de-factovaccinations can hold it down once its forced down by non-pharmaceutical interventions02:34
DocScrutinizer05LjL: you completely lost me, I didn't refer to any past thing02:35
LjL(in fact, considering how much more the UK sequences compared to most other countries including Italy and Germany, it's very possible the variant *did* arise somewhere else)02:35
LjLDocScrutinizer05, you just said that they donated "COVID-21" by losing the NPI battle02:36
DocScrutinizer05I'm talking about the *next* completely immune variant, not any yesterday's little mutation02:36
DocScrutinizer05and they are just about to breed this KNOWINGLY by their damn mod-o-fied regimen02:37
ubLIX[m]just about to knowingly risk breeding this02:38
DocScrutinizer05and they damn sure better resort to whatever NPI however "harsh" than going that path and donating a covid-21 to the world02:38
DocScrutinizer05ubLIX[m]: ok02:38
ubLIX[m]the wisdom of the gamble will depend on the extent to which subject matter experts can penetrate their analysis of the risks02:39
ubLIX[m]spitballing, but if experts can bound the risk by invoking known quantities about future infrastructure, there might be an argument02:40
ubLIX[m]idk02:40
de-factohow can they without data? they should make a new trial and wait for the results, then approve it, oh wait by then we have more vaccines on the market and think this whole approach was beyond stupid?02:41
LjL"risk evaluation" is a thing. risk is, by definition, an unknown02:41
LjLit means you lack data about something, and yet, you decide whether to do it anyway02:41
DocScrutinizer05no, not really. Risk management is about acquiring knowledge of probability. Otherwise it's not risk management but gambling02:43
de-factowe would need data on this, comparable to the magnitude of statement (both in significance and long term prediction) of the trials on which current vaccination schemes are based upon02:43
ubLIX[m]imagining silly numbers to make a point: do you save 5% of your population now at the risk of sacrificing 90% of your population later02:43
ubLIX[m]ok that 90% number is silly02:43
ubLIX[m]but the general idea, no you don't take that risk02:44
ubLIX[m]if you can get away with the 5% loss, when the alternative is total destruction with odds you have no insight into, then you eat the 5% loss02:44
ubLIX[m]so the question is how much do they know/how much can they constrain the risk of total catastrophe02:45
DocScrutinizer05:nod:02:45
DocScrutinizer05particularly if you *have* alternative options02:45
de-factothe efficiency of those vaccines is the only hope we got right now, i really think we should not risk to loose the only weapon we ever had against this, on the contrary, we even should minimize the probability that escaping mutants occur by doing everything our "shield" is not bruteforced too much02:45
DocScrutinizer05lose*02:45
de-factoyeah02:46
BrainstormNew from r/WorldNews: worldnews: How Those With 'Dark' Personality Traits Reacted To The COVID-19 Pandemic → https://is.gd/NOBa7q02:46
LjLby joining this channel02:46
DocScrutinizer05hahaha02:47
LjLalthough more seriously, i don't know what to make of that article. maybe the study itself would be more interesting02:50
BrainstormUpdates for Cayman Is.: +9 cases (now 347) since 4 days ago02:52
LjLfrom the study abstract:02:53
LjL"Narcissism and Machiavellianism predicted greater negative affect and perceptions of threat during the pandemic, while psychopathy predicted positive affect. Conversely, sadism predicted greater positive affect."02:53
LjLwhat is it called when you have the psychological issue that when someone's english is pretty bad, you value their findings less?02:53
LjLor if not their english, at least their copyediting02:54
LjLthat "conversely" is just wrong02:54
DocScrutinizer05don't get me started on psychologists. We just gad the "pleasure" to listen to one of those in prime time news, elaborating on >>when opening windows every 20 minutes, and wearing masks, then I consider the risk of opening schools bearable<< - and which qualification makes you think it's bearable? sucker! // sorry02:58
BrainstormNew from r/WorldNews: worldnews: Canada’s ‘slow’ rollout of coronavirus vaccine ’embarrassing’ experts say → https://is.gd/sSjv3r02:58
LjL/r/coronavirus: Moderna raises 2021 vaccine output forecast to at least 600 million doses (1014 votes) https://www.reuters.com/article/health-coronavirus-vaccines-moderna/update-1-moderna-raises-2021-vaccine-output-forecast-to-at-least-600-mln-doses-idUSL4N2JF30F | https://redd.it/kqdm3k03:01
LjLand we barely bought any. argh.03:01
