| Brainstorm | New from r/WorldNews: worldnews: Two residents in Brisbane aged care facility given four times the amount of Pfizer vaccine → https://is.gd/gJJYIf | 00:14 |
|---|---|---|
| LjL | err that might be an interesting "experiment" | 00:15 |
| de-facto | aaw too late :P | 00:15 |
| de-facto | in the north of Germany some got 5x the intended amount, a whole vial | 00:16 |
| de-facto | i am not sure how it went, but i did not read about any fatalities or such | 00:16 |
| LjL | ... or 6x then, depending which regulatory body you ask | 00:16 |
| de-facto | it was before that time but yeah | 00:16 |
| de-facto | so maybe they only got "very vaccinated" :D | 00:17 |
| LjL | ouch in this case it's "An 88-year-old man and a 94-year-old woman were given the doses yesterday", hope they'll be okay | 00:17 |
| de-facto | idk if it even increases antibody levels, maybe it does not make such a big difference at some threshold or such? (speculation) | 00:17 |
| LjL | really no idea | 00:18 |
| de-facto | .title https://www.reuters.com/article/us-health-coronavirus-germany-vaccinatio-idUSKBN2921F1 | 00:19 |
| Brainstorm | de-facto: From www.reuters.com: Vaccine overdose puts German care workers in hospital | Reuters | 00:19 |
| LjL | "flu-like symptoms" | 00:21 |
| LjL | depending on how bad they were, i guess they might have gotten them anyway | 00:21 |
| LjL | hard to tell from the article if they were sent to hospital on just a precautionary basis, or what | 00:21 |
| de-facto | yeah i dont know how it ended, but i assume not too bad | 00:23 |
| Brainstorm | New from r/WorldNews: worldnews: Guinea launches Ebola vaccination drive in country’s south → https://is.gd/MTmVqw | 00:26 |
| de-facto | in the phase i trials they also used 100µg (3-fold the regular dose of today) and it went fine | 00:32 |
| de-facto | more side effects of course | 00:32 |
| LjL | de-facto, well i just hope they unfroze the 5-dose vial before injecting it into those people :P | 00:39 |
| de-facto | btw how come those LNPs and the mRNA is not destroyed by ice crystals force? is it shock frosted so fast that no crystals can form? | 00:56 |
| de-facto | afaik Moderna does not even need to be diluted, right? (if so containing a lot of water) | 00:57 |
| Brainstorm | New from Medical Xpress: Overall deaths did NOT increase for most of China during initial COVID-19 outbreak: A new study involving researchers from the University of Oxford and the Chinese Center for Disease Control and Prevention (China CDC) has examined the change in overall and cause-specific death rates during the three months of the COVID-19 [... want %more?] → https://is.gd/FgmWyo | 01:03 |
| LjL | (@Brainstorm) well they had a very low number of deaths if you compare it to what the west has now been getting... | 01:05 |
| Brainstorm | Updates for Togo: +118 cases (now 6466) since a day ago — Netherlands: +5051 cases (now 1.1 million), +35 deaths (now 15358) since 23 hours ago — United Kingdom: +9574 cases (now 4.1 million) since 23 hours ago | 01:35 |
| LjL | <CarlSagan> [NPR - Science] Do 'Tight' Cultures Fare Better In The Pandemic Than 'Loose' Cultures? https://www.npr.org/sections/goatsandsoda/2021/02/23/970651869/do-tight-cultures-fare-better-in-the-pandemic-than-loose-cultures 2021-02-23T18:54:57 | 01:53 |
| -RSSBot[LjLmatrix- Feed: Il Presidente Draghi accoglie le salme delle vittime dell’attacco a Goma ( http://www.governo.it/it/articolo/il-presidente-draghi-accoglie-le-salme-delle-vittime-dell-attacco-goma/16269 ) | 01:53 | |
| LjL | perhaps not exceptionally interesting. i give it a 3/5 | 01:53 |
