libera/##covid-19/ Saturday, 2021-04-03

LjL	sigh	00:00
bin_sh	i wish the us didnt suck so much at tracking variations. idk why we cant get that right	00:00
LjL	unrelated, Brainstorm may bring this up later but anyway https://www.city-journal.org/who-report-on-covid-19-origins-is-an-avalanche-of-misdirection obviously an article with a strong bias, but looks like lots of interesting pointers	00:00
LjL	(also i feel some bias is okay to counterbalance the cringeworthy WHO bias)	00:00
de-facto	.title https://timesofindia.indiatimes.com/city/mumbai/maharashtra-double-mutation-variant-not-linked-to-surge-yet/articleshow/81677389.cms	00:01
Brainstorm	de-facto: From timesofindia.indiatimes.com: Maharashtra: Double mutation variant not linked to surge yet \| Mumbai News - Times of India	00:01
de-facto	"But director of the National Centre for Disease Control Dr Sujit Singh said, so far, no link has been established to say mutations alone have been responsible for the Covid-19 spike in some states. “There are various other reasons behind a surge,” he said."	00:03
de-facto	hmm	00:03
de-facto	yeah and for all those samples they dont tell the period of collecting them, so to me that does not say which of those samples were taken from the current peak	00:05
LjL	"alone" and "yet" are slight giveaways	00:05
Brainstorm	Updates for Banten, Indonesia: +37 deaths (now 107) since 7 months ago — Okinawa, Japan: +204 cases (now 9612), +63 deaths (now 129) since 2 days ago	00:05
de-facto	or even if they were collected equally over time or space	00:05
Brainstorm	New from Shane Crotty: @profshanecrotty: This is an outstanding article explaining clearly our current understanding of symptomless SARS-CoV-2 transmission (pre-symptomatic or asymptomatic). Well done @angie_rasmussen and @SaskiaPopescu ! → https://is.gd/Sjeq7d	00:06
de-facto	E484? probably is something immune escape, and L452R probably both immune escape and stronger receptor binding to hACE2 because its in the s-protein receptor binding motif	00:09
de-facto	.title https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00082-2	00:16
Brainstorm	de-facto: From www.cell.com: Home: Cell Press	00:16
de-facto	"...both E484K and E484Q reduced neutralization by the plasma from subject B (day 26) by 10-fold..."	00:16
de-facto	so probably pretty much as the B.1.351 or P.1 VoCs?	00:17
de-facto	yet they dont say anything about N501Y	00:27
de-facto	dangit why dont they publish a full sequence there	00:27
LjL	de-facto, https://outbreak.info/situation-reports?pango&muts=S%3AE484Q looks like it's been sequenced a bit of everywhere already	00:30
de-facto	interestingly also in CA	00:32
de-facto	are there many indians traveling between CA and India?	00:33
LjL	i dunno, many Indians are in technology sectors, and CA has Silicon Valley	00:33
LjL	de-facto, but i don't think California necessarily has many cases in that table, it doesn't choose the location by amount	00:35
LjL	add India and it'll be many more	00:35
de-facto	yeah indeed	00:35
de-facto	yet its interesting they share those two mutations	00:35
de-facto	E484Q and L452R	00:36
LjL	well the amount sequenced with E484Q is very small though	00:36
LjL	in Cali	00:36
de-facto	yes true	00:38
de-facto	but its always a question if those sequences are representative of any point in time or location or such	00:39
de-facto	i would assume not really as long as they are not sequencing a randomly chosen representative portion of all positive tests and plot that over time	00:40
LjL	not representative, but small is small	00:41
LjL	if anything it's more likely for rare variants to be overrepresented if they're looking for them	00:42
bin_sh	de-facto: did you see moderna put their vaccine on github	00:42
de-facto	indeed like sequencing reinfections or such	00:42
de-facto	moderna themselves or the reversed sequence with incomplete poly A tail?	00:42
de-facto	the later i linked here one hour after it was published there	00:43
de-facto	bin_sh, you mean this? https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273	00:45
bin_sh	de-facto: not sure i saw a headline about it im looking for	00:45
LjL	bin_sh, yes that's a reverse engineered effort. it has Pfizer too not just Moderna	00:46
bin_sh	ah yeah	00:46
bin_sh	i find it hilarious	00:47
bin_sh	that theyre like "we didn't reverse engineer the vaccine"	00:47
bin_sh	but everyone else is referring to it that way	00:47