BrainstormUpdates for Costa Rica: +3115 cases (now 172436), +44 deaths (now 2229) since 4 days ago03:11
DocScrutinizer05gosh! can't stop cursing about brits. They know NOTHING, they just *hope*. What if in 3 months they finaly learn that their flawed vaccination turned all their vaccinated people into superspreaders carrying the virus for weeks instead of days, without developing symptoms but infecting more other people than were "saved" by this idiot's approach. They well might shoot their own foot by this. And worse, everybody else's too03:12
DocScrutinizer05when they are so desperate to gamble with this, how hard can it be to instead tell their folks "now EVERYBODY STAYS AT HOME! 24/7, 3 weeks! You got water from tap, and if you starve, call 911 and some soldiers will drop a care packet at your door"03:16
generaor ask us for a Gulaschkanone )))03:21
genera(if they dare)03:22
BrainstormNew from The Indian Express: World: Israel’s health ministry authorises use of Moderna’s Covid-19 vaccine → https://is.gd/4Cis0U03:35
ubLIX[m]i think the UK military would struggle with that one. massive conscription of civilian helpers would be necessary, i'd guess. the initial bottleneck would be orchestration of a novel set up. as a nation, we don't exactly larp civil defense contingencies every second weekend.03:43
BrainstormNew from The Indian Express: World: Most US Covid-19 vaccines go idle as New York, Florida move to penalise hospitals → https://is.gd/ZbPtwO03:48
BrainstormUpdates for Netherlands: +4946 cases (now 831865), +47 deaths (now 11707) since 20 hours ago — France: +3016 cases (now 2.7 million) since 20 hours ago03:48
CoronaBot04/r/covid19: Moderna Provides COVID-19 Vaccine Supply Update (81 votes) | https://investors.modernatx.com/news-releases/news-release-details/moderna-provides-covid-19-vaccine-supply-update | https://redd.it/kqlm0d04:05
BrainstormUpdates for New Zealand: +5 cases (now 2186) since a day ago04:07
BrainstormNew from NPR: FDA Warns Health Officials Not To Mess With COVID-19 Vaccine Doses Schedule: Agency officials said reducing the number of doses creates a potential for harm in patients because "they may assume that they are fully protected when they are not" and may "take unnecessary risks." → https://is.gd/VzInSw04:12
CoronaBot04/r/covid19: COVID-19 alert level: update from the UK Chief Medical Officers (80 votes) | https://www.gov.uk/government/news/covid-19-alert-level-update-from-the-uk-chief-medical-officers | https://redd.it/kqhoeb04:41
BrainstormNew from r/WorldNews: worldnews: After Receiving Vaccine, Congresswoman Tests Positive For COVID-19 → https://is.gd/JW5NgO04:49
de-facto.title https://www.biorxiv.org/content/10.1101/2020.11.15.383323v205:21
Brainstormde-facto: From www.biorxiv.org: Immunological memory to SARS-CoV-2 assessed for up to eight months after infection | bioRxiv05:21
BrainstormUpdates for Belgium: +876 cases (now 650887), +49 deaths (now 19750) since a day ago05:52
BrainstormNew from r/WorldNews: worldnews: UK scientists expressed concern on Monday that COVID-19 vaccines being rolled out in Britain may not be able to protect against a new variant of the coronavirus that emerged in South Africa and has spread internationally. Mutations include extensive alterations to spike protein. → https://is.gd/vh3y6h06:50
BrainstormNew from r/WorldNews: worldnews: Venezuela is going back to extreme lockdown measures. → https://is.gd/Pl4gzO07:15
BrainstormNew preprint: High levels of plasminogen activator inhibitor-1, tissue plasminogen activator and fibrinogen in patients with severe COVID-19 by David Cabrera-Garcia et al, made available as preprint on 2021-01-04 at https://medrxiv.org/cgi/content/short/2020.12.29.20248869 [... want %more?]07:19
BrainstormUpdates for Rhode Island, United States: +4759 cases (now 92708), +78 deaths (now 1855) since 5 days ago — Minnesota, United States: +3144 cases (now 423688), +13 deaths (now 5502) since a day ago — Castile - Castile La Mancha, Spain: +2346 cases (now 103019), +14 deaths (now 4100) since 4 days ago — Extremadura, Spain: +2097 cases (now 39305), +16 deaths (now 1083) since 4 days ago07:38
BrainstormNew from r/WorldNews: worldnews: Pakistani court bans virginity tests for sexual assault victims → https://is.gd/8bOylv08:29
BrainstormNew from r/Coronavirus: Daily Discussion Thread | January 05, 2021: The WHO pages contain up-to-date and global information. Please refer to our Wiki for additional information. → https://is.gd/Yi8KKY09:07
