| Brainstorm | New from Derek Lowe: @kakape: RT by @Dereklowe: A lot to say about AZ vaccine pause in Europe, but I will try to stick to a two key questions in this thread (more later):1. What are the symptoms that have led to the pause?2. Is there a plausible mechanism for the vaccine causing them?Story is here: [... want %more?] → https://is.gd/XhV274 | 00:11 |
|---|---|---|
| Brainstorm | New from NIH Director's blog: Director's Album - Photos: Building Vaccine Confidence at the Washington National Cathedral → https://is.gd/Cw290f | 00:22 |
| Brainstorm | New from The Lancet (Online): [Comment] Risk of SARS-CoV-2 reinfection after natural infection: Since the start of the COVID-19 pandemic, the question of potential reinfection has been ever present. Although there has been much debate about potential reliance on herd immunity through natural infection, human coronaviruses are well adapted to subvert [... want %more?] → https://is.gd/BPRpGf | 00:32 |
| LjL | <Brainstorm> New from r/WorldNews: worldnews: Conflict grows between US and allies over vaccine supply → https://is.gd/QQoLlS | 00:32 |
| LjL | apparently AZ is being happily produced by the US site(s), while the vaccine is not yet approved, and so the doses are just kept in the fridge waiting for approval | 00:33 |
| LjL | "AstraZeneca’s 30,000-person U.S. trial didn’t complete enrollment until January. The company hasn’t given any hints of when initial results might be ready beyond an executive telling Congress last month he expected it would be “soon.”" | 00:34 |
| LjL | https://www.sciencemag.org/news/2021/03/it-s-very-special-picture-why-vaccine-safety-experts-put-brakes-astrazeneca-s-covid-19 | 01:01 |
| LjL | “It’s a very special picture” of symptoms, says Steinar Madsen, medical director of the Norwegian Medicines Agency. “Our leading hematologist said he had never seen anything quite like it.” | 01:02 |
| LjL | “Everyone’s scratching their heads: Is this a real signal?” If it is, he says, a lot of evidence is pointing to a crucial role for the complement system. Dysregulation of that system can lead to diseases that Brodsky terms “complementopathies”: “What complementopathies have in common is: They all have thrombosis as part of it, they all have thrombocytopenia as part of it, they all have relative resistance to traditional anticoagulant | 01:03 |
| LjL | s, and they all have triggers such as infections, inflammation, pregnancy, cancer, vaccines.” | 01:03 |
| LjL | In a paper published in October 2020 in Blood, Brodsky and colleagues showed the spike protein of SARS-CoV-2, by binding to the inner surface of blood vessels, can activate the complement system. In some people that leads to the cells lining the vessel being attacked, which in turn can lead to blood clotting and ultimately cause severe disease. Brodsky says he has had several patients with a complement disorder called paroxysmal nocturnal hemoglobinuria | 01:03 |
| LjL | whose symptoms worsened after receiving a COVID-19 vaccine. “It doesn’t prove anything, but there is a lot of smoke here.” | 01:03 |
| LjL | [In Germany] A group of experts convened on Monday “agreed unanimously that there seemed to be a pattern here and that a link to the vaccine was not implausible and that this should be investigated,” Cichutek says. | 01:03 |
| LjL | But the decision put PEI at odds with EMA, which says vaccinations should continue for now. | 01:03 |
| Brainstorm | New preprint: Multiplexed Flow Cytometric Approach for Detection of Anti-SARS-CoV-2 IgG, IgM and IgA Using Beads Covalently Coupled to the Nucleocapsid Protein by Ingrid Fatima Zattoni et al, made available as preprint on 2021-03-17 at https://api.figshare.com/v2/articles/14219999 | 01:05 |
| LjL | de-facto, https://translate.google.com/translate?sl=auto&tl=en&u=https://www.punto-informatico.it/passaporto-sanitario-certificato-verde-digitale/ | 01:17 |
| -Synapsestorm- 🏠 زلزال! Séisme! Earthquake! 6.0 Mww tremor, registered by US, occurred 33 minutes ago (00:04:07 UTC), with a crescent moon, Northern Algeria (36.92, 5.21), ↓10 km likely felt 270 km away (in Béjaïa ⴲⴳⴰⵢⴻⵝ بجاية, Jijel ⵉⵖⵉⵍ ⴳⵉⵍⵉ جيجل, Amizour, Oued Ghir, Tichy…) by 1.7 million people (service.iris.edu) | 01:39 | |
| Brainstorm | New from BBC Health: (news): Covid: From boom to bust - why lockdown hasn't led to more babies → https://is.gd/M5vZCN | 01:47 |
| de-facto | tbh i am not a fan of those | 01:47 |
| LjL | i had guessed | 01:47 |
| LjL | i'm not a fan either, at least not for this summer | 01:48 |
| de-facto | the pro is that documenting vaccinations may prevent fraud of documents if done correctly | 01:48 |
