CoronaBot | 04/r/covid19: Novavax COVID-19 Vaccine Demonstrates 89.3% Efficacy in UK Phase 3 Trial (84 votes) | https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3 | https://redd.it/l7aecn | 00:16 |
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de-facto | oh wow | 00:21 |
dTal | That's pretty good! | 00:26 |
de-facto | i would not have expected such good results from a protein based vaccine | 00:27 |
de-facto | "NVX-CoV2373 contains a full-length, prefusion spike protein made using Novavax’ recombinant nanoparticle technology and the company’s proprietary saponin-based Matrix-M™ adjuvant. The purified protein is encoded by the genetic sequence of the SARS-CoV-2 spike (S) protein and is produced in insect cells. It can neither cause COVID-19 nor can it replicate, is stable at 2°C to 8°C (refrigerated) and is shipped in a ready-to-use | 00:30 |
de-facto | liquid formulation that permits distribution using existing vaccine supply chain channels." | 00:30 |
charlie-french-w | https://thehill.com/policy/healthcare/536168-who-advises-against-pregnant-women-taking-moderna-covid-19-vaccine | 00:30 |
de-facto | "The study enrolled more than 15,000 participants between 18-84 years of age, including 27% over the age of 65. The primary endpoint of the UK Phase 3 clinical trial is based on the first occurrence of PCR-confirmed symptomatic (mild, moderate or severe) COVID-19 with onset at least 7 days after the second study vaccination in serologically negative (to SARS-CoV-2) adult participants at baseline." | 00:31 |
de-facto | "The first interim analysis is based on 62 cases, of which 56 cases of COVID-19 were observed in the placebo group versus 6 cases observed in the NVX-CoV2373 group, resulting in a point estimate of vaccine efficacy of 89.3% (95% CI: 75.2 – 95.4). Of the 62 cases, 61 were mild or moderate, and 1 was severe (in placebo group)." | 00:31 |
charlie-french-w | https://www.biopharmadive.com/news/merck-coronavirus-vaccine-discontinue-study-fail/593865/ | 00:31 |
de-facto | "Preliminary analysis indicates that the UK variant strain that was increasingly prevalent was detected in over 50% of the PCR-confirmed symptomatic cases (32 UK variant, 24 non-variant, 6 unknown). Based on PCR performed on strains from 56 of the 62 cases, efficacy by strain was calculated to be 95.6% against the original COVID-19 strain and 85.6% against the UK variant strain [post hoc]" | 00:31 |
Brainstorm | New from The Lancet (Online): [Comment] Urgent needs of low-income and middle-income countries for COVID-19 vaccines and therapeutics: WHO and partners have learnt from the mis-steps in the response to the 2009 H1N1 influenza pandemic1 and established the Access to COVID-19 Tools (ACT) Accelerator to promote equitable access to vaccines, therapeutics, [... want %more?] → https://is.gd/h7MAjh | 00:51 |
LjL | charlie-french-w: most definitely, pregnant women should not get the vaccine since during the trials it wasn't tested on pregnant women. That's why most drugs say to avoid using during pregnancy, because they simply weren't tested in that situation. | 01:06 |
LjL | de-facto, dTal: they're confusing me! they were all "next look for J&J results, they are coming LIKE NOW!" and then i get Novavax instead that i don't even remember the first thing about | 01:09 |
LjL | %vax novavax | 01:10 |
Brainstorm | LjL, NVX-CoV2373 Recombinant glycoprotein is a Protein subunit vaccine developed in USA by Novavax + Emergent BioSolutions + FUJIFILM Diosynth Biotechnologies + Serum Institute of India, which began its testing on humans on date May 6 with 30000 healthy volunteers aged 18+ → https://covidvax.org/covid19-vaccine/Novavax | 01:10 |
LjL | hm first comment on reddit: "This data shows 60% efficacy against the SA variant. Is there any reason to believe that we may see equally poor efficacy (poor compared to the overall 89.3%) on the SA variant from the Johnson and Johnson vaccine?" | 01:10 |
LjL | on the other hand i think the people who keep stating things like https://np.reddit.com/r/COVID19/comments/l7aecn/novavax_covid19_vaccine_demonstrates_893_efficacy/gl5qi7c/?context=3 are somehow failing to get something that seems obvious to me, i.e. that a vaccine with the 60% efficacy would have zero, zero chance of getting a population anywhere near herd immunity. just because the FDA and EMA etc have established 50% as the minimum threshold doesn't | 01:12 |
LjL | mean that anything even slightly above 50% is "good" | 01:12 |
de-facto | i think we need polyclonal vaccines in general, the Wuhan strain is more than a year old now | 01:14 |
Brainstorm | New from https://covid19.specops.network : ljl-covid: Add serology test list by the FDA → https://is.gd/W44VPb | 01:16 |
de-facto | also the people in SA were infected before, lots of them had antibodies in the blood prior to enrolling to the study as participants | 01:17 |
de-facto | hmm maybe not | 01:19 |
de-facto | "Importantly in this trial, approximately 1/3 of the patients enrolled (but not included in the primary analyses described above) were seropositive, demonstrating prior COVID-19 infection at baseline." | 01:19 |
Brainstorm | New from https://covid19.specops.network : ljl-covid: News: Novavax releases interim data with ~90% efficacy in UK, ~60% ag… → https://is.gd/jPffo7 | 01:28 |
LjL | <CarlSagan> [Ars Technica - Science] Coronavirus variants: What they do and how worried you should be https://arstechnica.com/?p=1738081 2021-01-29T00:00:21 | 01:34 |
LjL | looks like a nice article, detailed elaborations on each variant | 01:36 |
bin_bash | Am I the only one that gets kind of squicked out when you're talking to someone online and they tell you they have covid | 01:37 |
bin_bash | like there's this insanely irrational part of my brain that goes "what if it's contagious... ONLINE" | 01:37 |
bin_bash | prob just me i accept that | 01:40 |
LjL | lol | 01:40 |
LjL | i will go with probably just you :P | 01:40 |
Brainstorm | New from NPR: Novavax COVID-19 Vaccine Effective, But Less So Against Variant In South Africa: Novavax says its COVID-19 vaccine is 89% effective at preventing illness, according to an interim analysis of a U.K. study. But the vaccine wasn't as effective against some viral variants. → https://is.gd/zM5JQy | 01:41 |
CoronaBot | 04/r/coronavirus: Vaccine found 92% effective in Israel, in first controlled result outside trials (10001 votes) | https://www.timesofisrael.com/vaccine-found-92-effective-in-israel-in-first-controlled-result-outside-trials/ | https://redd.it/l6uzis | 01:46 |
LjL | oh, data from Israel, finally | 01:46 |
LjL | "Light illness in all the vaccinated who got it - article doesn't say if recovered already, so that might still change." ← important, since i wasn't believing that SO much from just the small numbers in the trials | 01:47 |