BrainstormNew from Medical Xpress: Researchers develop technology to aid COVID-19 vaccine immunity monitoring: As the COVID-19 vaccine becomes available to the public, immunity monitoring will play an important role in determining whether the vaccine is effective for an individual, and for how long. Benjamin Larimer, Ph.D., researcher at the University of [... want %more?] → https://is.gd/XDETeK09:44
BrainstormNew from Medical Xpress: As China vaccinates, makers say jab works against mutations: Chinese medics in Shanghai were given COVID-19 inoculations this week, as vaccine makers insisted their jab was effective against current virus mutations. → https://is.gd/Tc8xA009:56
BrainstormNew from The Indian Express: World: Pandemic propels India to strengthen itself and step up on global stage: Indian envoy to China → https://is.gd/hQvS2O10:09
BrainstormNew from Medical Xpress: EXPLAINER: US regulator weighs in on vaccine dosing debate: The first Americans vaccinated against COVID-19 are getting their second dose, while Britain has decided to postpone boosters and focus instead on giving more people a first shot—international differences that are adding to public confusion. → https://is.gd/zxOXwN10:21
ArsaneritThe newspaper I subscribe to (taz) has discovered a group apparently completely forgotten in the German vaccination strategy: (almost exclusively) eastern European private carers, directly privately employed by (rich) families and living with their employers.10:30
mobidropwould someone please think of the private medical personnel of the millionaires!10:32
BrainstormNew from Medical Xpress: Australia vows not to rush vaccine rollout, citing UK 'problems': Under mounting pressure to speed up coronavirus vaccinations, Australian Prime Minister Scott Morrison on Tuesday said he would not take "unnecessary risks" and emulate Britain's emergency drug approval. → https://is.gd/ohByGe10:33
Arsaneritmobidrop: well yes.  That personnel is at risk.10:35
DocScrutinizer05re "UK scientists expressed concern on Monday that COVID-19 vaccines being rolled out in Britain may not be able to protect"  DONT BOTHER! >>"Researches confident they can modify vaccine to include SA Covid variant if it proves resistant" is just as accurate given the actual article body. <<10:36
mobidropwon't a vaccine modification require everybody to get the jab again?10:39
mobidropwhat if tomorrow there's another new variant? will we require vaccine modifications every time a new mutation pops up?10:40
DocScrutinizer05Arsanerit: nasty lapse10:52
jason500[m]5 billion jabs per quarter10:53
DocScrutinizer05mobidrop: millionaires? those will get resident educated personal. It's the ones at low end that can't afford german nurse and have no other choice than getting eastern europe underpaid care10:55
DocScrutinizer05mobidrop: fewer incidences -> fewer mutants aka new strains. So no, not every week. Think flu vaccination that gets adapted each year10:57
DocScrutinizer05possibly even less since the corona virus mutates far less than e.g. the flu virus10:58
BrainstormNew from Medical Xpress: Italy extends virus curbs, delays high school start: Italy on Tuesday postponed the return of high schools as part of new coronavirus restrictions, as a charity warned thousands of students were dropping out after months of distance learning. → https://is.gd/GBXmSc10:58
mobidropDocScrutinizer05, did you read:: lmost exclusively) eastern European private carers, directly privately employed by (rich) families and living with their employers.10:58
mobidropGermany is not the USA, the poor get the same access to healthcare there10:59
mobidropDocScrutinizer05, yeah makes sense, if the virus stops spreading because of a vaccine then there's less opportunity for mutations10:59
DocScrutinizer05aaayes, not in my part of germany11:00
mobidrophere in the Netherlands poor immigrants don't even have to pay for health insurance11:02
jason500[m]u pay for it11:03
mobidropthe taxpayer does yeah11:04
DocScrutinizer05https://www.labournet.de/branchen/dienstleistungen/gesund/gesund-pflege/migrantinnen-der-pflege-niemand-ueberwacht-die-arbeitsbedingungen-privathaushalten/  there were several TV reports about that very topic recently as well, and I think there's even a change in law pending. Anyway needing care is expensive in Germany and hard to get full coverage by health insurance11:07
mobidropwhich is a small drop in the bucket compared to the amount of money that's being borrowed to compensate for the lockdowns11:09
DocScrutinizer05how's that related?11:12
BrainstormNew from The Indian Express (Health): Destination of the week: Revealed: 20 of the world’s safest airlines for COVID-19 compliance → https://is.gd/9es39V11:22
