libera/##covid-19/ Thursday, 2021-04-01

bin_bashyou said "what took them so long"00:00
bin_bashI must assume you're jokiong00:00
de-factoisnt B.1.351 almost 4 months old by now?00:01
de-factowe need to act much much faster with vaccinations and updates00:01
bin_bashokay well good, properly done science doesn't happen overnight00:02
de-factoi probably will get a vaccination offer with a two years old variant of the s-protein00:02
bin_bashimagine what would happen if they went prematurely into trials and things went south00:02
bin_bashor it was ineffective00:02
bin_bashor there was a mistake00:02
bin_bashhuman trials are a VERY serious thing00:02
de-factoyes of course they should do it properly00:02
bin_bashokay, well the fact that they even have a trial candidate in 4 months is extremely impressive00:03
bin_bashthat they're going into trials now is even more impressive00:03
najari[m]as a newb, I heard that the mrna vaccines are very easy to alter for a new variant00:03
najari[m]is this incorrect?00:04
de-factobut that does mean they should start to develop candidates for *each* variant of concern, well even for each variant of interest *right* after it was discovered. then directly start to evaluate the safety of the update and start trials with it00:04
bin_bashnajari[m]: correct, that's why they came up with a booster that's gone to trial in only 4 months00:04
de-factoits not like they would have to start with developing the vaccine from scratch again (unlike the viral vector ones)00:04
bin_bashde-facto: not necessarily. right now the SA variant is the most concern because of how existing vaccines don't target it exactly00:04
de-factothey *only* would have to update the sequence for the s-protein in their mRNA (and do all the codon optimization again, but still in principle the same way)00:05
najari[m]<bin_bash "najari: correct, that's why they"> since this is how mrna vaccines work, isn't 4 months not impressive, but expected?00:05
de-factoafaik they would need something like 6 weeks for implementing updates00:05
de-factohene should start as early as possible00:05
bin_bashnajari[m]: you're not really thinking about the whole picture here. These are the very first mRNA vaccines. This is the very first mRNA vaccine modification.00:06
de-factoif 99% of their candidates have to be discarded because the VoCs disappear again, so be it, but having 1% ready earlier is of great importance00:06
bin_bashonce the process is down then it should be much quicker00:06
najari[m]<bin_bash "once the process is down then it"> ah ok, I must've heard about this step00:06
bin_bashnajari[m]: what step?00:07
de-factoyes honestly i am very glad they are doing the updates, but i think they still need to improve that feedback and update loop00:07
de-factoadmitted it the first iteration, and thankfully its possible with the mRNA vaccines to do such a thing00:07
LjLI think you're both right. By normal scientific standards, a new vaccine flavor in 4 months is fast. But in the long run if we don't find a way to do this much faster, 4 months is enough for a new variant to have significant and widespread impact, which would mean we'd end up chasing variants for the rest of our lives00:07
bin_bashLjL: it's the very first one of its kind ever00:08
bin_bashso 4 months for the very first update is impressive00:08
najari[m]bin_bash: once we're experienced in mrna covid vaccines, popping them out00:08
de-factoits not only that a new update would have to get approved, it also would have to land in the arms of the people and therefore each day is of uttermost importance00:08
bin_bashnow if it's 4 months forever, well, that's STILL faster than typical vaccination changes00:08
de-factoyes of course00:08
de-factobut it has to be improved to be even faster00:08
bin_bashnajari[m]: right that's the idea, from my understanding. 4 months for any vaccine is incredibly fast so even if it were "expected", it's still impressive00:09
bin_bashthink about how many expectations are never met00:09
najari[m]bill gates seemed to be insinuating that mrna vaccines could even cure malaria, does this sound correct?00:09
bin_bashde-facto: right but before that can happen it has to be safe, otherwise it just fuels vaccine fear00:10
de-factoyes00:10
bin_bashnajari[m]: sure00:10
bin_bashalso for a universal flu vaccine, hopefully00:10
najari[m]between those malaria immune mosquitoes and mrna vaccines, things are looking good!00:11
de-factoof course, but its not entirely new vaccine, that update only produces a slightly different s-protein (i assume), yet you are correct it has to be tested properly, hence the sooner they start with testing the better00:11