LjL | %papers israel | 01:50 |
Brainstorm | LjL, 84 papers: Public events and delayed flight restrictions were the turning point of the COVID-19 mitigation policy of Israel by Ziv Klausner et al, made available as preprint on 2020-03-30 at http://medrxiv.org/cgi/content/short/2020.03.26.20044412 [... want %more?] | 01:50 |
LjL | %more | 01:50 |
Brainstorm | LjL, [...] and diagnostics.2 However, many high-income countries already have bilateral agreements with manufacturers of COVID-19 vaccines.3 The COVAX Facility of the ACT Accelerator has agreements to access 2 billion doses of WHO pre-qualified vaccines during 2021, but this represents only 20% of the vaccine needs of participating countries. → https://paste.ee/p/CmyVd | 01:50 |
Brainstorm | LjL, [...] Effect of socioeconomic and ethnic characteristics on COVID-19 infection: The case of the Ultra-Orthodox and the Arab communities in Israel by Mor Saban et al, made available as preprint on 2020-05-26 at http://medrxiv.org/cgi/content/short/2020.05.25.20111575 [...] → https://paste.ee/p/VDdDK | 01:50 |
LjL | %papers israel vaccine | 01:50 |
Brainstorm | LjL, 7 papers: COVID-19 Vaccine Hesitancy Worldwide: A Systematic Review of Vaccine Acceptance Rates by Malik Sallam et al, made available as preprint on 2020-12-29 at https://www.preprints.org/manuscript/202012.0717/v1 [... want %more?] | 01:50 |
LjL | %more | 01:50 |
Brainstorm | LjL, [...] Vaccine Hesitancy: The Next Challenge in the Fight Against COVID-19 by Amiel A. Dror et al, made available as preprint on 2020-06-13 at https://doi.org/10.21203/rs.3.rs-35372/v1 [...] → https://paste.ee/p/YcyF3 | 01:50 |
Brainstorm | New from https://covid19.specops.network : Add ArsTechnica "guide" to variants of concern: Adding to "Info" section although this may arguably go next to Emma Hodcroft's variants GitHub page, but this is not strictly a scientific article, although it links to a bunch of preprints... → https://is.gd/XrIdFm | 01:53 |
LjL | can't really the actual data | 01:54 |
bin_bash | LjL: i accept that lol I have some annoying medical anxiety that puts questions like that in my head, but fortunately the rational part is bigger and more powerful and slaps it down | 01:55 |
bin_bash | "No, bin, you can't get covid via the internet" *slap* | 01:55 |
LjL | heh | 01:56 |
LjL | my health anxiety is mostly why this channel exists as such :P | 01:56 |
bin_bash | fair lol | 01:57 |
bin_bash | I have to say though, LjL, I'm glad this and the other channel are here | 01:57 |
bin_bash | and even though we had a few misunderstandings i'm glad that we're friends now (or whatever it is on irc) | 01:58 |
LjL | thanks | 01:59 |
LjL | i think i got preeeetty close to thinking about banning you | 01:59 |
bin_bash | i know | 01:59 |
LjL | but on the other hand i understand throwing tantrums, i throw tantrums | 01:59 |
bin_bash | i had to like change how i say things and be less abrupt | 01:59 |
bin_bash | i tend to be really direct and abrupt and sometimes i guess combative without realizing it | 02:00 |
LjL | yeah, successful communication is a large number of small compromises :P | 02:00 |
bin_bash | yeah :) | 02:00 |
bin_bash | plus it's a very emotional time, and a very emotional issue | 02:00 |
bin_bash | but i really value this channel and the other, so i try to not be so aggressive although soemtimes it still does happen after built up frustrations | 02:01 |
LjL | yes you come across as combative. even if you aren't that sets the stage for escalation. i know someone who is jarring in a different way, doesn't answer things unless he feels he has something relevant to answer. i rationally understand his point of view but we haven't talked for weeks just because at some point i simply thought he didn't want to talk. simple things like "oh", "interesting", or i could make a thousand example... he thinks it's redundant | 02:01 |
LjL | but they have a reason to be | 02:01 |
Brainstorm | Updates for France: +12853 cases (now 3.1 million) since 22 hours ago — Germany: +605 deaths (now 55963) since 11 hours ago — Netherlands: +2395 cases (now 969461) since 22 hours ago | 02:01 |
LjL | not really the same, just another example of slightly flawed communication i had in mind | 02:02 |
bin_bash | yeah, i know someone like that too. and it has been pointed out to me that i'm abrupt and stuff | 02:02 |
bin_bash | yueah i know what you mean :) | 02:02 |
bin_bash | but i really do try to own when ive lost my temper and apologize | 02:03 |
dTal | Truly the pandemic has brought us all closer together | 02:04 |
LjL | i "ragequit" this channel a couple of times, and simply came back without saying anything after a while. apparently that was childish enough to make tinwhiskers leave and take away his bot and stuff. | 02:04 |
LjL | dTal, i wouldn't go that far :P | 02:04 |
bin_bash | ha it's a good pun | 02:05 |
bin_bash | :P | 02:05 |
dTal | (I am kidding but also serious) :p | 02:05 |
LjL | in fact, i'm not *allowed* to go that far | 02:05 |
bin_bash | also LjL i think there are cultural and language barriers that sometimes get in the way without realizing | 02:05 |
dTal | Hey, none of us are immune to losing our temper or doing childish things, including tinwhiskers | 02:05 |
LjL | yeah, i know i'm italian as fuck when i get mad | 02:05 |
bin_bash | like the whole dental dam thing. in the US theyre really largely known as a safe sex thing even though dentists do use them | 02:05 |
LjL | oh lord | 02:05 |
bin_bash | i wasnt trying to be a dick or gross or anything | 02:05 |
LjL | no, you were just wrong :P | 02:06 |
bin_bash | but i can totallky see how it came out that way | 02:06 |
bin_bash | yeah | 02:06 |
dTal | ....I won'task | 02:06 |
bin_bash | lol | 02:06 |
LjL | dTal, do ask your dentist whether they use dental dams, though | 02:06 |
LjL | it's important | 02:06 |
bin_bash | tl;dr i thought they were only really a safe sex thing, turns out that outside the US theyre commonly used as actual dental instruments and i looked like a foolish idiot | 02:06 |
LjL | also, might help against passing COVID! (not tested) | 02:06 |
bin_bash | yeah if i have to go to the dentist ill definitely request one | 02:07 |
LjL | they're commonly used in the US too, just not by dentists that are bad | 02:07 |
bin_bash | but ive been putting off routine dental | 02:07 |
dTal | wait, why should I ask that | 02:07 |
bin_bash | i mean pre-covid most dentists in the US didnt use them | 02:07 |
dTal | also I don't have a dentist, yay NHS | 02:07 |
bin_bash | now i dont know, i havent been to the dentist in a year :( | 02:07 |
bin_bash | i dont know if my dentist is even doing cleanings | 02:07 |