| de-facto | the contra is that this will lead to a two class society, and if free traveling is allowed by such vaccinated we already know which VoCs will be selected to be transported by such travelers | 01:49 |
| LjL | the con is that 1) we shouldn't really travel this summer and 2) it's not really fair considering most people who *want* a vaccine can't *get* it yet | 01:49 |
| de-facto | yes | 01:49 |
| LjL | but i guess #2 is partially defeated by the fact these passes will also certificate a (recent?) negative test | 01:50 |
| de-facto | we should not travel until incidence is brought down hence infection probability very low (vaccinated or not) | 01:50 |
| de-facto | they say its left to the countries what to do with the certs | 01:50 |
| LjL | de-facto, did you see the adorable thing about Pfizer openly saying they have an "opportunity" to "hike prices"? | 01:51 |
| de-facto | yes. | 01:51 |
| LjL | it's... something | 01:51 |
| de-facto | actually me, i only care about that they ramp up production rates. *massively* | 01:52 |
| LjL | think carefully | 01:52 |
| LjL | look at the points that article made | 01:52 |
| de-facto | yes i know | 01:52 |
| de-facto | breeding | 01:52 |
| LjL | it talked specifically about ramping up prices of *booster* vaccines which may have to be given indefinitely | 01:53 |
| LjL | they probably can't raise the prices of the initial vaccines because it's contractually agreed already | 01:53 |
| LjL | but... we'll either get a ton of variants that we'll need to keep chasing with new vaccines, or we won't get so many | 01:53 |
| LjL | the way to get many of them is to vaccinate people slowly | 01:53 |
| LjL | the way to *try* to avoid it is to vaccinate everyone quickly | 01:53 |
| LjL | guess what - these companies are kinda doing it slowly | 01:54 |
| * LjL goes COINCIDENCE?! | 01:54 | |
| LjL | i mean, there may be real production hurdles, but by the things Pfizer openly said, it's in their financial interest to have people vaccinated slowly | 01:54 |
| de-facto | yes i know, its what i am saying since many months already, we should vaccinate as fast as possible while bringing down incidence via NPIs | 01:55 |
| de-facto | that would minimize breeding of evasive mutants, if we do the opposite well the result will follow | 01:55 |
| LjL | that's not that i'm saying though | 01:56 |
| LjL | i'm saying specifically that it's in these companies' financial interest not to do so | 01:56 |
| de-facto | yes breeding | 01:56 |
| de-facto | its happening right now, and it working very well. | 01:57 |
| LjL | and since they are the ones ultimately deciding how fast we can vaccinate, given they make them, that is a problem | 01:57 |
| de-facto | i always was saying we should put more effort into ensuring production rates go up, at any price even if that means taking over of a company by a state | 01:58 |
| de-facto | anyhow if breeding can be prevented here its going to happen elsewhere, look at Brazil et al | 02:00 |
| de-facto | its going to continue as long as we dont provide *efficient* vaccines for everyone worldwide simultaneously and vaccinate with a very high rate | 02:00 |
| de-facto | i just cant believe that this is not possible | 02:01 |
| de-facto | that it not already happened means we are not trying hard enough. thats my opinion. | 02:01 |
| Brainstorm | New from Derek Lowe: @steveusdin1: RT by @Dereklowe: U.S. government limits distribution of a @LillyPad #COVID19 monoclonal antibody in 3 states bc of concerns it isn't effective vs "California variant." Another combo Lilly mAb and Regeneron's combo mAb are unaffected by the limits. @V2019N https://www.biocentury.com/article/635061 → https://is.gd/kJFApu | 02:07 |
| de-facto | lol | 02:08 |
| de-facto | oh really? | 02:08 |
| LjL | the california variant has just been upgraded to "of concern" | 02:09 |
| LjL | antibodies have been shown to work less well on it | 02:09 |
| LjL | doesn't seem as bad as SA variant though from what i've skimmed | 02:09 |
| de-facto | Germany bought Eli Lilly ist LY-CoV555 (inefficient) and Regeneron REGN10933 (inefficient) + REGN10987 (still works) in regards to SA-VOC B.1.351. | 02:13 |
| de-facto | well guess what happens if one of the mAbs in a cocktail became inefficient... | 02:13 |
| de-facto | .title https://www.nature.com/articles/s41586-021-03398-2_reference.pdf "Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 | 02:14 |
| de-facto | what would catch mutants that evade the *one* still working mAb in a cocktail then? | 02:15 |
| LjL | nothing, i guess | 02:16 |
| LjL | what's your point, we shouldn't be using mAbs? | 02:16 |