| LjL | ... not to Draghi, to the NPR interview ;( | 01:54 |
| Brainstorm | New from BBC Health: (news): Women to trial 'do-it-at-home' smear tests for NHS → https://is.gd/chqzxI | 02:05 |
| Brainstorm | Updates for St. Barthelemy: +61 cases (now 573) since 6 days ago | 03:02 |
| CoronaBot | /r/covid19: Critical COVID-19 represents an endothelial disease with high similarity to kidney disease on the molecular level (83 votes) | https://www.medrxiv.org/content/10.1101/2021.02.22.21252207v1 | https://redd.it/lque7y | 03:15 |
| Brainstorm | New from The Indian Express: World: Where a vaccination campaign faces skepticism, war and corruption → https://is.gd/gmpsuF | 03:18 |
| Brainstorm | New from The Indian Express: World: Israel gives vaccine to far-off allies, as Palestinians wait → https://is.gd/JKxrit | 05:23 |
| Brainstorm | New from r/WorldNews: worldnews: Failure to enact public duty law 'has worsened England inequality in pandemic' | Poverty → https://is.gd/qidF6d | 06:33 |
| Brainstorm | Updates for Belgium: +2102 cases (now 757696), +33 deaths (now 21956) since a day ago — New Zealand: +2 cases (now 2365) since a day ago — United Kingdom: +6372 cases (now 4.1 million) since 22 hours ago | 07:10 |
| Brainstorm | New from r/WorldNews: worldnews: Israel said to trade coronavirus vaccines for diplomatic support → https://is.gd/kA9b6t | 07:35 |
| Brainstorm | Updates for France: +21257 cases (now 3.7 million), +507 deaths (now 85120) since 23 hours ago — Lombardy, Italy: +2480 cases (now 583251), +43 deaths (now 28146) since 23 hours ago — Netherlands: +4871 cases (now 1.1 million), +82 deaths (now 15405) since 23 hours ago — Canada: +3303 cases (now 854371) since 23 hours ago | 07:54 |
| Brainstorm | New from r/WorldNews: worldnews: Philippines offers Britain nurses in exchange for vaccines → https://is.gd/tNBCSA | 07:59 |
| Brainstorm | New from r/WorldNews: worldnews: Israel Gives Vaccine to Far-Off Allies, as Palestinians Wait → https://is.gd/vNj7hF | 08:25 |
| Brainstorm | New from r/WorldNews: worldnews: The staggering rise in alcoholism b/c of COVID-19, signals America has added millions to the benzo dependency crisis. → https://is.gd/8KbB8B | 08:37 |
| Brainstorm | New preprint: International travel in times of the COVID-19 pandemic: Evidence from German school breaks by Andreas Backhaus et al, made available as preprint on 2021-02-23 at https://medrxiv.org/cgi/content/short/2021.02.19.21252062 [... want %more?] | 08:44 |
| Brainstorm | New from The Indian Express: World: Giving hope, and a place to mourn: Memorials to the pandemic → https://is.gd/Fz4awh | 08:49 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | February 24, 2021: The World Health Organization maintains up-to-date and global information. Please refer to our Wiki for additional information. You can find answers to frequently asked questions about Covid-19 and vaccines in our FAQ . → https://is.gd/4sXMvv | 09:02 |
| Brainstorm | Updates for Germany: +4946 cases (now 2.4 million) since 17 hours ago | 09:15 |
| Brainstorm | New from StatNews: Backed by Google, epidemiologists launch a sweeping Covid-19 data platform: Global.health, a new platform launched Wednesday, will enable open access to 10 million anonymized Covid-19 records from 160 countries. → https://is.gd/ldK03x | 10:13 |
| Brainstorm | New from StatNews: How Covid-19 could usher in a new role for continuous glucose monitoring in hospitals: The pandemic has given hospitals an opening to use CGMs to remotely monitor patients with diabetes — and has generated data on whether they can improve inpatient outcomes. → https://is.gd/VpkLDw | 10:38 |