bin_sh	https://www.vice.com/en/article/7k9gya/stanford-scientists-reverse-engineer-moderna-vaccine-post-code-on-github	00:47
bin_sh	this was the article	00:47
de-facto	yup thats them	00:47
LjL	> The scientists were light on details about how they acquired the Moderna sample. “For this work, RNAs were obtained as discards from the small portions of vaccine doses that remained in vials after immunization; such portions would have been required to be otherwise discarded and were analyzed under FDA authorization for research use,” they said.	00:48
LjL	how is that "light on details"	00:48
LjL	bin_sh, the reason they single out moderna is apparently "On December 25, 2020, PowerDNS founder Bert Hubert used publicly available information about the BioNTech/Pfizer vaccine to figure out its mRNA sequence." (which i didn't know)	00:49
bin_sh	it's light on how exactly they obtained discards of the vaccines	00:49
de-facto	hehe if only they would have allowed to pull 11 doses out of their vials :D	00:49
de-facto	now they will fill them with 15 doses anyhow though	00:49
de-facto	LjL, huh? i linked the word docs here long time ago, even before berts blog came out	00:52
LjL	well i didn't know it was related, or who Bert Hubert is	00:53
de-facto	now we have the old sequence of the moderna vaccine, how about the new one? :D	00:55
LjL	de-facto, did we realize that this guy https://covidvax.org/covid19-vaccine/BharatBiotech-inact is already being deployed in india, although i could only find https://www.medrxiv.org/content/10.1101/2020.12.21.20248643v1 which is phase 2, no phase 3 interim	00:59
de-facto	so there is mRNA-1273 (the current one in use), then they developed mRNA-1273.351 (against B.1.351) https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-it-has-shipped-variant-specific-vaccine and now even mRNA-1283 (normal fridge temp stable) https://investors.modernatx.com/news-releases/news-release-details/first-participants-dosed-phase-1-study-evaluating-mrna-1283	01:00
de-facto	LjL, isnt that pretty similar to the other killed SARS-CoV-2 + Adjuvant mixes (eg. SinoVac et al)?	01:02
LjL	de-facto: dunno, I'm not up to speed with the Chinese ones	01:03
LjL	I'm not entirely sure why we're not even considering good old inactivated vaccines in "the west"	01:03
LjL	Did they really really want to try out mRNA or is there another good reason	01:03
de-facto	i think there were some assumptions that this traditional approach would not yield such high efficacy or such iirc	01:04
de-facto	maybe because they would not make cells reproduce antigen?	01:05
Brainstorm	Updates for Switzerland: +1 deaths (now 10351) since 13 hours ago	01:07
de-facto	LjL, i take all that back, it seems to work differently https://www.bharatbiotech.com/intranasal-vaccine.html	01:08
de-facto	.title https://clinicaltrials.gov/ct2/show/NCT04751682	01:11
Brainstorm	de-facto: From clinicaltrials.gov: Safety and Immunogenicity of an Intranasal SARS-CoV-2 Vaccine (BBV154) for COVID-19 - Full Text View - ClinicalTrials.gov	01:11
LjL	de-facto: that's not the same vaccine	01:11
LjL	I think you're looking at the attenuated one	01:11
LjL	de-facto: well anyway cells only reproduce enough antigen as the amount or mRNA sequences (or S-proteins in the case of Novavax, not sure what happens with adenoviruses in terms of how many S-proteins each can get a cell to produce) there's in it, no?	01:13
de-facto	ah indeed BBV152 and BBV154	01:13
de-facto	LjL, i think only mRNA and viral vector vaccines hijack the cells protein production to annoy the immune system with producing the s-glycoprotein, hence also T-cells to kill that cell	01:15
de-facto	i dont think that inactivated full virions or full s-protein (e.g. on a saponin based adjuvant) can make a cell producing more of that	01:16
de-facto	as those directly would annoy the immune response without a cell "freshly" producing the suspicious alien protein like in a real infection	01:17
Brainstorm	New from BBC Health: (news): Covid-19: Care home residents in England allowed two visitors from 12 April → https://is.gd/ue4uOP	01:18
de-facto	i wonder if anyone tried to sniff adenovirus vector ones like AZ or mRNA ones like BioNTech or Moderna	01:18
de-facto	would that not also be expected to infect the mucus cells similar to a real pathogen challenge situation?	01:19
de-facto	but maybe its not that easy	01:19
de-facto	i just wonder what would happen	01:19
