libera/##covid-19/ Tuesday, 2021-03-30

de-facto.title https://www.bbc.com/news/uk-5655680600:14
Brainstormde-facto: From www.bbc.com: Covid: Secret filming exposes contamination risk at test results lab - BBC News00:14
de-factohmm maybe they need a slap in the face or such?00:15
BrainstormNew from r/WorldNews: worldnews: Stanford Scientists Reverse Engineer Moderna Vaccine, Post Code on Github → https://is.gd/jiGQaJ00:29
BrainstormNew from Medical Xpress: Fewer people sought medical help for severe asthma attacks during the COVID-19 pandemic: Fewer patients with severe attacks were seen by their GP or admitted to hospital during the COVID-19 pandemic, and fewer were admitted to hospital for pneumonia, influenza and chronic lung diseases, show findings from three papers published [... want %more?] → https://is.gd/9leSly00:39
BrainstormNew from BBC Health: (news): Evidence mounts Covid jab protects those around you → https://is.gd/aXTfrM01:51
LjL<CoronaBot> /r/coronavirus: One dose of Pfizer or Moderna vaccines was 80% effective in preventing Covid in CDC study of health workers (1007 votes)01:54
LjL<CoronaBot> https://www.cnbc.com/2021/03/29/cdc-study-shows-single-dose-of-pfizer-or-moderna-covid-vaccines-was-80percent-effective.html | https://redd.it/mfrhov01:54
LjL(this is about PCR-positive, not just symptomatic)01:54
rpifangreat but there arent enough to go around anyway02:03
rpifanso who cares02:03
LjLhmm?02:05
rpifanEvidence mounts Covid jab protects those around you02:05
LjLwell given the amount of cases still rising, evidently people go around other people02:07
de-factointeresting, how often did they test?02:16
de-factoand when did they collect data? was it D614G?02:17
de-facto"Dec. 14 and March 13" ok probably D614G then02:18
de-facto.title https://www.cdc.gov/mmwr/volumes/70/wr/mm7013e3.htm02:21
Brainstormde-facto: From www.cdc.gov: Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and [...]02:21
de-facto"...in eight U.S. locations during December 14, 2020–March 13, 2021, CDC routinely tested for SARS-CoV-2 infections every week regardless of symptom status and at the onset of symptoms consistent with COVID-19–associated illness."02:23
de-facto"Participants self-collected a midturbinate nasal swab weekly, regardless of COVID-19–associated illness symptom status and collected an additional nasal swab and saliva specimen at the onset of COVID-19–associated illness. Specimens shipped on cold packs were tested by RT-PCR assay at Marshfield Clinic Laboratory (Marshfield, Wisconsin) to determine SARS-CoV-2 infections (PCR-confirmed infection)"02:25
de-facto"Estimated adjusted vaccine effectiveness of full immunization was 90% (95% confidence interval [CI] = 68%–97%); vaccine effectiveness of partial immunization was 80% (95% CI = 59%–90%)"02:30
de-factowell thats very good, hopefully with the VoCs too02:32
BrainstormNew from Reddit (test): COVID19: r/COVID19 Change in Scope - PLEASE READ → https://is.gd/TQuxn002:32
de-facto.title https://imgur.com/a/5awmD9E https://i.imgur.com/8co1IoL.jpg "SARS-CoV-2 VoC B.1.1.7 and B.1.351 neutralization evasion" source: https://www.nature.com/articles/s41586-021-03398-2 "Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 | Nature"02:35
Brainstormde-facto: From imgur.com: SARS-CoV-2 VoC B.1.1.7 and B.1.351 neutralization evasion - Album on Imgur02:35
de-factoFigure 4 on page 802:36
BrainstormNew from r/WorldNews: worldnews: Leaders of 23 countries back pandemic treaty idea for future emergencies → https://is.gd/WsmSsx03:03
BrainstormNew from The Indian Express: World: Venezuela’s Maduro seeks to sideline opposition with ‘oil-for-vaccines’ plan: Lawmakers → https://is.gd/gZY1FD03:54
BrainstormNew from The Indian Express: World: Canada pauses AstraZeneca vaccine for under 55 → https://is.gd/FLxKWc04:15