| CoronaBot | /r/coronavirus: Once viewed as essential, grocery workers now treated as "expendable," union chief says (10070 votes) | https://www.cbsnews.com/news/grocery-workers-expendable-covid-vaccine-union/ | https://redd.it/lqw75k | 10:59 |
| Brainstorm | New from Emma Hodcroft: @firefoxx66: While not downplaying our current careful situation, I think we've got a lot to be optimistic about in 2021, if we can think globally 🌍 & act appropriately 💉😷I thoroughly enjoyed reading this interview with @fabiennekatrin: '1 year of [... want %more?] → https://is.gd/FkceQY | 11:01 |
| CoronaBot | /r/covid19: SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques (81 votes) | https://www.biorxiv.org/content/10.1101/2021.02.23.432474v1 | https://redd.it/lqufcn | 11:18 |
| Brainstorm | New from BBC Health: (news): People with learning disabilities to be prioritised for Covid vaccine → https://is.gd/CfxDqz | 11:38 |
| Brainstorm | New from BMJ: Vaccinating children to prevent long covid? More caution is needed in interpreting current epidemiological data: We are used to supporting children with chronic illness and have followed closely concerns raised by Simpson and Lokugamage regarding long covid in children.12 Media reports following the All Party... → https://is.gd/F8sN5J | 12:36 |
| Brainstorm | New from Scientific American: Unraveling the Complex Link Between COVID and Diabetes: The pandemic infection seems to trigger diabetes in some patients. Here are five plausible explanations as to why -- Read more on ScientificAmerican.com → https://is.gd/wrNz3l | 12:48 |
| Brainstorm | Updates for Germany: +5810 cases (now 2.4 million) since 21 hours ago | 13:11 |
| -RSSBot[LjLmatrix- Feed: Consiglio dei Ministri n. 3 ( http://www.governo.it/it/articolo/consiglio-dei-ministri-n-3/16272 ) | 14:19 | |
| -RSSBot[LjLmatrix- Feed: Convocazione del Consiglio dei Ministri n. 3 ( http://www.governo.it/it/articolo/consiglio-dei-ministri-n-3/16273 ) | 14:19 | |
| Brainstorm | New from NPR: FDA Analysis of Johnson & Johnson COVID-19 Vaccine Finds It Safe, Effective: The Food and Drug Administration released an analysis of Johnson & Johnson's COVID-19 vaccine Wednesday morning that appears to support its authorization for emergency use. → https://is.gd/9YyOK1 | 14:28 |
| Brainstorm | New from StatNews: New data shed light on efficacy of J&J’s single-dose vaccine against Covid-19: Johnson & Johnson revealed new, encouraging data showing its Covid-19 vaccine may do a better-than-expected job at protecting patients against new variants of the virus that causes the disease. → https://is.gd/h5cCkp | 15:15 |
| Brainstorm | Updates for Switzerland: +1343 cases (now 552698), +19 deaths (now 9938) since 23 hours ago | 15:15 |
| Brainstorm | Updates for Netherlands: +4190 cases (now 1.1 million), +73 deaths (now 15426) since 23 hours ago | 17:07 |
| Brainstorm | Updates for United Kingdom: +8984 cases (now 4.1 million), +512 deaths (now 121529) since 23 hours ago | 17:38 |
| CoronaBot | /r/covid19: Vaccines and Related Biological Products Advisory Committee Meeting February 26th 2021 (82 votes) | https://www.fda.gov/media/146217/download | https://redd.it/lrcibz | 17:38 |
| -RSSBot[LjLmatrix- Feed: Consiglio Europeo straordinario, videoconferenza Draghi - Michel ( http://www.governo.it/it/articolo/consiglio-europeo-straordinario-videoconferenza-draghi-michel/16275 ) | 17:53 | |
| Brainstorm | New from BBC Health: (news): Covax vaccine-sharing scheme delivers first doses to Ghana → https://is.gd/Iuubr6 | 18:41 |