LjL | dTal, the NHS covers you meaningfully for dentistry? here, if i have a dental problem that i want the SSN to solve, they'll give me an appointing in 6 months when the tooth has to be pulle | 02:08 |
bin_bash | they havent called me so im inclined to think theyre not | 02:08 |
dTal | I can't remember ever going to the dentit | 02:08 |
LjL | dTal, that explains the UK fame of bad teeth maybe ;( | 02:08 |
dTal | LjL: no, it was a sarcastic yay, that's why I haven't been | 02:08 |
LjL | ah | 02:08 |
LjL | dTal, anyway, "why should I ask that" - let me give you an example, while a really sloppy dentist i sadly had for a while was doing a root canal on my now-lost molar, he almost dropped a nice pointy piece of metal into my throat. it fell at the base of my tongue and his assistant carefully removed it, but i could see they were both very tense and were telling me like "don't move a muscle" | 02:09 |
dTal | oh yikes | 02:09 |
LjL | doing stuff while having a dental dam avoids those incidents as well as simpler things like saliva contaminating your root canal, which can mean you lose your tooth later | 02:10 |
LjL | (in my case i suspect i eventually lost the tooth because that initial root canal and connected restoration was done sloppily... it took a few years but, recently, the tooth just broke apart and had to be pulled) | 02:10 |
dTal | that's absurd then that it's not standard | 02:10 |
dTal | dentistry is weird | 02:10 |
bin_bash | ive never had anything dropped into my mouth *knock on wood* | 02:10 |
dTal | imagine if you had to ask your surgeon if they wore a mask | 02:10 |
LjL | dTal, i believe younger dentists are all taught to use it here. older ones, and ones that are sloppy, are another matter | 02:11 |
LjL | dTal, the other thing i remember about that dentist, which is what made me just ask to be seen by another one (in the same practice, just because it's the one i've gone to since i was a child, but the original dentist died...) was that he was doing dental work on me while talking on the phone about his yacht or some shit. and nope, not hands-free. | 02:12 |
Spec | lol, ridiculous | 02:12 |
bin_bash | wow | 02:12 |
bin_bash | that's crazy | 02:12 |
LjL | Spec, see who pops up when it's time to ridiculize italian practices! :P | 02:13 |
jacklsw | then some people will say dentists are not doctors | 02:13 |
dTal | That sounds like a nasty comedy sketch | 02:14 |
LjL | jacklsw, well, dentists are not medical doctors *anymore* here... they used to be, but now they have their own course of studies | 02:15 |
LjL | the past couple of days the Matrix bridge has been a bit beyond ridiculous :\ | 02:15 |
bin_bash | in the US dental school is harder than medical school in some cases | 02:16 |
bin_bash | and veterinarian school is even harder apparently | 02:16 |
Brainstorm | New from ScienceNews: Novavax’s COVID-19 vaccine is effective, but less so with some variants: Novavax’s vaccine fends off the original coronavirus and a U.K. variant, but had more trouble with a South Africa variant. → https://is.gd/Pq7vzs | 02:17 |
Spec | LjL: :D | 02:17 |
LjL | bin_bash, well, when dentists were MDs here, they'd have to attend medical school *and then* dentistry specialization... it's not like they could be dentists just because they were doctors | 02:18 |
bin_bash | ahh interesting | 02:19 |
bin_bash | there are oral surgeons here and they have to go to medical school | 02:19 |
bin_bash | or they do like a bridge type program | 02:19 |
bin_bash | integrated i think it's called? | 02:19 |
bin_bash | not sure | 02:19 |
LjL | i don't know about that. but in fact very few MDs here simply get their medical degree and then start working... i think even to be a GP you have to do a mini-specialization as a GP. not entirely sure. but *at best*, you could be a GP, without a specialization | 02:21 |
jacklsw | worst thing here is to read any medical advise from webmd | 02:24 |
bin_bash | ? webmd is not the worst | 02:26 |
LjL | well webmd is pretty good at making you think you have something | 02:28 |
LjL | it's not like the information is *wrong* per se | 02:28 |
bin_bash | oh yeah the diagnostic bit | 02:29 |
bin_bash | "i have this mole..." "CANCER" | 02:29 |
bin_bash | "my tummy is.." 'CANCER' | 02:29 |
LjL | :D | 02:34 |
Brainstorm | New from The Indian Express: World: First known US cases of potent South African COVID-19 variant found in South Carolina → https://is.gd/7LZiYS | 02:41 |
bin_bash | now i bet it's like "i have the sniffles.." "COVID" | 02:41 |
Brainstorm | New from BBC Health: Covid-19: 'Less exercise and more TV' than first lockdown: People are spending less time on hobbies and volunteering in the current lockdown, researchers say. → https://is.gd/GFiXVA | 03:05 |
DocScrutinizer05 | >>many very common viruses are the cause of various cancersmany very common viruses are the cause of various cancers<< the gossip had it for decades that cancer is contagious. Couldn't talk aloud about it or you'd get fired at least | 03:06 |
jacklsw | matrix unplugged | 03:11 |
DocScrutinizer05 | I'd be interested in a proper statistics about frequency above average in oncology nurses suffering cancer | 03:13 |
DocScrutinizer05 | I personally seen too many | 03:14 |
DocScrutinizer05 | actually rather care home nurses taking care of elderly who contract cancer | 03:15 |
Brainstorm | New from r/WorldNews: worldnews: Vietnam coronavirus outbreak spreads to Hanoi as nine more cases confirmed → https://is.gd/FFHsSF | 04:55 |
Brainstorm | Updates for Germany: +12078 cases (now 2.2 million) since 14 hours ago | 04:55 |
Brainstorm | Updates for Belgium: +2775 cases (now 702437), +49 deaths (now 20982) since 23 hours ago | 05:57 |
Brainstorm | New from The Indian Express: World: Mexico’s COVID-19 Death Toll Surpasses India, Becomes World’s Third Highest → https://is.gd/p9qSwn | 06:07 |
Brainstorm | Updates for New Zealand: +6 cases (now 2305) since a day ago | 06:15 |
Brainstorm | New from The Indian Express: World: AstraZeneca to seek Japan’s approval of COVID-19 vaccine as early as mid-Feb – Report → https://is.gd/IGduob | 06:20 |
CoronaBot | 04/r/coronavirus: The first 22M Americans have been vaccinated for COVID-19, and initial safety data shows everything is going well, CDC says (10129 votes) | https://www.usatoday.com/story/news/health/2021/01/28/covid-19-vaccines-cdc-safety-data-pfizer-moderna-coronavirus/4281434001/ | https://redd.it/l6zxys | 06:42 |
Brainstorm | New from r/WorldNews: worldnews: Vaccines Have Saved 37 Million Children's Lives Since 2000. Over the lifetime of those born between 2000 and 2030, the findings reveal 120 million deaths will be averted by vaccination, of which 96 million will be saved by the measles vaccine and the hepatitis vaccine together. → https://is.gd/Y236EN | 06:44 |