LjL	de-facto, but then, Novavax which is full S-protein turned out to be very effective	01:26
de-facto	i wonder is there a comparison between mRNA and Vector on one side and full antigen (e.g. Novavax) on the other side in terms of antibody to cellular immunity response?	01:29
de-facto	i would guess (speculative!) that pure antigen would more provoke the antibody response while maybe the "recipe" ones also produce a lot of cellular immunity (but maybe thats wrong, i just wonder)	01:31
LjL	i remember someone saying that adenovirus-based ones were expected to rely more on T-cell response	01:37
LjL	not really sure what that idea was based on	01:37
LjL	maybe it was you in which case i'd just be reinforcing this with echo :P	01:37
de-facto	well to me it would make sense that a cells infection with a real virus (even if its replication deficient) could trigger even more immune responses than only presenting the antigen itself	01:45
de-facto	but then i wonder if using an adenovirus and forcing the cell to produce the s-protein antigen would somehow be linked	01:46
de-facto	e.g. what would be the difference in immune response if it was not an infection with an adenovirus vector but with an attenuated real sars-cov-2?	01:47
de-facto	(ok those dont exist yet, still i am curious about the expected differences)	01:47
de-facto	i guess the mRNA ones specifically target the immune response at the s-protein, so it will work very well for that variant, but does such a highly specific response come at the costs that evasion from the s-protein mutating away is more easily achieved than if there also would be antibodies against other parts of the original virus, such as the n-protein etc?	01:50
de-facto	i dont know enough about immunology to know that, but i guess each additional antigen on the outer surface that can be used for an antibody to dock will make it more difficult for the virus to evade with such one or two mutations	01:52
de-facto	actually what i am worried about is the slow speed of vaccinations and now the recent raise in incidence in many parts of the world	01:56
de-facto	both work in favor of breeding new evasive mutants	01:57
LjL	de-facto, one concern i have with "traditional" vaccines in the case of COVID is that if you only use the S-protein, you can track what immunity is due to the vaccine, and what immunity is due to getting the actual virus. this may become important with the variants, to answer the question of whether people are getting reinfected (or infected after getting the vaccine, even if without symptoms maybe)	01:57
LjL	if you use attenuated or inactivated virus, you can't do that	01:57
de-facto	indeed	01:58
de-facto	a infection after immunization with the s-protein only would broaden the immune response to also include antibodies against n-protein etc	01:59
de-facto	but i wonder if that really is helpful because the n-protein is not on the outer surface, hence antibodies against n-protein cant bind prior to infection of a cell to prevent that from happening	02:00
de-facto	s-protein probably really is the best target to put the virus in a tight spot evolutionary because it would have to ensure both 1) evasion from antibody binding while 2) still being able to bind to receptors (eg ACE2 et al)	02:02
LjL	i guess so, although we saw it did manage to evolve in uncomfortable ways anyway	02:02
LjL	maybe we can hope there are not too many ways	02:02
de-facto	yet the evasive variants spread, so if there could be more diversity in the vaccine induced immunization in terms of included versions of possible (and predicted) s-protein mutations the opportunities for evasion might be lowered for the pathogen	02:03
de-facto	yes hopefully there are not too many ways for evasion	02:04
de-facto	yet i wonder how to estimate that number since it not only would depend on point mutations but also on indels and synergetic second order effects	02:05
de-facto	also the s-protein changes its configuration during fusion right?	02:08
Brainstorm	Updates for United Kingdom: +873 cases (now 4.4 million), +13 deaths (now 126898) since 14 hours ago — Canada: +2141 cases (now 992687), +11 deaths (now 23009) since 14 hours ago — Netherlands: +1936 cases (now 1.3 million), +5 deaths (now 16640) since 14 hours ago	02:09
de-facto	LjL, could that mean that the surface binding to ACE2 is "hidden" from antibodies in its prefusion configuration? i am not sure i have the full picture of the molecular dynamics during the fusion process	02:10