| de-facto | well my point being that they become inefficient very fast by evasion, they are static cant follow mutants | 02:17 |
| de-facto | what that means for people not using mAbs, idk | 02:17 |
| Brainstorm | New from Derek Lowe: @MedResJourno: RT by @Dereklowe: I swear I’m not just trying to promote my own articles, But I’d be interested in your thoughts about Dr. Woodcock’s proposal to build a clinical trials network into community practices to address the issues you raised. [... want %more?] → https://is.gd/2itz0O | 02:18 |
| de-facto | if they target the same epitopes than immune reaction from recovery or vaccination we might breed more VoCs with mAbs i guess | 02:21 |
| de-facto | that is if cocktails cant absolutely ensure no evasion cant happen | 02:21 |
| de-facto | and two mAbs with one already bruteforced is not nearly enough to ensure that | 02:21 |
| de-facto | but its a VERY lucrative deal for the manufacturers | 02:22 |
| LjL | and also one of the very few things we know that actually helps patients | 02:22 |
| de-facto | they get almost 2k€ per treatment | 02:22 |
| LjL | so i think it's going to be a tough sell that we shouldn't use them to avoid breeding VoCs | 02:22 |
| de-facto | i wonder if they research if selective pressure from mAbs might give rise to mutations convergent with immune evasion, because if that is so such variants will have such a big advantage for being able to circulate in a partly immune population that they might become the majority very fast | 02:25 |
| Brainstorm | de-facto, the URL could not be loaded | 02:57 |
| Brainstorm | New from r/WorldNews: worldnews: Wildlife Farms In China Likely Source Of Pandemic, Say WHO Investigators : Goats and Soda : NPR → https://is.gd/a2eRcm | 03:20 |
| LjL | Brainstorm, you must have tried loading it really hard | 03:28 |
| Brainstorm | Updates for Brazil: +90830 cases (now 11.7 million), +2736 deaths (now 285136) since 19 hours ago — Jordan: +9535 cases (now 504915), +56 deaths (now 5553) since 19 hours ago — Iraq: +5663 cases (now 774015), +33 deaths (now 13860) since 19 hours ago — Greece: +3458 cases (now 227247), +56 deaths (now 7252) since 19 hours ago | 03:44 |
| Brainstorm | New from r/WorldNews: worldnews: Biden administration is considering sending some AstraZeneca vaccine doses to Canada and Mexico → https://is.gd/422p5x | 04:02 |
| Brainstorm | New from Bloom Lab: @jbloom_lab: R to @jbloom_lab: And that's why I was disappointed to hear @PeterDaszak say WHO team didn't even *ask* Wuhan Institute of Virology to see database of virus sequences because *he* knows it doesn't have anything relevant (https://twitter.com/McWLuke/status/1369686004924309504). Science is sharing data, not assertions. (9/9) → https://is.gd/lqSHSc | 04:12 |
| Brainstorm | New from This Week In Virology: TWiV 732: Citizen science with Forest Rohwer and Marisa-Isabel Rojas: Forest and Marisa-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis. → https://is.gd/1tWWw8 | 05:15 |
| Brainstorm | New from BBC Health: Covid vaccine: Government facing questions over supply to UK: It is understood there is a delay to a shipment of millions of doses of the AstraZeneca jab from India. → https://is.gd/AjHdsN | 06:17 |
| Brainstorm | New preprint: Evaluation of RNA extraction free method for detection of SARS-COV-2 in salivary samples for mass screening for COVID-19 by Dr. Sally Mahmoud et al, made available as preprint on 2021-03-17 at https://medrxiv.org/cgi/content/short/2021.03.15.21253570 | 07:09 |
| Brainstorm | New from r/WorldNews: worldnews: Hit by US sanctions, Cuba and Iran join hands to secure Covid-19 vaccine → https://is.gd/aOqxBI | 08:00 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | March 18, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/BuVMiz | 08:11 |
| Brainstorm | New from The Indian Express: World: Some long COVID patients feel much better after getting the vaccine → https://is.gd/W2ysik | 08:21 |
| Brainstorm | New from The Indian Express: World: Woman gives birth to first known baby with antibodies against coronavirus, doctors say → https://is.gd/tLSPNR | 09:03 |
| Brainstorm | New from Medical Xpress: Key questions as EU watchdog rules on AstraZeneca: The EU's drug regulator, the European Medicines Agency, finds itself in the hot seat on Thursday when it will decide what to do about blood clot fears over the AstraZeneca coronavirus jab. → https://is.gd/XXfKNr | 09:13 |
| Brainstorm | Updates for East Flanders, Belgium: +828 cases (now 90596) since a day ago — Brussels, Belgium: +638 cases (now 101690) since a day ago — Ucayali, Peru: +337 cases (now 24237), +21 deaths (now 596) since 2 days ago — Miyagi, Japan: +107 cases (now 4333) since a day ago | 10:22 |
