| LjL | gigas_cedar: a "call" is one thing, actually having it, or even it actually being possible to have such a vaccine, is quite another | 00:14 |
|---|---|---|
| Brainstorm | New from The Atlantic: Every Major COVID-19 Indicator Has Been Falling for Weeks Now: Editor’s Note: The Atlantic is making vital coverage of the coronavirus available to all readers. Find the collection here . → https://is.gd/29Jbge | 00:24 |
| Brainstorm | New from The Lancet (Online): [Correspondence] Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients: In December, 2020, the Israeli Government approved the BNT162b2 COVID-19 vaccine and initiated a national immunisation campaign prioritising health-care workers (HCWs), as in other countries.1 This campaign coincided [... want %more?] → https://is.gd/Hu5szn | 00:37 |
| * gnos calls for an end to all disease | 00:49 | |
| gnos | huzzah! | 00:49 |
| LjL | gnos: are you... the WHO?! | 01:02 |
| Brainstorm | Updates for Germany: +9849 cases (now 2.4 million), +473 deaths (now 67547) since 23 hours ago — Canada: +2799 cases (now 838065), +55 deaths (now 21490) since 23 hours ago — United Kingdom: +9303 cases (now 4.1 million), +454 deaths (now 119387) since 20 hours ago — Switzerland: +14 deaths (now 9876) since 9 hours ago | 01:04 |
| Brainstorm | New from BBC Health: Covid: Health workers appeal to PM for better personal protection: In a letter, 20 organisations say measures to tackle airborne spread of coronavirus are "inadequate". → https://is.gd/LZvxHe | 01:14 |
| Brainstorm | Updates for Netherlands: +3981 cases (now 1.0 million), +80 deaths (now 15114) since 23 hours ago — Botswana: +722 cases (now 26524), +28 deaths (now 254) since 2 days ago | 01:16 |
| de-facto | NASA Perseverance successfully landed on MARS https://mars.nasa.gov/mars2020/ https://mars.nasa.gov/mars2020/mission/where-is-the-rover/ https://i.imgur.com/vT43qDS.png https://i.imgur.com/ZuWT7I7.png https://i.imgur.com/Rzv8sWf.png https://i.imgur.com/WhB2Mx1.png https://mars.nasa.gov/mars2020/multimedia/raw-images/ it had a COVID symbol https://i.imgur.com/AEeSen3.png on its outside https://i.imgur.com/CFqDirZ.png | 01:28 |
| de-facto | https://www.facebook.com/ExploreMarswithPerseveranceRover/photos/pb.108335084435735.-2207520000../117801513489092/ | 01:30 |
| LjL | Err, how is that a symbol of COVID? | 01:32 |
| de-facto | "The rover team wanted to recognize the challenges faced by the global community and honor the many healthcare workers who have risked their lives to help those affected by the pandemic." | 01:32 |
| de-facto | "A special aluminum plate on the rover's left side bears an image of planet Earth supported by the Rod of Asclepius, an ancient Greek symbol displaying a snake-entwined rod to symbolize healing and medicine." | 01:33 |
| de-facto | https://en.wikipedia.org/wiki/Rod_of_Asclepius | 01:33 |
| de-facto | so any future exploration finding the rover Perseverance on Mars will see that the earth (as origin of it) was dealing with a medical challenge at the time of its launch | 01:34 |
| LjL | Well it's a symbol of medicine, not a symbol of COVID, I mean I know what it is but doesn't calling it a "COVID symbol" kinda defeat the whole point it tries to make i.e. saluting the doctors, certainly not the virus? :P but maybe I'm just sticking to words too much | 01:36 |
| de-facto | yeah as they state in that fb text they want to honor all the people dealing with the medical crisis (from SARS-CoV-2 pandemic causing COVID) | 01:37 |
| LjL | Let's just hope no SARS-COV-2 got stuck to the walls of the rover :P | 01:38 |
| LjL | (Actually they do have protocols to deal with such possibilities) | 01:39 |
| de-facto | well unlike bacteria it could not replicate without the help of living cells, so it just would deteriorate | 01:39 |
| de-facto | (and yes they have very strict protocols to prevent contamination since one of their goals is to search for live on mars) | 01:40 |
| de-facto | Life on Mars ofc :) | 01:41 |
| gnos | i wish they would pick a spot in space and actually try to introduce life there | 01:41 |
| gnos | like on a moon or somethin | 01:41 |
| LjL | Any spot where life has a real chance to thrive would be a spot where life might already exist, so they really should make very sure they don't destroy existing life when they so that | 01:43 |
| gnos | tru | 01:43 |
| de-facto | well it would be very important to become a multi-planetary species especially since we now know how difficult it seems to be to contain a pathogen from spreading over a whole planet | 01:43 |
| gnos | lets try the moon | 01:44 |
| gnos | our moon | 01:44 |
| gnos | no life there is there | 01:44 |
| de-facto | there probably are plans for that indeed | 01:44 |
| gnos | zero water tho | 01:44 |
| gnos | there needs to be water id say | 01:44 |
| gnos | so nevermind. but maybe we could bring some water there and grow some bacteria on the surface of the moon that would be cool | 01:45 |