de-facto	that would be ingenious from the pathogen to "hide" its precious high efficiency binding surfaces and only expose those when really needed for fusion	02:10
de-facto	but maybe thats not how it works, i dont know that	02:11
de-facto[m]	The problem with such a mechanism might be the decoupling of antigen binding to antibodies from its actual biological purpose to bind to the cells receptors, so maybe that could maximize evasive mutation possibilities from antibodies without paying for that by decreased receptor binding fitness?	02:16
de-facto[m]	Hopefully that is not how s-protein molecular mechanics work	02:17
LjL	i really have no idea	02:18
de-facto[m]	that somehow reminds me on that paper about llama nanobodies triggering the fusion mechanism on the s-protein hence defusing it	02:23
LjL	it almost seems like many of these possible treatments were promising but there was never a real attempt to deploy them	02:24
LjL	maybe production would have been longer and more expensive than vaccines, i dunno	02:24
de-facto[m]	I really hope that decoupling antibody binding from receptor binding by avoiding to share the same surface for those functions is not one of the main functions of the s-protein, because it would mean that immune evasions would be extremely cheap for the virus	02:29
de-facto[m]	E.g. an endless series of evasions without paying too much with fitness	02:31
LjL	i don't know. this virus has shown it has cards on the table. for almost a year everyone seemed convinced "it wasn't mutating much, good". then boom.	02:34
de-facto	it all boils down to stupid humans allowing it to breed mutants	02:36
LjL	de-facto, https://www.reuters.com/article/us-health-coronavirus-germany-astrazenec-idUSKBN2BO6KZ	02:36
de-facto	if we had a much more aggressive containment and replications would be more limited also the probability of variants of concern arising would be much lower	02:36
LjL	%title	02:36
Brainstorm	LjL: From www.reuters.com: German experts say under 60s should not get second AstraZeneca vaccine \| Reuters	02:36
de-facto	yeah	02:37
de-facto	they even say second shot for younger should be mRNA	02:37
de-facto	idk about that since there are no trials i am not a fan of doing things without having proper stats from trials	02:38
LjL	yeah	02:39
LjL	de-facto, but what i'm thinking is if they make such a radical recommendation (and as they admit, without trials backing it), it means they must really be quite concerned about the safety of AZ	02:40
Brainstorm	Updates for San Juan, Dominican Rep.: +3 deaths (now 6) since 8 months ago	02:40
LjL	looks like Covidly is updating all the small places, lol	02:40
LjL	Pfizer/BNT is seeking FDA approval as a non-emergency vaccine now	02:43
najari[m]	why do people who have been fully vaccinated have to wear a mask still?	02:51
rpifan	id have an atenuated or dead virus vaccine	02:55
rpifan	do yall think we will still have lockdowns in the fall?	02:57
LjL	najari[m], because vaccination doesn't equate with full protection, but most importantly because other people around you don't know whether you're vaccinated	02:57
LjL	rpifan, in Europe, i'm afraid so	02:58
LjL	US and UK, probably not	02:58
rpifan	well thats good then	02:58
rpifan	i can travel to the uk and back	02:58
rpifan	lol	02:58
LjL	eh, travel is a different issue	02:58
de-facto	if we dont change our strategy probably we will have to assume it will continue as it is	02:58
najari[m]	thanks	02:59
rpifan	de-facto, do you think the germans will get it together?	02:59
de-facto	maybe if ministers listen to Merkel	02:59
najari[m]	some vaccines are saying like 90% covid prevention rate. For the 10% of ppl who still get sick, will they be less sick then if they had no vaccine?	03:00
de-facto	she is the only one with some sort of sense, the ministers are completely insane	03:00
LjL	najari[m], at this point that seems very likely	03:00
LjL	najari[m], however, those 90%+ protection rates may be lower with variants, for starters	03:00
najari[m]	true	03:00
de-facto	those 10% will breed evasive variants with each replication on cellular level	03:00
de-facto	hence incidence should be brought down by unspecific non pharmaceutical interventions	03:01
LjL	aren't you tired of saying that yet	03:01
najari[m]	does israel have a plan to convince antivaxxers to vax?	03:01