| eventcheck[m] | %cases France | 10:47 |
| Brainstorm | eventcheck[m]: In France, there have been 4.1 million confirmed cases (6.2% of the population) and 91220 deaths (2.2% of cases) as of 24 minutes ago. 57.9 million tests were performed (7.1% positive). See https://offloop.net/covid19/?default=France for time series data. | 10:47 |
| Brainstorm | New from EMA: What's new: Event: Press briefing on the conclusion of the investigation of COVID-19 Vaccine AstraZeneca and thromboembolic events by the Pharmacovigilance Risk Assessment Committee (PRAC), Virtual meeting, from 18/03/2021 to 18/03/2021 → https://is.gd/qVf9X7 | 10:48 |
| Brainstorm | New from Science-Based Medicine: Countering Geert Vanden Bossche’s dubious viral open letter warning against mass COVID-19 vaccination: Geert Vanden Bossche is a scientist who published an open letter warning of global catastrophe due to deadly variants of COVID-19 selected for by mass vaccination. His argument sounds a lot like an argument Andrew [... want %more?] → https://is.gd/Sp70OG | 11:08 |
| Brainstorm | New from BMJ: Seven days in medicine: 10-16 March 2021: Covid-19Vaccine is linked to lower transmissionA study by Public Health Scotland and the University of Glasgow of 300 000 healthcare workers employed by the NHS in Scotland and their households... → https://is.gd/cZYZJZ | 11:30 |
| rpifan | so it seems chile has one of the highest vaccine rates | 11:36 |
| Brainstorm | New from The Indian Express: World: AstraZeneca: EU regulator set to announce vaccine ruling → https://is.gd/78MCBz | 11:51 |
| Brainstorm | New from BMJ: Many “do not resuscitate” decisions in England during pandemic ignored equality and human rights laws, says CQC: Equality and human rights laws were flouted when “inappropriate” advance non-resuscitation decisions were taken during the covid-19 pandemic, the Care Quality Commission (CQC) has found in a... → https://is.gd/XQobcy | 12:12 |
| Brainstorm | New from ECDC: Data on testing for COVID-19 by week and country: The downloadable data file contains information about testing volume for COVID-19 by week and country. Each row contains the corresponding data for a country and a week. The file is updated weekly. You may use the data in line with ECDC’s copyright policy. → https://is.gd/1QzArh | 12:33 |
| Brainstorm | New from ECDC: Data on hospital and ICU admission rates and current occupancy for COVID-19: The downloadable data files contain information about hospitalisation and Intensive Care Unit (ICU) admission rates and current occupancy for COVID-19 by date and country. Each row contains the corresponding data for a certain date (day or week) and per country. [... want %more?] → https://is.gd/PGEWAF | 13:07 |
| Brainstorm | New from The Indian Express (Health): Destination of the week: Disneyland theme parks in California to reopen April 30 → https://is.gd/BhmXJ8 | 13:17 |
| Brainstorm | New from WHO Euro: WHO European Region: COVID-19 case incidence on the rise as deaths edge towards 1 million: Last week marked 1 year since WHO announced that the Public Health Emergency of International Concern declared on 30 January 2020 represented the first ever pandemic caused by a coronavirus. Since then, we’ve seen nearly 42 million cases in [... want %more?] → https://is.gd/SF6ohJ | 13:38 |
| Brainstorm | New from NIH Director's blog: Finding New Ways to Fight Coronavirus … From Studying Bats: David Veesler has spent nearly 20 years imaging in near-atomic detail the parts of various viruses, including coronaviruses, that enable them to infect Homo sapiens. In fact, his lab at the University of Washington, Seattle, was the first to elucidate the 3D [... want %more?] → https://is.gd/gqwKT3 | 14:11 |
| -Synapsestorm- ⭕ Sismo! Earthquake! 6.8 Mw tremor, registered by swifteqinfo, occurred 19 minutes ago (13:07:13 UTC), during daytime, Colombia (3.36, -69.92) ± 115 km, ↓50 km likely felt 470 km away (in Inírida, Mitú…) by 54600 people → https://twitter.com/swifteqinfo/status/1372538595236474881 https://twitter.com/swifteqinfo/status/1372538913177313281 (Twitter) | 14:27 | |
| Brainstorm | New from Derek Lowe: @Dereklowe: Spreading disinformation about vaccines is something that unites the crazies and liars of the Right with the crazies and liars of the Left:https://www.mediamatters.org/fox-news/way-fox-news-hosts-discuss-vaccines-public-health-nightmare → https://is.gd/T1HD5s | 14:32 |
| Haley[m] | %cases France | 14:36 |