| gnos | but not as cool as a self sustaining population of bacteria on a moon or planet that would be something. but yeah gotta look for it first | 01:46 |
| LjL | Here is water (ice) on the moon | 01:47 |
| LjL | There* | 01:47 |
| gnos | so maybe its possible then | 01:47 |
| de-facto | i would even go as far as stating: its our duty to spread life to other celestial bodies and make it self-persistent on other planets, simply because at some point we cant deny anymore that its in our capabilities | 01:49 |
| de-facto | humanity not only faces medical challenges such as planet wide pandemics, there are also threads by asteroids etc | 01:51 |
| LjL | I say let's try to fix the mess we've made on this planet instead of saying we can go somewhere else. I would like humans to expand to other places in the universe when/after they learn to cooperate with nature in a way that is not so detrimental. Otherwise, no thanks, we don't need to be the destroyers of the universe, we're doing enough damage in one place. | 01:51 |
| Brainstorm | New from Reddit (test): Covid2019: Damage to the heart found in more than half of COVID-19 patients discharged from hospital → https://is.gd/FWWEvb | 01:51 |
| LjL | Talking about duty seems a bit far-fetched. Sounds like certain people say we have a duty to procreate. I don't have a duty to procreate. We may certainly have an instinct for it, but since we do, there's no need to reinforce it with restrictive societal rules or taboos. | 01:52 |
| de-facto | i agree we of course should focus on re-balance for an equilibrium with nature (because that where we currently do damage and also ignore threads such as zoonosis etc.), yet i still think if we might have a certain capability to do good (e.g. redundancy of life from earth, without destroying other life if it would exist) we have some duty to at least try out best with our chances, not only for humans but for all species and biodiversity | 01:55 |
| LjL | Anyway I don't understand in the article Brainstorm just linked whether it's saying that they *selected* patients with elevated troponin levels, or they took a random sample of hospitalized patients and they *found* that they all had raised troponin | 01:55 |
| de-facto | yeah good question | 01:56 |
| de-facto | what portion of those released from severe COVID from hospital had raised troponin levels | 01:57 |
| de-facto | and if so why was their troponin levels raised if only 50% of them showed heart damage | 01:58 |
| de-facto | that article does not make much sense there | 01:58 |
| LjL | if only it linked to the actual study... (i think i've said these words before) | 02:00 |
| de-facto | oh gosh Oxford uni press :/ | 02:02 |
| de-facto | .title https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehab075/6140994 | 02:03 |
| Brainstorm | de-facto: From academic.oup.com: Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance | European Heart Journal | Oxford Academic | 02:03 |
| LjL | de-facto, i've stolen some of your words for commenting on reddit about that post | 02:03 |
| de-facto | .title https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916 | 02:03 |
| Brainstorm | de-facto: From jamanetwork.com: Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) | Cardiology | JAMA Cardiology | JAMA Network | 02:03 |
| LjL | de-facto, the abstract there makes it sound like they *selected* ones with elevated troponin | 02:04 |
| Brainstorm | New from Virology.ws: SARS-like bat coronaviruses are not only in China: It is well past the time to stop blaming a laboratory in China for the release of SARS-CoV-2. Such fallacies reflect an ignorance of scientific facts, including the recent finding of closely related coronaviruses in bats in Thailand. The bat CoV RatG13, sampled in 2013 in Yunnan [... want %more?] → https://is.gd/qXXpen | 02:04 |
| LjL | i think i remember that other study, de-facto. wasn't it also sort of debunked, though? | 02:04 |
| LjL | and are they related, apart from being on a similar subject? | 02:04 |
| LjL | also what's wrong woth Oxford press? | 02:05 |
| de-facto | its what they have linked below their article there | 02:05 |
| de-facto | Oxford press links always dont work for me idk why | 02:05 |
| LjL | oh | 02:05 |
| LjL | so i lied on reddit in saying they didn't link | 02:06 |
| LjL | whoops | 02:06 |
| LjL | well, they linked to a DOI that doesn't work | 02:06 |
| LjL | doesn't work yet*, supposedly | 02:06 |
| LjL | better than nothing | 02:06 |
| LjL | but the JAMA one is an older study | 02:06 |
| de-facto | yeah | 02:07 |
| LjL | https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehab075/6140994 ← even if you click on the doi linked here, instead of taking you... back to the study itself, it points to an "in progress" PDF, lol | 02:07 |
| de-facto | i think the broken Oxford DOI is the article i linked instead of it above | 02:08 |
| de-facto | yeah they messed their links up | 02:08 |