Brainstorm | New preprint: Immune response to SARS-CoV-2 in the nasal mucosa in children and adults by Clarissa M Koch et al, made available as preprint on 2021-01-28 at https://medrxiv.org/cgi/content/short/2021.01.26.21250269 [... want %more?] | 06:58 |
Brainstorm | New from BBC Health: Covid-19: Novavax vaccine shows 89% efficacy in UK trials: The Novavax jab is the first to show it is effective against the UK variant of the virus. → https://is.gd/zJ3SF3 | 07:21 |
zutt | %cases israel | 07:22 |
Brainstorm | zutt: In Israel, there have been 628895 confirmed cases (6.9% of the population) and 4669 deaths (0.7% of cases) as of 6 hours ago. 10.9 million tests were performed (5.8% positive). Fatality can be broadly expected to lie between 0.9% (assuming prevalence as in tests) and less than 0.8% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Israel for time series data. | 07:22 |
zutt | oh, fatality chance gone up by 0.1% :O | 07:22 |
Brainstorm | Updates for Schleswig-Holstein, Germany: +896 cases (now 35426), +40 deaths (now 834) since a day ago — United Kingdom: +5357 cases (now 3.7 million), +99 deaths (now 103225) since 13 hours ago — St Martin, France: +88 cases (now 1234) since 8 days ago — Lombardy, Italy: +2603 cases (now 532884), +88 deaths (now 26939) since a day ago | 07:42 |
Brainstorm | New from r/WorldNews: worldnews: The British Government launched - and quickly deleted - a Covid ad showing all household chores done by women → https://is.gd/3sK69n | 08:34 |
Brainstorm | New from r/WorldNews: worldnews: China starts 'much awaited' anal swabs to test for Covid-19 → https://is.gd/8Bpb2t | 08:46 |
Brainstorm | New from r/Coronavirus: Daily Discussion Thread | January 29, 2021: The WHO pages contain up-to-date and global information. Please refer to our Wiki for additional information. → https://is.gd/OBTdte | 09:20 |
MKVA51- | Going to go get checked for this today | 09:25 |
MKVA51- | I think I might have it' | 09:25 |
MKVA51- | Don't feel so good | 09:26 |
_io_ | I want an antibody test. | 09:57 |
_io_ | before I get a vaccine. | 09:57 |
Brainstorm | New from Medical Xpress: Mexico tops 155,000 COVID-19 deaths, may be 3rd highest: Mexico reached 155,145 confirmed deaths from COVID-19 Thursday, which would make it the country with the world's third-highest total, passing India's death toll of 153,847. → https://is.gd/30jxRe | 10:07 |
Brainstorm | New from Medical Xpress: WHO team visits Wuhan hospital that had early COVID patients: A World Health Organization team on Friday visited a hospital where China says the first COVID-19 patients were treated more than a year ago as part of the experts' long-awaited fact-finding mission on the origins of the coronavirus. → https://is.gd/B4Pm1r | 10:19 |
Brainstorm | New from StatNews: Pediatricians pivot to vaccines on the go as immunization rates drop during the pandemic: As routine immunizations for children in the U.S. plummeted during the pandemic, mobile and outdoor vaccination efforts have sprung up around the country to help close the gap. → https://is.gd/871s3K | 10:44 |
Brainstorm | New from StatNews: Health: Science communication in the Covid-19 era is a brave new world, for better and worse → https://is.gd/Y2vKkw | 10:56 |
Brainstorm | Updates for Saint Lucia: +77 cases (now 1106) since 16 hours ago — Germany: +12848 cases (now 2.2 million) since 20 hours ago | 11:13 |
Arsanerit | _io_: why? | 11:20 |
Brainstorm | Updates for Malaysia: +5725 cases (now 203933), +16 deaths (now 733) since 22 hours ago | 11:38 |
Brainstorm | New from ProPublica: “The People We Serve Are Paying Too Much for Energy:” Virginia Lawmakers Are Targeting Dominion Energy: by Patrick Wilson and Mel Leonor , Richmond Times-Dispatch ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. This article was produced [... want %more?] → https://is.gd/LkDQwh | 11:44 |
Arsanerit | ^^ not covid news? | 11:47 |
Brainstorm | New from BMJ: Increasing recruitment into covid-19 trials: Since March 2020, UK researchers have established over 70 urgent public health studies to investigate potential treatments, vaccines, and diagnostic tests for covid-19. NHS hospitals have had a vital... → https://is.gd/dMDJSD | 12:17 |
_io_ | Arsanerit: why would I want a vaccine if I'm already immune | 12:19 |
euod[m] | having had it doesn't mean you're immune? | 12:20 |
Arsanerit | _io_: To boost your immunity; vaccine immunity is probably superior and lasts longer to post-infection immunity. | 12:25 |
_io_ | hm | 13:01 |
Brainstorm | New from BMJ: Covid-19: Countries are learning what others paid for vaccines: A string of revelations about vaccine prices has focused attention on a practice considered normal in the drug industry but often frowned on elsewhere: charging different prices to different... → https://is.gd/UBs6Tw | 13:01 |
_io_ | I probably would want to just wait if I have good reason to think I am immune | 13:01 |
_io_ | at the very least to be last in line | 13:02 |
Brainstorm | New from The Indian Express: World: EU chief demands ‘plausible’ answers from AstraZeneca → https://is.gd/wOlkv1 | 13:25 |
Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: VERIFY: Ibuprofen/Acetaminophen should be avoided before vaccine → https://is.gd/UnrShx | 13:37 |
Brainstorm | New from StatNews: J&J one-dose Covid vaccine is 66% effective, a weapon but not a knockout punch: Johnson & Johnson said that its single-dose Covid-19 vaccine reduced rates of moderate and severe disease, but the shot appeared less effective against a new coronavirus variant. → https://is.gd/1R7lI9 | 14:08 |
Brainstorm | New from EMA: What's new: General: Data requirements for multi-strain dossiers for Inactivated vaccines against avian influenza (AI), blue tongue (BT) and foot-and-mouth disease (FMD) → https://is.gd/vxV3bW | 14:14 |
Brainstorm | New from The Indian Express: World: J&J 1-dose shot prevents COVID-19, but less than some others → https://is.gd/SEFb2c | 14:38 |
DocScrutinizer05 | moin | 14:43 |
rpifan | hi | 14:45 |
CoronaBot | 04/r/covid19: Johnson & Johnson Announces Single-Shot Janssen COVID-19 Vaccine Candidate Met Primary Endpoints in Interim Analysis of its Phase 3 ENSEMBLE Trial (92 votes) | https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial | https://redd.it/l7s3o0 | 14:45 |
DocScrutinizer05 | /nick nostradamus; /msg Germany will hit 50/100k7d in 3 weeks. Around that time shit will hit the fan regarding reverting of NPI like curfew and home office and SCHOOLS. If Germany acts like usual, this won't have effect until 2 more weeks later and in 6 weeks (with one week inertia) the incidences will reach 25/100k7d. UNLESS - most likely - the VOC beast eats us until then | 14:58 |
Arsanerit | There are still curfews in Germany? | 15:00 |
Arsanerit | I thought those had been lifted. | 15:00 |
DocScrutinizer05 | not in Bavaria | 15:01 |