| Brainstorm | Haley[m]: In France, there have been 4.1 million confirmed cases (6.2% of the population) and 91220 deaths (2.2% of cases) as of 4 hours ago. 57.9 million tests were performed (7.1% positive). See https://offloop.net/covid19/?default=France for time series data. | 14:36 |
| Brainstorm | New from Medical Xpress: Diseases, Conditions, Syndromes: Flu vaccines are updated every year. We can learn from this process as we respond to COVID variants → https://is.gd/E4x9lx | 15:14 |
| Brainstorm | New from The Indian Express (Health): Health: 54% Indian adults slept more during the COVID-19 pandemic, reveals survey → https://is.gd/rYGkU7 | 15:36 |
| rpifan | good | 15:38 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: Here's the slide deck I use when giving community talks on COVID vaccine safety. Please feel free to use them if you find them helpful.https://www.dropbox.com/s/iaxgn0r37bcbs9p/Crotty%20COVID%20vaccine%20safety%20March%2017.pptx?dl=0 → https://is.gd/uffQBA | 15:47 |
| najari[m] | is formite transmission basically not a problem? | 16:04 |
| Brainstorm | New from ClinicalTrials.gov: (news): Sensitivity of Frequent SARS-CoV-2 (COVID-19) Rapid Antigen Testing Regimen → https://is.gd/a2HSRJ | 16:08 |
| Brainstorm | New from ClinicalTrials.gov: (news): Evaluation of ADG20 for the Treatment of Mild or Moderate COVID-19 → https://is.gd/GOygtD | 16:19 |
| -RSSBot[LjLmatrix- Feed: Graduatoria finale di merito "dirigente specialista in funzioni operative di protezione civile” ( http://www.governo.it/it/articolo/graduatoria-finale-di-merito-dirigente-specialista-funzioni-operative-di-protezione-civile ) | 16:24 | |
| najari[m] | COVID-19 rarely spreads through surfaces. | 16:24 |
| najari[m] | https://www.nature.com/articles/d41586-021-00251-4 | 16:24 |
| zalamander[m] | I think that I was infected via an infected surface, because I had no close person-to-person interaction within a month of my infection. I think that I got it from the supermarket, either touching the cart or an item that someone else touched 🤔 Impossible to be sure, maybe someone did cough close enough to me and I did not notice.... But I was not able to think of a single possible exposure like that | 16:53 |
| Brainstorm | New from Medical Xpress: ACAAI updates guidance for allergic reactions to COVID-19 vaccines: (HealthDay)—The American College of Allergy, Asthma and Immunology (ACAAI) has updated its guidelines regarding the risk for allergic reactions with COVID-19 vaccines. → https://is.gd/i8lQAd | 17:12 |
| Brainstorm | New from Politico: EU drugs regulator: Oxford/AstraZeneca vaccine is safe: The decision comes after 20 EU countries either suspended, entirely or partially, their vaccination program with Oxford/AstraZeneca’s jab. → https://is.gd/nvHxax | 17:23 |
| Brainstorm | New from EMA: News and press releases: (news): COVID-19 Vaccine AstraZeneca: benefits still outweigh the risks despite possible link to rare blood clots with low blood platelets, PRAC, 18/03/2021 → https://is.gd/wjiI3L | 17:33 |
| LjL | zalamander[m]: if you've been at the supermarket, to me the number one hypothesis would be that you got it airborne. You don't have to be next to someone else coughing to get it, those are just guidelines to minimize the risk, they should not be confused with the impossibility of transmission occurring from aerosol simply present in the air | 17:40 |
| LjL | najari[m]: there has been increasing consensus that it's probably a very secondary means of transmission at best, but personally I'd say it's still not known with sufficient confidence to say that | 17:41 |
| Brainstorm | New from NPR: Addressing Racial Divides In Health Care Seen As Key To Boosting Black Vaccination: In many states, there are racial disparities in who has received a COVID-19 vaccine. A public health advocate says lack of health care access is a bigger impediment than a hesitancy to get vaccinated. → https://is.gd/hhSq2P | 17:44 |
| Brainstorm | New from The Indian Express: World: EU drug agency discounts any link between vaccine and clots → https://is.gd/ECTEKb | 17:55 |
| Brainstorm | New from BBC Health: AstraZeneca: UK and EU clot reviews confirm safety of vaccine: Regulators have looked at the evidence and say the vaccine is safe, effective and will save lives. → https://is.gd/71Zpfe | 18:06 |
| -RSSBot[LjLmatrix- Feed: Draghi, somministrazione vaccino AstraZeneca riprende da domani ( http://www.governo.it/it/articolo/vaccino-astrazeneca-nota-del-presidente-del-consiglio/16419 ) | 18:34 | |
| Brainstorm | New from Virological.org: Latest posts: The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the Spike protein: Methods SARS-CoV-2 and SARS-CoV-2-related coronavirus (SC2r-CoV) sequences Our genomic survey of SARS-CoV-2 positive samples sequenced by the [... want %more?] → https://is.gd/uUBgs2 | 18:37 |