BrainstormNew from The Indian Express: World: New York to open up COVID-19 vaccine to all adults on April 6 → https://is.gd/8qLvYN04:26
BrainstormNew from The Indian Express: World: Pfizer, Moderna COVID-19 vaccines highly effective after first shot: Study → https://is.gd/pKe2lE04:47
BrainstormNew from Bloom Lab: @jbloom_lab: Thanks to @tylernstarr, our #SARSCoV2 RBD mutant libraries are freely available in AddGene (https://www.addgene.org/pooled-library/bloom-sars-cov-2-rbd-dms/). Libraries contain nearly all single amino-acid mutations to RBD linked to 16-nt barcodes. (1/3) → https://is.gd/nrD3TJ06:10
BrainstormNew from r/WorldNews: worldnews: Bermuda premier warns of 'staggering’ number of Covid cases to come. → https://is.gd/UAzDcp06:30
BrainstormNew from r/WorldNews: worldnews: Leaders of 23 countries call for treaty to help world deal with future pandemics → https://is.gd/EO0WTN06:51
BrainstormNew from r/WorldNews: worldnews: Leaders of 23 countries back pandemic treaty idea for future emergencies → https://is.gd/kAIlXf07:12
BrainstormNew from r/WorldNews: worldnews: COVID-19 restrictions: B.C. temporarily halting indoor dining at restaurants, indoor fitness activities for adults → https://is.gd/yZlEYX08:34
BrainstormNew from r/WorldNews: worldnews: Leaders of 23 countries back pandemic treaty idea for future emergencies → https://is.gd/SU1ogI09:05
BrainstormNew from Medical Xpress: Your neighborhood may influence your COVID-19 risk: Markers of the pandemic's impact—testing rates, positivity ratio (cases among total tests), case rates by overall population and deaths—are clustered in neighborhoods, with low-income and predominantly minority communities experiencing worse outcomes than wealthier and [... want %more?] → https://is.gd/b28NHg09:16
BrainstormNew from Medical Xpress: Cuba begins testing 2nd COVID-19 vaccine on health care workers: Cuba began vaccinating tens of thousands of health care workers with a second COVID-19 vaccine on Monday, even though it has yet to complete clinical trials. → https://is.gd/EfdCus09:47
BrainstormNew from r/WorldNews: worldnews: Covid-19: World leaders call for international pandemic treaty → https://is.gd/HxPI1o09:57
BrainstormNew from r/WorldNews: worldnews: 'Ethical, safe?': Why are vaccine passports becoming a matter of concern → https://is.gd/i8v82F10:07
-RSSBot[LjLmatrix- Feed: Covid-19, il Presidente Draghi vaccinato con AstraZeneca all’hub di Roma Termini ( http://www.governo.it/it/articolo/covid-19-il-presidente-draghi-vaccinato-con-astrazeneca-all-hub-di-roma-termini/16520 )10:37
BrainstormNew from Politico: Aid and development: UK to prioritize own vaccine rollout before sharing shots with others → https://is.gd/LOTAnl10:38
mobidrop_the Party decides which experimental vaccines are mandatory, no travel without the right papers is allowed10:40
BrainstormNew from r/WorldNews: worldnews: Brazilian President Jair Bolsonaro replaces six ministers as Covid crisis balloons → https://is.gd/7lu6AS10:49
mobidrop_those who question the non-existing track record of mRNA technology and unknown long term health effects are reminded to "trust the science" and "if not for yourself, do it for others"10:55
BrainstormNew from r/WorldNews: worldnews: New Covid vaccines needed globally within a year, say scientists → https://is.gd/qyBRhs11:09
najari[m]what's this blood clot stuff I hear about astrazeneca?11:19
BrainstormNew from EMA: What's new: Medicine: Human medicines European public assessment report (EPAR): Comirnaty, COVID-19 mRNA vaccine (nucleoside-modified), COVID-19 virus infection, Date of authorisation: 21/12/2020, Revision: 4, Status: Authorised → https://is.gd/golaYG11:30
BrainstormNew from r/WorldNews: worldnews: City of London expects most workers to return after pandemic → https://is.gd/14l56R11:51