DocScrutinizer05 | we still got that *idiotic* night curfew | 15:02 |
DocScrutinizer05 | and I can't decide which pet to get to evade it | 15:02 |
rpifan | well | 15:03 |
rpifan | it works | 15:03 |
rpifan | i mean i was in barcelona | 15:03 |
rpifan | dnad we had a curfew | 15:03 |
rpifan | also malaga | 15:03 |
Brainstorm | New from Derek Lowe: @angie_rasmussen: RT by @Dereklowe: >@JNJNews vaccine results are in! While not as efficacious as Pfizer or Moderna it’s still great news—it was 85% efficacious at preventing severe disease requiring hospitalization. Not a “knockout punch” but still will be very [... want %more?] → https://is.gd/Pxss50 | 15:03 |
Arsanerit | DocScrutinizer05: fish? | 15:03 |
DocScrutinizer05 | should get a https://amazon.com/Battery-Operated-Walking-Barking-Sunglases/dp/B00Q3GNGAG | 15:04 |
DocScrutinizer05 | THIS ONE! https://www.aliexpress.com/item/32959326283.html?spm=a2g0o.search0302.0.0.6d39306eXvBV6U&algo_pvid=909d7124-eb3b-4573-82e2-4cf8ba0cb9ad&algo_expid=909d7124-eb3b-4573-82e2-4cf8ba0cb9ad-7&btsid=0b0a0ae216119291606125658e1811&ws_ab_test=searchweb0_0,searchweb201602_,searchweb201603_ | 15:06 |
DocScrutinizer05 | or maybe a real white mouse? | 15:08 |
rpifan | im not bothered by curfews | 15:13 |
rpifan | the way they do it in spain is good | 15:13 |
rpifan | everything is open and ormal during the day | 15:13 |
rpifan | until around 8pm | 15:13 |
rpifan | then everything shut downs | 15:13 |
rpifan | and you need to be hoem at 10pm | 15:13 |
rpifan | so it works out just fine | 15:14 |
rpifan | but most importantly | 15:14 |
Arsanerit | But in Spain hanging around at the street is a national pastime. | 15:14 |
rpifan | they have blocked the entry and exit of ppl | 15:14 |
rpifan | i only managed to move around | 15:14 |
rpifan | because i was headed bcak to germany | 15:14 |
Arsanerit | Whether or not you or I am bothered by curfews isn't relevant; the effect of measures should be weighed against the impact they have on basic rights. | 15:15 |
DocScrutinizer05 | >>in Spain hanging around at the street...<< while here such curfew has no point at all. The streets wereempty without curfew already | 15:15 |
Brainstorm | Updates for Switzerland: +1916 cases (now 521320), +35 deaths (now 9343) since 15 hours ago — Germany: +13431 cases (now 2.2 million), +802 deaths (now 56160) since 22 hours ago | 15:16 |
DocScrutinizer05 | >>effect of measures should be weighed against the impact<< that's no should, that's a MUST, and I'm completely disappointed this idiotic curfew hasn't been cancelled already by the courts | 15:26 |
Brainstorm | New from StatNews: STAT+: Pharmalittle: J&J and Novavax vaccines are effective to varying degrees; FDA delays decision on Biogen Alzheimer’s drug: Johnson & Johnson reported its single-dose Covid-19 vaccine reduced rates of moderate and severe disease, but appeared less effective in South Africa, where a new variant has become common. → https://is.gd/rkCI1i | 15:26 |
DocScrutinizer05 | umm >>it was 85% efficacious at preventing severe disease<< >>J&J one-dose Covid vaccine is 66% effective<< >>less effective in South Africa, where a new variant<< that's... BAD! | 15:30 |
DocScrutinizer05 | terrible | 15:31 |
DocScrutinizer05 | %vax curevac | 15:34 |
Brainstorm | DocScrutinizer05, mRNA is a RNA-based vaccine developed in Germany by CureVac + Bayer, which began its testing on humans on date Jun 18 with 36500 healthy volunteers aged 18+ → https://covidvax.org/covid19-vaccine/CureVac | 15:34 |
genera | %vax janssen | 15:36 |
Brainstorm | genera, Ad26 alone or with MVA boost is a Non-replicating viral vector vaccine developed in Belgium + USA by Janssen (Johnson & Johnson) + Beth Israel Deaconess Medical Center (Harvard Medical School) + Emergent BioSolutions + Catalent, which began its testing on humans on date Aug 11 with 60000 healthy volunteers aged 18+ → https://covidvax.org/covid19-vaccine/Janssen | 15:36 |
DocScrutinizer05 | ummm, LjL, what ist that data brainstorm cites on vax curevac? seems it's quite incorrect since >> PHASE 1 started June 18 2020 with **284** healthy volunteers aged 18-60<< and >>PHASE 2-3 (Tuebingen, Ger) started **December 14 2020** with 36500 healthy volunteers aged 18+<< | 15:50 |
DocScrutinizer05 | on a sidenote to this: starting a phase3 with 36k in Tuebingen, of all places, is quite... suboptimal for getting the needed number of positive cases in reference cohort. Tuebingen has a very very low incidence level | 15:53 |
DocScrutinizer05 | will probably take until autumn 2021 to get a somewhat meaningful dataset with reassuring CI from this study | 15:55 |
Brainstorm | New from BBC Health: Covid vaccine: Single dose Covid vaccine 66% effective: The health secretary says the vaccine could "significantly bolster" the UK's vaccination programme. → https://is.gd/n2O7Id | 16:00 |
CoronaBot | 04/r/coronavirus: Just 0.04% of Israelis caught COVID-19 after two shots of Pfizer vaccine (10055 votes) | https://www.jpost.com/israel-news/israel-shows-promising-results-from-pfizer-vaccination-campaign-657051 | https://redd.it/l7apag | 16:22 |
DocScrutinizer05 | EMA approves AZ for >=18 | 16:25 |
DocScrutinizer05 | If it works like last two times, the EC will confirm that within 2h | 16:26 |
DocScrutinizer05 | meanwhile | 16:28 |
DocScrutinizer05 | .title https://www.bloomberg.com/news/articles/2021-01-29/astrazeneca-discloses-eu-vaccine-contract-after-supply-dispute | 16:28 |
Brainstorm | DocScrutinizer05: From www.bloomberg.com: Bloomberg - Are you a robot? | 16:28 |
DocScrutinizer05 | LOL | 16:28 |
DocScrutinizer05 | .title https://ec.europa.eu/commission/presscorner/api/files/attachment/867990/APA%20-%20AstraZeneca.pdf | 16:31 |
DocScrutinizer05 | ^^^ the contract paper | 16:32 |
Haley[m] | Not downloadable. | 16:33 |
Brainstorm | DocScrutinizer05, the URL could not be loaded | 16:39 |
DocScrutinizer05 | o.O | 16:39 |
DocScrutinizer05 | what the... | 16:40 |
DocScrutinizer05 | WFM | 16:40 |
DocScrutinizer05 | how about this? https://ec.europa.eu/commission/presscorner/detail/en/ip_21_302 | 16:40 |
Haley[m] | works | 16:40 |
DocScrutinizer05 | the link is in there | 16:41 |
DocScrutinizer05 | "Related Documents" | 16:41 |
DocScrutinizer05 | "Referer"? | 16:41 |
Haley[m] | yeah. Works. Lol. 42 pages ... | 16:42 |
DocScrutinizer05 | I mean, maybe you only may download when your "Referer" header in HTTP request is from this site? | 16:42 |
Brainstorm | Updates for Guernsey: +35 cases (now 449) since 20 hours ago | 16:43 |
DocScrutinizer05 | ((42 pages)) yeah and NOT SEARCHABLE >:-( | 16:44 |
DocScrutinizer05 | morons | 16:44 |
DocScrutinizer05 | So I didn't find yet where they define the fab sites that are supposed to provide "the Goods" | 16:45 |
DocScrutinizer05 | if anybody has a pointer, much appreciated | 16:46 |