| Brainstorm | Updates for Italy: +16402 cases (now 2.8 million), +318 deaths (now 96666) since 23 hours ago — Spain: +389 deaths (now 68468) since 22 hours ago | 19:11 |
| de-facto[m] | .title https://www.sciencemediacentre.org/expert-reaction-to-preprint-looking-at-the-pfizer-biontech-covid-19-vaccine-efficacy-in-israel/ | 19:13 |
| Brainstorm | de-facto[m]: From www.sciencemediacentre.org: expert reaction to preprint looking at the Pfizer-BioNTech COVID-19 vaccine efficacy in Israel | Science Media Centre | 19:13 |
| Brainstorm | New from r/WorldNews: worldnews: Israel adopts law allowing names of unvaccinated to be shared → https://is.gd/kpTKz5 | 19:39 |
| Brainstorm | New from Derek Lowe: @Dereklowe: Now all of Twitter knows what my wife has known for years: I have no idea of what day of the week it is, most of the time (nor the day of the month!) The FDA hearing on the J&J vaccine is of course on Friday. → https://is.gd/MX2qz4 | 20:04 |
| -RSSBot[LjLmatrix- Feed: Gli impegni del Presidente Draghi del 25 e 26 febbraio ( http://www.governo.it/it/articolo/gli-impegni-del-presidente-draghi-del-25-e-26-febbraio/16277 ) | 20:23 | |
| -RSSBot[LjLmatrix- Feed: Attacco a Goma, il Presidente Draghi ai funerali di Stato delle vittime italiane ( http://www.governo.it/it/articolo/attacco-goma-il-presidente-draghi-ai-funerali-di-stato-delle-vittime-italiane/16278 ) | 20:28 | |
| Brainstorm | Updates for Canada: +3188 cases (now 855712), +40 deaths (now 21787) since 23 hours ago — France: +17330 cases (now 3.7 million), +237 deaths (now 85188) since 22 hours ago | 20:38 |
| -RSSBot[LjLmatrix- Feed: Comunicato stampa del Consiglio dei Ministri n. 3 ( http://www.governo.it/it/articolo/comunicato-stampa-del-consiglio-dei-ministri-n-3/16281 ) | 21:08 | |
| CoronaBot | /r/covid19: The J&J Vaccine at the FDA (81 votes) | https://blogs.sciencemag.org/pipeline/archives/2021/02/24/the-jj-vaccine-at-the-fda | https://redd.it/lrhavm | 21:09 |
| pwr22 | LjL: I have to have *another* blood test lol | 21:11 |
| Brainstorm | New from r/WorldNews: worldnews: Dozens catch Covid at indoor conference hosted by founder of Covid vaccine company → https://is.gd/FgKRdr | 21:13 |
| Brainstorm | Updates for Nepal: +618 deaths (now 2684) since 8 hours ago | 21:21 |
| LjL | pwr22, is it something they could have thought of the first time ;( | 21:34 |
| LjL | "And the differences between the three adenovirus vector vaccines themselves are pretty significant: J&J’s data are for one shot of an Ad26 vector (a two-shot trial is still running), and their sequence has the stabilizing protein mutations in the Spike." ← what are these stabilizing mutations? | 21:37 |
| CoronaBot | /r/coronavirus: FDA staff endorses Johnson & Johnson’s single-shot Covid vaccine for emergency use (10118 votes) | https://www.cnbc.com/2021/02/24/covid-vaccine-fda-staff-endorses-jjs-single-shot-for-emergency-use.html | https://redd.it/lrcn3y | 21:39 |
| -RSSBot[LjLmatrix- Recent Commits to links:master: Add FDA approval of J&J (Janssen) and Pipeline and Statnews discussio… ( https://github.com/ljl-covid/links/commit/a195b28fb66c5b1a09d6254b7c1246ca5a2eae35 ) | 21:44 | |
| de-facto | LjL, the two point mutations stabilizing the s-glycoprotein in its prefusion config (to ensure it exposes the same immunologic surfaces as if it was on a virion) | 21:45 |
| de-facto | K986P and V987P | 21:48 |
| Brainstorm | New from https://covid19.specops.network : Add FDA approval of J&J (Janssen) and Pipeline and Statnews discussio…: Add FDA approval of J&J (Janssen) and Pipeline and Statnews discussions of itI have added no actual data, I should add some later when I actually read the document → https://is.gd/eQdgyn | 21:49 |