BrainstormNew from EMA: What's new: News: EMA working on COVID-19 over holiday period → https://is.gd/34O3M712:02
BrainstormNew from EMA: What's new: Document: COVID-19 vaccine safety update for Comirnaty: 29 March 2021 → https://is.gd/UtlW2z12:12
BrainstormNew from EMA: What's new: Document: COVID-19 vaccine safety update for Vaxzevria (previously COVID-19 Vaccine AstraZeneca): 29 March 2021 → https://is.gd/xaqzQH12:23
BrainstormNew from EMA: News and press releases: EU recommendations for 2021-2022 seasonal flu vaccine composition, , 30/03/2021: EMA has issued the recommendations for the influenza virus strains that vaccine manufacturers should include in vaccines for the prevention of seasonal... → https://is.gd/Lvrwu612:34
BrainstormNew from BBC Health: (news): Covid: Half of UK has antibodies from vaccination or infection → https://is.gd/rOE6l812:44
CoronaBot/r/covid19: NACI rapid response: Recommended use of AstraZeneca COVID-19 vaccine in younger adults (83 votes) | https://www.canada.ca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci/rapid-response-recommended-use-astrazeneca-covid-19-vaccine-younger-adults.html | https://redd.it/mg0yd513:04
BrainstormNew from Politico: Aid and development: Austria threatens to halt EU’s 100M vaccine buy until it gets greater share of jabs → https://is.gd/yRTo2713:16
BrainstormNew from r/WorldNews: worldnews: An israeli covid mutation has been discovered : → https://is.gd/VfVZ4r13:37
BrainstormNew from r/WorldNews: worldnews: Germany's vaccine regulator reports 31 cases of blood disorder after AstraZeneca shot → https://is.gd/JVcF1u13:47
BrainstormNew from r/Coronavirus: Daily Discussion Thread | March 30, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/fUwKRY14:40
BrainstormNew from NPR: Many World Leaders Call For Treaty On Future Pandemics: Given a lack of international coordination that has beset the current coronavirus pandemic, whether such a treaty could be reached or adhered to is an open question. → https://is.gd/6H8Mrf15:01
BrainstormNew from NIH Director's blog: Infections with ‘U.K Variant’ B.1.1.7 Have Greater Risk of Mortality: Since the genome sequence of SARS-CoV-2, the virus responsible for COVID-19, was first reported in January 2020, thousands of variants have been reported. In the vast majority of cases, these variants, which arise from random genomic changes as [... want %more?] → https://is.gd/VssbYy15:12
BrainstormNew from StatNews: Pharma: STAT+: Pharmalittle: Pfizer and BioNTech to boost Covid-19 vaccine production; lawmakers ask FTC to probe insulin pricing → https://is.gd/tUfG8q15:33
BrainstormNew from BMJ: Tomorrow’s doctors, tomorrow’s leaders: More than a year since we first entered lockdown, much has changed in terms of our working lives, as well as our personal or social lives... → https://is.gd/hMQkZ616:05
BrainstormNew from Shane Crotty: @profshanecrotty: This excellent study is good to see published. The vaccine results are very consistent with earlier studies from the UK & Israel, and again consistent with these vaccines being good at stopping transmission. → https://is.gd/UIqZ7r16:37
BrainstormNew from mRNA sequences: Update README.md: Added a section regarding the objectives/goals of this work, explaining the differences between an mRNA sequence and a full vaccine. → https://is.gd/uvcEUP16:48
BrainstormNew from ClinicalTrials.gov: (news): The Impact of the COVID-19 Pandemic on Diabetes Management → https://is.gd/OvPvzO17:09
BrainstormNew from LitCovid: (news): The Target Sign and Its Variant in COVID-19 Pneumonia. → https://is.gd/QV0Sby17:20
de-facto.title https://berthub.eu/articles/posts/sadly-you-cant-print-your-own-vaccine/17:21
Brainstormde-facto: From berthub.eu: Sadly, You Can't Print Your Own (safe) mRNA Vaccine - Articles17:21
de-facto.title https://www.who.int/health-topics/coronavirus/origins-of-the-virus17:26