DocScrutinizer05 | page 2, section with blackened text has >>Best Reasonable Effort (as defined below)<< the definition is p.3 "1.9" | 16:48 |
DocScrutinizer05 | useless, without proper definition about which sites will produce/provide the vaccine | 16:49 |
Brainstorm | New from BBC Health: EU drugs regulator approves AstraZeneca vaccine: The European Medicines Agency approves use of the AstraZeneca Covid vaccine for people across the bloc. → https://is.gd/8Bs89b | 16:57 |
DocScrutinizer05 | ouch >>5.1. Initial Europe Doses, AZ shall use its Best Reasonable Effort to manufacture the Initial Europe Doses **within the EU**...<< I guess that rules out GB fabs | 16:57 |
DocScrutinizer05 | lost case | 16:58 |
Brainstorm | Updates for Netherlands: +5365 cases (now 973635), +93 deaths (now 13890) since 22 hours ago | 17:02 |
Arsanerit | DocScrutinizer05: It says elsewhere in the text that for the purpose of this paragraph, the UK should be still considered as part of the EU, despite Brexit. | 17:35 |
DocScrutinizer05 | just reading 5.4. | 17:35 |
DocScrutinizer05 | https://i.imgur.com/otg2vFL.png | 17:36 |
DocScrutinizer05 | and particularly https://i.imgur.com/wicTOOT.png | 17:40 |
DocScrutinizer05 | in 5.5. there's obviously missing a >>(c) as soon as AZ realizes they are not within schedule regarding time and volume of produced stuff<< | 17:43 |
DocScrutinizer05 | arguably it's implicit in 5.4. | 17:44 |
DocScrutinizer05 | whatever the legal situation, the "at no profit or loss" approach makes AZ pretty much immune against any leverage by EU, and in real life it's about getting doses from GB to EU which I bet BoJo will forbid | 17:49 |
DocScrutinizer05 | the question is if AZ hadn't been obliged to report much earlier and more detailed about progress, expected yield and risks/CI of such forecasts, to allow EU for pulling 5.4. options | 17:57 |
DocScrutinizer05 | and not nailing that down in detail in the contract is solely EU fault | 17:59 |
DocScrutinizer05 | 6.3. covers base material supply bottlenecks, but *not* yield in AZs own production process | 18:03 |
Brainstorm | New from EMA: What's new: Withdrawn applications: Withdrawn application: Dexamethasone Taw, dexamethasone phosphate, Date of withdrawal: 20/01/2021, Initial authorisation → https://is.gd/jdAyX7 | 18:06 |
LjL | DocScrutinizer05, why incorrect? it picks the one with the most people, which means if there's a phase 3, it usually picks the phase 3 | 18:10 |
LjL | oh, the date | 18:10 |
LjL | the date is obtained separately | 18:11 |
LjL | but it's still not so wrong, is it? it began its testing on humans on jun 18, and right now, the testing on humans has 36500 people | 18:11 |
DocScrutinizer05 | that's not what the text says | 18:11 |
LjL | at the end of the day there's a URL to click on to get the actual details :P | 18:11 |
LjL | DocScrutinizer05, if i said "with currently" would that work? | 18:12 |
DocScrutinizer05 | yes | 18:12 |
LjL | or "currently with", maybe that's more english | 18:12 |
LjL | ", currently employign" | 18:12 |
LjL | except without the typo | 18:12 |
DocScrutinizer05 | "with most recent study employing" | 18:13 |
LjL | that may be a bit too long, these descriptions are already *barely* fitting into one irc line | 18:13 |
DocScrutinizer05 | I see | 18:14 |
DocScrutinizer05 | %vax curevac | 18:14 |
Brainstorm | DocScrutinizer05, mRNA is a RNA-based vaccine developed in Germany by CureVac + Bayer, which began its testing on humans on date Jun 18 with 36500 healthy volunteers aged 18+ → https://covidvax.org/covid19-vaccine/CureVac | 18:14 |
DocScrutinizer05 | "first testing on humans on date Jun 18, last employing 36500 healthy ..." | 18:16 |
DocScrutinizer05 | discard "which began its" | 18:16 |
DocScrutinizer05 | roughly same length in total | 18:17 |
Brainstorm | Updates for Mozambique: +1275 cases (now 37108) since 23 hours ago — Albania: +896 cases (now 76350), +8 deaths (now 1358) since 23 hours ago — United Kingdom: +13281 cases (now 3.8 million) since 23 hours ago | 18:17 |
LjL | %vax curevac | 18:19 |
Brainstorm | LjL, mRNA is a RNA-based vaccine developed in Germany by CureVac + Bayer, which started testing on humans initially on Jun 18, currently employing 36500 healthy volunteers aged 18+ → https://covidvax.org/covid19-vaccine/CureVac | 18:19 |
DocScrutinizer05 | perfect | 18:22 |
LjL | de-facto, DocScrutinizer05: we already saw this one before https://gabgoh.github.io/COVID/index.html but i think they overhauled at least the UI completely, i don't remember it like this | 18:39 |
LjL | maybe you already have the news, but i learn them now (not great news) | 18:49 |
LjL | J&J has announced 66% efficacy | 18:49 |
LjL | (insisting on single-dose) | 18:50 |
LjL | and the EMA is approving AstraZeneca for all adults, including 65+, even though they do say there are insufficient data to state its efficacy on them | 18:50 |
LjL | J&J: "Overall efficacy against severe cases 85%, with none recorded beyond 49 days post-vaccination." so, worse than other vaccines, which claim no severe cases, although i always doubt those since it seems like they have too few cases to go on | 18:52 |
LjL | someone says "But I say these are important results, because J&J had a very thorough definition of severe cases" | 18:53 |
LjL | also, Moderna announces, too, a cut of 20% not sure if just to Italy or to the whole EU (presumably whole EU since we're buying it all together) | 18:53 |
DocScrutinizer05 | LjL: yep, seems to have changed | 18:57 |
DocScrutinizer05 | https://gabgoh.github.io/COVID/index.html that is | 18:59 |
DocScrutinizer05 | didn't hear of the last one, the moderna cut | 18:59 |
LjL | DocScrutinizer05, i have it from an italian article, i'll grab it in a minute | 19:00 |
DocScrutinizer05 | [29 Jan 2021 15:30:36] <DocScrutinizer05> umm >>it was 85% efficacious at preventing severe disease<< >>J&J one-dose Covid vaccine is 66% effective<< >>less effective in South Africa, where a new variant<< that's... BAD! [29 Jan 2021 15:31:24] <DocScrutinizer05> terrible | 19:01 |
LjL | meanwhile i wonder, J&J, "85 percent effective in preventing severe disease across all regions studied, [i] 28 days after vaccination" and "Janssen’s COVID-19 vaccine candidate was 66% effective overall in preventing moderate to severe COVID-19, 28 days after vaccination". when Pfizer and Moderna released their data, do i remember wrongly, or did they consider ALL infections no matter when they happened? or did they also wait 28 days or similar? | 19:01 |
DocScrutinizer05 | don't know | 19:03 |
LjL | "Overall fever rates were 9% and Grade 3 fever 0.2%" ← this would be much less than what they reported in phase 2, so de-facto would be vindicated in warning me about that :P | 19:03 |
DocScrutinizer05 | LjL: did you notice the AZ contract stuff? | 19:04 |