| Brainstorm | New from r/WorldNews: worldnews: Biden will send four million of the US's unused doses of AstraZeneca's Covid vaccine to Mexico and Canada → https://is.gd/L40z63 | 18:59 |
| LjL | so AZ is back on board in Italy, security theater completed | 19:00 |
| LjL | the EMA didn't say anything we didn't already know and they hadn't already said, but just saying it again more officially is clearly enough to reassure every country we can proceed | 19:00 |
| Brainstorm | New from Medical Xpress: Vaccines alone may not be enough to end pandemic: study: Even as vaccines are becoming more readily available in the U.S., protecting against the asymptomatic and pre-symptomatic spread of the virus (SARS-CoV-2) that causes COVID-19 is key to ending the pandemic, say two Georgetown infectious disease experts. → https://is.gd/7XhZz8 | 19:10 |
| LjL | bleh! https://github.com/google/exposure-notifications-internals/issues/27#issuecomment-801842081 | 19:19 |
| LjL | de-facto, ↑ | 19:19 |
| LjL | if transparency was important before, it's also important after they make substantial changes, surely | 19:19 |
| rpifan | lol | 19:22 |
| LjL | i was pretty sure they had also promised to take down this whole thing after the end of 2020... clearly circumstances make that unwise, but it would have been nice if they had said anything about, notified users, something | 19:22 |
| de-facto | .title https://www.ema.europa.eu/en/news/covid-19-vaccine-astrazeneca-benefits-still-outweigh-risks-despite-possible-link-rare-blood-clots | 19:24 |
| Brainstorm | de-facto: From www.ema.europa.eu: COVID-19 Vaccine AstraZeneca: benefits still outweigh the risks despite possible link to rare blood clots with low blood platelets | European Medicines Agency | 19:24 |
| LjL | yes, that's what they've been saying all along. their opinion hasn't changed, and the fact that the link to those rare blood clots is still possible also hasn't changed | 19:25 |
| LjL | so they "completed their investigation" by... doing nothing | 19:25 |
| de-facto | "the benefits of the vaccine in combating the still widespread threat of COVID-19 (which itself results in clotting problems and may be fatal) continue to outweigh the risk of side effects;" | 19:40 |
| de-facto | "the vaccine is not associated with an increase in the overall risk of blood clots (thromboembolic events) in those who receive it;" | 19:41 |
| de-facto | "there is no evidence of a problem related to specific batches of the vaccine or to particular manufacturing sites;" | 19:41 |
| de-facto | "however, the vaccine may be associated with very rare cases of blood clots associated with thrombocytopenia, i.e. low levels of blood platelets (elements in the blood that help it to clot) with or without bleeding, including rare cases of clots in the vessels draining blood from the brain (CVST)." | 19:41 |
| de-facto | "These are rare cases – around 20 million people in the UK and EEA had received the vaccine as of March 16 and EMA had reviewed only 7 cases of blood clots in multiple blood vessels (disseminated intravascular coagulation, DIC) and 18 cases of CVST. A causal link with the vaccine is not proven, but is possible and deserves further analysis." | 19:41 |
| Brainstorm | New from r/WorldNews: worldnews: 'God bless America': Ontario premier says U.S. coming to Canada's rescue after Biden agrees to share vaccine doses → https://is.gd/bCveLi | 19:41 |
| de-facto | "The PRAC involved experts in blood disorders in its review, and worked closely with other health authorities including the UK’s MHRA which has experience with administration of this vaccine to around 11 million people. Overall the number of thromboembolic events reported after vaccination, both in studies before licensing and in reports after rollout of vaccination campaigns (469 reports, 191 of them from the EEA), was lower than tha | 19:42 |
| de-facto | t expected in the general population." | 19:42 |
| de-facto | so afaik in the UK it was mainly elderly receiving the vaccine there | 19:43 |
| de-facto | "This allows the PRAC to confirm that there is no increase in overall risk of blood clots." | 19:43 |
| de-facto | "However, in younger patients there remain some concerns, related in particular to these rare cases." | 19:43 |
| de-facto | so maybe this risk should be estimated as function of age then? | 19:43 |
| de-facto | "The Committee’s experts looked in extreme detail at records of DIC and CVST reported from Member States, 9 of which resulted in death. Most of these occurred in people under 55 and the majority were women." | 19:44 |
