| DocScrutinizer05 | hmmm >>We found significant changes in erythrocyte deformability, lymphocyte stiffness, monocyte size, and neutrophil size and deformability. While some of these changes recovered to normal values after hospitalization, others persisted for months after hospital discharge, evidencing the long-term imprint of COVID-19 on the body<< ^^^ | 00:11 |
|---|---|---|
| Brainstorm | New from Derek Lowe: @gadboit: RT by @Dereklowe: AFAIK _all_ vaccine attempts for SARS1 had enhancement. These guys used an MVA vector vaccine encoding the SARS1 spike. Just like a modern SARS2 vax. It enhanced. As did some MERS vaccines (but not ChAdOx). I wish we knew why/not and what was going on.https://doi.org/10.1172/jci.insight.123158 → https://is.gd/qBm0Yx | 00:16 |
| Brainstorm | New from r/WorldNews: worldnews: Flyers in German tram blame Jews for pandemic → https://is.gd/NvoRIP | 01:07 |
| CoronaBot | /r/covid19: Calcifediol Treatment and COVID-19-Related Outcomes (80 votes) | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3771318 | https://redd.it/lj9o0o | 01:44 |
| Brainstorm | New from r/WorldNews: worldnews: Catalonia holds regional election, gauging separatists' strength in the coronavirus pandemic era → https://is.gd/S4nqix | 01:44 |
| LjL | how many more vitamin D (or similar) papers will it take before it becomes a staple of prevention and treatment? | 01:51 |
| LjL | they show that tocilizumab "works" despite ridiculously small differences in numbers (and despite another trial having previously being interrupted due to heightened mortality?!) | 01:52 |
| LjL | it was like 32% vs 29% | 01:53 |
| LjL | here we have 6.5% deaths in the calcifediol group and 15 in the standard of care group | 01:53 |
| LjL | ffs, just use it | 01:53 |
| gigasu_shida | we need vitamin D but we also need more probiotics to allow conversion into the 'activated' form of the vitamin | 01:54 |
| gigasu_shida | they go hand in hand | 01:54 |
| LjL | calcifediol is already the "activated" form | 01:56 |
| gigasu_shida | oh, can we take calcifediol as a liquid supplement now? | 01:58 |
| gigasu_shida | i didn't know about that | 01:59 |
| gigasu_shida | i'm not sure you're correct ljl but i'll have to read more | 01:59 |
| gigasu_shida | i only read 2 papers on the matter | 02:00 |
| LjL | i doubt it's available as a supplement. | 02:01 |
| gigasu_shida | oh it's known as rayaldee | 02:03 |
| gigasu_shida | i've honestly never heard of this so i need to read more | 02:03 |
| Brainstorm | Updates for France: +10756 cases (now 3.5 million) since 23 hours ago — Netherlands: +4460 cases (now 1.0 million), +75 deaths (now 14820) since 23 hours ago — Canada: +3958 cases (now 824936), +64 deaths (now 21226) since 23 hours ago | 02:38 |
| Brainstorm | New from r/WorldNews: worldnews: Fury at ‘do not resuscitate’ notices given to Covid patients with learning disabilities → https://is.gd/20U7ub | 02:46 |
| ryouma | and where are the human rights orgs? they seem to have disappeared from the planet. | 02:55 |
| Brainstorm | New from r/WorldNews: worldnews: Autopsies found in dead tiger cubs conclude they may have died of COVID → https://is.gd/TuWan5 | 02:59 |
| jack_lsw | human rights org are just several individuals rights | 03:05 |
| ryouma | ? | 03:10 |
| Brainstorm | New from r/WorldNews: worldnews: Oxford University launches trial to test COVID-19 vaccine response among children for first time → https://is.gd/LWW7s6 | 03:11 |
| gigasu_shida | wow, DNR for ppl with learning disabilities...that's awful to hear about | 03:22 |
| gigasu_shida | i'm on the autism spectrum that could've been me | 03:26 |
| Brainstorm | New from r/WorldNews: worldnews: New Zealand reports three new COVID-19 local cases, first since January → https://is.gd/DpdG9x | 03:35 |
| Brainstorm | New from The Indian Express: World: White House cites ‘deep concerns’ about WHO COVID report, demands early data from China → https://is.gd/Eequ4V | 04:00 |
| pigpigxiu | LjL: how much vit d, do you take/day | 04:16 |
| Brainstorm | Updates for United Kingdom: +9993 cases (now 4.0 million) since 20 hours ago | 04:18 |