Brainstormde-facto: From www.who.int: Virus origin / Origins of the SARS-CoV-2 virus17:26
BrainstormNew from ClinicalTrials.gov: (news): Consequences of COVID 19 Pandemic on Childhood Asthma → https://is.gd/nEW3Of17:32
BrainstormNew from ClinicalTrials.gov: EFFICACY and SAFETY OF BEVACIZUMAB (ZIRABEV®) IN PATIENTS WITH SEVERE HYPOXEMIC COVID-19: Conditions :    Corona Virus Infection;   SARS (Severe Acute Respiratory Syndrome);   Virus Diseases;   Coronaviridae Infections;   Nidovirales Infections;   RNA Virus Infections;   Respiratory Tract Infections;   [... want %more?] → https://is.gd/Xie2wp17:42
CoronaBot/r/covid19: BioNTech Raises Covid Vaccine Target to 2.5 Billion Doses (81 votes) | https://www.bloomberg.com/news/articles/2021-03-30/biontech-raises-2021-covid-vaccine-target-to-2-5-billion-doses?srnd=premium | https://redd.it/mgfqor17:48
BrainstormNew from ClinicalTrials.gov: (news): Clinical Efficiency of Surgical Masks and Filtering Face-piece 2 Masks → https://is.gd/SEWS5r17:52
BrainstormNew from ClinicalTrials.gov: (news): Study of HEarT DiseAse and ImmuNiTy After COVID-19 in Ireland → https://is.gd/9xhOqT18:03
BrainstormNew from ClinicalTrials.gov: (news): Lung Ultrasound Signs and Patterns in COVID-19 Pregnant Women → https://is.gd/lxdh5A18:13
BrainstormNew from ClinicalTrials.gov: (news): Anti COVID-19 Antibodies in Follicular Fluid and Spermatic Fluid → https://is.gd/FRCm7018:24
BrainstormNew from ClinicalTrials.gov: (news): Respiratory Tele Monitoring COVID 19 (TMR COVID-19) → https://is.gd/598K0z18:35
BrainstormNew from Medical Xpress: Can my kids hug their grandparents now that they're vaccinated?: Q: My parents have had both doses of the COVID vaccine. Can my kids visit them and safely hug them? → https://is.gd/RVSvMi18:46
LjLAs usual... lockdown: https://wtf.roflcopter.fr/pics/s6VNG55v/HeNL5HIR18:52
bin_bash%deaths india18:53
bin_bash%cases india18:53
Brainstormbin_bash: In India, there have been 11.9 million confirmed cases (0.9% of the population) and 161155 deaths (1.4% of cases) as of 2 days ago. 239.8 million tests were performed (5.0% positive). Fatality can be broadly expected to lie between 0.2% (assuming prevalence as in tests) and less than 1.4% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=India for time series data.18:54
BrainstormNew from r/WorldNews: worldnews: Coronavirus cases are rising all over the world → https://is.gd/Wy7AzP18:57
BrainstormNew from r/WorldNews: worldnews: Brazil biggest city, Sao Paulo, to use school vans to transport bodies from Covid-19 victims, as the funeral system gets overwhelmed. → https://is.gd/xVagTg19:08
BrainstormNew from Politico: Coronavirus: Poland’s government promises speedier vaccines in bid to head off political backlash → https://is.gd/f1LyDt19:29
de-factoLjL, as long as those people are outdoors they cant be indoors, i think the real problem is when people are visiting friends indoors, but that cant be easily separated from allowing walks in the park19:33
rpifanwell today it was really warm in berlin19:39
rpifanthe park was packed full of ppl19:39
BrainstormNew from Politico: Coronavirus: German regions suspend Oxford/AstraZeneca vaccine for those under 60 → https://is.gd/FQOyeH19:39
rpifanlol19:41
rpifanagain?19:41
CoronaBot/r/covid19: German cities suspend AstraZeneca vaccine use for under-60s (83 votes) | https://abcnews.go.com/Health/wireStory/german-state-suspends-astrazeneca-vaccine-60s-76766477 | https://redd.it/mgh4ee19:42
BrainstormNew from Scientific American: Health: WHO Report into COVID Pandemic Origins Zeroes in on Animal Markets, Not Labs → https://is.gd/6Om9vG19:50
rpifaneven if it were a lab would they say it was?19:51