najari[m]<bin_bash "also for a universal flu vaccine"> I don't expect this to happen, I suspect the cost of developing a universal flu vaccine is greater than the cost of saving people from the flu :(00:13
najari[m]in the short run00:13
bin_bashthat's silly00:13
LjLPerhaps more concerningly, Pfizer and others already stated that their cash cow is going to be periodic boosters00:13
bin_bashthey've been working on it for a long time00:13
de-factothis will be the start of an entirely new approach to immuno-mediated individualized medicine00:13
LjLSo there is an economic incentive to keep selling boosters instead of finding one definitive remedy00:14
bin_bashfor covid, but i was referring to the universal flu vaccine00:14
bin_bashwhich is a different program00:14
LjLSure, but it could be a somewhat similar economic... thing00:14
najari[m]<de-facto "this will be the start of an ent"> I will add mrna vaccines to my list of "greatest inventions of the 2020s"00:15
BrainstormNew from r/WorldNews: worldnews: 15 million doses of Johnson & Johnson's vaccine ruined by ingredient mix-up → https://is.gd/AGgg1h00:15
bin_bashLjL: theyve already been working on a universal flu vaccine though00:16
bin_bashlike that's been a project for a while, and the mrna breakthrough could change it a lot.00:16
najari[m]I've heard people saying stem cells were a great discovery that will change everything, here I am still waiting for the change everything :P00:18
bin_bashmaybe you've not been paying attention then00:18
najari[m]yes00:19
najari[m]but the hype was like regrowing organs00:19
bin_bashstem cells have been SEVERELY limited by the religious right00:19
bin_bashthey;'re not being allowed to be used for their full potential00:20
de-factonajari[m], not only vaccines, its like a platform technology, depending on what the mRNA encoding it could almost do anything00:20
de-factonajari[m], not only vaccines, its like a platform technology, depending on what the mRNA is encoding it could almost do anything00:20
bin_bashwhy'd you send that twice00:20
bin_bashnajari[m]: not to mention that stem cells are actually being used for organ 3d printin00:21
najari[m]i can't quite remember the hype promises of stem cells00:24
najari[m]but remember the self driving car hype that elon was pushing?00:24
de-factosometimes i forget to type a word because i always hit enter too soon00:24
najari[m]elon said like level 4/5 self driving cars in like 2019 or so00:25
de-factosure it will take some time, but its a fundamental change in the possibilities for individualized treatment00:26
de-factomaybe with targeting specific cells it will become even more advanced00:26
najari[m]<de-facto "sure it will take some time, but"> yea i think this is the key about scientific key - it'll happen eventually00:27
najari[m]yea i think this is the key about scientific research** - it'll happen eventually00:29
CoronaBot/r/covid19: Why indoor spaces are still prime COVID hotspots (80 votes) | https://www.nature.com/articles/d41586-021-00810-9 | https://redd.it/mh8sey00:30
LjLnajari[m], if you listen to the hype, just hype is what you'll get. i feel that when you look at realistic sources, of course they aren't crystal balls either, but the claims are more... realistic.00:32
BrainstormNew from Medical Xpress: Mass COVID testing at UK universities is haphazard and unscientific, finds BMJ investigation: The costly rollout of asymptomatic screening for COVID-19 at UK universities has found very few positive cases following its launch in December as part of the Government's ambitious £100bn Moonshot programme, finds an investigation [... want %more?] → https://is.gd/WVAIPN00:36
najari[m]yea00:37
najari[m]<de-facto "i guess we will see quite a lot "> this years hotest commodity. customers reviews say "a fever pitched dream come true", "coughing up an entire lung", "fun for the whole family"00:41
najari[m]<de-facto "if they want to travel, they als"> we have ankle bracelets00:48
de-facto14 day controlled quarantine seems to work quite well for countries like China or New Zealand00:59
de-factoat least a lot better than for EU countries where we always ensure we import the newest updated variants of concern and seed them everywhere01:00
de-factonot sure about USA they seem to do less sequencing or such01:00
de-factobtw why? does USA really do so much less sequencing or do they just not publish it?01:01
najari[m]<de-facto "btw why? does USA really do so m"> not sure what's happening now, but before the officials were talking about injecting bleach01:04
LjL"the officials"? Trump was01:07