| LjL | figure 1 makes it look like a *heavy* selection of hospitalized patients, quite unlike what it suggests in the article | 02:08 |
| LjL | out of 1888 patients, 1068 simply didn't have raised troponin, or it wasn't measured, so they were discounted (which answers my question) | 02:09 |
| LjL | but then of the remaining 820, 441 were discounted as "inappropriate" | 02:09 |
| de-facto | weird its going to get much warmer in EU, early spring in Feb? Maybe thats good for seasonality of COVID transmission? | 02:24 |
| LjL | i never believed in seasonality so much, but let's hope so, since with all these variants and a hectic vaccine rollout (to say the least), i have lost track of what to hope for | 02:26 |
| de-facto | .title https://science.sciencemag.org/content/371/6531/759 this is an interesting proposal to combine efforts for an universal CoV vaccine | 02:43 |
| Brainstorm | de-facto: From science.sciencemag.org: A universal coronavirus vaccine | Science | 02:43 |
| de-facto | actually it would make a lot of sense to establish a safe and agile vaccine platform ready to react and produce very fast at very high rates the newest antigens known from surveillance | 02:50 |
| de-facto | hence going from building this for SARS-CoV-2 VOCs a low latency updating closed feedback loop from sequencing surveillance and making that more and more universal for all sorts of CoVs | 02:51 |
| ubLIX | some predictioneering: https://astralcodexten.substack.com/p/coronavirus-links-discussion-open | 03:40 |
| ubLIX | nothing astonishing but it does end with "Prediction: 50% chance that sometime in 2021, the FDA grants a pharmaceutical company general approval for coronavirus vaccines which can adapt to changing virus strains without going through the entire FDA approval process again, and ..." | 03:40 |
| ubLIX | predictably, the first in the comment thread begins: "It's a little far out to be speculating about this but I wonder what the unintended consequences of fast-tracking regulatory approval for more modular vaccine platforms will be." | 03:41 |
| LjL | ubLIX, where are the good vaccine betting sites | 03:51 |
| LjL | but meanwhile, i won't even link to the article because it's just three sentences, so here are the sentences | 03:51 |
| LjL | TOKYO - Japanese health authorities have found more than 90 cases of a new strain of the COVID-19 virus, the Mainichi newspaper reported on Friday. | 03:51 |
| LjL | The variant is believed to have come from overseas but is different from strains that originated in Britain and South Africa, according to the report which cited Japan's National Institute of Infectious Diseases. | 03:51 |
| de-facto | If i remember correctly PEI (responsible for vaccine and bioproducts approval in Germany) was asked about the approval process for new updates and they said something like it would not have to go through the full process but only revalidate those parts that changed (whatever that exactly means) | 03:55 |
| ubLIX | betting, of sorts: https://www.metaculus.com/questions/ | 03:56 |
| ubLIX | not sure that's what you meant, though | 03:56 |
| de-facto | hence when they only change one or two amino acids on the s-protein antigen the approval process should be possible in much less time i guess | 03:56 |
| de-facto | i mean thats how they do it for influenza vaccines too, they have an approved platform and do updates to it every year | 03:58 |
| LjL | ubLIX, well, it's as close to what i meant as possible while still being accessible from Italy, i guess, given our nice, totally not censor-y, block of foreign betting sites | 03:58 |
| LjL | that sounds like a good question - how is it done with influenza | 03:59 |
| LjL | are there human trials at all, even small ones, before delivering the year's vaccine out to people | 03:59 |
| de-facto | i dont know but its an established process for updates that was optimized for decades | 04:00 |
| de-facto | so its nothing completely new to do frequently small updates to the antigen contained in a vaccination platform | 04:01 |
| de-facto | sure, the influenza vaccines are a completely different platform for a completely different pathogen, yet still the general process and pipeline should not be too different from what we need for CoVs, right? | 04:02 |
| LjL | i can hardly say i know | 04:02 |
| de-facto | they do some screening (probably at the origin of new waves in Asia), then there are predictions and from them recommendations (e.g. from RKI) which strains to include in the annual updated influenza vaccines (some with 3 variants others with 4 variants) and they go for producing them (afaik in chicken eggs). How they approve each update? i am not sure | 04:04 |
| ubLIX | in the astralcodex link above, he remarks that safety testing is much easier (faster?) than testing for efficacy, so that skipping on the efficacy tests might be a strategy to help speed things | 04:06 |