LjLde-facto, okay... i guess that makes sense, but at the same time, right now there *is* a lockdown where in theory you're not allowed to be in the park, and also that you must wear a mask outdoors and indoors (and most of the kids in the park don't have masks). maybe it's not a tragedy but it shows the lockdown rules are completely ignored20:02
rpifanLjL, where is trhat20:02
LjLitaly20:02
rpifanoh20:03
BrainstormNew from r/WorldNews: worldnews: Pfizer, Moderna COVID-19 vaccines highly effective after first shot in real-world use – U.S. study → https://is.gd/z5sAy420:11
LjLrpifan, Lombardy, to be precise... and you'd expect people here to have been "burned" enough20:12
de-factoLjL, same here people dont care anymore, yet we dont have  curfew... yet20:16
rpifande-facto, what bundesland r u in20:16
de-factobtw again you live at a beautiful place there :)20:17
de-factorpifan, bw20:17
rpifanah i know someone else from baden20:17
de-factoyou were be?20:17
rpifanbe?20:20
BrainstormNew from Politico: Coronavirus: Ireland ready for slow easing of lockdown measures, says PM Martin → https://is.gd/5OAE6I20:22
de-factoberlin20:41
BrainstormNew from WebMD: Brain Scraper: Why Do Some COVID Tests Hurt So Much?: The nasopharyngeal swab -- aka the Brain Tickler -- is considered the gold standard for COVID tests. The problem is no two noses are exactly a like and different people will have different reactions. → https://is.gd/P8ZMQd20:43
rpifanive never been bothered20:45
rpifanby the swab covid20:45
LjLi feel it would hurt me21:24
LjLmy nose is quite perennially clogged21:24
LjLi had a nose endoscopy (not sure if it has a more specific name) once, and the doctor could only check one nostril because the other was just too slammed shut to get into21:25
LjLtbh i think covid tests could also be done with just a saliva swab and be almost equally accurate21:25
de-factoi just gargled today, its super easy21:30
de-factofor screening purpose, i do it every week now21:30
de-factothey give a little bottle, a straw and a tiny sample tube (7x50mm). in the morning one would sip the salty water from the bottle, gargle with it 30s, use the straw to put it back in the bottle, then cough and pull up the nose several times and try to put the result with the straw in the bottle, close it, shake it, and fill it with the pointed "pipette" like tip into the sampling tube21:32
de-factosuper easy and takes like 2 minutes, collecting from all over the mucus (but surface, hence averaging out concentrations)21:33
de-factono cotton swabs or such needed for that method, but also does not collect from inside the nasal surface21:34
de-factowhat would be the to be assumed disadvantages?21:34
de-factoi wonder how sensitivity would compare to classic cotton swab especially in the early infection21:37
LjLde-facto, there was a paper that said it's actually better to use saliva, but it's an old paper. i vaguely remember something that came out later that said nose is more accurate. so maybe it's not so clear21:38
LjL%links salive21:38
BrainstormLjL, https://www.medrxiv.org/content/10.1101/2020.04.16.20067835v1 (Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs), an observation that may free us from those cringey swabs, if it gets past preprint stage21:38
LjL%links saliva21:38
BrainstormLjL, https://www.medrxiv.org/content/10.1101/2020.04.16.20067835v1 (Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs), an observation that may free us from those cringey swabs, if it gets past preprint stage21:38
LjLyeah that21:38
LjLhaha my comment on that21:39
de-factooh wow nice21:39
LjLit did get past preprint stage after all21:40
LjLhttps://www.nejm.org/doi/full/10.1056/NEJMc201635921:41
LjLalthough it's as a letter to the editor apparently (so not peer-reviewed?)21:41
de-facto"When we compared SARS-CoV-2 detection from patient-matched nasopharyngeal and saliva samples, we found that saliva yielded greater detection sensitivity and consistency throughout the course of infection. Furthermore, we report less variability in self-sample collection of saliva."21:42