| de-facto | btw afaik *all* vaccines have those two point mutations | 21:59 |
| de-facto | (unless they recently changed that) | 21:59 |
| Brainstorm | New from StatNews: Moderna ready to test version of Covid-19 vaccine aimed at worrisome variant: Moderna is pressing forward with a modified version of its Covid-19 vaccine meant to protect against an emerging virus variant, planning to start a clinical trial as soon as regulators… → https://is.gd/IdvARn | 22:25 |
| de-facto | oh wow. | 22:33 |
| de-facto | finally | 22:34 |
| de-facto | .title https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-it-has-shipped-variant-specific-vaccine | 22:35 |
| Brainstorm | de-facto: From investors.modernatx.com: Moderna Announces it has Shipped Variant-Specific Vaccine Candidate, mRNA-1273.351, to NIH for Clinical Study | Moderna, Inc. | 22:35 |
| de-facto | hopefully that is what EU bought from them | 22:35 |
| de-facto | .title https://www.gsk.com/en-gb/media/press-releases/gsk-and-curevac-to-develop-next-generation-mrna-covid-19-vaccines/ | 22:47 |
| Brainstorm | de-facto: From www.gsk.com: GSK and CureVac to develop next generation mRNA COVID-19 vaccines | GSK | 22:47 |
| de-facto | "Through this new exclusive co-development agreement, GSK and CureVac will contribute resources and expertise to research, develop, and manufacture a number of novel mRNA vaccine candidates, including multi-valent and monovalent approaches. " | 22:48 |
| de-facto | .title https://www.curevac.com/en/2021/02/05/curevac-and-uk-government-to-collaborate-on-development-of-vaccines-against-sars-cov-2-variants/ | 22:48 |
| Brainstorm | de-facto: From www.curevac.com: CureVac and UK Government to collaborate on development of vaccines against SARS-CoV-2 variants - CureVac | 22:48 |
| de-facto | “The UK Government and its Vaccines Taskforce (VTF) has been at the forefront of surveillance, vaccine development and delivery of vaccines for deployment during this pandemic. At CureVac, we believe we have the ability to quickly adapt our mRNA technology to address current variants and prepare for the emergence of new strains. This collaboration is expected to bring to bear our significant combined forces to ensure vaccines keep winnin | 22:51 |
| de-facto | g against COVID-19.” | 22:51 |
| LjL | de-facto: well he says "Oxford/AZ is a different adenovirus (from the chimpanzee population), and their sequence is wild-type Spike without the stabilization." | 22:55 |
| de-facto | whut? | 23:00 |
| de-facto | ADZ-1222 does *not* have those two stabilizing mutations? | 23:00 |
| de-facto | AZD1222 (ChAdOx1 nCoV-1) | 23:01 |
| de-facto | LjL, source? | 23:01 |
| LjL | de-facto, same as i quoted from originally, Brainstorm's Derek Lowe link | 23:02 |
| LjL | https://blogs.sciencemag.org/pipeline/archives/2021/02/24/the-jj-vaccine-at-the-fda | 23:02 |
| Brainstorm | New from StatNews: Health: Pfizer-BioNTech vaccine performs as well in the real world as in clinical trials, new study concludes → https://is.gd/CINlmx | 23:03 |
| de-facto | seems to really be the case https://www.mdpi.com/2076-393X/9/1/39/htm | 23:04 |
| de-facto | well that would explain a thing or two i guess (efficacy etc) | 23:05 |
| de-facto | i did not know that before | 23:05 |
| de-facto | LjL, good catch! | 23:06 |
| LjL | :\ | 23:07 |
| LjL | i'd rather have bad catches and good vaccines | 23:07 |
| de-facto | damn that really would explain some stuff | 23:08 |