LjLwho else ever mentioned anything remotely like that01:07
BrainstormNew from Politico: Johnson & Johnson subcontractor ruins 15 million vaccine doses: Workers at Emergent BioSolutions mistakenly mixed ingredients from two Covid-19 vaccines together. → https://is.gd/1NRHUb01:08
LjLurgh01:08
rpifanugh01:09
rpifangood01:09
rpifandouble vaccine01:09
rpifanlol01:09
LjLyeah keep the doses, it'll just take the EMA 6 months or so to approve it as a new vaccine :P01:09
LjL"The company added: "This batch was never advanced to the filling and finishing stages of our manufacturing process. This is an example of the rigorous quality control applied to each batch of drug substance."01:10
LjLi mean... if this is a *good* example... oh look, we had our vaccine mixed up with another one, BUT WE NOTICED! we're cool!01:10
LjLalso it doesn't look like the article cares to mention *which* other vaccine was involved01:11
LjLpresumably there's another vaccine that may be suffering effects from this incident01:11
LjLbut another article almost spills the beans01:12
LjL"The plant is run by Emergent BioSolutions, a manufacturing partner to both Johnson & Johnson and AstraZeneca."01:12
LjLhttps://www.nytimes.com/2021/03/31/world/johnson-and-johnson-vaccine-mixup.html01:12
LjLi guess it's not farfetched to guess which other vaccine was involved :\01:13
de-factoaaw maybe they would have discovered the mix would have been more efficient than any of the two taken separately :P01:15
de-facto(bad joke, but hey would not be the first time something like that would have been discovered by mistake)01:15
rpifanlol01:16
najari[m]i volunteer as tribute01:16
rpifanit has happened01:16
de-factolike half the intended dose for example...01:17
LjLoooor a longer time between doses?01:17
LjLwe'll never know!01:17
de-factowell we will not know what made it more effective, but half the dose was unintentional01:18
najari[m]have any countries tried anything like putting death tolls on billboards?01:21
LjLtrue... but the longer time was just a direct effect of that unintentional mistake01:21
LjLnajari[m], not something i've heard of01:21
najari[m]or live stream ppl digging graves for corona victims01:21
LjLnot sure i'd feel great about that, but i guess that would be the point01:22
najari[m]it sounds like the kind of thing that might get rightwingers to believe a little bit more01:22
de-factobtw why are not all countries running representative screening of 1) unvaccinated control group with the same demographic and constituents than each 2) vaccinated group with each of the vaccines and sequence any breakthrough variant of concern?01:23
de-factowe need ongoing stats but are completely blind what is going on with the vaccinated groups and how their efficacy develops over time01:24
de-factoafaik only the phase 3 trial members are observed for longer01:25
de-factowell and some local studies such as in healthcare workers etc, but why not use all the numbers01:25
de-factolike Israel does it01:25
LjLi don't have a better answer than "because the EU is consistently doing everything wrong"01:26
de-factofor each mutant with breakthrough we should have a probability graph for each age group with the infection probability over time01:26
de-factohow can we do informed decisions without such data?01:27
de-factomaybe the B,1,351 variant has a breakthrough, maybe vaccines become leaky over time, maybe we need updates, but why dont we quantify that with real life data?01:27
de-factoif we had curves on this we also could do predictions and extrapolations into the future, hence we could have estimates on how fast updates should be developed etc01:28
najari[m]<de-facto "how can we do informed decisions"> we cant01:29
najari[m]I think john oliver summarized it best:01:30
najari[m]"I know it's easy, but it feels too hard"01:30
de-factowe happily vaccinate right into rising incidence and assume nothing will go wrong with that, heck we dont even monitor for breakthrough or efficacy against mutants over time? why is that? the data is right there we only have to write it down01:31
najari[m]srs answer01:32
najari[m]maybe the psychology of "learnt helplessness"01:32
de-factothis is the opportunity to study immunity driven convergent evolution of a pathogen due to similarity in the human B-cell reaction to a given antigen (encoded in the vaccines)01:34
de-factoif this can be understood better, maybe such convergent evolution can be predicted and vaccine updates potentially could be developed and tested ahead of a convergent mutation also occurring in the wild01:35
de-factomaybe... idk if that is possible but that would be awesome01:35