LjL"Collection of saliva samples by patients themselves negates the need for direct interaction between health care workers and patients. This interaction is a source of major testing bottlenecks and presents a risk of nosocomial infection."21:42
LjLde-facto, what did i say, that among the things Merkel announced last time, it was all pretty "meh", except the free weekly rapid test would be a welcome thing21:43
de-factoi think it makes sense that saliva samples are more sensitive in the later progressions when it starts to travel down both the airways and the gastrointestinal tract, but what about the very early stages (where it would be most important to detect it)?21:45
BrainstormNew from Medical Xpress: Pfizer to move up COVID vaccine deliveries to Canada: PM: Pfizer has agreed to move up deliveries of its COVID-19 vaccine to Canada, Prime Minister Justin Trudeau said Tuesday, one day after restricting AstraZeneca jabs over safety concerns. → https://is.gd/jgcA5d21:46
de-factoLjL, they probably will make testing mandatory in working places soon (hopefully) because participation is pretty "meh". also in schools i heard that for a given class of 13 children 11 would come with a written document from their parents that they dont allow participation in testing of their kids because they fear quarantine21:47
de-factoso sometimes a little pressure may help people to do the right thing21:48
LjLyeah i remember you mentioned that21:50
LjLsilly people21:50
BrainstormNew from ScienceNews: Moderna and Pfizer COVID-19 vaccines may block infection as well as disease: The mRNA vaccines are about 90 percent effective at blocking coronavirus infection, which could lead to reduced transmission, real-world data suggest. → https://is.gd/YF8xYl21:57
BrainstormNew from r/WorldNews: worldnews: WHO chief says data withheld from team probing COVID-19 origins in China → https://is.gd/p9lDQ522:08
BrainstormNew from Medical Xpress: Spain extends AstraZeneca vaccine jabs to over 65s: Spain's health ministry announced Tuesday that it was extending the roll-out of the AstraZeneca COVID-19 vaccine to the over-65s, after recent scientific reassurances about its safety. → https://is.gd/Jwolz822:39
BrainstormNew from The Atlantic: The Fourth Surge Is Upon Us. This Time, It’s Different.: Across the United States, cases have started rising again. In a few cities, even hospitalizations are ticking up. The twists and turns of a pandemic can be hard to predict, but this most recent increase was almost inevitable: A more transmissible and more deadly variant [... want %more?] → https://is.gd/LSpDGg23:01
CoronaBot/r/coronavirus: Half of people in England now have antibodies against Covid, study says (10013 votes) | https://www.independent.co.uk/news/health/covid-antibodies-coronavirus-ons-study-b1824292.html | https://redd.it/mgcmhn23:08
LjLwhat study, sounds like bollocks to me23:18
LjLoh, vaccine-elicited antibodies23:19
LjLi take it back then, not bollocks23:19
LjL"But the ONS warned it was seeing evidence of a reduction in antibodies in older people in the most recent data."23:19
BrainstormNew from Politico: Coronavirus: Merkel and Spahn: No more Oxford/AstraZeneca jabs for under 60s → https://is.gd/v8yGPS23:32
LjLde-facto, well so now Germany is restricting AZ to younger people too23:48
LjLso much for "naaaah it's fine --EMA"23:48
LjLi bet now that Germany did this, everyone will follow suit sooner or later (EMA and WHO perhaps only at last)23:50
LjLthree people were arrested and the health minister of Sicily is under investigation, because their COVID data were falsified in order to avoid being locked down23:59
LjLi'm not sure i'm even surprised23:59

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