LjL	najari[m], from word of mouth, in israel vaccination is nearly mandatory (i.e. "strongly encouraged" by employers, etc)	03:02
de-facto	im not tired of repeating that as long as we tolerate such insane high incidence scenarios in partly immune populations	03:02
najari[m]	"do it or be fired" sounds mostly effective	03:02
LjL	well with any luck some German government member will land here someday and hear you	03:02
de-facto	btw Israel looks very well now	03:03
LjL	yes, 200 cases a day or so	03:03
najari[m]	prob some antivax protests, but it's literally easier to just vax so i dont think the antivax movement will be too big rn	03:03
CoronaBot	/r/covid19: Moderna Provides Storage Update & Announces the U.S. FDA Authorizes Up To 15-Doses Per Vial of its COVID-19 Vaccine (83 votes) \| https://investors.modernatx.com/news-releases/news-release-details/moderna-provides-storage-update-announces-us-fda-authorizes-15 \| https://redd.it/miolpy	03:03
de-facto	both incidence and fatalities went down a LOT	03:03
LjL	najari[m], polls in the US have steadily gone towards more acceptance of vaccines	03:03
najari[m]	i read tdy US announced vaccinated ppl can travel. Antivaxxers must now be like ":O give me vax now" lmao	03:04
najari[m]	once they announce vaccinated ppl don't have to wear mask, like 90% will vax imo	03:05
de-facto[m]	Yeah and everyone will of course claim to be vaxed	03:08
najari[m]	<de-facto "hence incidence should be brough"> dexamethasome?	03:08
najari[m]	dexamethasone*	03:09
najari[m]	<de-facto[m] "Yeah and everyone will of course"> cool to see u on matrix! it can't be that hard to maintain a database of who has received a vaccine and who hasn't for buying plane/bus/train tickets	03:10
de-facto[m]	distancing, lower contact rates	03:10
najari[m]	anyone have a fav vid on monoclonal antibodies?	03:11
de-facto[m]	Nope but they should be consumed in polyclonal cocktails to prevent evasion	03:13
rpifan	my grandma	03:13
rpifan	is never gonna get vaccinated	03:13
rpifan	she is convinced its a ploy from the global elites	03:13
rpifan	to use us as guinea pigs	03:13
rpifan	she is in fact trying to travel now before they force ppl to get it to travel she says	03:13
najari[m]	will they let her buy tickets?	03:17
rpifan	well atm im struggling wit the consulate to authorize her to come to europe	03:18
rpifan	as i have a surgery and i need to be accompanied	03:18
rpifan	so lets see what they say	03:18
najari[m]	when do you think monoclonal antibodies will be ready for covid use?	03:18
najari[m]	wow mAb sound expensive, I haven't gotten to a section yet that doesn't mention using rat spleens	03:26
najari[m]	or rabbits	03:26
najari[m]	it's not possible to make them without using some other animal?	03:29
snowkitten[m]	You can make them with anything, cows actually from what I remember are the best	03:30
snowkitten[m]	Because they have to be similar enough to humans to work and cows are at least as close as rats or rabbits and they can produce a ton of them	03:31
najari[m]	sorry what I mean is, it's not possible to make them in like bacteria or yeast or something?	03:34
snowkitten[m]	But I think cows are harder to house and care for	03:34
de-facto[m]	They are grown in immortal cell cultures https://en.m.wikipedia.org/wiki/Monoclonal_antibody	03:35
najari[m]	yea I think using mammals would make it quite expensive	03:35
snowkitten[m]	I don’t think so. The antibodies are made in cells that are basically antibody factories. If you wanted to do it in a bacteria or a yeast you would have to import all the machinery to do it, and why do that when you can just use cells from a cow or rabbit that already has all the machinery	03:36
najari[m]	yea I was trying to read that wiki page, too complicated for me	03:36
najari[m]	<snowkitten[m] "I don’t think so. The antibodies"> makes sense, thanks!	03:37
snowkitten[m]	I’m eating at a restaurant right now	03:41
snowkitten[m]	And I’m not wearing my covid diaper	03:42
pwr22	<LjL "i think it should be suspended b"> Isn't it still less dangerous that covid on a population level though?	03:43
LjL	pwr22, i wouldn't say so until we have a clearer picture of the impact. until a few days ago everyone was like "why isn't it happening in the UK?!", and now we have 30 cases in the UK 7 of which died. in Norway, if you take the mortality from COVID in women less than 60 years old, it's pretty much on par with the mortality they had from the vaccine	03:44
najari[m]	<snowkitten[m] "And I’m not wearing my covid dia"> lmao the mask?	03:44