| de-facto | yet there might be an additional difference for ongoing vaccinations: immune reactions against the vaccine platform itself (apart from the desired immune reaction against the updated variant of the antigen) | 04:09 |
| Brainstorm | Updates for Paraguay: +1369 cases (now 148622), +17 deaths (now 3008) since a day ago — France: +16918 cases (now 3.6 million), +203 deaths (now 83400) since 19 hours ago — United Kingdom: +9054 cases (now 4.1 million) since 19 hours ago — Cameroon: +1651 cases (now 33749), +44 deaths (now 523) since 6 days ago | 04:10 |
| de-facto | what if Adenovirus vectors "burned" because the immune system attacks them prior to them being able to infect enough cells to produce the antigen? | 04:10 |
| LjL | what if, and i'm making a huge leap of imagination here, it turned out that mRNA vaccines are superior to adenovirus ones for that and other reasons | 04:11 |
| de-facto | what if the allergic reactions against the lipids in the LNPs from the mRNA vaccines go more violent each time the immune system is presented with those? | 04:11 |
| LjL | i hope not, but the allergic reactions so far have seemed very rare | 04:11 |
| LjL | have seemed? have seemed to be, whatever | 04:11 |
| de-facto | some speculated that only the ones being (internally) exposed before to PEG develop those allergic reactions | 04:12 |
| LjL | i do realize allergies often involve a process of sensitivization, although i don't really know how it all happens | 04:12 |
| de-facto | then the platforms themselves would also have to be updated to prevent those immune reactions against the "messenger" | 04:12 |
| LjL | but then we would likely be witnessing anaphylaxis cases with the booster shot that didn't have issues with the first shot. have we? | 04:13 |
| LjL | also, what ballpark adenoviruses do we have that are sufficiently different from each other to be used effectively in vaccines? | 04:13 |
| de-facto | good question, afaik the adverse effects for booster are more intense than for the primer in those mRNA vaccines | 04:13 |
| de-facto | yeah idk how many Adenovirus vectors there are, different enough from each others to assume a naive immune reaction to their first presence | 04:14 |
| de-facto | i mean, maybe there is no problem at all, but maybe its not as easy as only updating the antigen recipe and invite people for an update shot | 04:15 |
| de-facto | something that would not happen with an attenuated "original" SARS-CoV-2 vaccine | 04:16 |
| Brainstorm | New from The Indian Express: World: Study in Israel shows Pfizer vaccine 85% effective after first dose – The Lancet → https://is.gd/62u6tQ | 04:19 |
| de-facto | i guess it should be investigated to: 1) update the antigen recipes by sequencing feedback of current VOCs 2) update an arsenal of Adenovirus vectors to have sequence of different delivery viruses 3) find out more about the allergic reactions in the mRNA platforms and update their LNPs (and maybe even modRNA) accordingly 4) investigate more about the possibility to safely attenuate SARS-CoV-2 itself by changing its RNA sequence (codon | 04:24 |
| de-facto | de-optimization and/or deleting parts of its sequence etc) | 04:24 |
| de-facto | ooh LjL look Israel also predicts 85% effective protection after first dose | 04:28 |
| de-facto | citing myself on 2021-01-19 "in placebo we would have 82-47 = 35 and in vaccinated ~4 group between 12 days after 1st dose and date of 2nd dose (21 days after 1st dose) hence VE = ((35/21686) - (4/21669)) / (35/21686) = 0.885625 or ~86%" | 04:29 |
| de-facto | .title https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00448-7/fulltext | 04:31 |
| Brainstorm | de-facto: From www.thelancet.com: Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients - The Lancet | 04:31 |
| de-facto | so i was 1% off with my prediction a month ago | 04:31 |
| de-facto | "Adjusted rate reductions of COVID-19 disease were 47% (95% CI 17–66) and 85% (71–92) for days 1–14 and days 15–28 after the first dose, respectively." | 04:33 |
| LjL | de-facto, i never look at the exact numbers because my maths are bad, but i'm sure it's fairly effective even with just one dose. but for how long? i still think "sticking to the label" (i.e. what the trials did) is the right thing to do, but i do see all the arguments for a more "flexible" use... which boil down to "we're pretty desperate" | 04:40 |
| de-facto | oh i very much agree to that, we must stick to the trials and do the primer and booster shots exactly as we know the predictions from the trials | 04:49 |
| de-facto | it was just for estimating how effective the early protection from 14 days after the first shot might be to the second shot at day 21 | 04:50 |
| LjL | by the way, the WHO has a statement on Europe, in the unlikely case anyone cares | 04:51 |
| LjL | <Brainstorm> New from WHO News: Overcoming COVID-19 and its collateral effects: Copenhagen, 18 February 2021, Dr Hans Henri P. Kluge, WHO Regional Director for Europe: What matters now, is how we respond to positive epidemiological trends. → https://is.gd/OKeyiZ | 04:51 |