| LjL | pigpigxiu, 1000IU | 04:20 |
| Brainstorm | New from The Indian Express: World: New Zealand reports three new COVID-19 local cases, first since January → https://is.gd/X337kt | 04:37 |
| pigpigxiu | LjL: i seem to take 4-6000 | 04:38 |
| LjL | i think i've often herd 4000 as the maximum daily safe value without clear medical indications and checks or special situations | 04:38 |
| LjL | but 1000 is what my mom was given when she had a moderate deficiency | 04:38 |
| pigpigxiu | capsules I have are 2000iu, bottle says to take 1 | 04:40 |
| pigpigxiu | ah but in small print, does call it 'extra strength' maybe i'll take 4000iu max | 04:43 |
| LjL | i wouldn't exceed that. it's already a pretty heavy dose. as much as it might be potentially useful for COVID, an excess of vitamin D can be harmful too. | 04:44 |
| LjL | there are also "megadoses" which are like an order of magnitude above that, but they are given in special circumstances and not on a prolonged daily basis | 04:45 |
| Brainstorm | Updates for New Zealand: +2 cases (now 2330) since a day ago | 05:08 |
| pigpigxiu | yeah, 'cept I've been doing it all last year, as I recall, it's not really known what is the suggested limit, i'm also indoors all day , lol | 05:22 |
| Brainstorm | New from r/WorldNews: worldnews: Fury at ‘do not resuscitate’ notices given to Covid patients with learning disabilities → https://is.gd/2tZAeB | 05:28 |
| DocScrutinizer05 | I think cjolecalciferol (dubbed "vitamin D3") will also be bioavaliable without any severe metabolizing | 05:34 |
| Brainstorm | Updates for Belgium: +1895 cases (now 737115), +35 deaths (now 21634) since 22 hours ago — Germany: +239 deaths (now 65275) since 19 hours ago | 06:03 |
| Brainstorm | New from This Week In Virology: TWiV 720: With vaccines, Offit is on it: Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more. → https://is.gd/nde84N | 06:18 |
| Brainstorm | New from The Indian Express: World: Saudi Arabia extends entertainment, dine-in coronavirus restrictions: SPA → https://is.gd/1bitx7 | 07:08 |
| Brainstorm | Updates for Zakarpattia Oblast, Ukraine: +485 cases (now 34803), +3 deaths (now 788) since a day ago — United Kingdom: +5900 cases (now 4.0 million), +110 deaths (now 117018) since 13 hours ago — Ohio, United States: +2799 cases (now 937541), +1204 deaths (now 16340) since a day ago — Lombardy, Italy: +2277 cases (now 561091), +61 deaths (now 27760) since a day ago | 07:24 |
| Brainstorm | New from r/WorldNews: worldnews: New Zealand returning to Covid lockdown restrictions following 3 positive community cases in South Auckland → https://is.gd/VZyvz5 | 07:33 |
| Brainstorm | New from r/WorldNews: worldnews: New Zealand’s largest city to go to level 3 lockdown amid 3 community cases found → https://is.gd/8lenVl | 08:47 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | February 14, 2021: The World Health Organization maintains up-to-date and global information. Please refer to our Wiki for additional information. You can find answers to frequently asked questions about Covid-19 and vaccines in our FAQ . → https://is.gd/OWXvZv | 09:12 |
| Brainstorm | New from The Indian Express: World: New Zealand imposes 3-day lockdown on Auckland after 3 new local COVID-19 cases → https://is.gd/zUF31m | 09:24 |
| Brainstorm | New from r/WorldNews: worldnews: Covid-19 pandemic: New Zealand's biggest city ordered into lockdown with discovery of 3 community cases. → https://is.gd/ZnVevG | 10:26 |
| Brainstorm | New from r/WorldNews: worldnews: First known patient reinfected with South Africa coronavirus variant is in critical condition → https://is.gd/TrRDFL | 11:53 |
| genera | article is already deleted. bc paywall. | 11:57 |
| Brainstorm | New from r/WorldNews: worldnews: New Zealand locks down Auckland after 3 new local COVID-19 cases → https://is.gd/eSBPMr | 12:17 |
| Brainstorm | Updates for Canada: +66 deaths (now 21228) since 17 hours ago | 12:42 |
| Brainstorm | New from r/WorldNews: worldnews: WHO investigator claims China refused to hand over key Covid information → https://is.gd/GghCT4 | 12:55 |