de-factomaybe having the latest mutant doing many serial passages in cell cultures in vitro under non-neutralizing selection pressure by human blood plasma containing the currently prevalent version of antibodies in the population, then if convergent evolution really would only give rise to a few certain advantageous evasive point mutations maybe they would appear in vitro prior to in vivo?01:38
LjLde-facto, you realize though that's pretty much gain-of-function research ;P01:39
BrainstormNew from r/WorldNews: worldnews: 15 million J&J Covid vaccines thrown away after ingredient mix-up. → https://is.gd/g0EtKT01:39
de-factoLjL, yes of course such mutants must be shielded very carefully not to escape the labs01:40
de-factohaving identified such a probable future convergent mutation one could even re-iterate the whole process by developing a vaccine from that variant of the s-protein, giving it to a human to get the next iteration of antibodies and start all over again...01:40
de-facto(i dont know if such a process is possible at all though, it strongly depends on the probability of two such independent pipelines coming to the same result, e.g. how few of such convergent mutations would occur in nature)01:41
de-factointerestingly enough it seems they were able to "breed" E484K in the lab independent of its occurrence in the wild, so somehow they had the same factors leading to the same mutant (hence convergent evolution)01:42
de-facto.title https://www.biorxiv.org/content/10.1101/2020.12.28.424451v101:43
Brainstormde-facto: From www.biorxiv.org: SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma | bioRxiv01:43
de-facto"To investigate the evolution of SARS-CoV-2 in the immune population, we co-incubated authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for 7 passages, but after 45 days, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed at day 8001:43
de-factoby an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization."01:43
LjL*completely* resistant :\01:44
de-factoi wonder if it would be possible to develop vaccine variants ahead of time by that01:44
LjLmy guess would be yes01:44
LjLwhether it'd be considered practical/economical/ethical/etc to do so, i don't know01:44
de-factoit depends on how predictable such convergent mutations are and if they really could be identified by such a process01:44
de-factobut it seems they are arising due to the similarity in the human B-cell answer to the presence of a specific version of the antigen01:45
LjLde-facto, the more "inevitable" they are to occur (like E484K), the better the chances a process like this could spot them01:46
LjLand the ultimately inevitable ones are probably the most worrisome ones01:46
de-factoindeed01:46
de-factobecause they would be of most advantage to pathogen spread01:46
de-factohence if a vaccine would already be ready as soon as they occur it only would be a question of production rate to contain such a variant01:47
de-factolike develop many vaccine variants in parallel, approve them, test them etc so one directly could begin with vaccination campaign as soon as a new mutant makes problems01:48
LjLi guess a variant could also occur with an "important" mutation like E484K but also with some other mutations that are not very important but just happened to... happen during the evolution of that variant. then the question is, will those be enough to stop a vaccine that only targets the "important" changes from producing neutralizing antibodies01:50
de-facto[m]Yes somehow the important mutations must be identified, so once a mutant explodes under neutralizing plasma this evasion should be studied further, e.g. by variation maybe with neutralization assays as they did it with fhe current VoCs too, each contained mutation separately and combos etx01:56
de-facto[m]Once interest is rised at looking into a evasive mutation it also can be studied in silico and in humanized mouse models etc pp01:57
LjLfinding solid ways to pinpoint potentially dangerous mutations in silico would probably be the way to meaningfully beat the virus "for good"01:58
LjL(still not meaning it'd be gone, animal reservoirs etc, but for a decent definition of "for good")01:59
BrainstormNew from r/WorldNews: worldnews: Political turbulence in Brazil overshadows Covid-19 crisis → https://is.gd/1pSEYs01:59
de-facto[m]Ofc immune response is dynamic (follows antigen drift) and also contains cellular immunity etc02:01
de-facto[m]but maybe that somehow can be estimated with an iterated series of such feedback loops ping pong between in vitro breeding evasuons and in vivo provoking the next iteration of immune reactuon against the updated antigen, then start recursion02:03