| Brainstorm | New from The Indian Express: World: Harris taps growing political power of women lawmakers to promote U.S. COVID-19 relief → https://is.gd/vpAzz9 | 05:33 |
| Brainstorm | New from r/WorldNews: worldnews: Researchers urge delaying Pfizer vaccine's second dose as first highly effective → https://is.gd/7LWgJR | 05:57 |
| Brainstorm | New from The Lancet (Online): [Comment] Ending the HIV epidemic in US Latinx sexual and gender minorities: A focus of the US Ending the HIV Epidemic (EHE) initiative in 2019 was the 57 geographical areas with a high burden of new HIV diagnoses.1 Yet the most vulnerable populations are not usually well represented in the activities to implement this [... want %more?] → https://is.gd/0rNq26 | 06:10 |
| Brainstorm | New from r/WorldNews: worldnews: China Says US Lab Fort Detrick Could Be COVID-19 Origin; Claims Explode On Chinese Twitter → https://is.gd/NZZxBk | 06:23 |
| Brainstorm | Updates for New Zealand: +4 cases (now 2348) since a day ago | 06:45 |
| Brainstorm | New preprint: Evaluation of a fully automated high-throughput SARS-CoV-2 multiplex qPCR assay with build-in screening functionality for DelHV69/70- and N501Y variants such as B.1.1.7 by Dominik Nörz et al, made available as preprint on 2021-02-18 at https://medrxiv.org/cgi/content/short/2021.02.12.21251614 [... want %more?] | 06:57 |
| CoronaBot | /r/coronavirus: A U.S. Vaccine Surge Is Coming, With Millions of Doses Promised (10016 votes) | https://www.bloomberg.com/news/articles/2021-02-18/how-many-vaccine-doses-are-available-u-s-should-see-a-surge?srnd=premium | https://redd.it/lmwb6t | 07:38 |
| Brainstorm | Updates for Ivano-Frankivsk Oblast, Ukraine: +799 cases (now 57299), +10 deaths (now 1077) since 22 hours ago — Vinnytsia Oblast, Ukraine: +514 cases (now 31194), +9 deaths (now 596) since 22 hours ago — Zakarpattia Oblast, Ukraine: +500 cases (now 36102), +10 deaths (now 822) since 22 hours ago — France: +22548 cases (now 3.6 million), +271 deaths (now 83468) since 22 hours ago | 07:41 |
| Brainstorm | New from The Indian Express: World: Biden to pledge $4 billion to COVAX vaccine program at G7 meeting Friday → https://is.gd/Qv0gXe | 08:14 |
| whytek | https://www.irishtimes.com/news/health/covid-19-strikes-wicklow-nursing-home-days-before-second-vaccine-dose-1.4488873 | 08:20 |
| whytek | So, according to that article, the 1st dose is "52% effective" | 08:21 |
| whytek | after ~12 days | 08:22 |
| gigas_cedar | wow whytek | 08:22 |
| gigas_cedar | some ppl think they're invincible after first dose | 08:23 |
| whytek | and given that this place had it's 2nd dose due in "days.." after the "outbreak" one might assume that the 1st dose was at least 20 days old | 08:23 |
| whytek | WHat's a little annoying is shitty "journalism" like this, and also, why don't they just state the data? | 08:24 |
| whytek | Give numbers instead of letting the press write "outbreak" | 08:25 |
| whytek | And just giver up the data on dates as well. | 08:25 |
| whytek | Otherwise it just sounds like hiding things. | 08:25 |
| whytek | Oh dear, they are going to reopen schools in Ireland. That might not be such a great idea. | 08:27 |
| whytek | in a couple of weeks... | 08:28 |
| Brainstorm | New from r/WorldNews: worldnews: Florida county commissioner limited vaccine drive to the two richest zip codes and then created a 'VIP list' → https://is.gd/RNcyLH | 08:38 |
| CoronaBot | /r/covid19: Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double-blind, dose-response study in Lagos (80 votes) | https://academic.oup.com/qjmed/advance-article/doi/10.1093/qjmed/hcab035/6143037 | https://redd.it/lmvlra | 08:56 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | February 19, 2021: The World Health Organization maintains up-to-date and global information. Please refer to our Wiki for additional information. You can find answers to frequently asked questions about Covid-19 and vaccines in our FAQ . → https://is.gd/WCE8ff | 09:03 |
| gigas_cedar | yeah it's not great journalism but we get the point whytek | 09:12 |
| Brainstorm | New from The Indian Express: World: 2.5 million women left the workforce during the pandemic. Kamala Harris sees a ‘national emergency’ → https://is.gd/268iQW | 09:27 |
| Brainstorm | New from r/WorldNews: worldnews: Covid vaccines: Macron proposes sending 4-5% of doses to poorer nations → https://is.gd/a3Yyph | 10:04 |
| Brainstorm | New from BBC Health: (news): Covid vaccines: Boris Johnson pledges surplus to poorer countries at G7 → https://is.gd/VqPzlo | 10:28 |
| Brainstorm | New from StatNews: To get ahead of variants, Covid-19 drug makers use evolutionary biology as a guide: The same evolutionary forces that nudged the coronavirus to become less susceptible to certain treatments can be used to our advantage as well, guiding ongoing development of better antibody drugs. → https://is.gd/4srS1v | 10:41 |