| Brainstorm | New from StatNews: Opinion: A monument to our monumental suffering can help America heal from this pandemic: Lanterns can be extinguished. Ceremonies are transient and, in time, forgotten. We need a monument to heal our monumental suffering from Covid-19. We need a monument to never forget. → https://is.gd/lzhVBy | 13:07 |
| Brainstorm | New from Ars Technica: The digital divide is giving American churches hell: Covid-19 has upended churchgoing in the US, and, the impacts are not felt equally. → https://is.gd/K5heTl | 13:19 |
| Brainstorm | New from r/WorldNews: worldnews: UK says it shares U.S. concerns over WHO COVID-19 mission to China → https://is.gd/k0ssoF | 14:21 |
| Brainstorm | New from Reddit (test): COVID19: Natural Mucosal Barriers and COVID-19 in Children → https://is.gd/iseQII | 14:46 |
| CoronaBot | /r/coronavirus: USA 7-day average of cases drops below 100,000 (10078 votes) | https://www.ft.com/content/8d681939-a09c-367a-b984-018ddb78bd18 | https://redd.it/ljg30t | 15:07 |
| Brainstorm | New from r/WorldNews: worldnews: WHO Wuhan mission finds possible signs of wider original outbreak in 2019 → https://is.gd/TyO67f | 15:23 |
| Brainstorm | Updates for Germany: +6190 cases (now 2.3 million), +242 deaths (now 65278) since 23 hours ago | 15:42 |
| Brainstorm | New from r/WorldNews: worldnews: Covid-19: More than 15 million in UK have first vaccine jab → https://is.gd/jpnU0P | 16:13 |
| Brainstorm | New from Reddit (test): China_Flu: Wuhan Lab Got Patents for Bat Cages to Keep Animals, Conduct Experiments Months Before Pandemic: Report → https://is.gd/DuLkQe | 16:26 |
| Brainstorm | New from BBC Health: Covid-19: 'Significant milestone' as 15 million get Covid jab in UK: The PM calls it an "extraordinary feat", reached just over two months after the first vaccine was delivered. → https://is.gd/w2Et6E | 16:39 |
| Pickchea | Hello! I have a question to which I could not find an answer online. How soon after an infection can nasal/throat swab tests detect the disease and what is this time period called? | 16:42 |
| Brainstorm | New from r/WorldNews: worldnews: A top Guinea health official said Sunday that the country has plunged into an Ebola "epidemic situation" with seven cases confirmed in the West African nation, including three deaths → https://is.gd/PEzd0w | 17:05 |
| de-facto[m] | .title https://twitter.com/MoetiTshidi/status/1360855147669299201 | 17:20 |
| Brainstorm | de-facto[m]: From twitter.com: error parsing title ('NoneType' object has no attribute 'string') | 17:20 |
| de-facto[m] | "Very concerned by reports of 4 suspected Ebola deaths in Guinea." | 17:22 |
| de-facto[m] | .title https://www.dw.com/en/guinea-officially-declares-new-ebola-outbreak/a-56562877 | 17:27 |
| Brainstorm | de-facto[m]: From www.dw.com: Guinea officially declares new Ebola outbreak | News | DW | 14.02.2021 | 17:27 |
| CoronaBot | /r/covid19: Natural Mucosal Barriers and COVID-19 in Children (83 votes) | https://www.medrxiv.org/content/10.1101/2021.02.12.21251310v1 | https://redd.it/ljnghp | 17:50 |
| Brainstorm | New from r/WorldNews: worldnews: U.S. 'gravely damaged' coronavirus cooperation, China says as row erupts over WHO probe → https://is.gd/RgGgLE | 17:55 |
| Brainstorm | Updates for United Kingdom: +5038 cases (now 4.0 million), +159 deaths (now 117067) since 13 hours ago | 17:59 |
| Brainstorm | Updates for Italy: +221 deaths (now 93577) since 21 hours ago | 18:17 |
| Brainstorm | New from r/WorldNews: worldnews: China Urged to Release 7 Journalists Who Reported on COVID-19 → https://is.gd/uBsqUO | 18:19 |
| LjL | Or politicians, and the scientists hired by them, are idiots. Until yesterday they were going to open ski resorts... tomorrow. Of course that meant the ski resorts were preparing to open, which is a cost, and even more of a cost now when they had to introduce additional protocols | 18:26 |
| LjL | But NOW the scientific committee said that no, they can't open. Apparently they only look at data from the week before the current one, so they completely ignore any recent trends. | 18:26 |