BrainstormNew from WHO Euro: Slow vaccine roll-out prolonging pandemic: As variants of concern continue to spread and strain on hospitals grows, religious holidays are leading to increased mobility. Speeding up vaccination roll-out is crucial as new cases in the WHO European Region are increasing in every age group, apart from one. → https://is.gd/fxAW6Z02:10
CoronaBot/r/covid19: T Cells Recognize Recent SARS-CoV-2 Variants (82 votes) | https://www.niaid.nih.gov/news-events/t-cells-recognize-recent-sars-cov-2-variants | https://redd.it/mhdh3h02:19
de-factoif this vaccine generation established a very effective platform (mRNA), maybe the next generation should establish a polyclonal (hence multivalent) version of it blocking all the most probable (predicted and observed) convergent mutants evasion paths hence surrounding the pathogen with a sufficiently large quantity of variance (in immunity) to not allow evasive mutants?02:28
de-factomaybe there is a threshold where the immune system gets enough time advantage relative to pathogen reproduction on cellular level that it stops almost all variants right away, hence also the pandemic?02:29
de-factoi think its just a question of working on a time advantage against the pathogen (and since its mutation rate is not the fastest, maybe that has a chance)02:30
de-factoa multivalent polyclonal vaccine almost would be like shooting with a shotgun, aiming would not have to be as precise (targeted on one specific variant only) but rather the spread would guarantee one of the clones would neutralize the evasion tries of the target trying to drift away with a certain mutation speed02:33
de-facto(ok ok that all is completely crazy speculation but heh its fun)02:33
de-factong802:33
de-factogn802:33
n3pthe true that hides WHO https://rumble.com/vf8ekp-ep-838-winnie-the-pooh-tedros-and-tony-fauci-walk-into-wuhanhow-taxpayers-f.html03:27
LjLn3p, with all the criticism that can be moved towards the WHO, that sort of caricatured scandalist stuff is not welcome here03:53
n3pThe true is not welcome everywhere. We are living in CLOWNWORLD and I can see this channel is just that03:54
LjLokay03:55
BrainstormNew from FDA Press Releases: FDA: Coronavirus (COVID-19) Update: FDA Continues to Advance Over-the Counter and Other Screening Test Development → https://is.gd/Z3tjOt04:04
CoronaBot/r/covid19: Johnson & Johnson Statement on U.S. COVID-19 Vaccine Manufacturing (82 votes) | https://www.jnj.com/johnson-johnson-statement-on-u-s-covid-19-vaccine-manufacturing | https://redd.it/mhhf8x04:32
BrainstormNew from Ars Technica: Science: Factory mix-up spoils 15 million doses of J&J COVID vaccine → https://is.gd/pbLqRb04:50
BrainstormNew from The Indian Express: World: Brazil detects new coronavirus variant similar to South African → https://is.gd/OBCqjU05:10
BrainstormNew from The Indian Express: World: US: Factory mix-up ruins up to 15 million Johnson & Johnson vaccine doses → https://is.gd/epTKtC05:21
BrainstormNew from This Week In Virology: TWiV 737: SARS-CoV-2 in NYC wastewater: John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern. → https://is.gd/DOZSWP06:13
BrainstormNew from EurekAlert!: UTSA criminology professor studies impact of COVID-19on gender-based violence: The University of Texas at San Antonio criminology and criminal justice professor Kellie Lynch, along with professor TK Logan from the University of Kentucky, worked with the National Coalition Against Domestic Violence on a national survey to [... want %more?] → https://is.gd/HcpdyU06:24
BrainstormNew from mRNA sequences: Add files via upload: ##version 0.2Beta 03/30/21: (update intended to (i) clarify the clinical and research importance of sequence informationand strand topology measurements, and (ii) clarify that the mRNA sequence is not a recipe to produce vaccine)## → https://is.gd/Wgn0CU06:45
BrainstormNew from r/WorldNews: worldnews: Italy makes vaccine mandatory for all health workers → https://is.gd/5fQmIJ07:05
CoronaBot/r/coronavirus: Data Suggests Vaccinated Individuals Don't Carry Virus or Get Sick: CDC (10104 votes) | https://www.nbcbayarea.com/news/coronavirus/vaccinated-individuals-dont-carry-virus-or-get-sick-cdc/2506677/ | https://redd.it/mhcmbn07:15
BrainstormNew from The Indian Express: World: See how rich countries got to the front of the vaccine Line → https://is.gd/Ri5EDU08:07
BrainstormNew from Politico: Boris Johnson’s most senior Black aide has quit: Samuel Kasumu is the No. 10 point man for outreach with minority communities and voices, including on vaccines. → https://is.gd/jMclf808:18