| Brainstorm | New from StatNews: Opinion: The effect of Covid-19 vaccines will — finally — be tested in pregnant people like me: Choosing to be vaccinated against Covid-19 without an affirmative recommendation to do so made me feel vulnerable, not protected. But it doesn't have to be that way for others. → https://is.gd/4T1IaR | 11:02 |
| Brainstorm | New from BMJ: Prophylactic anticoagulation for patients in hospital with covid-19: Most people with covid-19 have mild disease, but after 5-10 days an important minority develop pneumonia and require hospital admission to treat hypoxia. This group is in a marked prothrombotic state... → https://is.gd/dO7K8v | 11:31 |
| Brainstorm | New from Reddit (test): CoronavirusUK: After 4 weeks of having no smell and little taste, my daughters disgusting nappy finally broke through the covid nose. Never been so happy to smell shit 🥳🎉 → https://is.gd/tbtZ3Q | 11:43 |
| Brainstorm | New from The Indian Express: World: Japan reports new variant of COVID-19 → https://is.gd/W34EG6 | 12:30 |
| Brainstorm | New from ECDC: Data on 14-day notification rate of new COVID-19 cases and deaths: These files contain data on the 14-day notification rate of newly reported COVID-19 cases per 100 000 population and 14-day notification rate of reported deaths per million population by week and country, in EU/EEA and the UK. Each row contains the corresponding data for [... want %more?] → https://is.gd/cALMTg | 12:54 |
| Brainstorm | Updates for Germany: +8701 cases (now 2.4 million) since 22 hours ago | 13:22 |
| CoronaBot | /r/covid19: Novavax Announces Memorandum of Understanding with Gavi for Cumulative Supply to COVAX Facility of 1.1 Billion Doses of COVID-19 Vaccine (80 votes) | https://ir.novavax.com/news-releases/news-release-details/novavax-announces-memorandum-understanding-gavi-cumulative | https://redd.it/lmyg8b | 13:34 |
| Brainstorm | New from Retraction Watch: Widely shared vitamin D-COVID-19 preprint removed from Lancet server: A preprint promoted by a member of the UK Parliament for claiming to show that vitamin D led to an “80% reduction in need for ICU and a 60% reduction in deaths” has been removed from a server used by The Lancet family of journals. The preprint, [... want %more?] → https://is.gd/9a8J8c | 14:47 |
| Brainstorm | New from BBC Health: Covid vaccine passports could discriminate, experts warn: They are 'feasible' but need to meet 12 tests before being brought in, the Royal Society says. → https://is.gd/cK4Cys | 15:12 |
| CoronaBot | /r/covid19: The different types of COVID-19 vaccines (84 votes) | https://www.who.int/news-room/feature-stories/detail/the-race-for-a-covid-19-vaccine-explained | https://redd.it/lnbza3 | 15:17 |
| Brainstorm | New from Medical Xpress: Fears loom for teens undergoing vital brain development during COVID—telling stories might help: "At the end of the war men returned from the battlefield grown silent—not richer, but poorer in communicable experience", wrote Walter Benjamin after the first world war. So too, school students may reflect on the pandemic of [... want %more?] → https://is.gd/UXOuML | 15:47 |
| Brainstorm | New from The Lancet (Online): [Articles] Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials: The results of this primary analysis of two doses of ChAdOx1 nCoV-19 were consistent with those seen in the interim [... want %more?] → https://is.gd/UE3vSz | 16:11 |
| Brainstorm | New from BMJ: Covid-19: Ethnicity vaccination gap narrows in England, but concerns remain: The gap between the number of black people and white people vaccinated against covid-19 in England has slightly narrowed in the past few weeks, although it is still a concern and requires attention,... → https://is.gd/bttXAb | 16:36 |
| Brainstorm | New from Medical Xpress: BioNTech/Pfizer say vaccine can stand warmer temperatures: Germany's BioNTech and its US partner Pfizer on Friday said tests have shown that their coronavirus vaccine can stand warmer temperatures than initially thought, potentially simplifying the jab's complex cold-chain logistics. → https://is.gd/Erqx47 | 16:48 |
| CoronaBot | /r/covid19: Pfizer and BioNTech Submit COVID-19 Vaccine Stability Data at Standard Freeze Temperature to the U.S. FDA (81 votes) | https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-submit-covid-19-vaccine-stability-data | https://redd.it/lngp4r | 16:59 |
| Brainstorm | New from r/WorldNews: worldnews: Pfizer says vaccine can be stored in normal freezers → https://is.gd/6xerCt | 17:25 |
| LjL | well it would be helpful if hey had said it sooner maybe? :\ | 18:04 |
| LjL | "Pfizer submitted data to the Food and Drug Administration (FDA) showing the vaccine is stable when stored between minus 13 degrees and 5 degrees Fahrenheit, temperatures commonly found in pharmaceutical freezers and refrigerators." | 18:05 |
| LjL | that's... quite a difference | 18:05 |
| LjL | the first comment on reddit reasonably says that there's only one way to find out: test, and it takes time | 18:06 |