| de-facto | "Because these events are rare, and COVID-19 itself often causes blood clotting disorders in patients, it is difficult to estimate a background rate for these events in people who have not had the vaccine. However, based on pre-COVID figures it was calculated that less than 1 reported case of DIC might have been expected by 16 March among people under 50 within 14 days of receiving the vaccine, whereas 5 cases had been reported." | 19:44 |
| de-facto | so indeed they say that | 19:45 |
| de-facto | "Similarly, on average 1.35 cases of CVST might have been expected among this age group whereas by the same cut-off date there had been 12. A similar imbalance was not visible in the older population given the vaccine." | 19:45 |
| de-facto | So although the say in general that | 19:45 |
| de-facto | "The Committee was of the opinion that the vaccine’s proven efficacy in preventing hospitalisation and death from COVID-19 outweighs the extremely small likelihood of developing DIC or CVST." | 19:45 |
| de-facto | they put that statement into relation with saying | 19:46 |
| de-facto | "However, in the light of its findings, patients should be aware of the remote possibility of such syndromes, and if symptoms suggestive of clotting problems occur patients should seek immediate medical attention and inform healthcare professionals of their recent vaccination." | 19:46 |
| LjL | and they should be aware that if that happens, they're very likely to die anyway | 19:46 |
| de-facto | actually i hoped they would have found some more explanation (e.g. a link that makes those cases more specific) | 19:48 |
| de-facto | if we understood the mechanism in more detail maybe it could be predicted (hence avoided) | 19:48 |
| de-facto | but that probably is not so easy to determine | 19:49 |
| de-facto | if they have seen an order of magnitude more CVST in the young (mostly female) group than the expectation value and no such effect in the elderly it would have to be something more or less exclusive to younger women | 19:50 |
| de-facto | hence might be something related to female sexual hormones et al? (speculation!) | 19:51 |
| de-facto | would be interesting if they would have found cases post menopause or if there was any time correlation with monthly cycles? | 19:51 |
| Brainstorm | New from NIH Director's blog: Director's Album - Photos: First Anniversary of NIH’s COVID-19 Testing Car Line → https://is.gd/SpJ30w | 19:52 |
| de-facto | similar if there could have been any association with combined oral contraceptive pill? | 19:52 |
| de-facto | also could it be some kind of auto-immunity relatedo issue? | 19:53 |
| de-facto | afaik such problems also occur more often in young females compared to males of same age or elderly | 19:54 |
| de-facto | i think we need more information on those cases (and their medical history etc) | 19:55 |
| Brainstorm | New from r/WorldNews: worldnews: Researchers in Thailand have successfully trained six sniffer Labrador retrievers as part of a six-month pilot project to identify the coronavirus in just two seconds - with an accuracy rate of 94.8% → https://is.gd/Ve0Xr8 | 20:15 |
| Brainstorm | Updates for France: +26627 cases (now 4.2 million), +209 deaths (now 91425) since 16 hours ago — Italy: +24901 cases (now 3.3 million), +423 deaths (now 103855) since 16 hours ago — Spain: +6216 cases (now 3.2 million), +117 deaths (now 72910) since 16 hours ago — Yemen: +89 cases (now 3126), +10 deaths (now 723) since 16 hours ago | 20:39 |
| Brainstorm | New from Medical Xpress: Countries to resume AstraZeneca jabs after EU agency deems it 'safe': Several countries said Thursday they would resume AstraZeneca vaccinations after Europe's medical regulator said the jab is "safe and effective" and not associated with a higher blood clot risk after days of commotion around the shot. → https://is.gd/WN9KOo | 20:48 |
| Brainstorm | New from WebMD: On the Front Lines: Violence Against Nurses on the Rise: Violence against health care workers has reached epidemic proportions. According to the Emergency Nurses Association, health care workers account for approximately 50% of all victims of workplace violence. → https://is.gd/mMcghL | 20:58 |
| Jigsy | %cases UK | 21:07 |
| Brainstorm | Jigsy: In United Kingdom, there have been 4.3 million confirmed cases (6.4% of the population) and 125926 deaths (2.9% of cases) as of 28 minutes ago. 110.9 million tests were performed (3.9% positive). See https://offloop.net/covid19/?default=United%20Kingdom for time series data. | 21:07 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.03.03.21252856v1 | 21:26 |