BrainstormNew from r/Coronavirus: Daily Discussion Thread | April 01, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/vKwS1c09:10
BrainstormNew from Medical Xpress: COVID-19 pandemic worsened pregnancy outcomes for women and babies worldwide: Pregnancy outcomes for mothers and babies have worsened during the COVID-19 pandemic, a review of data from 40 studies representing 17 countries published today in The Lancet Global Health journal has revealed. → https://is.gd/SKf19309:41
BrainstormNew from r/WorldNews: worldnews: CDC confirms vaccinated individuals dont spread covid19 → https://is.gd/RgBPxN09:52
BrainstormNew from Medical Xpress: Puerto Rico vaccinates thousands in 15-hour mass event: Thousands of people were vaccinated against COVID-19 on Wednesday as part of a mass inoculation event in Puerto Rico's capital that was scheduled to last 15 hours. → https://is.gd/2mtMFZ10:13
BrainstormNew from Medical Xpress: Company at heart of J&J vaccine woes has series of citations: The company at the center of quality problems that led Johnson & Johnson to discard an unknown amount of its coronavirus vaccine has a string of citations from U.S. health officials for quality control problems. → https://is.gd/8ZO8gj10:23
BrainstormNew from Medical Xpress: Brazil closes out deadliest month of pandemic by far: Hard-hit Brazil closed out its deadliest month of the coronavirus pandemic by far on Wednesday, with 66,573 people killed by COVID-19 in March, more than double the previous record. → https://is.gd/xaHtVH10:44
BrainstormNew from Medical Xpress: Brazil grants emergency approval to J&J COVID vaccine: Brazil approved Johnson & Johnson's single-dose COVID-19 vaccine for emergency use Wednesday, the fourth vaccine to get regulatory approval in the hard-hit country. → https://is.gd/1M8EnE10:54
BrainstormNew from Medical Xpress: Genome sequencing shows coronavirus variation drives pandemic surges: Genome sequencing of thousands of SARS-CoV-2 samples shows that surges of COVID-19 cases are driven by the appearance of new coronavirus variants, according to new research from the School of Veterinary Medicine at the University of California, Davis [... want %more?] → https://is.gd/uub3RW11:05
BrainstormNew from BMJ: Covid-19 vaccination during Ramadan: Vaccine hesitancy has been reported among people and healthcare staff from ethnic minorities.1 This is a serious concern given covid-19 is the largest global public health challenge in recent years.... → https://is.gd/Ce4sox11:26
BrainstormNew from BBC Health: (news): Long Covid: More than a million affected in February, survey suggests → https://is.gd/ye82y612:08
BrainstormNew from BMJ: Covid-19: Brazil’s spiralling crisis is increasingly affecting young people: Brazil continues to break records for all the wrong reasons as it faces its deadliest episode of the pandemic yet, amid an escalating political crisis.More than 3780 covid-19 deaths were recorded on... → https://is.gd/iTK3aX12:29
BrainstormNew from Virology.ws: Are the SARS-CoV-2 Vaccines Safe for Pregnant and Lactating People?: Accumulating data suggest that SARS-CoV-2 vaccination of pregnant and lactating people is both safe and beneficial for both mother and child. → https://is.gd/JUFnfL13:00
BrainstormNew from BMJ: Covid-19 vaccine passports: access, equity, and ethics: With millions of people receiving covid-19 vaccines globally, some countries have already started planning the implementation of “vaccine passports”—accessible certificates confirming covid-19... → https://is.gd/g4dJbc13:11
BrainstormNew from BMJ: What is my covid risk?: In this 10-Minute Consultation by Samuel Finnikin and David Spiegelhalter (BMJ 2021;372:n637, doi:10.1136/bmj.n637), the table of estimated covid-19 mortality wrongly gave a ~1 in 8 chance of dying... → https://is.gd/YO51j113:54
CoronaBot/r/covid19: WHO report into COVID pandemic origins zeroes in on animal markets, not labs (81 votes) | https://www.nature.com/articles/d41586-021-00865-8 | https://redd.it/mhdssw14:00
BrainstormNew from The Indian Express (Health): Fashion: The pandemic has brought a newfound love for Indian crafts and techniques: Designer Monica Shah → https://is.gd/jrNExH14:04
BrainstormNew from BMJ: Covid-19: EMA defends AstraZeneca vaccine as Germany and Canada halt rollouts: The Oxford AstraZeneca covid-19 vaccine is facing a further wave of scepticism and restrictions as Canada and Germany halt its use in younger patients, citing reports of clotting disorders in... → https://is.gd/vrG3I014:15