| LjL | and, granted, understandable. but still, dammit, we've made such a big fuss about the need to preserve at -80°C and how logistically difficult that can be... and now we can use a cranked up fridge | 18:06 |
| LjL | but i shouldn't be so negative. hey, good news! we can use normal freezers! | 18:08 |
| Brainstorm | New from In The Pipeline: How Antidepressants Work, At Last?: Over the years I’ve very much enjoyed being startled by the scientific literature, and there haven’t been many times when I’ve been more surprised than I was this morning. I’ve been making references on this blog for years about how we don’t even know how antidepressants work, but [... want %more?] → https://is.gd/5VDPc1 | 18:10 |
| bin_bash | LjL: they had to prove it first | 18:29 |
| bin_bash | it would be catastrophic if they said it was fine and then it turned out it wasn't | 18:29 |
| bin_bash | similar to the measles vaccine scandal in the 80s | 18:30 |
| Brainstorm | New from BMJ: Covid-19: Hancock’s failure to publish contracts was unlawful: The UK government acted unlawfully in failing to publish details of dozens of contracts awarded without competition for goods and services such as personal protective equipment (PPE) needed during... → https://is.gd/HXcaSJ | 18:46 |
| Brainstorm | Updates for Italy: +15470 cases (now 2.8 million), +348 deaths (now 95235) since a day ago — United Kingdom: +12000 cases (now 4.1 million), +431 deaths (now 119818) since 17 hours ago — Germany: +7914 cases (now 2.4 million) since 23 hours ago — Switzerland: +1021 cases (now 547775), +5 deaths (now 9880) since 21 hours ago | 18:58 |
| Brainstorm | New from Medical Xpress: Battered by winter storms, U.S. vaccine rollout to redouble efforts next week: (HealthDay)—After a week of brutal winter storms that stalled the country's coronavirus vaccination rollout, U.S. health officials said Thursday that vaccination efforts will have to ramp up rapidly as soon as the bad weather ends. → https://is.gd/s71yUN | 19:11 |
| -RSSBot[LjLmatrix- Feed: Il Presidente Draghi alla riunione dei leader del G7 ( http://www.governo.it/it/articolo/il-presidente-draghi-alla-riunione-dei-leader-del-g7/16248 ) | 19:25 | |
| Brainstorm | New from Ars Technica: Science: It took a year, but Gwyneth Paltrow figured out how to exploit the pandemic → https://is.gd/RcRQVk | 19:59 |
| rmonten[m] | Maybe this has been asked & answered here before, but is there any logic to the naming of coronavirus lineages (variants)? Do the numbers B.1.1.7 ("UK variant"), B.1.153 ("South African variant"), P1 or B.1.1.28.1 ("Brazilian variant") mean anything? Wikipedia and nextstrain don't seem to use these names, but the media certainly do. | 20:14 |
| genera | wikipedia at least mentions that there are several institute inventing names | 20:16 |
| genera | https://en.wikipedia.org/w/index.php?title=Variants_of_SARS-CoV-2 | 20:17 |
| LjL | rmonten[m], those B names are, i believe, so-called PANGOLIN name | 20:17 |
| LjL | i believe PANGOLIN is a framework for working with genomes | 20:18 |
| LjL | https://github.com/cov-lineages/pangolin https://pangolin.cog-uk.io/ | 20:18 |
| LjL | also https://cov-lineages.org/ | 20:19 |
| -RSSBot[LjLmatrix- Feed: Concorso per titoli ed esami, a 40 posti di Referendario di T.A.R. - anno 2021 ( http://www.governo.it/it/articolo/concorso-titoli-ed-esami-40-posti-di-referendario-di-tar-anno-2021/16249 ) | 20:20 | |
| rmonten[m] | Ok, thanks! So the names are not pulled out of thin air, but they're also not really based on the underlying mutations | 20:20 |
| rmonten[m] | Oh cool, apparently there is some logic to it. There's a footnote to a graph here: https://cov-lineages.org/pango_lineages.html | 20:22 |
| rmonten[m] | "Note that C.1 is equivalent to B.1.1.1.1, with C being an alias for B.1.1.1 to shorten the name so it does not become infinitely long while still preserving the link to the parent lineages" | 20:22 |
| LjL | rmonten[m], no, it's probably more a tree kind of thing, but i don't know how exactly they are assigned | 20:22 |
| LjL | non-infinitely-long names seems like a useful property | 20:23 |
| rmonten[m] | So the lineages are indeed identified based on their evolutionary tree and shortcuts are arbitrarily introduced along the way | 20:23 |
| rmonten[m] | LjL: still countable though ;-) | 20:23 |
| LjL | these names are probably gaining ground because 1) they are easier than "VOC-whatever" especially since that's apparently a UK-specific term 2) many people now work with PANGOLIN so that's what they converge on | 20:25 |
| LjL | i'm kinda just guessing | 20:25 |
| rmonten[m] | Right, makes sense | 20:25 |
| rmonten[m] | That leaves "P.1" to be explained though | 20:25 |