ArsaneritI'm not convinced that people with a net worth of even €1 million (i.e. marginally millionaires) can even afford a fully privately paid 24/7 carer paid a standard German care salary.  And it's not as to whether this staff gets healthcare when they need it — of course they do — but if and when they're invited to be vaccinated.11:25
ArsaneritThere are also those who work "black", which are even harder to "catch".11:25
Arsanerit(not sure how to say in English, I mean the informal labour market, unreported to any authorities)11:26
BrainstormUpdates for Germany: +683 deaths (now 35788) since 22 hours ago11:27
BrainstormNew from r/WorldNews: worldnews: Britain will allow mixing of COVID-19 vaccines on rare occasions → https://is.gd/QSmEFn11:59
BrainstormNew from BBC Health: Covid: England and Scotland begin new lockdowns as cases rise: Michael Gove says "we are doing everything we can" to get people vaccinated at a "very difficult time". → https://is.gd/Vulg2l12:12
BrainstormNew from r/WorldNews: worldnews: UK heads for deeper double dip recession with third lockdown → https://is.gd/7sKDEf12:24
BrainstormNew from BBC Health: Covid: England and Scotland begin new lockdowns as cases rise: Michael Gove says "we are doing everything we can" to get people vaccinated at a "very difficult time". → https://is.gd/Vulg2l12:36
BrainstormNew from r/WorldNews: worldnews: Egypt: Entire ICU ward dies after oxygen supply fails → https://is.gd/huVcQx12:48
DocScrutinizer05tr <de Schwarzarbeit12:53
DocScrutinizer05%tr <de Schwarzarbeit12:53
BrainstormDocScrutinizer05, German to English: Unreported employment (MateCat, Wikipedia) — Moonlighting (Google) — *Schwarzarbeit (Apertium)12:53
elchupacabra420[Thats such a hard word, lets better call it income-optimized breadwinning.13:09
Arsaneritdeepl translate > google translate13:39
BrainstormNew from Medical Xpress: The pandemic and childhood weight gain: There's plenty of talk of the COVID 20—meaning the extra weight that adults are putting on during the pandemic. But what about children? Even before the pandemic, the percentage of American children who have overweight or obesity—defined as body mass index (BMI) being in the 85th to [... want %more?] → https://is.gd/Zk654a14:02
BrainstormNew from Medical Xpress: BioNTech warns against delaying second vaccine dose: German firm BioNTech warned Tuesday there is no data backing the "safety and efficacy" of delaying the second shot of its COVID-19 vaccine beyond three weeks, as some countries push back the jab to give more people their first dose. → https://is.gd/YnxXGq14:14
BrainstormNew from Medical Xpress: How we cook changed during lockdown – and we can learn from this for life after the pandemic: Before the pandemic, we were cooking less and less. Research suggests that a decline was underway in home cooking, cooking skills and confidence in a number of countries including the UK to the U.S., Canada and Australia. → https://is.gd/SIw9tM14:26
BrainstormUpdates for Liechtenstein: +22 cases (now 2246), +4 deaths (now 45) since 23 hours ago14:33
BrainstormNew from Medical Xpress: Just 1% of Californians immunized amid slow vaccine rollout: Distribution hiccups and logistical challenges have slowed the initial coronavirus vaccine rollout in California, setting a pace that's "not good enough," Gov. Gavin Newsom said. → https://is.gd/eAPQQ114:39
BrainstormNew from r/WorldNews: worldnews: Is The Pandemic Causing A Surge In Female Genital Mutilation? | Kenya's president pledged to stamp out the practice by 2022. But since the pandemic began, activists say more girls are being cut — and married off afterward. → https://is.gd/ptfUO814:52
BrainstormUpdates for Sweden: +32369 cases (now 469748), +258 deaths (now 8985) since 6 days ago — Switzerland: +4020 cases (now 465981) since 23 hours ago — Canada: +165 deaths (now 16074) since 20 hours ago14:58
BrainstormNew from Medical Xpress: Looking forward rather than backward safeguards wellbeing during COVID-19 lockdowns: Practicing gratitude and looking to the future will help safeguard our mental wellbeing during future COVID-19 lockdowns, a new study in the Journal of Positive Psychology reports. → https://is.gd/5ulKBC15:04
DocScrutinizer05psychologists :-/15:11
BrainstormNew from Medical Xpress: Britain shuts schools as Germany braces for extended lockdown: Britain closed its schools Tuesday ahead of a new national lockdown, with Germany set to extend its own restrictions as Europe battles surging coronavirus infections. → https://is.gd/8dfhvX15:17
DocScrutinizer05even worse, a MOVEMENT15:17
elchupacabra420[Their business is booming that much they already preordering some Teslas each. :s15:17
elchupacabra420[Booked up for years...15:18