DocScrutinizer05 | prolly the first real contract we get to see | 19:04 |
LjL | DocScrutinizer05, you mean the fact in the EU we have a "best-effort" contract? that's what i read in the interview with the AZ CEO | 19:04 |
LjL | oh, it's now available? | 19:04 |
pigughs | The vaccine’s efficacy rate dropped from 72 percent in the United States to just 57 percent in South Africa, where a highly contagious variant is driving most cases. | 19:05 |
DocScrutinizer05 | [29 Jan 2021 16:31:53] <DocScrutinizer05> .title https://ec.europa.eu/commission/presscorner/api/files/attachment/867990/APA%20-%20AstraZeneca.pdf [29 Jan 2021 16:40:39] <DocScrutinizer05> how about this? https://ec.europa.eu/commission/presscorner/detail/en/ip_21_302 | 19:05 |
LjL | lol, page 4, already all censored out | 19:05 |
pigughs | nyt subheader on johnsons | 19:06 |
LjL | pigughs, the drop with Novavax was even higher, 90% general, but 60%ish in SA | 19:07 |
pigughs | Studies suggest that this variant also blunts the effectiveness of Covid vaccines made by Pfizer-BioNTech, Moderna and Novavax | 19:08 |
Brainstorm | New from https://covid19.specops.network : ljl-covid: Add newly-published contract between AstraZeneca and the EU → https://is.gd/tvWrMa | 19:14 |
genera | but .. the reduction is not by testing on a variant, the reducation is by testing in a certain location. is it? | 19:15 |
LjL | genera, what? O.o | 19:15 |
genera | the reduction from 90 to 60 percent efficacy | 19:16 |
genera | ok not with biontech. they did in vitro studies afaik | 19:16 |
genera | but what do i know \o/ | 19:17 |
DocScrutinizer05 | BNT supposed to be >>efficient against the UK and SA variants<< | 19:17 |
DocScrutinizer05 | didn't read the papers, only the headline, so please doiblecheck | 19:18 |
DocScrutinizer05 | s/ headline / bot summary | 19:19 |
Brainstorm | Updates for Italy: +13563 cases (now 2.5 million), +477 deaths (now 87858) since 23 hours ago — Spain: +12706 cases (now 2.7 million) since 22 hours ago — Canada: +3453 cases (now 769260), +99 deaths (now 19725) since 23 hours ago — Netherlands: +4478 cases (now 973637) since 23 hours ago | 19:19 |
DocScrutinizer05 | [25 Jan 2021 15:40:44] <CoronaBot> /r/covid19: Moderna COVID-19 Vaccine Retains Neutralizing Activity Against Emerging Variants First Identified in the U.K. and the Republic of South Africa | Moderna, Inc. (81 votes) | https://investors.modernatx.com/news-releases/news-release-details/moderna-covid-19-vaccine-retains-neutralizing-activity-against | https://redd.it/l4o9oa | 19:22 |
LjL | %title https://translate.google.com/translate?sl=it&tl=en&u=https://www.repubblica.it/cronaca/2021/01/29/news/arcuri_anche_moderna_tagliera_il_20_delle_dosi_-284760327/ DocScrutinizer05 | 19:34 |
Brainstorm | LjL: From translate.google.com: Google Translate | 19:34 |
rmonten[m] | Dang... J&J | 19:34 |
LjL | genera, oh well yes and no, they did ascertain that 95% of the cases in SA were from the SA variant, so in practice, the 60% is related to the SA variant | 19:35 |
Brainstorm | Updates for Sierra Leone: +100 cases (now 3382), +2 deaths (now 79) since a day ago | 19:38 |
DocScrutinizer05 | LjL: https://www.nzz.ch/schweiz/coronavirus-moderna-meldet-lieferengpaesse-ld.1598970 same | 19:39 |
DocScrutinizer05 | I simply missed out on that | 19:39 |
LjL | :\ | 19:39 |
LjL | de-facto, DocScrutinizer05: a pretty long article on modelling and shorcomings thereof https://www.quantamagazine.org/the-hard-lessons-of-modeling-the-coronavirus-pandemic-20210128/ which includes a version of the interactive SIR modeler at some point in the middle | 19:40 |
DocScrutinizer05 | nice :-) thanks | 19:41 |
DocScrutinizer05 | LjL: don't miss my former "nostradamus of the week" ;-D | 19:41 |
DocScrutinizer05 | a pity R_eff is nailed to 0.9 here | 19:42 |
DocScrutinizer05 | until it cracks on VOC | 19:43 |
DocScrutinizer05 | [29 Jan 2021 14:58:36] <DocScrutinizer05> /nick nostradamus; /msg Germany will hit 50/100k7d in 3 weeks. Around that time shit will hit the fan regarding reverting of NPI like curfew and home office and SCHOOLS. If Germany acts like usual, this won't have effect until 2 more weeks later and in 6 weeks (with one week inertia) the incidences will reach 25/100k7d. UNLESS - most likely - the VOC beast eats us until then | 19:43 |
LjL | bad news from Lombardy too | 19:44 |
LjL | we're going back to "yellow level", which is the minimum | 19:44 |
DocScrutinizer05 | should have said "hit the fan re public bitching about reverting..." | 19:44 |
LjL | so, expect a rise in cases | 19:45 |
LjL | and also we still don't have a government | 19:45 |
DocScrutinizer05 | /o\ | 19:45 |
LjL | it seems less and less likely than the current PM can form a new one | 19:45 |
LjL | so... elections looming, which polls say would be won by the right wing | 19:45 |
DocScrutinizer05 | damn | 19:46 |
LjL | DocScrutinizer05, when you saw the news on J&J, you said "BAD!", and i think i agree. but when you look at r/COVID19, most people are enthusiastic, and those who aren't get downvoted. that's supposed to be the "scientific" subreddit. and then also Derek Lowe says this | 19:55 |
LjL | <Brainstorm> New from Derek Lowe: @angie_rasmussen: RT by @Dereklowe: >@JNJNews vaccine results are in! While not as efficacious as Pfizer or Moderna it’s still great news—it was 85% efficacious at preventing severe disease requiring hospitalization. Not a “knockout punch” but still will be very [... want %more?] → https://is.gd/Pxss50 | 19:55 |
LjL | i have the feeling that if on the one hand we have "deniers", on the other extreme we have "science fans" who will say that anything that passes the 50% approval threshold is GREAT | 19:55 |
LjL | but a vaccine with 51% efficacy is not great at all, especially when we know we can reach 95% | 19:55 |
LjL | the fact we'll be forced to use much worse vaccines because the better ones aren't delivering enough doses is not great at all | 19:55 |
LjL | and with AZ it was, "hey but it takes away ALL the severe cases so that's great!" (even though i doubt it does, too small numbers to say) | 19:56 |
LjL | now this one takes 85% hospitalizations, so, not all, but it's still great | 19:56 |
LjL | how low do we have to get before it's NOT great? | 19:56 |
DocScrutinizer05 | *nod* | 19:59 |
LjL | the "science fans" thing reminds me of this video | 19:59 |
LjL | %title https://www.youtube.com/watch?v=CVPy25wQ07k | 19:59 |
Brainstorm | LjL: From www.youtube.com: The Problem with the 'Yay Science!' Crowd - YouTube | 19:59 |
dTal | We wouldn't have or need a "yay science" crowd if there weren't an unreasonably idiotic "boo science" crowd | 20:13 |
pigughs | LjL: is there some kind of trade-off with using 50% vaccines? like an increase in variants, as with folks who don't complete antibiotics courses | 20:13 |