| Brainstorm | New from Virological.org: Latest posts: Preliminary in silico assessment of the specificity of published molecular assays and design of new assays using the available whole genome sequences of 2019-nCoV: Updated to 565,366 COVID-19 WGS from GISAID. Table 1. Results from PSET analysis. The five Noblis assays were compared alongside the four assays from [... want %more?] → https://is.gd/ZsoUfV | 20:45 |
| darsie | https://www.spektrum.de/news/vektor-impfstoff-wird-adenovirus-dna-ins-genom-eingebaut/1835725 | 20:53 |
| Brainstorm | New from r/WorldNews: worldnews: Israel to vaccinate 100,000 Palestinian laborers, PA says → https://is.gd/sFqhrp | 20:57 |
| Brainstorm | New from Scientific American: Health: Coronavirus News Roundup, February 13 - February 19 → https://is.gd/85WYy4 | 21:10 |
| Brainstorm | New from FDA Press Releases: FDA: Coronavirus (COVID-19) Update: February 19, 2021 → https://is.gd/Z18vyH | 21:23 |
| aradesh | lots of people in the UK not taking their covid jabs: https://www.dailymail.co.uk/news/article-9277667/Only-50-appointments-Covid-jabs-mass-centre-Manchester-taken-up.html | 21:34 |
| aradesh | only 50% of people invited turning up | 21:35 |
| aradesh | is 50% vaccinated enough? | 21:35 |
| Brainstorm | New from The Atlantic: Listen: ‘A Disaster for Feminism’: Nearly a year ago, Atlantic staff writer Helen Lewis predicted the pandemic would be “ a disaster for feminism ,” and far too many of her predictions have proven true. With women leaving the workforce at unprecedented rates, why has the pandemic’s burden fallen so much harder on them? [... want %more?] → https://is.gd/W5d5Rn | 21:35 |
| LjL | aradesh, no, especially when vaccination doesn't have a 100% efficacy | 21:38 |
| LjL | as a matter of fact, since we don't know whether vaccines provide sterile immunity, or to what percentage of people, we really have no clue what the herd immunity threshold is | 21:38 |
| aradesh | what is sterile immunity? | 21:40 |
| LjL | aradesh, it means the virus never really has a chance to replicate in you. in practice, it's often used (like by me) just to say that not only you don't get physically sick, but you also aren't contagious | 21:41 |
| LjL | that is not to be taken for granted, because during most vaccine trials, they've only watched for people with symptoms. they haven't PCR tested everyone periodically | 21:42 |
| LjL | (AstraZeneca has, and the results weren't great) | 21:42 |
| LjL | so you can be safe from disease, or safe from serious disease, but still contagious, and we don't really know to what extent | 21:42 |
| LjL | we'll basically have to see what happens in countries like Israel that have vaccinated a lot of people already | 21:42 |
| aradesh | ah i see | 21:43 |
| Brainstorm | New from r/WorldNews: worldnews: Israel has agreed to vaccinate 100,000 Palestinian workers in Israel → https://is.gd/bn8W1I | 21:47 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.02.06.21251283v1 | 22:04 |
| Brainstorm | de-facto: From www.medrxiv.org: Decreased SARS-CoV-2 viral load following vaccination | medRxiv | 22:04 |
| de-facto | "Here, analyzing positive SARS-CoV-2 test results following inoculation with the BNT162b2 mRNA vaccine, we find that the viral load is reduced 4-fold for infections occurring 12-28 days after the first dose of vaccine. These reduced viral loads hint to lower infectiousness, further contributing to vaccine impact on virus spread." | 22:04 |
| de-facto | "Analyzing infection Ct values over time, we find that mean viral load substantially decreased 12 days post-vaccination, coinciding with the known onset of the early vaccine protection" | 22:11 |
| de-facto | "Our results show that infections occurring 12 days or longer following vaccination have significantly reduced viral loads, potentially affecting viral shedding and contagiousness as well as severity of the disease" | 22:12 |
| genera | which country is that? | 22:15 |
| de-facto | Israel | 22:18 |
| de-facto | Afaik their deal with Pfizer/BioNTech involves that they provide stats | 22:19 |
| CoronaBot | /r/coronavirus: Study in Israel shows Pfizer vaccine 85% effective after first dose - The Lancet (10005 votes) | https://www.reuters.com/article/health-coronavirus-israel-vaccine-idUSL1N2KP00T | https://redd.it/lndwjs | 22:49 |
| Brainstorm | Updates for Gabon: +446 cases (now 13553) since a day ago — Spain: +11435 cases (now 3.1 million), +397 deaths (now 67101) since a day ago — Germany: +5970 cases (now 2.4 million), +175 deaths (now 67722) since 21 hours ago — Canada: +3138 cases (now 841203), +70 deaths (now 21560) since 21 hours ago | 23:00 |
| Brainstorm | New from Ars Technica: Science: Pfizer vaccine rollout might get a lot easier—ultra-cold storage not required → https://is.gd/EqzozS | 23:01 |
| Brainstorm | Updates for France: +240 deaths (now 83633) since 22 hours ago | 23:37 |
| Brainstorm | New from Medical Xpress: Toronto's lockdown extended until at least March 8: A lockdown and stay at home order is being extended in Canada's largest city until at least March 8. → https://is.gd/haVlIG | 23:49 |
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