DocScrutinizer05https://en.wikipedia.org/wiki/Martin_Seligman15:22
DocScrutinizer05Positive Psychology .oO( - - - )15:24
BrainstormNew from r/WorldNews: worldnews: North Korea requests Covid vaccine after months of claiming to have never had a case → https://is.gd/KvyPJs15:29
BrainstormNew from StatNews: STAT+: Pharmalittle: FDA warns against changing Covid-19 vaccine dosing; Moderna to increase vaccine production: The FDA warned health care workers that any changes to the authorized dosing schedules of Covid-19 vaccines currently being administered would significantly place public health at risk. → https://is.gd/IjvIRe15:41
BrainstormUpdates for Seychelles: +32 cases (now 354) since a day ago15:42
de-factoquite interesting https://en.wikipedia.org/wiki/Tozinameran#Manufacturing15:48
de-facto.title 15:48
Brainstormde-facto: From en.wikipedia.org: Tozinameran - Wikipedia15:48
de-facto"Pfizer is manufacturing the vaccine in its own facilities in a three-stage process. The first stage, conducted at a small pilot plant in St. Louis, involves the molecular cloning of DNA plasmids that code for the spike protein by infusing them into Escherichia coli bacteria."15:51
de-facto"After four days of growth, the bacteria are killed and broken open, and the contents of their cells are purified over a week and a half to recover the desired DNA product. The DNA is stored in tiny bottles and frozen for shipment."15:51
de-facto"The second stage is being conducted at plants in Andover, Massachusetts, and in Germany. The DNA is used as a template to build the desired mRNA strands. Once the mRNA has been created and purified, it is frozen in plastic bags about the size of a large shopping bag, of which each can hold up to 5 to 10 million doses."15:51
de-facto"The third stage is being conducted at plants in Kalamazoo, Michigan, and Puurs, Belgium. This stage involves combining the mRNA with lipid nanoparticles, then filling vials, boxing vials, and freezing them."15:51
de-facto"Croda International subsidiary Avanti Polar Lipids is providing the requisite lipids. As of November 2020, the major bottleneck in the manufacturing process was combining mRNA with lipid nanoparticles."15:51
de-facto.title https://de.wikipedia.org/wiki/BNT162b2#Produktion15:55
Brainstormde-facto: From de.wikipedia.org: BNT162b2 – Wikipedia15:55
de-facto"Biontech produces its vaccine in Mainz and Idar-Oberstein. In order to expand the production capacity, Biontech acquired the Novartis plant at the Behring site in Marburg in September 2020, where production is to start from February 2021."15:55
de-facto"The plant is expected to produce up to 250 million cans in the first half of 2021. According to their own statements, the federal government and Biontech are trying to create a second production facility in Germany."15:55
de-facto"The cooperation partner Pfizer produces BNT162b2 at three locations in the USA and in Puurs, Belgium. 15:55
de-factoOther companies involved in the production are Dermapharm, Siegfried, Polymun, and Rentschler."15:55
de-facto"The cans for Europe are produced at the two Biontech locations in Germany and in Puurs."15:55
de-facto(translated via Google)15:55
IndoAnonwhew15:56
de-factoRKI Germany COVID-19 (new years affected reporting?) 2021-01-05: Weekly Incidence 134.7/100k, Infections +11897 (1787410 total), Fatalities +944 (35518 total), COVID@ICU 5652 (incl 3172 on ventilator)16:00
BrainstormNew from StatNews: Health: STAT+: STAT+ Conversations: A (continued) conversation on the Covid-19 vaccine rollout → https://is.gd/4GbMHJ16:06
de-facto.title https://imgur.com/a/HtZNQ17 https://i.imgur.com/7RAXU5M.png source: https://www.intensivregister.de/#/aktuelle-lage/zeitreihen16:13
Brainstormde-facto: From imgur.com: COVID-19 Germany: Occupied ICU beds and their daily change - Album on Imgur16:13
de-factoDocScrutinizer05, ^^16:13
IndoAnon>GERMANY TO RESTRICT NON-ESSENTIAL TRAVEL TO 15 KILOMETRE (9 MILE) RANGE IN CORONAVIRUS HOTSPOTS - SOURCES16:24
BrainstormNew from Medical Xpress: EXPLAINER: Why the smallest state has a big virus challenge: For a few days in December, Rhode Island was one of the worst places on the planet when it came to new cases of COVID-19 per capita. → https://is.gd/9UfQzy16:43
CoronaBot04/r/covid19: Prior SARS-CoV-2 infection is associated with protection against symptomatic reinfection (80 votes) | https://www.journalofinfection.com/article/S0163-4453(20)30781-7/fulltext | https://redd.it/kqra8616:52
DocScrutinizer05de-facto: that's quite nice16:54