LjL | pigughs, it's unclear, but i think it's possible | 20:14 |
LjL | dTal, well that doesn't really justify becoming another dumb crowd in response | 20:14 |
LjL | "it's their fault if we act idiotic, they started first" | 20:14 |
LjL | like it almost seems like i'm expected to either love or hate the vaccines. can't have some sound degree of skepticism and carefulness | 20:15 |
dTal | it doesn't justify it, but it does cause it | 20:20 |
Brainstorm | Updates for France: +29316 cases (now 3.2 million), +776 deaths (now 75395) since 23 hours ago | 20:40 |
whytek | This is kind of like mRNA for dummies guide: https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ | 20:50 |
whytek | Interesting to know of any comments from people here. | 20:50 |
Brainstorm | Updates for United Kingdom: +383 deaths (now 103608) since 13 hours ago — Switzerland: +45 deaths (now 9353) since 22 hours ago | 21:23 |
Brainstorm | New from BBC Health: Covid: EU approves AstraZeneca vaccine amid supply row: The EU approves AstraZeneca's Covid vaccine, but accuses the firm of breaking supply commitments. → https://is.gd/8Bs89b | 21:24 |
Brainstorm | New from University of Washington: United World Antiviral Research Network (UWARN) Partners Collaborate to Expand Understanding of New COVID Variants, Key to Future Vaccine Development (includes Wesley C. Van Voorhis and Michael Gale): Van Voorhis, Wesley_Headshot 2019.jpg Close Wesley Van Voorhis, Adjunct Professor, UW Dept. of Global Health View [... want %more?] → https://is.gd/V9IP8c | 21:36 |
DocScrutinizer05 | wiIt's already known and appreciated here. I wouldn't call it "for dummies" though | 21:59 |
DocScrutinizer05 | whytek: ^^^ | 22:00 |
Brainstorm | New from StatNews: Additional Covid-19 vaccines bring choices — and complications — to the rollout: All vaccines are not equal, and increasingly, we will be dealing with shots with varying attributes: different storage requirements, efficacy, dosing regimens, and manufacturing platforms. → https://is.gd/J8R2Ti | 22:12 |
Arsanerit | 19:55:43 < LjL> but a vaccine with 51% efficacy is not great at all, especially when we know we can reach 95% | 22:15 |
Arsanerit | LjL: Which one is that? | 22:15 |
de-facto | LjL, i remember that UI of that Epidemic calculator to be like this, but maybe they did some changes that i did not remember | 22:24 |
Brainstorm | New from ScienceNews: What do COVID-19 vaccines mean for daily life in the months ahead?: Effective COVID-19 vaccines are a ray of hope. But masks and distancing are still necessary, especially with contagious variants spreading. → https://is.gd/qWWnpc | 22:24 |
Raf[m] | Isn't the AZ vaccine a lot lower in efficacy than the mRNA types? Like 65% or so? | 22:24 |
de-facto | LjL, where is that cite from with J&J fever? | 22:25 |
de-facto | LjL, afair the Pfizer study included only cases one week after 2nd dose (hence 28 days after 1st dose) | 22:28 |
de-facto | ah I see the cite of J&J was from https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial | 22:29 |
de-facto | whytek, see https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rna-vaccines-and-their-lipids for Derek Lowes comment on your link | 22:40 |
LjL | Arsanerit: 51% wasn't from any particular vaccine, I just meant "anything above 50%" (although 51% is in the confidence interval of the AZ interim with full dose iirc...) | 22:42 |
de-facto | .title https://www.ema.europa.eu/en/news/ema-recommends-covid-19-vaccine-astrazeneca-authorisation-eu | 23:11 |
Brainstorm | de-facto: From www.ema.europa.eu: EMA recommends COVID-19 Vaccine AstraZeneca for authorisation in the EU | European Medicines Agency | 23:11 |
de-facto | .title https://ec.europa.eu/commission/presscorner/detail/en/ip_21_302 | 23:14 |
Brainstorm | de-facto: From ec.europa.eu: Press corner | European Commission | 23:14 |
de-facto | .title https://www.astrazeneca.com/media-centre/press-releases/2021/covid-19-vaccine-authorised-for-use-in-the-eu.html | 23:14 |
Brainstorm | de-facto: From www.astrazeneca.com: COVID-19 Vaccine AstraZeneca authorised for use in the EU | 23:14 |
de-facto | .title https://www.astrazeneca.com/media-centre/press-releases/2021/covid-19-vaccine-astrazeneca-recommended-for-use-in-the-eu.html | 23:15 |
Brainstorm | de-facto: From www.astrazeneca.com: COVID-19 Vaccine AstraZeneca recommended for use in the EU | 23:15 |
de-facto | .title https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2021/Ausgaben/05_21.pdf?__blob=publicationFile | 23:17 |
Brainstorm | de-facto, the URL could not be loaded | 23:17 |
de-facto | .tr <de Der COVID-19-Impfstoff von AstraZeneca wird aktuell aufgrund der derzeit verfügbaren Daten nur für Personen im Alter von 18 bis 64 Jahren empfohlen; zur Beurteilung der Impfeffektivität ab 65 Jahren liegen bisher keine ausreichenden Daten vor. Abgesehen von dieser Einschränkung wird dieser Impfstoff ebenfalls als geeignet zum Individualschutz und zur Bekämpfung der Pandemie angesehen. Direkte Vergleichsstudien zwischen | 23:18 |
de-facto | den verschiedenen Impfstoffen fehlen. | 23:18 |
Brainstorm | de-facto, German to English: AstraZeneca's COVID-19 vaccine is currently only recommended for people aged 18 to 64 years based on currently available data; To date, insufficient data are available to assess the effectiveness of the vaccine from the age of 65. Apart from this limitation, this vaccine is also considered suitable for individual protection and for combating the [... want %more?] | 23:18 |
de-facto | .title https://www.youtube.com/watch?v=wO_F0UrHKxY <-- press conference from today in German language | 23:20 |
Brainstorm | de-facto: From www.youtube.com: Pressekonferenz zur aktuellen Corona-Lage u.a. mit Spahn, Wieler, Cichutek - YouTube | 23:20 |
de-facto | .title https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32661-1/fulltext | 23:26 |
Brainstorm | de-facto: From www.thelancet.com: Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK - The Lancet | 23:27 |
de-facto | On the horizon; Janssen, CureVac, NoxaVax.. | 23:30 |
de-facto | Interesting point from Marylyn Addo on the press conference: Ofc its very good to have some approved vaccines on the market already, yet the ones not ready yet have the opportunity to get tested against the new variants of concern in their phase III trials | 23:40 |
de-facto | example: Novavax | 23:41 |
Brainstorm | New from NPR: Navajo Nation Begins Mass Vaccinations After Lifting Lockdown Order: The Navajo Nation is shifting its focus to mass vaccinations in order to fight against the pandemic's hold on Indigenous communities. → https://is.gd/4qtVI5 | 23:43 |
Brainstorm | Updates for Canada: +3381 cases (now 769733), +113 deaths (now 19739) since 23 hours ago | 23:46 |
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