LjL	it seems to be less in bigger countries, but i'm not entirely convinced that isn't due to less strict follow-ups	03:45
snowkitten[m]	Yeah the face diaper	03:45
najari[m]	you could also use a thong as a mask	03:46
najari[m]	LjL: if somebody gets those blood clots, what happens if it doesn't kill them? full recovery in a few days?	03:47
LjL	i don't know, but doubtful	03:48
dTal	probably all kinds of damage	03:48
LjL	you're having clots and hemorrhagies in your brain	03:48
najari[m]	wow, holy!	03:48
LjL	you're going to be lucky if you get out of it without important neurological damage, i'd guess	03:48
snowkitten[m]	And you could use mortality rates that are almost identical to the 2018 flu and use them as justification for forcing a vaccine on people or deciding which is better getting covid or getting the vaccine but then you’d be wasting everyone’s time and creating more social discord and stress than it’s worth	03:49
najari[m]	I low key the blood clot issue was antivax propaganda up until recently	03:49
snowkitten[m]	Blood clots block blood flow. When that happens in your brain it’s called a stroke	03:50
snowkitten[m]	No it usually is not full recovery	03:50
najari[m]	how did the AZ blood clot escape the phase 1, 2, 3, 4 trials? how did nobody notice until a few days ago?	03:51
LjL	snowkitten[m], you're not going to call masks "face diapers" or other stupidly disparging terms like that in this channel	03:52
LjL	najari[m], chiefly because it's rarer than the amount of people they had in trials	03:52
snowkitten[m]	Ooooo censorship. Big surprise	03:52
LjL	snowkitten[m], would you like some more of it?	03:52
snowkitten[m]	I’m sure whatever I say you will not be open minded about it	03:53
LjL	okay, then how about you don't say it and just leave and go talk to some other nutters who think masks are face diapers	03:53
najari[m]	<LjL "najari, chiefly because it's rar"> thanks	03:53
snowkitten[m]	You are chiefly upset that I’m not scared of you	03:53
najari[m]	good call on the ban	03:54
najari[m]	shame, I thought he was just a memer at first	03:54
Brainstorm	Updates for Yemen: +373 cases (now 4620), +34 deaths (now 916) since 2 days ago — Kujawsko-Pomorskie, Poland: +50 deaths (now 50) since 7 months ago — France: +23350 cases (now 4.7 million) since 16 hours ago — Tottori, Japan: +28 cases (now 270) since 2 days ago	04:07
CoronaBot	/r/covid19: Johnson & Johnson Expands Phase 2a Clinical Trial of COVID-19 Vaccine Candidate to Include Adolescents (81 votes) \| https://www.jnj.com/johnson-johnson-expands-phase-2a-clinical-trial-of-covid-19-vaccine-candidate-to-include-adolescents \| https://redd.it/mivpfs	04:27
Brainstorm	Updates for Curacao: +337 cases (now 9171), +4 deaths (now 42) since 17 hours ago	04:38
CoronaBot	/r/covid19: Single-Dose COVID-19 Nasal Vaccine Limits Infection in Monkeys (80 votes) \| https://www.niaid.nih.gov/news-events/covid-19-nasal-vaccine \| https://redd.it/mionp3	04:39
pugusas	Twelve percent of Kansas’ coronavirus tests are coming back positive. Alabama’s positivity rate is 12.8 percent. The rate in Idaho is 27.3 percent, highest in the country. In New York, it’s just 3.5 percent.	04:41
Brainstorm	Updates for Belgium: +3 deaths (now 23048) since 17 hours ago	05:09
Brainstorm	New from r/Coronavirus: Coronavirus: 100 Million Americans Have Received At Least 1 Vaccine Dose → https://is.gd/YEZP4m	05:32
Brainstorm	New from The Indian Express: World: Fully vaccinated people can travel safely again, says CDC guidance → https://is.gd/Vi06sH	05:52
Brainstorm	Updates for Germany: +11425 cases (now 2.9 million) since 19 hours ago	06:29
Brainstorm	New from r/WorldNews: worldnews: Hindu right-wing groups in US got $833,000 of federal COVID fund → https://is.gd/eOwwXI	06:33
Brainstorm	Updates for Callao, Peru: +3458 cases (now 75180), +9 deaths (now 2773) since 6 hours ago — France: +35020 cases (now 4.8 million), +242 deaths (now 96283) since 19 hours ago — Lombardy, Italy: +3941 cases (now 743908), +97 deaths (now 30959) since 19 hours ago — Netherlands: +5661 cases (now 1.3 million), +14 deaths (now 16649) since 19 hours ago	07:00
Brainstorm	New from The Indian Express: World: Iraq judge who presided over Saddam’s trial dies of COVID-19 → https://is.gd/3T87Hj	07:25