DocScrutinizer05>>The next phase of vaccine production involves creating a more stable freeze-dried version and expanding production capabilities, for example, by finally building those bigger pizza ovens that could make formulation go faster<< [from WP, liked to by wikipedia]  Might explain a bit about why and how ramp-up is doing like it does16:56
DocScrutinizer05https://www.washingtonpost.com/health/2020/11/17/coronavirus-vaccine-manufacturing/16:56
DocScrutinizer05linked, even16:57
CoronaBot04/r/covid19: Ivermectin reduces the risk of death from COVID-19 -a rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance (84 votes) |16:58
CoronaBothttps://www.researchgate.net/profile/Theresa_Lawrie/publication/348230894_Ivermectin_reduces_the_risk_of_death_from_COVID-19_-a_rapid_review_and_meta-analysis_in_support_of_the_recommendation_of_the_Front_Line_COVID-19_Critical_Care_Alliance/links/5ff41e0745851553a01de435/Ivermectin-reduces-the-risk-of-death-from-COVID-19-a-rapid-review-and-meta-analysis-in-support-of-the-recommendation-of-the-Front-Line-COVID-19-Critical-Care-Alliance.pdf |16:58
CoronaBothttps://redd.it/kqxcp416:58
DocScrutinizer05maxpathnamelen-test-suite17:01
ArsaneritApparently I will no longer be allowed to travel more than 15 km from my home.17:03
ArsaneritThe last time I did travel more than 15 km was in December, for a forest hike in which we met almost no other hikers all day.17:04
Haley[m]yeah. we had the same in france. Then kids needed to go to school anyway and stick 35kids into 20m² rooms ...17:06
Haley[m]Completely stupid IMHO. But then again, I'm not a politician so by default the IQ is a little bit higher ;)17:06
ArsaneritI don't think they're reopening schools17:09
ArsaneritI think they want to prevent scenes where thousands are all going to the same sledge slope17:09
de-factoDocScrutinizer05, i am still not sure how much such clinical stats depend on Xmess or NewYears, i mean people in need for ICU probably dont have the option to wait 17:23
de-factoand if their reporting is delayed still, i somewhat doubt it17:23
DocScrutinizer05:nod:17:25
BrainstormNew from r/WorldNews: worldnews: Pakistan court outlaws 'virginity tests'. The "two-finger test" is performed manually by inserting one or two fingers into a woman's vagina to test for its laxity and for the presence of a hymen - in theory to determine whether or not the woman is sexually active and to what extent. → https://is.gd/q2VAw717:33
BrainstormNew from Reddit (test): Tuesday 05 January 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://is.gd/fwS09G17:45
BrainstormNew from r/WorldNews: worldnews: UK records more than 60,000 new coronavirus cases → https://is.gd/uFkISF17:58
Jigsy%cases UK18:03
BrainstormJigsy: In United Kingdom, there have been 2.7 million confirmed cases (4.1% of the population) and 75488 deaths (2.8% of cases) as of 10 hours ago. 56.7 million tests were performed (4.8% positive). See https://offloop.net/covid19/?default=United%20Kingdom for time series data.18:03
BrainstormNew from EMA: What's new: PIP: Opinion/decision on a Paediatric investigation plan (PIP): COVID-19 vaccine (ChAdOx1-S [recombinant]) (AZD1222), decision type: , therapeutic area: , PIP number: P/0003/2021 → https://is.gd/5Mpg2018:10
BrainstormUpdates for United Kingdom: +56894 cases (now 2.8 million), +817 deaths (now 76305) since 10 hours ago — UAE: +1967 cases (now 216699), +3 deaths (now 685) since a day ago — Italy: +15375 cases (now 2.2 million), +649 deaths (now 76329) since a day ago — Comoros: +131 cases (now 995) since 2 days ago18:11
BrainstormNew from BMJ: Covid-19: UK study aims to understand effects on ethnic minority healthcare workers: A new study has launched in the UK to understand the impact of covid-19 on healthcare workers of different ethnic groups.The UK-Reach study brings together researchers and clinicians with the General... → https://is.gd/FTKhYL18:22
BrainstormNew from BMJ: Why were breastfeeding women in the UK denied the covid-19 vaccine?: On 30 December, a month after licensing the Pfizer BioNTech covid-19 vaccine, the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) revised its guidance to enable pregnant and... → https://is.gd/pnuIpO18:35
BrainstormNew from Medical Xpress: Research article reviews century of data showing COVID-19 likely to impact the brain: An article published Jan. 5 in Alzheimer's & Dementia: The Journal of the Alzheimer's Association cites decades of published scientific evidence to make a compelling case for SARS-CoV-2's expected long-term effects on the brain and nervous system. → https://is.gd/5XLslu18:47