| LjL | And this scientific adviser to the health minister went on TV to say that he'd lock everything down, "but it's up to politics to decide". Normally if you pull a stunt like that you get fired... | 18:27 |
| LjL | Maximum clarity for everyone, always. No confusion or contradiction at all. | 18:27 |
| Arsanerit | How are the scientists at fault? | 18:28 |
| LjL | Arsanerit: by virtue of having given the go-ahead for ski resorts weeks ago and then ignoring recent data until the last minute...? | 18:29 |
| Arsanerit | Ok. | 18:31 |
| de-facto | a "scientist" giving a go weeks ahead sells his reputation to the lobbyists because afterwards his name is burnt | 18:42 |
| LjL | consider also that the scientific committee that advises the government is made up of 30 people | 18:44 |
| LjL | i can only imagine the confusion | 18:44 |
| LjL | "committees", "task forces", it's all been a lot of that. maybe try something else since it's working pretty shittily and it's not the first time the government tells workers to prepare and then "wait no we were only kidding" | 18:45 |
| LjL | people are upset enough about the economy and closures, this is just adding insult to injury for them. | 18:46 |
| de-facto | also it damages the reputation of "science" (as in the sense of public trust in what they consider the black box of "science") because most would not distinguish between real empirical evidence based scientific claims and the "experts opinion" that is merely based on reputation rather than facts | 18:49 |
| LjL | today in "people who actually exist": https://www.reddit.com/r/worldnews/comments/ljdr1y/fury_at_do_not_resuscitate_notices_given_to_covid/gnczuxz/ | 18:52 |
| de-facto | scientific committees are a very good approach, but their conclusions should be based on empiric data as a metric for the validity of their claims, transparently published so that everyone could confirm their statements (tbh i dont trust the word of anyone, regardless of reputation) | 18:53 |
| de-facto | example: i have seen studies from very reputable Professors of medicine about "no evidence for schools being the driving momentum in the pandemic situation" based on data that was collected in the first wave when schools were closed | 18:55 |
| de-facto | taking that data as a metric for their claims in that example: they are completely invalidated imho. | 18:55 |
| de-facto | the opposite also can be the case though, good representative datasets underlining the claims, or even meta-studies estimating the validity of data and concluding from many studies about a similar situation | 18:58 |
| genera | they should write in Latin | 19:07 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Four people in Oregon who received both doses of vaccine test positive for coronavirus → https://is.gd/AXGq5h | 19:11 |
| tempate | Hello there | 19:32 |
| tempate | I was with someone on Thursday and they just told me they've tested positive | 19:33 |
| tempate | Should I get the test done asap or wait a few days? | 19:33 |
| pigpigxiu | 5 days is usual onset for Sx , where and how long were you 'with them' | 19:35 |
| pigpigxiu | tempate: | 19:36 |
| tempate | pigpigxiu: let's just say we were together indoors for quite a while | 19:36 |
| pigpigxiu | they tested positive with a PCR test? | 19:37 |
| tempate | I believe so, yes | 19:37 |
| LjL | https://np.reddit.com/r/COVID19/comments/liyx8z/physical_phenotype_of_blood_cells_is_altered_in/gna6p0y/ | 19:40 |
| pigpigxiu | i believe your supposed to self isolate 10-14 and/or be tested | 19:40 |
| tempate | so it'll probably be a good idea to do a PCR tomorrow morning, right? | 19:41 |
| LjL | you may not immediately test positive, but while 5 days is the average for onset of symptoms, the *test* should be positive sooner than that | 19:41 |
| tempate | oh, alright | 19:42 |
| LjL | yeah get tested | 19:42 |
| LjL | but also inform yourself on what you're supposed to be doing | 19:42 |
| LjL | don't just strand into a hospital, obviously | 19:42 |