| de-facto | see, thats *exactly* why i want them to publish their full sequences (as discussed the other day) | 23:09 |
| de-facto | it would have been a 5 minute copy and paste easy enough for everyone with a browser to make such an analysis | 23:10 |
| LjL | de-facto, what am i looking for in https://www.mdpi.com/2076-393X/9/1/39/htm ? my ctrl+f is out of ideas and i'd rather get covid than read it all (not really) | 23:13 |
| de-facto | oh sorry, i meant their Table 1 Vaccine Targets column | 23:21 |
| LjL | de-facto, ah, i see. what are those mutations meant to do, roughly speaking? i see it's in the furin cleavage site, which i've definitely heard of before, but i don't know about it. also i see that Novavax also has the full S-protein, without the stabilizing mutation (but does it matter since it's directly the protein?) | 23:37 |
| Brainstorm | Updates for Germany: +12729 cases (now 2.4 million), +416 deaths (now 69253) since 23 hours ago — Canada: +2846 cases (now 855892), +43 deaths (now 21790) since 23 hours ago — Switzerland: +4 deaths (now 9942) since 8 hours ago — Netherlands: +2377 cases (now 1.1 million) since 22 hours ago | 23:38 |
| LjL | our government says that our Rt is about to become > 1 | 23:38 |
| de-facto | yeah here its already R>1 | 23:47 |
| de-facto | those two mutations are meant to make the s-trimer more stable in the prefusion config, meaning like it appears on the virion itself (in order to expose the relevant immunologic surfaces, so antibodies would fit also for the virions) | 23:48 |
| de-facto | the trimer can collapse and then it is not like prior to fusion of a virion | 23:49 |
| de-facto | those mutations exchange two amino acids that make it more stable in the configuration prior to fusion | 23:50 |
| de-facto | basically ensuring that more of the s-protein trimers induce that kind of antibodies that are desired (because they bind to the prefusion s-protein on the virions) | 23:50 |
| de-facto | at least thats my understanding of it | 23:50 |
| de-facto | weird that Sputnik claims such good efficiancy without those | 23:51 |
| LjL | fusion = attachment to the receptor? | 23:51 |
| de-facto | yep | 23:53 |
| de-facto | proteins can fold and have their "mechanics" according to the binding strengths and charge distribs etc | 23:54 |
| de-facto | virions are metastable structures, they are at their local potential energetic minimum but as soon as they enter a cell they disassemble hence were in a higher energetic state before | 23:55 |
| de-facto | similar probably with those s-trimers on a virions surface, maybe something like a spring under tension but without the trigger to be released | 23:56 |
| LjL | de-facto, is it more stable in the virion itself (before it enters a cell) simply because it's attached to the other proteins of the virus? | 23:56 |
| de-facto | (the last part about the s-protein being in a higher potential energy i dont know exactly, but i guess that would make sense) | 23:56 |
| de-facto | LjL, probably, i am not sure about that, but its in the prefusion config on the virions, and i guess it would make sense if it was stabilized in that config in order to release its "tension" during the fusion process (otherwise it could not fuse, hence be useless and would mean a negative selection in terms of evolution) | 23:58 |
| -RSSBot[LjLmatrix- Recent Commits to links:master: Add Moderna South African variant vaccine announcement ( https://github.com/ljl-covid/links/commit/1930136502273c6930d96e6aa3a6e8477910ca13 ) | 23:59 | |
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