Brainstorm	Updates for British Virgin Islands, United Kingdom: +13 cases (now 166) since a month ago — Tver, Russia: +97 cases (now 42408), +3 deaths (now 890) since 4 hours ago — Tyumen, Russia: +54 cases (now 40216), +6 deaths (now 431) since 4 hours ago — Ryazan, Russia: +52 cases (now 32940), +6 deaths (now 406) since 4 hours ago	08:33
Brainstorm	New from The Indian Express: World: Germany: Lockdown plus home-working equals bad 2020 for burglars → https://is.gd/LnVWv5	08:36
Brainstorm	Updates for Ulyanovsk, Russia: +99 cases (now 51021), +8 deaths (now 985) since 8 hours ago — Arkhangelsk, Russia: +82 cases (now 59852), +2 deaths (now 829) since 8 hours ago	09:04
Brainstorm	New from r/Coronavirus: Daily Discussion Thread \| April 03, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/9X9MI2	09:07
Brainstorm	New from The Indian Express: World: UK regulator found total of 30 cases of blood clot events after AstraZeneca vaccine use → https://is.gd/OH8AVs	09:48
finely[m]	<najari[m] "how did the AZ blood clot escape"> If I remember correctly, some of the trial phases were skipped/combined because the vaccines were so urgently needed. And its a very rare reaction, if it is indeed a vaccine reaction. So the odds are heavily in favour if still getting the vaccine if you are in a country with the virus circulating.	10:03
finely[m]	<najari[m] "LjL: if somebody gets those bloo"> There is speculation traditional anticoagulant drugs could make this condition worse. If it isnt treated with heparin (or the other one), then you recover quickly. Still very early days in terms of evidence and understanding of what's going on. The podcast Coronacast had good info on this a few times last week.	10:09
finely[m]	<najari[m] "why do people who have been full"> We are not sure how good the vaccines are at stopping you getting COVID19 and spreading it to others. They are very good at stopping you from getting severe COVID19 and potentially dying.	10:13
Brainstorm	New from r/WorldNews: worldnews: Australia to continue AstraZeneca vaccination despite blood clotting case → https://is.gd/IrALtA	11:10
Brainstorm	New from Medical Xpress: California to allow indoor gatherings as virus cases plummet: California on Friday cleared the way for people to attend indoor concerts, theater performances and NBA games for the first time in more than a year as the rate of people testing positive for the coronavirus in the state nears a record low. → https://is.gd/jhnt8l	12:11
Brainstorm	New from Medical Xpress: Latin America passes 25 million coronavirus infections: Latin America and the Caribbean passed the 25 million mark Friday for recorded coronavirus cases as a surge in infections saw countries place restrictions on travel and movement while vaccine campaigns catch up. → https://is.gd/8SjvQf	12:21
Brainstorm	New from The Indian Express: World: Bangladesh to impose 7-day nationwide lockdown amid spike in Covid-19 cases → https://is.gd/oW9HCC	13:01
finely[m]	* If I remember correctly, some of the trial phases were skipped/combined because the vaccines were so urgently needed. And its a very rare reaction, if it is indeed a vaccine reaction. So the odds are heavily in favour of still getting the vaccine if you are in a country with the virus circulating.	13:27
Brainstorm	New from Politico: Coronavirus: German president warns of pandemic ‘crisis of trust’ → https://is.gd/CsnWA5	13:32
darsie	Germany has a president?	13:33
darsie	yes	13:33
CoronaBot	/r/covid19: A realistic touch-transfer method reveals low risk of transmission for SARS-CoV-2 by contaminated coins and bank notes (81 votes) \| https://www.biorxiv.org/content/10.1101/2021.04.02.438182v1 \| https://redd.it/miunyy	13:37
Brainstorm	New from Gazzetta Ufficiale italiana: MINISTERO DELLA SALUTE - ORDINANZA 2 aprile 2021: Ulteriori misure urgenti in materia di contenimento e gestionedell'emergenza epidemiologica da COVID-19. (21A02151) → https://is.gd/inMr4k	14:23
Brainstorm	Updates for Loja, Ecuador: +42 deaths (now 107) since 7 months ago	15:16
Brainstorm	New from The Indian Express: World: Germany faces “crisis of trust” in pandemic, president says → https://is.gd/2NDDp6	15:25
rpifan	loja?	15:31
rpifan	thats a bit random	15:31
rpifan	darsie, yes but he is not a real thing	15:31
rpifan	he is only a figurehead	15:32
darsie	Like in Austria.	15:34
darsie	Heinz Fischer has rejected a minister.	15:34
rpifan	well basically the job of president used to be the kaiser	15:37
rpifan	and when they got rid of him they had to create something to fill it	15:37