| LjL | but every place has its own procedures | 19:43 |
| tempate | yeah, alright | 19:43 |
| tempate | thanks for the help | 19:43 |
| LjL | someone "published" a criticism to yesterday's calcifediol paper https://github.com/GShotwell/vitamin_d_covid/pull/24/commits/c56a129516d94d71a11b44ba086d9cf40c1af680 | 19:45 |
| Brainstorm | New from r/WorldNews: worldnews: If World Manages to Conquer Covid, It Will Be Because of India: Canadian PM Justin Trudeau → https://is.gd/VI8kmR | 19:49 |
| tempate | should I take a PCR or the blood thing? | 19:54 |
| Brainstorm | New from NPR: New Zealand City Goes Back Into Lockdown After New Coronavirus Cases Detected: Most residents of Auckland are asked to stay home for three days while health officials determine the source of the virus, and test for community spread. The rest of the country is on high alert. → https://is.gd/RfVBse | 20:02 |
| de-facto | PCR | 20:21 |
| Brainstorm | New from r/WorldNews: worldnews: Guinea declares Ebola epidemic: First deaths since 2016 → https://is.gd/rHMF6t | 20:52 |
| LjL | tempate, the blood things are (mostly) antibody tests. antibodies only form, or become detectable anyway, after several days | 21:13 |
| LjL | get a PCR test | 21:13 |
| LjL | let us know | 21:14 |
| tempate | well, the thing is that the someone I was with on Thursday tested positive on a blood test | 21:27 |
| tempate | I'm even wondering if they just have anti-bodies or something | 21:27 |
| Brainstorm | New from r/WorldNews: worldnews: Serbia donates Pfizer COVID-19 vaccines to North Macedonia → https://is.gd/yLDzPn | 21:41 |
| Brainstorm | Updates for France: +12870 cases (now 3.5 million) since 23 hours ago — Germany: +5133 cases (now 2.3 million), +231 deaths (now 65328) since 23 hours ago — Canada: +2337 cases (now 826256), +50 deaths (now 21257) since 23 hours ago | 22:07 |
| Brainstorm | New from r/WorldNews: worldnews: Mexico gets AstraZeneca COVID vaccine shipment from India → https://is.gd/LYYxJh | 22:18 |
| CoronaBot | /r/covid19: COVID-19-related symptoms 6 months after the infection - Update on a prospective cohort study in Germany (80 votes) | https://www.medrxiv.org/content/10.1101/2021.02.12.21251619v1 | https://redd.it/ljnfz2 | 22:34 |
| Brainstorm | New from Medical Xpress: UK hits target: Gives at least 1 vaccine shot to 15 million: The U.K. announced Sunday that it had reached its goal of giving at least one COVID-19 vaccine shot to the most vulnerable people in the country, increasing pressure on ministers to clarify when they will ease a lockdown imposed in early January. → https://is.gd/FNck20 | 22:43 |
| de-facto | .title https://virological.org/t/the-emergence-and-ongoing-convergent-evolution-of-the-n501y-lineages-coincided-with-a-major-global-shift-in-the-sars-cov-2-selective-landscape/618 | 22:56 |
| Brainstorm | de-facto: From virological.org: The emergence and ongoing convergent evolution of the N501Y lineages coincided with a major global shift in the SARS-Cov-2 selective landscape - SARS-CoV-2 Molecular Evolution - Virological | 22:56 |
| LjL | tempate, unless they were feeling sick recently, you really have no way to know | 22:58 |
| tempate | oh really? | 22:59 |
| CoronaBot | /r/covid19: NERVTAG update note on B.1.1.7 severity (80 votes) | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/961042/S1095_NERVTAG_update_note_on_B.1.1.7_severity_20210211.pdf | https://redd.it/lj87yu | 23:04 |
| Brainstorm | New from Medical Xpress: UK's virus jabs pass 15 mn, as New Zealand orders city lockdown: Britain's coronavirus vaccination programme passed the 15 million mark on Sunday, hours after New Zealand, so far largely spared by the pandemic, ordered its largest city into lockdown. → https://is.gd/iDpyBQ | 23:08 |
| LjL | tempate, well, if you can get them to get a PCR test too, that might be useful, but really even if that turned out negative you should still get tested | 23:56 |
| LjL | uh oh NERVTAG update | 23:56 |
| LjL | well, i'd say it looks pretty established now that the variant has higher severity | 23:57 |
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