BrainstormNew from Derek Lowe: @JeffreyGoldberg: RT by @Dereklowe: In which @DKThomp performs a public service: https://www.theatlantic.com/ideas/archive/2021/04/pandemics-wrongest-man/618475/https://is.gd/z7pW9E14:25
CoronaBot/r/covid19: Pfizer and BioNTech Confirm High Efficacy and No Serious Safety Concerns Through Up to Six Months Following Second Dose in Updated Topline Analysis of Landmark COVID-19 Vaccine Study (82 votes) |14:30
CoronaBothttps://investors.pfizer.com/investor-news/press-release-details/2021/Pfizer-and-BioNTech-Confirm-High-Efficacy-and-No-Serious-Safety-Concerns-Through-Up-to-Six-Months-Following-Second-Dose-in-Updated-Topline-Analysis-of-Landmark-COVID-19-Vaccine-Study/default.aspx | https://redd.it/mhspf814:30
BrainstormNew from Emma Hodcroft: @firefoxx66: 🗓️http://CoVariants.org is now updated with data through 1st April (not a joke 🙃)🗓️We've now added a handy feature top-right so you can tell when the site was last updated!I aim to update 2-3 times a week, but (pandemic) life gets in the way sometimes! 😁 → https://is.gd/LRCvFJ14:58
-RSSBot[LjLmatrix- Feed: Concorso a 3 posti di Consigliere di Stato 2020, nomina della Commissione esaminatrice ( http://www.governo.it/it/articolo/concorso-3-posti-di-consigliere-di-stato-2020-nomina-della-commissione-esaminatrice/16531 )15:03
BrainstormNew from NIH Director's blog: Could CRISPR Gene-Editing Technology Be an Answer to Chronic Pain?: Gene editing has shown great promise as a non-heritable way to treat a wide range of conditions, including many genetic diseases and more recently, even COVID-19. But could a version of the CRISPR gene-editing tool also help deliver long-lasting pain [... want %more?] → https://is.gd/VX3a5G15:09
rpifanmp15:21
rpifanno15:21
rpifancrispr is deadly15:21
mobidrop"this completely new technology we discovered a couple of years ago is cool, let's forcibly give it to 100% of the global population"15:25
BrainstormNew from StatNews: Pharma: STAT+: Pharmalittle: 15 million doses of J&J Covid-19 vaccine ruined by ‘human error’; Bristol Myers fights U.S. over a $1.4 billion tax bill → https://is.gd/QPo5D815:30
BrainstormNew from ScienceNews: 4 takeaways from the WHO’s report on the origins of the coronavirus: The leading theory is that the coronavirus spread to people from bats via a yet-to-be-identified animal, but no animals have tested positive so far. → https://is.gd/ZetgO315:51
BrainstormNew from Medical Xpress: Why kids hold the key to herd immunity: To win the battle against the pandemic, kids will be vital. → https://is.gd/gNb7di16:13
BrainstormNew from Shane Crotty: @profshanecrotty: R to @profshanecrotty: No safety concerns, with 12,000 subjects tracked for at least six months after the 2-doses!44,000 subjects totalhttps://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-confirm-high-efficacy-and-no-serioushttps://is.gd/7WdLic16:34
-RSSBot[LjLmatrix- Feed: 2 aprile, Giornata di consapevolezza sull&#39;Autismo ( http://www.governo.it/it/articolo/2-aprile-giornata-di-consapevolezza-sullautismo/16529 )16:43
BrainstormNew from Medical Xpress: Malawi starts vaccination drive with AstraZeneca from COVAX: Malawi is vaccinating health care workers, the elderly and those with health conditions that put them at higher risk of severe COVID-19, using the AstraZeneca doses that arrived early in March. → https://is.gd/9kymmX16:44
BrainstormNew from Medical Xpress: Thailand reduces quarantine, paperwork for vaccinated: Thailand on Thursday began halving the quarantine time for vaccinated visitors as a first step to allowing inoculated people into the country without the need to isolate. → https://is.gd/fEmIZe16:55
BrainstormNew from LitCovid: (news): COVID-19 and ethics: We learn as we go. But where are we going? → https://is.gd/cCzlPM17:06
-RSSBot[LjLmatrix- Feed: Otto per mille dell’Irpef a diretta gestione statale, la Relazione al Parlamento anno 2020 ( http://www.governo.it/it/articolo/otto-mille-dell-irpef-diretta-gestione-statale-la-relazione-al-parlamento-anno-2020/16533 )17:38
BrainstormNew from ClinicalTrials.gov: (news): Vitamin D Supplementarion in Pregnant Women at Risk and COVID-19 → https://is.gd/ndEEud17:59
BrainstormNew from ClinicalTrials.gov: (news): Incidence of Infection Reported by COVID-19 in Attendees of a Commercial Music Concert → https://is.gd/8boATV18:09
BrainstormNew from ClinicalTrials.gov: (news): Evaluation of Inflammatory Cytokines During SARS-CoV2 Infection → https://is.gd/eDzGwP18:19
-RSSBot[LjLmatrix- Feed: Dpcm 24 settembre 2020, ordinanza TAR Lazio 3024/2021 ( http://www.governo.it/it/articolo/dpcm-24-settembre-2020-ordinanza-tar-lazio-30242021/16535 )18:28