| Brainstorm | de-facto: From www.medrxiv.org: REACT-1 round 9 final report: Continued but slowing decline of prevalence of SARS-CoV-2 during national lockdown in England in February 2021 | medRxiv | 21:26 |
| de-facto | hence about 1 in 200 | 21:26 |
| gigasu_shida | ljl which vaccine would you get? j&j, mod, or pfi ? | 21:34 |
| LjL | gigasu_shida: given a choice, I'd get moderna or Pfizer, although it would be great if they had human efficacy data for the SA variant | 21:38 |
| gigasu_shida | parents had moderna and didn't have any major side effects. since my immune system is probably similar enough to theirs i'm leaning toward moderna i guess | 21:39 |
| gigasu_shida | the variants will prob require an updated vaccine i'm guessing. ugh | 21:39 |
| rmonten[m] | Funny enough I was offered this choice on Tuesday. Actually only between Moderna and J&J, so I got Moderna and so far so good | 21:57 |
| Brainstorm | New from Medical Xpress: Surveys find strong support for COVID mitigation measures over time, with differences by age, beliefs, party affiliation: A set of surveys fielded last year found that a large majority of U.S. adults support COVID-19 mitigation measures, including indoor mask wearing, social distancing, and contact tracing, with significant [... want %more?] → https://is.gd/20fuNH | 22:12 |
| de-facto | lucky guys | 22:20 |
| Brainstorm | New from r/WorldNews: worldnews: Paris region to enter month-long coronavirus lockdown → https://is.gd/dPH4rC | 22:23 |
| rpifan | so thats bad news | 22:41 |
| Brainstorm | New from Politico: EU Confidential #192: AstraZeneca limbo — Vaccine export bans — COVID disinformation: Vaccine suspensions and possible export bans are up for discussion in this episode, along with elections in Germany and the Netherlands. We also delve into the issue of COVID-19 disinformation. As the European Commission proposes a digital [... want %more?] → https://is.gd/fAXyB8 | 22:44 |
| Brainstorm | New from r/WorldNews: worldnews: Paris goes into lockdown as COVID-19 variant rampages → https://is.gd/qdrtAL | 22:54 |
| Brainstorm | New from Bloom Lab: @jbloom_lab: R to @jbloom_lab: Cool aside: @PaulBieniasz @theodora_nyc have performed elegant VSV-spike escape selections with many of these antibodies. If we overlap @AllieGreaney’s binding escape & @tstarr’s ACE2-affinity deep mutational scanning, great concordance with their viral selections! (10/n) → https://is.gd/fWgNdP | 23:04 |
| LjL | de-facto: riddle me this, how rapid are the rapid tests if this thing https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=302327&WT.mc_id=USNSF_1 which is presumably kind of expensive and high tech takes an hour | 23:22 |
| Brainstorm | New from Politico: A year of lockdowns — How the pandemic changed Westminster: Jack Blanchard heads back to Westminster on the anniversary of the first coronavirus lockdown to hear how the pandemic has changed British politics for good. Guests in this season’s finale include Leader of the Commons Jacob Rees-Mogg, who discusses the pros and cons of [... want %more?] → https://is.gd/VJMuS7 | 23:35 |
| de-facto | "Mechanical engineer Peter Lillehoj has developed a stamp-sized microfluidic chip that measures the concentration of SARS-CoV-2 nucleocapsid (N) protein, a biomarker for COVID-19, in blood serum from a standard finger prick. The nanobeads bind to SARS-CoV-2 N protein in the chip and transport it to an electrochemical sensor that detects minute amounts of the biomarker." | 23:39 |
| de-facto | interesting, i wonder how sensitive those are | 23:39 |
| de-facto | "Lillehoj said a longer incubation yields more accurate results when using whole serum. The lab found that 55 minutes was an optimum amount of time for the microchip to sense SARS-CoV-2 N protein at concentrations as low as 50 picograms (billionths of a gram) per milliliter in whole serum. The microchip could detect N protein in even lower concentrations, at 10 picograms per milliliter, in only 25 minutes by diluting the serum fivefold." | 23:40 |
| de-facto | no idea how much a typical infection would cause | 23:41 |
| de-facto | .title https://pubs.acs.org/doi/10.1021/acssensors.0c02561 | 23:41 |
| Brainstorm | de-facto: From pubs.acs.org: Microfluidic Magneto Immunosensor for Rapid, High Sensitivity Measurements of SARS-CoV-2 Nucleocapsid Protein in Serum | ACS Sensors | 23:41 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: Here are our current thoughts on COVID-19 immunity, incorporating the important issue of variants of concern, notably the South Africa variant (B.1.351). → https://is.gd/IUe2CY | 23:57 |
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