CoronaBot04/r/coronavirus: COVID Death Toll Among Vets Surpasses Fatalities in Iraq, Afghanistan Wars (10191 votes) | https://www.msn.com/en-us/news/us/covid-death-toll-among-vets-surpasses-fatalities-in-iraq-afghanistan-wars/ar-BB1ctgBc?ocid=uxbndlbing | https://redd.it/kqxdn319:11
BrainstormUpdates for Sierra Leone: +51 cases (now 2724) since a day ago — Switzerland: +96 deaths (now 8014) since 17 hours ago19:13
BrainstormNew from Medical Xpress: Heading off the next pandemic: As the COVID-19 pandemic heads for a showdown with vaccines it's expected to lose, many experts in the field of emerging infectious diseases are already focused on preventing the next one. → https://is.gd/87awYD19:24
DocScrutinizer05Arsanerit: 15km doesn't apply within city limits. Those are 15km starting from city limits. 19:34
BrainstormNew from Medical Xpress: Child physical abuse encounters declined during COVID-19: (HealthDay)—Declines in child physical abuse (CPA) encounters at U.S. hospitals were seen during the COVID-19 pandemic, according to a study published online Dec. 30 in Pediatrics. → https://is.gd/f2uUgO19:36
LjLinformation about how the UK variant (vs the standard version) was doing until recently in various places in the UK: https://ichef.bbci.co.uk/live-experience/cps/624/cpsprodpb/vivo/live/images/2021/1/5/b6c150e9-aafb-44d4-a46d-c50f9f291f54.png  i guess the good news is that tier 4 lockdowns were sort of working already?19:49
BrainstormNew from Medical Xpress: EXPLAINER: How do I know when to get my 2nd vaccine shot?: As U.S. health officials try to get COVID-19 vaccines to people more quickly, it's already time for some people to get their second shots. → https://is.gd/5phIUS20:01
BrainstormUpdates for Spain: +23700 cases (now 2.0 million), +439 deaths (now 51430) since 23 hours ago — France: +8160 cases (now 2.7 million), +833 deaths (now 66038) since 23 hours ago20:02
Elpolaco!corona PL20:08
CoronaBotPoland: Global rank: #14, cases: 1,330,543 (+7,624), fatalities: 29,502 (+341), active cases: 222,149, total recovered: 1,078,892, in a serious condition: 1,629. Mortality: 2.22%, case fatality rate: 2.66%, cases/1M: 35176.0, deaths/1M: 780.0. Case rate: 4,404/24h, death rate: 42/24h. Tests: 7,381,821, tests/1M: 195,156.20:08
BrainstormNew from Medical Xpress: Facing slow vaccine rollout, scientists weigh new tactics: Should COVID-19 boosters be delayed? Could the dose levels be reduced by half, and would mixing and matching shots made by different makers work just as well? → https://is.gd/sbt1qG20:13
BrainstormNew from Virology.ws: Musings of an anonymous, pissed off virologist: by Paul Bieniasz Dr. Bieniasz is Professor and Investigator of the Howard Hughes Medical Institute at Rockefeller University. As viruses go, SARS-CoV-2, is quite easy to neutralize with antibodies and, it turns out, straightforward to generate effective vaccines based on the spike [... want %more?] → https://is.gd/sPTrXc20:38
euod[m]LjL: so probably understated 20:47
euod[m]judging by the numbers. 20:47
bin_bashhttps://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html20:49
bin_bashBieniasz is right btw. it's so fucking infuriating. I can't believe the UK is delaying the second dose. Absolutely incredible.20:50
euod[m]wouldn't the same thing with antibiotics apply here?20:51
euod[m]it's enforcing selection of the better virus. 20:52
BrainstormUpdates for Canada: +10751 cases (now 618227) since 23 hours ago20:52
P1gassuhttps://www.motherjones.com/food/2020/08/industrial-hog-farms-are-breeding-the-next-pandemic/20:54
Mr_Pinkhttps://consequenceofsound.net/2021/01/grammys-postponed-2021/21:00
BrainstormNew from StatNews: Messonnier: The slow vaccine rollout should speed up ‘pretty massively’ in coming weeks: Top CDC official Nancy Messonnier acknowledged that the administration’s vaccine rollout has been rocky so far. But in a conversation with STAT, she predicted that it’ll speed up soon. → https://is.gd/4jgg1z21:03
bin_basheuod[m]: similar to AB resistance you mean? I think so, yeah21:09
BrainstormUpdates for Zimbabwe: +1365 cases (now 17194), +34 deaths (now 418) since 22 hours ago — Isle of Man: +6 cases (now 386) since 3 days ago — Netherlands: +6452 cases (now 835851), +122 deaths (now 11808) since 22 hours ago21:10
BrainstormNew from Emma Hodcroft: @firefoxx66: R to @firefoxx66: This build & S:E484 aren't yet linked on my SARS-CoV-2 Variant Tracking site - but they will be up very soon! I'll be adding it to the regularly tracked & updated builds  👍🏻8/8https://github.com/hodcroftlab/covariantshttps://is.gd/Crmoys21:15
BrainstormNew from BBC Health: (news): Covid-19: UK daily coronavirus cases top 60,000 for first time → https://is.gd/YiJbLF21:28