BrainstormNew from ProPublica: Barreras falsas: estas cosas no deberían impedirle vacunarse contra COVID-19: por Caroline Chen y Maryam Jameel Read in English. ProPublica es un medio independiente y sin ánimo de lucro que produce periodismo de investigación en pro del interés público. Suscríbete para recibir sus historias en español por correo [... want %more?] → https://is.gd/kAU4no18:30
BrainstormNew from Medical Xpress: New OTC rapid COVID-19 test approved by FDA: (HealthDay)—An over-the-counter rapid COVID-19 test made by Abbott Laboratories has been approved by the U.S. Food and Drug Administration, the company says. → https://is.gd/mCmJbj18:40
-RSSBot[LjLmatrix- Feed: Dpcm 24 settembre 2020, ordinanza TAR Lazio 3026/2021 ( http://www.governo.it/it/articolo/dpcm-24-settembre-2020-ordinanza-tar-lazio-30262021/16537 )18:48
BrainstormNew from WebMD: Some Hospitalized COVID Patients Develop Seizures: Now, a new study says some hospitalized COVID-19 patients have non-convulsive seizures that may increase their risk of death. → https://is.gd/Uo3IcL18:51
LjLde-facto, https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-confirm-high-efficacy-and-no-serious19:10
LjL"In South Africa, where the B.1.351 lineage is prevalent and 800 participants were enrolled, nine cases of COVID-19 were observed, all in the placebo group, indicating vaccine efficacy of 100% (95% CI, [53.5, 100.0]). In an exploratory analysis, the nine strains were sequenced and six of the nine were confirmed to be of the B.1.351 lineage."19:10
LjLsmall numbers, wide confidence interval, but still gives hope for better efficacy than AZ on that variant19:10
-RSSBot[LjLmatrix- Recent Commits to links:master: Add Pfizer press release about follow-up efficacy and safety, and eff… ( https://github.com/ljl-covid/links/commit/7b0ccec76dda2111b36b46b9c9175e808bbf573f )19:19
BrainstormNew from WebMD: COVID: More Cancers Being Diagnosed at Later Stages: Cancer screening rates are beginning to rebound after plummeting during the first year of the coronavirus pandemic, a new survey finds. → https://is.gd/yaAyb619:23
BrainstormNew from WebMD: Poll: 1 in 4 Parents Won't Vaccinate Their Kids Against COVID: More than one-quarter of U.S. parents don't plan to vaccinate their kids for COVID-19, and roughly as many oppose school-required coronavirus shots, a new study finds. → https://is.gd/FRUPRh20:37
CoronaBot/r/coronavirus: Pfizer says Covid-19 vaccine protection lasts at least six months, protects against variants (10133 votes) | https://www.cnn.com/2021/04/01/health/pfizer-covid-vaccine-efficacy-six-months-bn/index.html | https://redd.it/mhsp1v20:38
-RSSBot[LjLmatrix- Recent Commits to links:master: Reword entry about study on B.1.351 plasma and vaccine efficacy reduc… ( https://github.com/ljl-covid/links/commit/88e5d4bd63b724dbcd632a0e17f014cb9c04d9f9 )20:54
-RSSBot[LjLmatrix- Recent Commits to links:master: Add missing link about Novavax ( https://github.com/ljl-covid/links/commit/57a2a3e635e4140ec1bae57fb049216d9f15d337 )20:54
BrainstormNew from StatNews: Resistance from health experts and business owners could doom ‘vaccine passports’ even before they launch: Another roadblock for “vaccine passports”: Many businesses don’t want to enforce them, and even some public health advocates don’t like the precedent they’d set. → https://is.gd/Upv20721:39
BrainstormNew from NPR: Taiwan And Palau Launch Coronavirus Travel Bubble: Palau has seen no COVID-19 cases and Taiwan has kept the virus in check. Taiwan's first tourist flight to Palau during the pandemic era landed Thursday. Travelers do not need to quarantine on arrival. → https://is.gd/tJOCKS22:22
BrainstormNew from Medical Xpress: EU squabbles over 10 million doses of Pfizer vaccine: EU nations fell out Thursday over how to divide up 10 million extra doses of coronavirus vaccine with Austria, Slovenia and the Czech Republic refusing to help five struggling countries. → https://is.gd/QkbZFQ22:44
BrainstormNew from Gazzetta Ufficiale italiana: DECRETO-LEGGE 1 aprile 2021, n.44: Misure urgenti per il  contenimento  dell'epidemia  da  COVID-19,  inmateria di vaccinazioni anti SARS-CoV-2, di giustizia e  di  concorsipubblici. (21G00056) → https://is.gd/xBqTJO23:36
eventcheck[m]%cases france23:57
Brainstormeventcheck[m]: In France, there have been 4.6 million confirmed cases (6.9% of the population) and 95416 deaths (2.1% of cases) as of a day ago. 64.0 million tests were performed (7.2% positive). See https://offloop.net/covid19/?default=France for time series data.23:57

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