rpifan	ah apparently the last austrian kaiser was charles 2	15:38
darsie	Franz Joseph	15:49
rpifan	Charles succeeded to the thrones in November 1916 following the death of Franz Joseph	15:55
stupidfox	%cases USA	16:41
Brainstorm	stupidfox: In United States, there have been 30.9 million confirmed cases (9.4% of the population) and 560411 deaths (1.8% of cases) as of an hour ago. 408.7 million tests were performed (7.6% positive). Fatality can be broadly expected to lie between 2.2% (assuming prevalence as in tests) and less than 2.3% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=United%20States for time series data.	16:41
Brainstorm	New from This Week In Virology: TWiV 738: COVID-19 clinical update #56 with Dr. Daniel Griffin: In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world [... want %more?] → https://is.gd/aQczyF	16:47
Brainstorm	New from The Indian Express: World: 7 blood clot deaths after 18.1mn jabs, AstraZeneca vaccine safe: UK regulator → https://is.gd/dTfBp2	17:08
Brainstorm	New from Reddit (test): Saturday 03 April 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://is.gd/w2ovgV	17:29
LjL	Brainstorm: New from r/WorldNews: worldnews: Netherlands temporarily halts AstraZeneca COVID vaccinations \| Coronavirus pandemic News → https://is.gd/g4GV0c	17:36
Brainstorm	New from r/WorldNews: worldnews: Belgium must lift 'all Covid-19 measures' within 30 days, Brussels court rules → https://is.gd/HN1ga6	17:39
Brainstorm	Updates for Canada: +5247 cases (now 995793), +26 deaths (now 23027) since 23 hours ago — Netherlands: +5198 cases (now 1.3 million) since 18 hours ago — Germany: +10439 cases (now 2.9 million) since 23 hours ago — United Kingdom: +2458 cases (now 4.4 million) since 15 hours ago	17:57
Brainstorm	New from Reddit (test): CoronaVirus_2019_nCoV: Millennials to be offered single-shot Johnson & Johnson Covid vaccine to ‘jab and go’ → https://is.gd/MSKVq8	18:51
rpifan	hm	20:04
Brainstorm	New from r/WorldNews: worldnews: Ontario reports 6,098 new COVID-19 cases and 39 new deaths over past 2 days → https://is.gd/82ORUk	20:04
Brainstorm	Updates for Kursk, Russia: +4 deaths (now 583) since 16 hours ago — Italy: +21247 cases (now 3.7 million), +376 deaths (now 110704) since a day ago — Tver, Russia: +3 deaths (now 890) since 16 hours ago — Astrakhan, Russia: +2 deaths (now 724) since 16 hours ago	20:38
Quant1	.theo	20:43
Quant1	.whois	21:02
CoronaBot_	/r/covid19: CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants (84 votes) \| https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab143/6189113 \| https://redd.it/mjb79p	21:10
Brainstorm	Updates for Netherlands: +5213 cases (now 1.3 million) since 22 hours ago	21:28
Brainstorm	New from r/Coronavirus: Coronavirus: Dolly Parton got her second dose of the Covid-19 vaccine → https://is.gd/vCRv7s	21:47
Brainstorm	New from r/WorldNews: worldnews: COVID-19: Police shut down Good Friday church service and threaten worshippers with fines → https://is.gd/E2nmsv	21:57
CoronaBot_	/r/coronavirus: More extroverted people suffered mood declines while more introverted people actually saw mood improvements during the COVID-19 pandemic, finds a new study of students at a US university. (10096 votes) \| https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248895 \| https://redd.it/mj89m1	22:59
Brainstorm	New from Medical Xpress: Italy enters 3-day Easter lockdown amid vaccination snags: Italy entered a three-day nationwide coronavirus lockdown Saturday to deter Easter travel and get-togethers even as the country's variant-fueled spike in new infections began to wane. → https://is.gd/yCPnFj	23:09
rpifan	nice	23:09
rpifan	lol that acutally explains it	23:09
rpifan	in general im introverted	23:09
rpifan	and ive enjoyed the lockdown	23:10
rpifan	lol	23:10
rpifan	i dont wnat it to end	23:10
LjL	i'm introverted too, but that's a bit weird	23:19
Brainstorm	New from Medical Xpress: Five things to know about the AstraZeneca/Oxford vaccine: Cheap and easy to store, the Oxford-AstraZeneca vaccine has boosted the global fight against coronavirus but fears over cases of rare blood clots and production delays have marred its rollout. → https://is.gd/yb4x7J	23:19
Brainstorm	Updates for Moscow Oblast, Russia: +12 deaths (now 5467) since 20 hours ago — Canada: +4840 cases (now 997070), +24 deaths (now 23031) since 23 hours ago	23:32

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