CoronaBot04/r/covid19: FDA Statement on Following the Authorized Dosing Schedules for COVID-19 Vaccines (81 votes) | https://www.fda.gov/news-events/press-announcements/fda-statement-following-authorized-dosing-schedules-covid-19-vaccines | https://redd.it/kqou2921:30
BrainstormUpdates for Monaco: +30 cases (now 947) since 23 hours ago21:35
de-factowow 60k is a LOT even for UK :/21:48
BrainstormNew from Medical Xpress: EU could authorise second vaccine 'in coming hours': The European Union could authorise a second coronavirus vaccine "in the coming hours", European Council chief Charles Michel said Tuesday, adding that leaders would hold a virtual summit on the health crisis later this month. → https://is.gd/qnWCsD22:18
BrainstormNew from Ars Technica: Policy: COVID-19 contact-tracing data is fair game for police, Singapore says → https://is.gd/mj8sYi22:30
BrainstormUpdates for Chad: +60 cases (now 2289), +1 deaths (now 105) since a day ago22:37
BrainstormNew from NPR: Germany To Extend Lockdown As COVID-19 Deaths Continue To Rise: While daily new infections have declined somewhat, more than 1,000 Germans are dying per day. All 16 German states are in favor of keeping restrictions in place. → https://is.gd/cx117G22:42
de-factoDaily Fatalities: USA ~2700 with some signs of plateauing, Germany ~690 and rising steeply, since population USA/GER ~ 3.95 those ~690 cases would be equivalent to 2726 in USA hence above their average22:56
de-factoquite sad that it had to come to that, we are world champion in ... daily new COVID-19 fatalities per capita. Bravo.22:58
de-factoand those values are the 7 day rolling averages22:59
karaaltmyPTIOislTo convince antivaxxers to vaccinate, officials could gamify vaccinations the way mobile games do23:26
BrainstormNew from r/WorldNews: worldnews: ‘It’s insulting’: UK firms plead for more support as third lockdown threatens to push them to the wall → https://is.gd/oIFLn723:32
elchupacabra420[Or pay them a good award in cash, say a monthsalary. They would beat a path to their doors, literally.23:34
karaaltmyPTIOislI'm not sure if many govs could afford to pay ppl a monthsalary for jabs. With the gambling/gamification approach, govs might save money23:36
karaaltmyPTIOisltho govs could definitely pay poor-anti-vaxxers into doing it23:37
elchupacabra420[Hehe they cant affort this situation anyways. We have to payback these debs next decades anyways.23:37
karaaltmyPTIOisltrue lol. Make the millenials/zoomers/Xers pay back the debt23:40
karaaltmyPTIOislrip23:41
de-factobtw "their" money us borrowed from every citizen and their future offspring, just saying...23:42
elchupacabra420[new global war could be an alternative too, impact has been proven many times in history.23:42
de-facto*is borrowed from ...23:43
karaaltmyPTIOislget elon to crash a gold asteroid into wakanda and then convince him to share the profit to pay off our covid debts lol23:44
BrainstormNew from r/WorldNews: worldnews: In one week, France vaccinated barely 500 people. Why so many are saying 'non' → https://is.gd/8qA26423:44
de-factolol yeah except a whole asteroid of gold... would make the gold price fall significantly23:44
BrainstormUpdates for British Virgin Islands: +11 cases (now 97) since 17 days ago23:45
karaaltmyPTIOisltrue23:46
karaaltmyPTIOislgold OPEC agreement, sell it slowly. Would still dmg gold prices tho23:46
de-factobasically everything is relative, so if everyone makes dept it equalizes out... oh wait there have been countries that managed this a lot better ... than most western countries hmm23:47
elchupacabra420[The debts or the pandemic?23:51
karaaltmyPTIOisla relative pandemic? Thats interesting23:53
de-facto.title https://www.imf.org/external/datamapper/NGDP_RPCH@WEO/OEMDC/ADVEC/WEOWORLD/ <-- scroll the timeslider to the end of 202023:53
Brainstormde-facto: From www.imf.org: error parsing title ('NoneType' object has no attribute 'string')23:53
de-facto"Real GDP growth Annual percent change"23:53
de-factoand then look at ... China +1.9% growth even in 202023:54
CoronaBot04/r/covid19: SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection (80 votes) | https://www.medrxiv.org/content/10.1101/2021.01.03.21249162v1 | https://redd.it/kr1dwn23:55
de-factoso relative to everyone else in deep recession it is even more significant23:56
karaaltmyPTIOisl<de-facto "and then look at ... China +1.9%"> wow i see it! How?! Is this made up?23:56
de-factothey managed it a lot better i think and also had a growing economy in 2019 etc23:57
elchupacabra420[.cn profits a lot of global lockdown, assumed the numbers arent polished.23:58
karaaltmyPTIOislgood year for egypt apparently23:58

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